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Journal Articles

Gab3 Plays an Essential Role in CD8 + T-Cell Expansion through Regulating IL-2-Mediated Activation of PI3K/AKT/mTOR and Erk/FoxO Pathways

Guoping Fu, Yongwei Zheng, Gang Xin, Zhengqi Wang, Kevin D. Bunting, Weiguo Cui, Arthur Salomon, Renren Wen

Blood (2023) 142 (Supplement 1): 3931.

https://doi.org/10.1182/blood-2023-185077

Published: 2023

Journal Articles

Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Multipotent Progenitor Niche Factors

Zhengqi Wang, Grace Emmel, Hong Seo Lim, Astrid Kosters, Eliver Ghosn, Peng Qiu, Kevin D. Bunting

Blood (2022) 140 (Supplement 1): 1263–1264.

https://doi.org/10.1182/blood-2022-158988

Published: 2022

Journal Articles

Unique Roles for Grb2-Associated Binding (Gab) Adaptors in Hematopoietic Stem Cell Homeostasis and Repopulation

Zhengqi Wang, PhD, Gen-sheng Feng, PhD, Kevin D. Bunting, PhD

Blood (2017) 130 (Supplement 1): 2431.

https://doi.org/10.1182/blood.V130.Suppl_1.2431.2431

Published: 2017

Journal Articles

Imipramine Blue Sensitively and Selectively Targets FLT3 and c-Kit Mutant Acute Myeloid Leukemia

Jonathan L. Metts, MD, Heath L. Bradley, M.S., Neil P. Shah, Reuben Kapur, PhD, Jack L. Arbiser, MD, PhD, Kevin D. Bunting, PhD

Blood (2015) 126 (23): 3688.

https://doi.org/10.1182/blood.V126.23.3688.3688

Published: 2015

Journal Articles

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

Xia Liu, Hong Zheng, Wen-Mei Yu, Todd M. Cooper, Kevin D. Bunting, Cheng-Kui Qu

Blood (2015) 125 (10): 1562–1565.

https://doi.org/10.1182/blood-2014-04-568949

Published: 2015

Includes: Supplemental data

Journal Articles

Dysregulated Macrophage Pro-Inflammatory Cytokine Production and Chronic Colitis in Mice Lacking Both Gab2 and Gab3

Tamisha Y. Vaughan-Whitley, Hikaru Nishio, Barry Imhoff, Zhengqi Wang, Silvia T. Bunting, Pamela Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Kevin D. Bunting

Blood (2014) 124 (21): 457.

https://doi.org/10.1182/blood.V124.21.457.457

Published: 2014

Journal Articles

Critical Role of Stat5 in the Maintenance of Leukemic Stem Cells in Ptpn11 -Associated Juvenile Myelomonocytic Leukemia

Wei Liu, Xia Liu, Wen-Mei Yu, Kevin D. Bunting, Cheng-Kui Qu

Blood (2014) 124 (21): 818.

https://doi.org/10.1182/blood.V124.21.818.818

Published: 2014

Journal Articles

Synergistic Cytotoxicity in Acute Myeloid Leukemia By Combined Treatment with Metformin and 6-Benzylthioinosine

Himalee S. Sabnis, Shweta Tripathi, Heath L Bradley, Wen-Mei Yu, William Tse, Cheng-Kui Qu, Kevin D. Bunting

Blood (2014) 124 (21): 3754.

https://doi.org/10.1182/blood.V124.21.3754.3754

Published: 2014

Journal Articles

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence

Yulan Qing, Zhengqi Wang, Kevin D. Bunting, Stanton L. Gerson

Blood (2014) 123 (7): 1002–1011.

https://doi.org/10.1182/blood-2013-08-521716

Published: 2014

Includes: Supplemental data

Journal Articles

Rescue of the HSC Maintenance Defects in Ku70-Deficient Mice by Overexpression of Bcl2 Reveals a Novel Role of Bcl2 in HSC

Yulan Qing, PhD, Zhengqi Wang, PhD, Shigemi Matsuyama, PhD, Kevin D. Bunting, PhD, Stanton L. Gerson, MD

Blood (2012) 120 (21): 1235.

https://doi.org/10.1182/blood.V120.21.1235.1235

Published: 2012

Journal Articles

STAT5 Promotes Hematopoietic Stem Cell Maintenance by Increasing Quiescence-Associated Gene Expression and Suppressing Lymphoid Commitment

Zhengqi Wang, PhD, Geqiang Li, PhD, Zizhen Kang, MD, Tamisha Y. Vaughan, PhD, Silvia T Bunting, MD, William Tse, MD, Kevin D. Bunting, PhD

Blood (2012) 120 (21): 851.

https://doi.org/10.1182/blood.V120.21.851.851

Published: 2012

Journal Articles

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

Blood (2012) 120 (13): 2669–2678.

https://doi.org/10.1182/blood-2011-08-375873

Published: 2012

Includes: Supplemental data

Journal Articles

HIF-1 α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

Jinwei Du, Yu Chen, Qiang Li, Xiangzi Han, Cindy Cheng, Zhengqi Wang, David Danielpour, Sally L. Dunwoodie, Kevin D. Bunting, Yu-Chung Yang

