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Journal Articles

PI3K Signaling Is Essential for Leukemic Transformation of Tet2 Mutated Pre-Leukemic Hematopoietic Stem Cells

Lakshmi Reddy Palam, Baskar Ramdas, Katelyn Pickerell, Maegan L. Capitano, Reuben Kapur

Blood (2022) 140 (Supplement 1): 5736.

https://doi.org/10.1182/blood-2022-166430

Published: 2022

Journal Articles

Asparagine Bioavailability Regulates the Translation of MYC oncogene in Lymphoid Malignancies

Sankalp Srivastava, Jie Jiang, Gretchen Seim, Jagannath Misra, Utpal Dave, Reuben Kapur, Jiehao Zhou, Jing Fan, Ronald Wek, Ji Zhang

Blood (2022) 140 (Supplement 1): 3040–3041.

https://doi.org/10.1182/blood-2022-170024

Published: 2022

Journal Articles

Molecular Landscaping of Exosomal Protein and miRNA Cargo in Acute Myeloid Leukemia

Kinjal Bhadresha, Sanam Rezaei Benam, Alexander R. Maldeney, H. Scott Boswell, Reuben Kapur, Reza Shahbazi

Blood (2022) 140 (Supplement 1): 3397–3398.

https://doi.org/10.1182/blood-2022-169595

Published: 2022

Journal Articles

P62SQSTM1 Affects Interacting Substrates MDM2, MDMX and Casein Kinase 1alpha to Yield Protection of Beta-Catenin Along with p53 Silencing for Refractory AML

Justin Layer, Sravanti Rangaraju, Santhosh Pasupuleti, Larry D. Cripe, Hamid Sayar, Katie J Sargent, Jill Weisenbach, Huda S. Salman, G. David Roodman, Linsey Mayo, Reuben Kapur, Utpal P Dave', H. Scott Boswell

Blood (2022) 140 (Supplement 1): 11546–11547.

https://doi.org/10.1182/blood-2022-156329

Published: 2022

Journal Articles

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Arafat Aljoufi, Chi Zhang, James Ropa, Wennan Chang, Lakshmi Reddy Palam, Scott Cooper, Baskar Ramdas, Maegan L. Capitano, Hal E. Broxmeyer, Reuben Kapur

Blood (2022) 140 (11): 1263–1277.

https://doi.org/10.1182/blood.2022015499

Published: 2022

Includes: Supplemental data

Journal Articles

Immunotherapy Targeting ST2/IL-33 Signaling in Myeloid Leukemia Stem Cells

Denggang Fu, Hua Jiang, Alan Long, Hong fen Guo, Maegan L. Capitano, Baskar Ramdas, Reuben Kapur, Nai-Kong V. Cheung, Sophie Paczesny

Blood (2021) 138 (Supplement 1): 23.

https://doi.org/10.1182/blood-2021-149672

Published: 2021

Journal Articles

Obesity-Induced Inflammation Co-Operates with Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutants to Promote Leukemia Development and Cardiovascular Disease

Santhosh Kumar Pasupuleti, Baskar Ramdas, Sarah S. Burns, Ramesh Kumar, Taruni Reddy Pandhiri, George Sandusky, Zhi Yu, Michael Honigberg, Alexander G. Bick, Gabriel K. Griffin, Abhishek Niroula, Benjamin L. Ebert, Pradeep Natarajan, Reuben Kapur

Blood (2021) 138 (Supplement 1): 1094.

https://doi.org/10.1182/blood-2021-153521

Published: 2021

Journal Articles

Targeting M2-Tumor Associated Macrophages By Arginase-1 and PD-L1 in Regulating Juvenile Myelomonocytic Leukemia (JMML) Development and Relapse

Santhosh Kumar Pasupuleti, Baskar Ramdas, Kai Yang, Chujing Zhang, Elliot Stieglitz, Reuben Kapur

Blood (2021) 138 (Supplement 1): 1471.

https://doi.org/10.1182/blood-2021-153976

Published: 2021

Journal Articles

Hyperglycemia Cooperates with Tet2 Heterozygosity to Induce Leukemia Driven By Pro-Inflammatory Cytokine Induced Lncrna Morrbid

Zhigang Cai, Reuben Kapur, PhD, Xiaoyu Lu, Chi Zhang, PhD, Sai Nelanuthala, Jonathan Kotzin, Adam Williams, Jorge Henao-Mejia, Fabiola Aguilera, Abigail Hadley, Fang Fang, Kenneth Nephew

Blood (2020) 136 (Supplement 1): 30.

https://doi.org/10.1182/blood-2020-141335

Published: 2020

Journal Articles

Lncrna Morrbid Regulates Myeloid Cell Survival of AML Driven By a Combination of FLT3ITD and Epigenetic Mutations

Zhigang Cai, PhD, Baskar Ramdas, PhD, Jonathan Kotzin, Martin P. Carroll, MD, Gerald Wertheim, MD, PhD, Adam Williams, Jorge Henao-Mejia, Reuben Kapur, PhD

Blood (2019) 134 (Supplement_1): 915.

https://doi.org/10.1182/blood-2019-130653

Published: 2019

Journal Articles

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3 ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Raghuveer Singh Mali, PhD, Zhigang Cai, PhD, Ruchi Pandey, PhD, Reuben Kapur, PhD

