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Journal Articles

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Blood (2023) 141 (3): 244–259.

https://doi.org/10.1182/blood.2022016580

Published: 2023

Includes: Supplemental data

Journal Articles

Molecular Landscaping of Exosomal Protein and miRNA Cargo in Acute Myeloid Leukemia

Kinjal Bhadresha, Sanam Rezaei Benam, Alexander R. Maldeney, H. Scott Boswell, Reuben Kapur, Reza Shahbazi

Blood (2022) 140 (Supplement 1): 3397–3398.

https://doi.org/10.1182/blood-2022-169595

Published: 2022

Journal Articles

P62SQSTM1 Affects Interacting Substrates MDM2, MDMX and Casein Kinase 1alpha to Yield Protection of Beta-Catenin Along with p53 Silencing for Refractory AML

Justin Layer, Sravanti Rangaraju, Santhosh Pasupuleti, Larry D. Cripe, Hamid Sayar, Katie J Sargent, Jill Weisenbach, Huda S. Salman, G. David Roodman, Linsey Mayo, Reuben Kapur, Utpal P Dave', H. Scott Boswell

Blood (2022) 140 (Supplement 1): 11546–11547.

https://doi.org/10.1182/blood-2022-156329

Published: 2022

Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2019) 134 (Supplement_1): 5051.

https://doi.org/10.1182/blood-2019-124384

Published: 2019

Journal Articles

Integrative Analysis of AML Cell Response to Cytarabine Reveals Synergistic Opportunities Centered on Cholesterol Metabolism

Fangli Chen, MD PhD, Xue Wu, PhD, Rogozea Adriana, Bin Guo, PhD, H. Scott Boswell, MD, George A. Calin, MD PhD, Mircea Ivan, MD PhD, Heiko Konig, MD PhD

Blood (2018) 132 (Supplement 1): 2631.

https://doi.org/10.1182/blood-2018-99-113634

Published: 2018

Journal Articles

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, Daniela Nicoleta Petrusca, PhD, Larry D Cripe, MD, Katie J Sargent, RN, G. David Roodman, MD PhD, Hamid Sayar, MD MSc, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Rajasubramaniam Shanmugam, PhD, Adriana Rogozea, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2018) 132 (Supplement 1): 3949.

https://doi.org/10.1182/blood-2018-99-111181

Published: 2018

Journal Articles

Final Results of Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib in Acute Myeloid Leukemia with FLT3-ITD Mutation or Poor-Risk Cytogenetics

Antoine N Saliba, MD, H. Scott Boswell, MD, Larry D Cripe, MD, Mohammad Issam Abu Zaid, MBBS, Jill Weisenbach, RN, OCN, Hamid Sayar, MD MSc

Blood (2017) 130 (Supplement 1): 3897.

https://doi.org/10.1182/blood.V130.Suppl_1.3897.3897

Published: 2017

Journal Articles

Minimal Intensity Fludarabine/Cyclophosphamide Versus Myeloablative Thiotepa/Cyclophosphamide Followed By Allogeneic Hematopoetic Stem Cell Transplantation (HSCT) for the Treatment of Acute Myeloid Leukemia (AML)— a Retrospective Single Institution Experience

Nabin Khanal, MBBS, Brian E Johnson, MD, H. Scott Boswell, MD, Heiko Konig, MDPhD, Susan M Perkins, PhD, Robert P. Nelson, Jr., MD

Blood (2017) 130 (Supplement 1): 5471.

https://doi.org/10.1182/blood.V130.Suppl_1.5471.5471

Published: 2017

Journal Articles

The Combination of the Novel Syk Inhibitor TAK659 with Decitabine Exerts Synergistic Cytotoxic Effects Against FLT3/ITD Mutated Acute Myeloid Leukemia Cells

Edwin Stage, MS, Magdalena Czader, MD PhD, Heather O'Leary, PhD, H. Scott Boswell, MD, Larry D. Cripe, MD, Hamid Sayar, MD, Cedric Dos Santos, PhD, Mark J. Levis, MD PhD, Heiko Konig, MDPhD

Blood (2015) 126 (23): 4928.

https://doi.org/10.1182/blood.V126.23.4928.4928

Published: 2015

Journal Articles

Gain-of-Function Mutant p53 Enhances Hematopoietic Stem Cell Self-Renewal

Sisi Chen, Hao Yu, PhD, Michihiro Kobayashi, MDPhD, Rui Gao, PhD, H. Scott Boswell, MD, Yan Liu, PhD

Blood (2014) 124 (21): 260.

https://doi.org/10.1182/blood.V124.21.260.260

Published: 2014

Journal Articles

Unique and Unexpected Functional Activities of Hematopoietically Active Cytokines Truncated By Dipeptidylpeptidase-4 (DPP4)