Blood (2012) 119 (12): 2789–2798.

https://doi.org/10.1182/blood-2011-10-387902

Published: 2012

Includes: Supplemental data

Journal Articles

STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma

Zhengqi Wang, Geqiang Li, Zizhen Kang, Silvia T Bunting, William Tse, Kevin D. Bunting, PhD

Blood (2011) 118 (21): 919.

https://doi.org/10.1182/blood.V118.21.919.919

Published: 2011

Journal Articles

Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a,

Harini Nivarthi, Andriy Tsyrulnyk, Wolfgang Warsch, Zhengqi Wang, Susanne Winkler, Lukas Kenner, MD, Mathias Müller, DVM, Christopher Baum, MD, Kevin D. Bunting, PhD, Veronika Sexl, MD, Thomas Rülicke, D.V.M., Richard Moriggl, PhD

Blood (2011) 118 (21): 3399.

https://doi.org/10.1182/blood.V118.21.3399.3399

Published: 2011

Journal Articles

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

Peilin Ma, MD, PhD, Raghuveer Mali, Ph.D., Li-Fan Zeng, PhD, Holly Martin, Baskar Ramdas, Ph.D., Yantao He, PhD, Emily Sims, Joydeep Ghosh, Ph.D, Sarah C Nabinger, Shuo Li, Veerendra Munugalavadla, PhD, Anindya Chatterjee, PhD, George Sandusky, MD, Andrew Craig, PhD, Kevin D. Bunting, PhD, Gen-Sheng Feng, Rebecca J. Chan, MD, PhD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD

Blood (2011) 118 (21): 868.

https://doi.org/10.1182/blood.V118.21.868.868

Published: 2011

Journal Articles

Cited2 Regulates Hematopoietic Stem Cell Quiescence Through HIF-1α Dependent and Independent Pathways

Jinwei Du, Yu Chen, Qiang Li, Zhengqi Wang, Sally Dunwoodie, Kevin D. Bunting, PhD, Yu-Chung Yang, PhD

Blood (2011) 118 (21): 912.

https://doi.org/10.1182/blood.V118.21.912.912

Published: 2011

Journal Articles

Multiple Apoptotic Defects In Hematopoietic Cellsfrom Mice Lacking Lipocalin 24p3.

L.R. Devireddy, DVM, PhD, Zhuoming Liu, Alieta Ciocea, Amy Yang, Zhengqi Wang, Kevin D. Bunting, PhD, Michael Green

Blood (2010) 116 (21): 1560.

https://doi.org/10.1182/blood.V116.21.1560.1560

Published: 2010

Journal Articles

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Dan Xu, Siying Wang, Wen-Mei Yu, Gordon Chan, Toshiyuki Araki, Kevin D. Bunting, Benjamin G. Neel, Cheng-Kui Qu

Blood (2010) 116 (18): 3611–3621.

https://doi.org/10.1182/blood-2010-01-265652

Published: 2010

Includes: Supplemental data

Journal Articles

Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation

Katrin Friedbichler, Marc A. Kerenyi, Boris Kovacic, Geqiang Li, Andrea Hoelbl, Saliha Yahiaoui, Veronika Sexl, Ernst W. Müllner, Sabine Fajmann, Sabine Cerny-Reiterer, Peter Valent, Hartmut Beug, Fabrice Gouilleux, Kevin D. Bunting, Richard Moriggl

Blood (2010) 116 (9): 1548–1558.

https://doi.org/10.1182/blood-2009-12-258913

Published: 2010

Includes: Supplemental data

NARROW

Gab3 Plays an Essential Role in CD8 + T-Cell Expansion through Regulating IL-2-Mediated Activation of PI3K/AKT/mTOR and Erk/FoxO Pathways

Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Multipotent Progenitor Niche Factors

Unique Roles for Grb2-Associated Binding (Gab) Adaptors in Hematopoietic Stem Cell Homeostasis and Repopulation

Imipramine Blue Sensitively and Selectively Targets FLT3 and c-Kit Mutant Acute Myeloid Leukemia

Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

Dysregulated Macrophage Pro-Inflammatory Cytokine Production and Chronic Colitis in Mice Lacking Both Gab2 and Gab3

Critical Role of Stat5 in the Maintenance of Leukemic Stem Cells in Ptpn11 -Associated Juvenile Myelomonocytic Leukemia

Synergistic Cytotoxicity in Acute Myeloid Leukemia By Combined Treatment with Metformin and 6-Benzylthioinosine

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence

Rescue of the HSC Maintenance Defects in Ku70-Deficient Mice by Overexpression of Bcl2 Reveals a Novel Role of Bcl2 in HSC

STAT5 Promotes Hematopoietic Stem Cell Maintenance by Increasing Quiescence-Associated Gene Expression and Suppressing Lymphoid Commitment

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

HIF-1 α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma

Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a,

KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML

Cited2 Regulates Hematopoietic Stem Cell Quiescence Through HIF-1α Dependent and Independent Pathways

Multiple Apoptotic Defects In Hematopoietic Cellsfrom Mice Lacking Lipocalin 24p3.

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation

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American Society of Hematology

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American Society of Hematology

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