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Journal Articles

Vitamin C Enhances PARPi Efficacy for the Treatment of AML

John P Brabson, Tiffany Leesang, Byron Fang, Jingjing Wang, Victoria Strippoli, Yoon-Sing Yap, Sofia Mohammad, Carolina Bañuelos, Peter Lyon, Sana Chaudhry, Minh Lam, Benjamin G Neel, Stephen Nimer, Ramiro E Verdun, Daniel Bilbao, Maria E. Figueroa, Luisa Cimmino

Blood (2021) 138 (Supplement 1): 1168.

https://doi.org/10.1182/blood-2021-153884

Published: 2021

Journal Articles

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions

Marie Bellio, Cédric Garcia, Thomas Edouard, Sophie Voisin, Benjamin G. Neel, Cendrine Cabou, Philippe Valet, Jun Mori, Alexandra Mazharian, Yotis A. Senis, Armelle Yart, Bernard Payrastre, Sonia Severin

Blood (2019) 134 (25): 2304–2317.

https://doi.org/10.1182/blood.2019001543

Published: 2019

Includes: Supplemental data

Journal Articles

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

Zoltan Nagy, Timo Vögtle, Mitchell J. Geer, Jun Mori, Silke Heising, Giada Di Nunzio, Ralph Gareus, Alexander Tarakhovsky, Arthur Weiss, Benjamin G. Neel, Guillaume E. Desanti, Alexandra Mazharian, Yotis A. Senis

Blood (2019) 133 (4): 331–343.

https://doi.org/10.1182/blood-2018-09-877787

Published: 2019

Includes: Supplemental data

Journal Articles

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

Shengqing Gu, Wayne W. Chan, Golam Mohi, Joel Rosenbaum, Azin Sayad, Zhibin Lu, Carl Virtanen, Shaoguang Li, Benjamin G. Neel, Richard A. Van Etten

Blood (2016) 127 (14): 1803–1813.

https://doi.org/10.1182/blood-2015-06-653006

Published: 2016

Includes: Supplemental data

Journal Articles

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Charles B Goodwin, Xing Jun Li, Raghuveer S. Mali, Gordon Chan, Michelle Kang, Ziyue Liu, Bart Vanhaesebroeck, Benjamin G. Neel, Mignon L. Loh, Brian J. Lannutti, Reuben Kapur, Rebecca J. Chan

Blood (2014) 123 (18): 2838–2842.

https://doi.org/10.1182/blood-2013-10-535104

Published: 2014

Journal Articles

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Alexandra Mazharian, Jun Mori, Ying-Jie Wang, Silke Heising, Benjamin G. Neel, Steve P. Watson, Yotis A. Senis

Blood (2013) 121 (20): 4205–4220.

https://doi.org/10.1182/blood-2012-08-449272

Published: 2013

Includes: Multimedia, Supplemental data

Journal Articles

Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis

Gordon Chan, Shengqing Gu, Benjamin G. Neel

Blood (2013) 121 (18): 3594–3598.

https://doi.org/10.1182/blood-2012-12-476200

Published: 2013

Includes: Supplemental data

Journal Articles

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

Muneyoshi Futami, Quan-sheng Zhu, Zakary L. Whichard, Ling Xia, Yuehai Ke, Benjamin G. Neel, Gen-Sheng Feng, Seth J. Corey

Blood (2011) 118 (4): 1077–1086.

https://doi.org/10.1182/blood-2009-12-261636

Published: 2011

Journal Articles

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

Gordon Chan, Laurene S. Cheung, Wentian Yang, Michael Milyavsky, Ashley D. Sanders, Shengqing Gu, Wan Xing Hong, Aurora X. Liu, Xiaonan Wang, Mary Barbara, Tarun Sharma, Joehleen Gavin, Jeffery L. Kutok, Norman N. Iscove, Kevin M. Shannon, John E. Dick, Benjamin G. Neel, Benjamin S. Braun

Blood (2011) 117 (16): 4253–4261.

https://doi.org/10.1182/blood-2010-11-319517

Published: 2011

Includes: Supplemental data

Journal Articles

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Dan Xu, Siying Wang, Wen-Mei Yu, Gordon Chan, Toshiyuki Araki, Kevin D. Bunting, Benjamin G. Neel, Cheng-Kui Qu

Blood (2010) 116 (18): 3611–3621.

https://doi.org/10.1182/blood-2010-01-265652

Published: 2010

Includes: Supplemental data

Journal Articles

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

Gordon Chan, Demetrios Kalaitzidis, Tatiana Usenko, Jeffery L. Kutok, Wentian Yang, M. Golam Mohi, Benjamin G. Neel

Blood (2009) 113 (18): 4414–4424.

https://doi.org/10.1182/blood-2008-10-182626

Published: 2009

Includes: Supplemental data

Journal Articles

A Noncatalytic, Ras-Independent Function of SHP-2 Is Essential in Hematopoietic Progenitors.

