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Journal Articles

Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma

Jennifer Totman, Dorothy Brach, Vinny Motwani, Selene Howe, Emily Deutschman, John Lampe, Thomas V. Riera, Cuyue Tang, Sean T. Eckley, Josh Alford, Kenneth W. Duncan, Neil A. Farrow, Daniel T. Dransfield, Alejandra Raimondi, Michael J. Thomeius, Kat Cosmopoulos, Jeffery L Kutok

Blood (2021) 138 (Supplement 1): 1142.

https://doi.org/10.1182/blood-2021-151147

Published: 2021

Journal Articles

Dual Inhibition of PI3K-Delta and Gamma By Duvelisib (IPI-145) Impairs CLL B- and T-Cell Migration, Survival and Proliferation in a Murine Xenograft Model Using Primary Chronic Lymphocytic Leukemia Cells

Shih-Shih Chen, PhD, Steven Ham, Kanti R. Rai, MD, Karen McGovern, PhD, Jeffery L. Kutok, MD PhD, Nicholas Chiorazzi, MD

Blood (2015) 126 (23): 1753.

https://doi.org/10.1182/blood.V126.23.1753.1753

Published: 2015

Journal Articles

Duvelisib (IPI-145) Inhibits Malignant B-Cell Proliferation and Disrupts Signaling from the Tumor Microenvironment through Mechanisms That Are Dependent on PI3K-δ and PI3K-γ

Marisa Peluso, MS, Kerrie Faia, MS, David Winkler, PhD, Nidhi Patel, MS, Erin Brophy, BS, Kerry White, BA, Mark Douglas, MS, Howard M. Stern, MD PhD, Vito Palombella, PhD, Karen McGovern, PhD, Jeffery L. Kutok, MD PhD

Blood (2014) 124 (21): 328.

https://doi.org/10.1182/blood.V124.21.328.328

Published: 2014

Journal Articles

The Potent PI3K-δ,γ Inhibitor, IPI-145, Exhibits Preclinical Activity In Murine and Human T-Cell Acute Lymphoblastic Leukemia

Xiaoyan Huang, MD., MSc, Jennifer Proctor, B.S., Yaling Yang, PhD, Xiuhua Gao, MD, PhD, Weihong Zhang, M.D., Shenjiao Huang, MD, PhD, Paul Changelian, PhD, Jeffery L. Kutok, MD, PhD, Karen McGovern, PhD, M. James You, MD, PhD

Blood (2013) 122 (21): 1438.

https://doi.org/10.1182/blood.V122.21.1438.1438

Published: 2013

Journal Articles

The Potent PI3K-δ,γ Inhibitor IPI-145 Exhibits Differential Activity In Diffuse Large B-Cell Lymphoma (DLBCL) Cell Lines

Veronica Campbell, BS, Ryan Thompson, PhD, Vivian Villegas, MS, Jennifer Proctor, B.S., Karen McGovern, PhD, Jeffery L. Kutok, MD, PhD, Howard M. Stern, M.D., Ph.D.

Blood (2013) 122 (21): 1832.

https://doi.org/10.1182/blood.V122.21.1832.1832

Published: 2013

Journal Articles

Evidence That Activated Hedgehog Signaling Predicts for Poor Clinical Outcome in Acute Myeloid Leukemia

Veronica Campbell, BS, Eleni Tholouli, MD, PhD, M. Travis Quigley, MS, John Keilty, MS, Patrick Kelly, MD, Karen McGovern, PhD, Margaret Read, PhD, Jeffery L. Kutok, MD, PhD, Richard Byers, PhD, MBChB

Blood (2012) 120 (21): 1441.

https://doi.org/10.1182/blood.V120.21.1441.1441

Published: 2012

Journal Articles

ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia

Julie Rousseau, Vincent Gagné, Malgorzata Labuda, Cyrielle Beaubois, Daniel Sinnett, Caroline Laverdière, Albert Moghrabi, Stephen E. Sallan, Lewis B. Silverman, Donna Neuberg, Jeffery L. Kutok, Maja Krajinovic

