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Journal Articles

PI3K Signaling Is Essential for Leukemic Transformation of Tet2 Mutated Pre-Leukemic Hematopoietic Stem Cells

Lakshmi Reddy Palam, Baskar Ramdas, Katelyn Pickerell, Maegan L. Capitano, Reuben Kapur

Blood (2022) 140 (Supplement 1): 5736.

https://doi.org/10.1182/blood-2022-166430

Published: 2022

Journal Articles

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Arafat Aljoufi, Chi Zhang, James Ropa, Wennan Chang, Lakshmi Reddy Palam, Scott Cooper, Baskar Ramdas, Maegan L. Capitano, Hal E. Broxmeyer, Reuben Kapur

Blood (2022) 140 (11): 1263–1277.

https://doi.org/10.1182/blood.2022015499

Published: 2022

Includes: Supplemental data

Journal Articles

Immunotherapy Targeting ST2/IL-33 Signaling in Myeloid Leukemia Stem Cells

Denggang Fu, Hua Jiang, Alan Long, Hong fen Guo, Maegan L. Capitano, Baskar Ramdas, Reuben Kapur, Nai-Kong V. Cheung, Sophie Paczesny

Blood (2021) 138 (Supplement 1): 23.

https://doi.org/10.1182/blood-2021-149672

Published: 2021

Journal Articles

Obesity-Induced Inflammation Co-Operates with Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutants to Promote Leukemia Development and Cardiovascular Disease

Santhosh Kumar Pasupuleti, Baskar Ramdas, Sarah S. Burns, Ramesh Kumar, Taruni Reddy Pandhiri, George Sandusky, Zhi Yu, Michael Honigberg, Alexander G. Bick, Gabriel K. Griffin, Abhishek Niroula, Benjamin L. Ebert, Pradeep Natarajan, Reuben Kapur

Blood (2021) 138 (Supplement 1): 1094.

https://doi.org/10.1182/blood-2021-153521

Published: 2021

Journal Articles

Targeting M2-Tumor Associated Macrophages By Arginase-1 and PD-L1 in Regulating Juvenile Myelomonocytic Leukemia (JMML) Development and Relapse

Santhosh Kumar Pasupuleti, Baskar Ramdas, Kai Yang, Chujing Zhang, Elliot Stieglitz, Reuben Kapur

Blood (2021) 138 (Supplement 1): 1471.

https://doi.org/10.1182/blood-2021-153976

Published: 2021

Journal Articles

Lncrna Morrbid Regulates Myeloid Cell Survival of AML Driven By a Combination of FLT3ITD and Epigenetic Mutations

Zhigang Cai, PhD, Baskar Ramdas, PhD, Jonathan Kotzin, Martin P. Carroll, MD, Gerald Wertheim, MD, PhD, Adam Williams, Jorge Henao-Mejia, Reuben Kapur, PhD

Blood (2019) 134 (Supplement_1): 915.

https://doi.org/10.1182/blood-2019-130653

Published: 2019

Journal Articles

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3 ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Raghuveer Singh Mali, PhD, Zhigang Cai, PhD, Ruchi Pandey, PhD, Reuben Kapur, PhD

Blood (2019) 134 (Supplement_1): 3754.

https://doi.org/10.1182/blood-2019-131172

Published: 2019

Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2019) 134 (Supplement_1): 5051.

https://doi.org/10.1182/blood-2019-124384

Published: 2019

Journal Articles

Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a

Lakshmi Reddy Palam, PhD, Baskar Ramdas, PhD, Katelyn Pickerell, Reuben Kapur, PhD

Blood (2019) 134 (Supplement_1): 723.

https://doi.org/10.1182/blood-2019-131036

Published: 2019

Journal Articles

Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells

Lakshmi Reddy Palam, PhD, Baskar Ramdas, PhD, Sridhar reddy Srivatsan, MS, Sarath Chandra Janga, PhD, Axel Roers, PhD, Alexander Gerbaulet, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 3055.

https://doi.org/10.1182/blood-2018-99-118721

Published: 2018

Journal Articles

Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML

Roshni Patel, BS, Baskar Ramdas, PhD, Lisa Deng, PhD, Victoria Jideonwo-Auman, PhD, Rebecca J Chan, MD PhD, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 2623.

https://doi.org/10.1182/blood-2018-99-118802

Published: 2018

Journal Articles

Rap1 Gtpases Regulate the Retention and Engraftment of Hematopoietic Stem and Progenitor Cells

Baskar Ramdas, PhD, Joydeep Ghosh, PhD, Raghuveer Singh Mali, PhD, Zollman Amy, Nadia Carlesso, MD PhD, Malgorzata Kamocka M, Dunn W Kenneth, PhD, Lawrance Quilliam, PhD, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 326.

https://doi.org/10.1182/blood-2018-99-117197

Published: 2018

Journal Articles

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Larry D Cripe, MD, Katie J Sargent, RN, G. David Roodman, MD PhD, Hamid Sayar, MD MSc, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Rajasubramaniam Shanmugam, PhD, Adriana Rogozea, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2018) 132 (Supplement 1): 3949.

