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Journal Articles

Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL

Kamil Bojarczuk, Kirsty Wienand, Jeremy A. Ryan, Linfeng Chen, Mariana Villalobos-Ortiz, Elisa Mandato, Joanna Stachura, Anthony Letai, Lee N. Lawton, Bjoern Chapuy, Margaret A. Shipp
Journal: Blood
Blood (2019) 133 (1): 70–80.
https://doi.org/10.1182/blood-2018-08-872465
Published: 2019
Includes: Supplemental data
Journal Articles

Targeted Inhibition of PI3K α/δ Is Synergistic with BCL-2 Blockade in Genetically Defined Subtypes of DLBCL

Kamil Bojarczuk, PhD, Kirsty Wienand, PhD, Jeremy A. Ryan, SM, Linfeng Chen, PhD, Mariana Villalobos-Ortiz, Elisa Mandato, PhD, Joanna Stachura, MSc, Lee N. Lawton, PhD, Anthony Letai, MD PhD, Bjoern Chapuy, MDPhD, Margaret A. Shipp, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 39.
https://doi.org/10.1182/blood-2018-99-113647
Published: 2018
Journal Articles

Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease

Bjoern Chapuy, Hongwei Cheng, Akira Watahiki, Matthew D. Ducar, Yuxiang Tan, Linfeng Chen, Margaretha G. M. Roemer, Jing Ouyang, Amanda L. Christie, Liye Zhang, Daniel Gusenleitner, Ryan P. Abo, Pedro Farinha, Frederike von Bonin, Aaron R. Thorner, Heather H. Sun, Randy D. Gascoyne, Geraldine S. Pinkus, Paul van Hummelen, Gerald G. Wulf, Jon C. Aster, David M. Weinstock, Stefano Monti, Scott J. Rodig, Yuzhuo Wang, Margaret A. Shipp
Journal: Blood
Blood (2016) 127 (18): 2203–2213.
https://doi.org/10.1182/blood-2015-09-672352
Published: 2016
Includes: Supplemental data
Journal Articles

Diffuse Large B-Cell Lymphoma Patient-Derived Xenograft Models Capture Molecular and Biologic Heterogeneity and Inform Therapy

Bjoern Chapuy, MDPhD, Honwei Cheng, MDPhD, Akira Watahiki, MDPhD, Matthew D Ducar, PhD, Daniel Gusenleitner, MS, Linfeng Chen, PhD, Margaretha GM Roemer, MS, Jing Quyang, PhD, Amanda L Christie, B.S., Liye Zhang, PhD, Yuxiang Tan, Ryan P Abo, PhD, Frederike Bonin, Aaron R Thorner, PhD, Heather H. Sun, Geraldine S Pinkus, MD, Paul van Hummelen, PhD, Gerald G Wulf, MD, Jon C Aster, MDPhD, David M Weinstock, MD, Stefano Monti, PhD, Scott J Rodig, MD PhD, Yuzhuo Wang, PhD, Margaret A. Shipp, MD
Journal: Blood
Blood (2015) 126 (23): 817.
https://doi.org/10.1182/blood.V126.23.817.817
Published: 2015
Journal Articles

CXCR4 Upregulation Is a Biomarker Of Sensitivity To Targeted Inhibition Of B-Cell Receptor Signaling In Diffuse Large B-Cell Lymphoma

Linfeng Chen, PhD, Yansheng Hao, MD, PhD, Jing Ouyang, PhD, Bjoern Chapuy, MD, PhD, Donna S. Neuberg, ScD, Thomas M Habermann, MD, Przemyslaw Juszczynski, MD, PhD, Scott J Rodig, MD, PhD, Stefano Monti, PhD, Margaret A Shipp, MD
Journal: Blood
Blood (2013) 122 (21): 631.
https://doi.org/10.1182/blood.V122.21.631.631
Published: 2013
Journal Articles

BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt

Przemyslaw Juszczynski, Linfeng Chen, Evan O'Donnell, Jose M. Polo, Stella M. Ranuncolo, Riccardo Dalla-Favera, Ari Melnick, Margaret A. Shipp
Journal: Blood
Blood (2009) 114 (26): 5315–5321.
https://doi.org/10.1182/blood-2009-02-204362
Published: 2009
Includes: Supplemental data
Journal Articles

BCL6 Regulates Tonic BCR Signaling in Diffuse Large B-Cell Lymphomas by Repressing the SYK Phosphatase, PTPROt

Przemyslaw JuszczynsKi, Linfeng Chen, Jose M. Polo, Stella M. Ranuncolo, Riccardo Dalla-Favera, Ari Melnick, Margaret A. Shipp
Journal: Blood
Blood (2008) 112 (11): 802.
https://doi.org/10.1182/blood.V112.11.802.802
Published: 2008
Journal Articles

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

Linfeng Chen, Stefano Monti, Przemyslaw Juszczynski, John Daley, Wen Chen, Thomas E. Witzig, Thomas M. Habermann, Jeffery L. Kutok, Margaret A. Shipp
Journal: Blood
Blood (2008) 111 (4): 2230–2237.
https://doi.org/10.1182/blood-2007-07-100115
Published: 2008
Includes: Supplemental data
Journal Articles

Tonic B-Cell Receptor Signaling Promotes the Survival of Diffuse Large B-Cell Lymphomas: Identification of SYK as a Rational Treatment Target.

Linfeng Chen, PhD, Przemyslaw Juszczynski, M.D., Ph.D., Yasumichi Hitoshi, Ph.D., Wen Chen, M.D., Jeffery L. Kutok, M.D., Margaret A. Shipp, M.D.
Journal: Blood
Blood (2006) 108 (11): 226.
https://doi.org/10.1182/blood.V108.11.226.226
Published: 2006
Journal Articles

Protein Tyrosine Phosphatase Receptor-Type O Truncated (PTPROT) Regulates SYK Phosphorylation, Proximal B-Cell Receptor Signaling and Cellular Proliferation.

Linfeng Chen, PhD, Przemyslaw Juszczynski, M.D., Ph.D., Kunihiko Takeyama, M.D., Ph.D., Ricardo C.T. Aguiar, M.D., Ph.D., Margaret A. Shipp, M.D.
Journal: Blood
Blood (2006) 108 (11): 933.
https://doi.org/10.1182/blood.V108.11.933.933
Published: 2006
Journal Articles

Protein tyrosine phosphatase receptor–type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell–receptor signaling, and cellular proliferation

Linfeng Chen, Przemyslaw Juszczynski, Kunihiko Takeyama, Ricardo C. T. Aguiar, Margaret A. Shipp
Journal: Blood
Blood (2006) 108 (10): 3428–3433.
https://doi.org/10.1182/blood-2006-03-013821
Published: 2006