Blood (2011) 118 (22): 5883–5890.

https://doi.org/10.1182/blood-2011-05-355560

Published: 2011

Includes: Supplemental data

Journal Articles

MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia

Richard J. Byers, Treeve Currie, Eleni Tholouli, Scott J. Rodig, Jeffery L. Kutok

Blood (2011) 118 (10): 2857–2867.

https://doi.org/10.1182/blood-2011-04-346767

Published: 2011

Includes: Supplemental data

Journal Articles

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Gordon Chan, Laurene S. Cheung, Wentian Yang, Michael Milyavsky, Ashley D. Sanders, Shengqing Gu, Wan Xing Hong, Aurora X. Liu, Xiaonan Wang, Mary Barbara, Tarun Sharma, Joehleen Gavin, Jeffery L. Kutok, Norman N. Iscove, Kevin M. Shannon, John E. Dick, Benjamin G. Neel, Benjamin S. Braun

Blood (2011) 117 (16): 4253–4261.

https://doi.org/10.1182/blood-2010-11-319517

Published: 2011

Includes: Supplemental data

Journal Articles

Viral induction and targeted inhibition of galectin-1 in EBV + posttransplant lymphoproliferative disorders

Jing Ouyang, Przemyslaw Juszczynski, Scott J. Rodig, Michael R. Green, Evan O'Donnell, Treeve Currie, Myriam Armant, Kunihiko Takeyama, Stefano Monti, Gabriel A. Rabinovich, Jerome Ritz, Jeffery L. Kutok, Margaret A. Shipp

Blood (2011) 117 (16): 4315–4322.

https://doi.org/10.1182/blood-2010-11-320481

Published: 2011

Includes: Supplemental data

Journal Articles

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

Shilpee Dutt, Anupama Narla, Katherine Lin, Ann Mullally, Nirmalee Abayasekara, Christine Megerdichian, Frederick H. Wilson, Treeve Currie, Arati Khanna-Gupta, Nancy Berliner, Jeffery L. Kutok, Benjamin L. Ebert

Blood (2011) 117 (9): 2567–2576.

https://doi.org/10.1182/blood-2010-07-295238

Published: 2011

Includes: Supplemental data

Journal Articles

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma

Michael R. Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd R. Golub, Jeffery L. Kutok, Margaret A. Shipp

Blood (2010) 116 (17): 3268–3277.

https://doi.org/10.1182/blood-2010-05-282780

Published: 2010

Includes: Supplemental data

Journal Articles

Elevated IL-17 produced by Th17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma

Rao H. Prabhala, Dheeraj Pelluru, Mariateresa Fulciniti, Harsha K. Prabhala, Puru Nanjappa, Weihua Song, Christine Pai, Samir Amin, Yu-Tzu Tai, Paul G. Richardson, Irene M. Ghobrial, Steven P. Treon, John F. Daley, Kenneth C. Anderson, Jeffery L. Kutok, Nikhil C. Munshi

Blood (2010) 115 (26): 5385–5392.

https://doi.org/10.1182/blood-2009-10-246660

Published: 2010

Journal Articles

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

Ke Cheng, Paolo Sportoletti, Keisuke Ito, John G. Clohessy, Julie Teruya-Feldstein, Jeffery L. Kutok, Pier Paolo Pandolfi

Blood (2010) 115 (16): 3341–3345.

https://doi.org/10.1182/blood-2009-03-208587

Published: 2010

Includes: Supplemental data

Journal Articles

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

Gordon Chan, Demetrios Kalaitzidis, Tatiana Usenko, Jeffery L. Kutok, Wentian Yang, M. Golam Mohi, Benjamin G. Neel

Blood (2009) 113 (18): 4414–4424.

https://doi.org/10.1182/blood-2008-10-182626

Published: 2009

Includes: Supplemental data

Journal Articles

Selective Expression of the Immunoregulatory Lectin, Galectin-1, in Precursor B Cell Acute Lymphoblastic Leukemias (ALLs) with MLL Rearrangements