https://doi.org/10.1182/blood-2018-99-111181

Published: 2018

Journal Articles

Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis

Zhigang Cai, PhD, Jonathan Kotzin, Baskar Ramdas, PhD, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, PhD, Ruchi Pandey, Raghuveer Mali, PhD, Yan Liu, PhD, Mark R. Kelley, George Sandusky, DVM, PhD, Morvarid Mohseni, Adam Williams, Jorge Henao-Mejia, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 1288.

https://doi.org/10.1182/blood-2018-99-116703

Published: 2018

Journal Articles

PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis

Lakshmi Reddy Palam, PhD, Raghuveer Mali, PhD, Baskar Ramdas, PhD, Bart Vanhaesebroeck, PhD, Reuben Kapur, PhD

Blood (2017) 130 (Supplement 1): 3754.

https://doi.org/10.1182/blood.V130.Suppl_1.3754.3754

Published: 2017

Journal Articles

S6K1 Regulates Self-Renewal of Leukemia Initiating Cells and Normal Hematopoietic Stem Cells

Joydeep Ghosh, MSc, Anindya Chatterjee, MS,PhD, Baskar Ramdas, PhD, Michihiro Kobayashi, MD PhD, Peilin Ma, MD PhD, Yan Liu, PhD, David Plas, PhD, Reuben Kapur, PhD

Blood (2015) 126 (23): 442.

https://doi.org/10.1182/blood.V126.23.442.442

Published: 2015

Journal Articles

Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells

Raghuveer Mali, PhD, Holly Rene Martin, PhD, Baskar Ramdas, PhD, Lakshmi Palam, PhD, Valeria Visconte, PhD, Tiu Ramon, MD, Helmut Hanenberg, MD, Mingjiang Xu, MD PhD, Reuben Kapur, PhD

Blood (2015) 126 (23): 775.

https://doi.org/10.1182/blood.V126.23.775.775

Published: 2015

Journal Articles

Novel Mechanisms of Growth Inhibition By Histone Deacetylase Inhibitors in MPN

Ruchi Pandey, PhD, Raghuveer Mali, PhD, Baskar Ramdas, PhD, Reuben Kapur, PhD

Blood (2015) 126 (23): 1633.

https://doi.org/10.1182/blood.V126.23.1633.1633

Published: 2015

Journal Articles

Modulation in the Expression of p70S6 Kinase Impairs the Engraftment and Self-Renewal of Hematopoietic Stem Cells

Joydeep Ghosh, MS, Baskar Ramdas, PhD, Anindya Chatterjee, MS,PhD, Peilin Ma, MD PhD, Michihiro Kobayashi, MDPhD, Raghuveer Mali, PhD, Yan Liu, PhD, David R. Plas, PhD, Reuben Kapur, PhD

Blood (2014) 124 (21): 252.

https://doi.org/10.1182/blood.V124.21.252.252

Published: 2014

Journal Articles

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Sarah C Nabinger, PhD, Xing Jun Li, MD, PhD, Baskar Ramdas, Ph.D., Yantao He, PhD, Xian Zhang, Ph.D., Briana Richine, Joshua Bowling, Seiji Fukuda, MD, PhD, Shreevrat Goenka, Ph.D., Ziyue Liu, Ph.D., Gen-Sheng Feng, PhD, Menggang Yu, Ph.D., George Sandusky, MD, H. Scott Boswell, MD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2012) 120 (21): 2420.

https://doi.org/10.1182/blood.V120.21.2420.2420

Published: 2012

NARROW

PI3K Signaling Is Essential for Leukemic Transformation of Tet2 Mutated Pre-Leukemic Hematopoietic Stem Cells

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Immunotherapy Targeting ST2/IL-33 Signaling in Myeloid Leukemia Stem Cells

Obesity-Induced Inflammation Co-Operates with Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutants to Promote Leukemia Development and Cardiovascular Disease

Targeting M2-Tumor Associated Macrophages By Arginase-1 and PD-L1 in Regulating Juvenile Myelomonocytic Leukemia (JMML) Development and Relapse

Lncrna Morrbid Regulates Myeloid Cell Survival of AML Driven By a Combination of FLT3ITD and Epigenetic Mutations

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3 ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a

Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells

Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML

Rap1 Gtpases Regulate the Retention and Engraftment of Hematopoietic Stem and Progenitor Cells

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis

PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis

S6K1 Regulates Self-Renewal of Leukemia Initiating Cells and Normal Hematopoietic Stem Cells

Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells

Novel Mechanisms of Growth Inhibition By Histone Deacetylase Inhibitors in MPN

Modulation in the Expression of p70S6 Kinase Impairs the Engraftment and Self-Renewal of Hematopoietic Stem Cells

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

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American Society of Hematology

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American Society of Hematology

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