Heather A. O'Leary, PhD, Charlie Mantel, Man Ryul Lee, PhD, Xianyin Lai, PhD, Scott Cooper, BS, Giao Hangoc, DVM, PhD, H. Scott Boswell, MD, Hal E. Broxmeyer, PhD

Blood (2014) 124 (21): 2922.

https://doi.org/10.1182/blood.V124.21.2922.2922

Published: 2014

Journal Articles

Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib in Acute Myeloid Leukemia with FLT3-ITD Mutation or Monosomy 5, 7, or Complex Cytogenetics

Mohammad Abu Zaid, MBBS, H. Scott Boswell, MD, Larry D. Cripe, MD, Yan Liu, PhD, Jill Weisenbach, BS, Hamid Sayar, MD MS

Blood (2014) 124 (21): 976.

https://doi.org/10.1182/blood.V124.21.976.976

Published: 2014

Journal Articles

High-Risk AML, Including Flt3ITD+, Exhibits Resistance To Conventional Cytarabine Induction Associated With Diminished ENT1 and p16INK Expression: Evidence For Epigenetic Repression and HDAC Inhibitor Modulated De-Repression

H. Scott Boswell, MD, Sushil Gupta, Rui Gao, PhD, Katie J Sargent, Larry D. Cripe, MD, Mehdi Nassiri, MD, Hamid Sayar, MD, Yan Liu, PhD

Blood (2013) 122 (21): 2525.

https://doi.org/10.1182/blood.V122.21.2525.2525

Published: 2013

Journal Articles

DPP4 (CD26) Truncation Of GM-CSF and IL-3 Alters Their Signaling and Functional Activity In Normal and Leukemic Hematopoietic Stem and Progenitor Cells

Heather A. O'Leary, Ph.D., Charlie Mantel, Xianyin Lai, Ph.D., Scott Cooper, BS, Giao Hangoc, DVM, Ph.D., H. Scott Boswell, M.D., Frank Witzmann, Ph.D., Hal E. Broxmeyer, PhD

Blood (2013) 122 (21): 1206.

https://doi.org/10.1182/blood.V122.21.1206.1206

Published: 2013

Journal Articles

Loss Of Canonic Notch Signaling In The Microenvironment Causes a Myeloproliferative Syndrome Via Derepression Of The miR155 Promoter

Lin Wang, PhD, Huajia Zhang, BS, Sonia Rodriguez-Rodriguez, PhD, Liyun Cao, PhD, Jonathan Parish, BS, Amy Zollman, BS, Malgorzata Kamocka, PhD, H. Scott Boswell, M.D., Edward F. Srour, Ph.D., Brahmananda Reddy Chitteti, PhD, Taghi Manshouri, Ph.D., Srdan Verstovsek, MD, PhD, Reuben Kapur, PhD, Angelo A. Cardoso, MD, PhD, Nadia Carlesso, MD, PhD

Blood (2013) 122 (21): 339.

https://doi.org/10.1182/blood.V122.21.339.339

Published: 2013

Journal Articles

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Sarah C Nabinger, PhD, Xing Jun Li, MD, PhD, Baskar Ramdas, Ph.D., Yantao He, PhD, Xian Zhang, Ph.D., Briana Richine, Joshua Bowling, Seiji Fukuda, MD, PhD, Shreevrat Goenka, Ph.D., Ziyue Liu, Ph.D., Gen-Sheng Feng, PhD, Menggang Yu, Ph.D., George Sandusky, MD, H. Scott Boswell, MD, Zhong-Yin Zhang, PhD, Reuben Kapur, PhD, Rebecca J. Chan, MD, PhD

Blood (2012) 120 (21): 2420.

https://doi.org/10.1182/blood.V120.21.2420.2420

Published: 2012

Journal Articles

Unraveling a Novel Mechanism of Stat5 Regulation by FAK and Rac1 in Flt3ITD Induced Leukemogenesis

Anindya Chatterjee, MS, PhD, Joydeep Ghosh, Baskar Ramdas, Ph.D., Sasidhar Vemula, PhD, Holly Martin, Raghuveer Mali, Ph.D., Sarah C Nabinger, PhD, Charles B Goodwin, H. Scott Boswell, MD, Rebecca J. Chan, MD, PhD, Reuben Kapur, PhD

Blood (2012) 120 (21): 858.

https://doi.org/10.1182/blood.V120.21.858.858

Published: 2012

Journal Articles

Cyclic Administration of Combination of Sorafenib and Vorinostat In Poor-Risk AML: A Pharmacodynamically-Oriented Extended Phase I Trial

Hamid Sayar, MD, Larry Cripe, MD, Mary Cangany, Jill Weisenbach, RN, OCN, Katie J. Sargent, RN, Chirayu Goswami, PhD., Lang Li, PhD., Annique Wilson-Weekes, MS, Rajasubramaniam Shanmugam, PhD, H. Scott Boswell, MD

Blood (2010) 116 (21): 3272.

https://doi.org/10.1182/blood.V116.21.3272.3272

Published: 2010

Journal Articles

A Pathway-focused GSEA Platform In AML That Interrogates Interaction of Flt3ITD and tMLL with Their Epigenetic Targets (p16INK4a, DAPK1, and RUNX3), While Accurately Reporting Broad-based AML Prognosis and Targeting-agent Sensitivity.