Benjamin S. Braun, MD, PhD, Laurene S. Cheung, Gordon G. Chan, PhD, Wentian A. Yang, PhD, Joehleen A. Archard, Benjamin G. Neel, MD, PhD, Kevin Shannon, MD

Blood (2007) 110 (11): 85.

https://doi.org/10.1182/blood.V110.11.85.85

Published: 2007

Journal Articles

Activating Shp2 Mutations Cause Progressive Myeloproliferative Disorder in Mice.

M. Golam Mohi, PhD, Gordon Chan, Ph.D, Toshiyuki Araki, Ph.D., Wentien Yang, Ph.D., Lily Pao, Ph.D., Demetrios Kalaitzidis, Ph.D., Benjamin G. Neel, M.D., Ph.D.

Blood (2006) 108 (11): 3614.

https://doi.org/10.1182/blood.V108.11.3614.3614

Published: 2006

Journal Articles

Myelopoiesis Requires a Noncatalytic, Ras-Independent Function of SHP-2.

Benjamin S. Braun, MD, PhD, Joehleen A. Archard, Wentian Yang, PhD, Gordon Chan, PhD, Benjamin G. Neel, MD, PhD, Kevin Shannon, MD

Blood (2006) 108 (11): 635.

https://doi.org/10.1182/blood.V108.11.635.635

Published: 2006

Journal Articles

ADAP is required for normal αIIbβ3 activation by VWF/GP Ib-IX-V and other agonists

Ana Kasirer-Friede, Barry Moran, Jennifer Nagrampa-Orje, Ken Swanson, Zaverio M. Ruggeri, Burkhart Schraven, Benjamin G. Neel, Gary Koretzky, Sanford J. Shattil

Blood (2006) 109 (3): 1018–1025.

https://doi.org/10.1182/blood-2006-05-022301

Published: 2006

Journal Articles

Structural and Signaling Requirements for Transformation Mediated by Shp2 Mutants.

M. Golam Mohi, PhD, Benjamin G. Neel, MD, PhD

Blood (2005) 106 (11): 3508.

https://doi.org/10.1182/blood.V106.11.3508.3508

Published: 2005

Journal Articles

Oncogenic Ras Requires SHP-2 To Induce Myeloproliferative Disease (MPD).

Benjamin S. Braun, MD, PhD, Joehleen Archard, Wentian Yang, PhD, Gordon Chan, PhD, Benjamin G. Neel, MD, PhD, Kevin M. Shannon, MD

Blood (2005) 106 (11): 3517.

https://doi.org/10.1182/blood.V106.11.3517.3517

Published: 2005

Journal Articles

Mechanism of Oncogenesis by Leukemia-Associated Mutants of Shp2 (PTPN11).

M. Golam Mohi, Ph.D, Heike Keilhack, Ph.D., Sarah Cohen, Christina Boulton, Toshiyuki Araki, Ph.D., Ifor Williams, M.D., Ph.D., Jeffery L. Kutok, M.D., Ph.D., D. Gary Gilliland, M.D., Ph.D., Benjamin G. Neel, M.D., Ph.D.

Blood (2004) 104 (11): 199.

https://doi.org/10.1182/blood.V104.11.199.199

Published: 2004

Journal Articles

PTP-1B Is the Protein Tyrosine Phosphatase That Initiates Integrin αIIbβ3 Outside-In Signaling in Platelets.

Elena G. Arias-Salgado, Ph.D., Fawaz Haj, Ph.D., Christophe Dubois, Ph.D., Barbara C. Furie, Ph.D., Bruce Furie, M.D., Benjamin G. Neel, M.D., Sanford J. Shattil, M.D.

Blood (2004) 104 (11): 330.

https://doi.org/10.1182/blood.V104.11.330.330

Published: 2004

Journal Articles

A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

Dwayne L. Barber, Bryan K. Beattie, Jacqueline M. Mason, Melody H.-H. Nguyen, Monique Yoakim, Benjamin G. Neel, Alan D. D'Andrea, David A. Frank

Blood (2001) 97 (8): 2230–2237.

https://doi.org/10.1182/blood.V97.8.2230

Published: 2001

NARROW

Vitamin C Enhances PARPi Efficacy for the Treatment of AML

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions

Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1

PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML

Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function

Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis

G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

A Noncatalytic, Ras-Independent Function of SHP-2 Is Essential in Hematopoietic Progenitors.

Activating Shp2 Mutations Cause Progressive Myeloproliferative Disorder in Mice.

Myelopoiesis Requires a Noncatalytic, Ras-Independent Function of SHP-2.

ADAP is required for normal αIIbβ3 activation by VWF/GP Ib-IX-V and other agonists

Structural and Signaling Requirements for Transformation Mediated by Shp2 Mutants.

Oncogenic Ras Requires SHP-2 To Induce Myeloproliferative Disease (MPD).

Mechanism of Oncogenesis by Leukemia-Associated Mutants of Shp2 (PTPN11).

PTP-1B Is the Protein Tyrosine Phosphatase That Initiates Integrin αIIbβ3 Outside-In Signaling in Platelets.

A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation

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American Society of Hematology

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ASH Publications

American Society of Hematology

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