Przemyslaw Juszczynski, MD, PhD, Scott J. Rodig, MD, PhD, Kunihiko Takeyama, MD, PhD, Jing Ouyang, PhD, Jorg Faber, MD, PhD, Scott Armstrong, MD, PhD, Jeffery L. Kutok, MD, PhD, Margaret A. Shipp, MD

Blood (2008) 112 (11): 2539.

https://doi.org/10.1182/blood.V112.11.2539.2539

Published: 2008

Journal Articles

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

Linfeng Chen, Stefano Monti, Przemyslaw Juszczynski, John Daley, Wen Chen, Thomas E. Witzig, Thomas M. Habermann, Jeffery L. Kutok, Margaret A. Shipp

Blood (2008) 111 (4): 2230–2237.

https://doi.org/10.1182/blood-2007-07-100115

Published: 2008

Includes: Supplemental data

Journal Articles

Wilms Tumor 1 Gene (WT1) Isoforms in Leukemia and Lymphoma.

Aihong Li, MD, PhD, Ulla-Britt Westman, BMA, Irina Golovleva, PhD, Jeffery L. Kutok, MD, PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Goran Roos, MD, PhD

Blood (2007) 110 (11): 4265.

https://doi.org/10.1182/blood.V110.11.4265.4265

Published: 2007

Journal Articles

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

Tanyel Kiziltepe, Teru Hideshima, Kenji Ishitsuka, Enrique M. Ocio, Noopur Raje, Laurence Catley, Chun-Qi Li, Laura J. Trudel, Hiroshi Yasui, Sonia Vallet, Jeffery L. Kutok, Dharminder Chauhan, Constantine S. Mitsiades, Joseph E. Saavedra, Gerald N. Wogan, Larry K. Keefer, Paul J. Shami, Kenneth C. Anderson

Blood (2007) 110 (2): 709–718.

https://doi.org/10.1182/blood-2006-10-052845

Published: 2007

Includes: Supplemental data

Journal Articles

Tonic B-Cell Receptor Signaling Promotes the Survival of Diffuse Large B-Cell Lymphomas: Identification of SYK as a Rational Treatment Target.

Linfeng Chen, PhD, Przemyslaw Juszczynski, M.D., Ph.D., Yasumichi Hitoshi, Ph.D., Wen Chen, M.D., Jeffery L. Kutok, M.D., Margaret A. Shipp, M.D.

Blood (2006) 108 (11): 226.

https://doi.org/10.1182/blood.V108.11.226.226

Published: 2006

NARROW

Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma

Dual Inhibition of PI3K-Delta and Gamma By Duvelisib (IPI-145) Impairs CLL B- and T-Cell Migration, Survival and Proliferation in a Murine Xenograft Model Using Primary Chronic Lymphocytic Leukemia Cells

Duvelisib (IPI-145) Inhibits Malignant B-Cell Proliferation and Disrupts Signaling from the Tumor Microenvironment through Mechanisms That Are Dependent on PI3K-δ and PI3K-γ

The Potent PI3K-δ,γ Inhibitor, IPI-145, Exhibits Preclinical Activity In Murine and Human T-Cell Acute Lymphoblastic Leukemia

The Potent PI3K-δ,γ Inhibitor IPI-145 Exhibits Differential Activity In Diffuse Large B-Cell Lymphoma (DLBCL) Cell Lines

Evidence That Activated Hedgehog Signaling Predicts for Poor Clinical Outcome in Acute Myeloid Leukemia

ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia

MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Viral induction and targeted inhibition of galectin-1 in EBV + posttransplant lymphoproliferative disorders

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma

Elevated IL-17 produced by Th17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

Selective Expression of the Immunoregulatory Lectin, Galectin-1, in Precursor B Cell Acute Lymphoblastic Leukemias (ALLs) with MLL Rearrangements

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

Wilms Tumor 1 Gene (WT1) Isoforms in Leukemia and Lymphoma.

JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

Tonic B-Cell Receptor Signaling Promotes the Survival of Diffuse Large B-Cell Lymphomas: Identification of SYK as a Rational Treatment Target.

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American Society of Hematology

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American Society of Hematology

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