Tareq Al Baghdadi, MD, Chirayu Goswami, PhD., Hamid Sayar, MD, Katie J. Sargent, RN, Larry Cripe, MD, Lang Li, PhD., Rajasubramaniam Shanmugam, H. Scott Boswell, MD

Blood (2010) 116 (21): 1660.

https://doi.org/10.1182/blood.V116.21.1660.1660

Published: 2010

Journal Articles

Transcriptional Repression of DAPK1 Characterizes a Resistant Phenotype of AML Enforced by Flt3 Signaling and Exclusive Nuclear Abundance of Non-Canonical NFkB2/p52: Synergistic Activity for Flt3 Inhibition along with HDAC Inhibition, or by NFkB Inhibition, for Potentiating ER Stress Apoptosis.

Rajasubramaniam Shanmugam, PhD., Annique Wilson-Weekes, MS, Hamid Sayar, MD, Attaya Suvannasankha, MD, Angelo A. Cardoso, MD., PhD, Katie J Sargent, RN, Larry D. Cripe, MD, Dhananjaya V Kalvakolanu, PhD., H. Scott Boswell, MD

Blood (2009) 114 (22): 2387.

https://doi.org/10.1182/blood.V114.22.2387.2387

Published: 2009

NARROW

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Molecular Landscaping of Exosomal Protein and miRNA Cargo in Acute Myeloid Leukemia

P62SQSTM1 Affects Interacting Substrates MDM2, MDMX and Casein Kinase 1alpha to Yield Protection of Beta-Catenin Along with p53 Silencing for Refractory AML

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Integrative Analysis of AML Cell Response to Cytarabine Reveals Synergistic Opportunities Centered on Cholesterol Metabolism

Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML

Final Results of Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib in Acute Myeloid Leukemia with FLT3-ITD Mutation or Poor-Risk Cytogenetics

Minimal Intensity Fludarabine/Cyclophosphamide Versus Myeloablative Thiotepa/Cyclophosphamide Followed By Allogeneic Hematopoetic Stem Cell Transplantation (HSCT) for the Treatment of Acute Myeloid Leukemia (AML)— a Retrospective Single Institution Experience

The Combination of the Novel Syk Inhibitor TAK659 with Decitabine Exerts Synergistic Cytotoxic Effects Against FLT3/ITD Mutated Acute Myeloid Leukemia Cells

Gain-of-Function Mutant p53 Enhances Hematopoietic Stem Cell Self-Renewal

Unique and Unexpected Functional Activities of Hematopoietically Active Cytokines Truncated By Dipeptidylpeptidase-4 (DPP4)

Phase I/II Study of Combination of Sorafenib, Vorinostat, and Bortezomib in Acute Myeloid Leukemia with FLT3-ITD Mutation or Monosomy 5, 7, or Complex Cytogenetics

High-Risk AML, Including Flt3ITD+, Exhibits Resistance To Conventional Cytarabine Induction Associated With Diminished ENT1 and p16INK Expression: Evidence For Epigenetic Repression and HDAC Inhibitor Modulated De-Repression

DPP4 (CD26) Truncation Of GM-CSF and IL-3 Alters Their Signaling and Functional Activity In Normal and Leukemic Hematopoietic Stem and Progenitor Cells

Loss Of Canonic Notch Signaling In The Microenvironment Causes a Myeloproliferative Syndrome Via Derepression Of The miR155 Promoter

The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells.

Unraveling a Novel Mechanism of Stat5 Regulation by FAK and Rac1 in Flt3ITD Induced Leukemogenesis

Cyclic Administration of Combination of Sorafenib and Vorinostat In Poor-Risk AML: A Pharmacodynamically-Oriented Extended Phase I Trial

A Pathway-focused GSEA Platform In AML That Interrogates Interaction of Flt3ITD and tMLL with Their Epigenetic Targets (p16INK4a, DAPK1, and RUNX3), While Accurately Reporting Broad-based AML Prognosis and Targeting-agent Sensitivity.

Transcriptional Repression of DAPK1 Characterizes a Resistant Phenotype of AML Enforced by Flt3 Signaling and Exclusive Nuclear Abundance of Non-Canonical NFkB2/p52: Synergistic Activity for Flt3 Inhibition along with HDAC Inhibition, or by NFkB Inhibition, for Potentiating ER Stress Apoptosis.

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American Society of Hematology

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American Society of Hematology

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