Blood (2019) 134 (Supplement_1): 3754.

https://doi.org/10.1182/blood-2019-131172

Published: 2019

Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2019) 134 (Supplement_1): 5051.

https://doi.org/10.1182/blood-2019-124384

Published: 2019

Journal Articles

Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a

Lakshmi Reddy Palam, PhD, Baskar Ramdas, PhD, Katelyn Pickerell, Reuben Kapur, PhD

Blood (2019) 134 (Supplement_1): 723.

https://doi.org/10.1182/blood-2019-131036

Published: 2019

Journal Articles

Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells

Lakshmi Reddy Palam, PhD, Baskar Ramdas, PhD, Sridhar reddy Srivatsan, MS, Sarath Chandra Janga, PhD, Axel Roers, PhD, Alexander Gerbaulet, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 3055.

https://doi.org/10.1182/blood-2018-99-118721

Published: 2018

Journal Articles

P38α/JNK Signaling Restrains Erythropoiesis By Suppressing Ezh2-Mediated Epigenetic Silencing of Bim

Ping Hu, MD PhD, Angel Nebreda, PhD, Helmut Hanenberg, MD, Garrett Kinnebrew, MD, Mircea Ivan, MD PhD, Mervin C. Yoder, MD, Marie-Dominique Filippi, PhD, Hal E. Broxmeyer, PhD, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 3837.

https://doi.org/10.1182/blood-2018-99-117098

Published: 2018

Journal Articles

Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML

Roshni Patel, BS, Baskar Ramdas, PhD, Lisa Deng, PhD, Victoria Jideonwo-Auman, PhD, Rebecca J Chan, MD PhD, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 2623.

https://doi.org/10.1182/blood-2018-99-118802

Published: 2018

Journal Articles

Rap1 Gtpases Regulate the Retention and Engraftment of Hematopoietic Stem and Progenitor Cells

Baskar Ramdas, PhD, Joydeep Ghosh, PhD, Raghuveer Singh Mali, PhD, Zollman Amy, Nadia Carlesso, MD PhD, Malgorzata Kamocka M, Dunn W Kenneth, PhD, Lawrance Quilliam, PhD, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 326.

https://doi.org/10.1182/blood-2018-99-117197

Published: 2018

Journal Articles

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Larry D Cripe, MD, Katie J Sargent, RN, G. David Roodman, MD PhD, Hamid Sayar, MD MSc, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Rajasubramaniam Shanmugam, PhD, Adriana Rogozea, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2018) 132 (Supplement 1): 3949.

https://doi.org/10.1182/blood-2018-99-111181

Published: 2018

Journal Articles

Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis

Zhigang Cai, PhD, Jonathan Kotzin, Baskar Ramdas, PhD, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, PhD, Ruchi Pandey, Raghuveer Mali, PhD, Yan Liu, PhD, Mark R. Kelley, George Sandusky, DVM, PhD, Morvarid Mohseni, Adam Williams, Jorge Henao-Mejia, Reuben Kapur, PhD

Blood (2018) 132 (Supplement 1): 1288.

https://doi.org/10.1182/blood-2018-99-116703

Published: 2018

Journal Articles

PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis

Lakshmi Reddy Palam, PhD, Raghuveer Mali, PhD, Baskar Ramdas, PhD, Bart Vanhaesebroeck, PhD, Reuben Kapur, PhD

Blood (2017) 130 (Supplement 1): 3754.

https://doi.org/10.1182/blood.V130.Suppl_1.3754.3754

Published: 2017

NARROW

PI3K Signaling Is Essential for Leukemic Transformation of Tet2 Mutated Pre-Leukemic Hematopoietic Stem Cells

Asparagine Bioavailability Regulates the Translation of MYC oncogene in Lymphoid Malignancies

Molecular Landscaping of Exosomal Protein and miRNA Cargo in Acute Myeloid Leukemia

P62SQSTM1 Affects Interacting Substrates MDM2, MDMX and Casein Kinase 1alpha to Yield Protection of Beta-Catenin Along with p53 Silencing for Refractory AML

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Immunotherapy Targeting ST2/IL-33 Signaling in Myeloid Leukemia Stem Cells

Obesity-Induced Inflammation Co-Operates with Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutants to Promote Leukemia Development and Cardiovascular Disease

Targeting M2-Tumor Associated Macrophages By Arginase-1 and PD-L1 in Regulating Juvenile Myelomonocytic Leukemia (JMML) Development and Relapse

Hyperglycemia Cooperates with Tet2 Heterozygosity to Induce Leukemia Driven By Pro-Inflammatory Cytokine Induced Lncrna Morrbid

Lncrna Morrbid Regulates Myeloid Cell Survival of AML Driven By a Combination of FLT3ITD and Epigenetic Mutations

Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3 ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a

Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells

P38α/JNK Signaling Restrains Erythropoiesis By Suppressing Ezh2-Mediated Epigenetic Silencing of Bim

Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML

Rap1 Gtpases Regulate the Retention and Engraftment of Hematopoietic Stem and Progenitor Cells

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis

PI3Kinase Inactivation through Combined Loss of Catalytic Subunits p110α, p110β and p110δ Derails Hematopoietic Homeostasis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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