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Journal Articles

Gab3 Plays an Essential Role in CD8 + T-Cell Expansion through Regulating IL-2-Mediated Activation of PI3K/AKT/mTOR and Erk/FoxO Pathways

Guoping Fu, Yongwei Zheng, Gang Xin, Zhengqi Wang, Kevin D. Bunting, Weiguo Cui, Arthur Salomon, Renren Wen

Blood (2023) 142 (Supplement 1): 3931.

https://doi.org/10.1182/blood-2023-185077

Published: 2023

Journal Articles

Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Multipotent Progenitor Niche Factors

Zhengqi Wang, Grace Emmel, Hong Seo Lim, Astrid Kosters, Eliver Ghosn, Peng Qiu, Kevin D. Bunting

Blood (2022) 140 (Supplement 1): 1263–1264.

https://doi.org/10.1182/blood-2022-158988

Published: 2022

Journal Articles

Unique Roles for Grb2-Associated Binding (Gab) Adaptors in Hematopoietic Stem Cell Homeostasis and Repopulation

Zhengqi Wang, PhD, Gen-sheng Feng, PhD, Kevin D. Bunting, PhD

Blood (2017) 130 (Supplement 1): 2431.

https://doi.org/10.1182/blood.V130.Suppl_1.2431.2431

Published: 2017

Journal Articles

Dysregulated Macrophage Pro-Inflammatory Cytokine Production and Chronic Colitis in Mice Lacking Both Gab2 and Gab3

Tamisha Y. Vaughan-Whitley, Hikaru Nishio, Barry Imhoff, Zhengqi Wang, Silvia T. Bunting, Pamela Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Kevin D. Bunting

Blood (2014) 124 (21): 457.

https://doi.org/10.1182/blood.V124.21.457.457

Published: 2014

Journal Articles

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence

Yulan Qing, Zhengqi Wang, Kevin D. Bunting, Stanton L. Gerson

Blood (2014) 123 (7): 1002–1011.

https://doi.org/10.1182/blood-2013-08-521716

Published: 2014

Includes: Supplemental data

Journal Articles

Rescue of the HSC Maintenance Defects in Ku70-Deficient Mice by Overexpression of Bcl2 Reveals a Novel Role of Bcl2 in HSC

Yulan Qing, PhD, Zhengqi Wang, PhD, Shigemi Matsuyama, PhD, Kevin D. Bunting, PhD, Stanton L. Gerson, MD

Blood (2012) 120 (21): 1235.

https://doi.org/10.1182/blood.V120.21.1235.1235

Published: 2012

Journal Articles

STAT5 Promotes Hematopoietic Stem Cell Maintenance by Increasing Quiescence-Associated Gene Expression and Suppressing Lymphoid Commitment

Zhengqi Wang, PhD, Geqiang Li, PhD, Zizhen Kang, MD, Tamisha Y. Vaughan, PhD, Silvia T Bunting, MD, William Tse, MD, Kevin D. Bunting, PhD

Blood (2012) 120 (21): 851.

https://doi.org/10.1182/blood.V120.21.851.851

Published: 2012

Journal Articles

HIF-1 α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

Jinwei Du, Yu Chen, Qiang Li, Xiangzi Han, Cindy Cheng, Zhengqi Wang, David Danielpour, Sally L. Dunwoodie, Kevin D. Bunting, Yu-Chung Yang

Blood (2012) 119 (12): 2789–2798.

https://doi.org/10.1182/blood-2011-10-387902

Published: 2012

Includes: Supplemental data

Journal Articles

STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma

Zhengqi Wang, Geqiang Li, Zizhen Kang, Silvia T Bunting, William Tse, Kevin D. Bunting, PhD

Blood (2011) 118 (21): 919.

https://doi.org/10.1182/blood.V118.21.919.919

Published: 2011

Journal Articles

Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a,

Harini Nivarthi, Andriy Tsyrulnyk, Wolfgang Warsch, Zhengqi Wang, Susanne Winkler, Lukas Kenner, MD, Mathias Müller, DVM, Christopher Baum, MD, Kevin D. Bunting, PhD, Veronika Sexl, MD, Thomas Rülicke, D.V.M., Richard Moriggl, PhD

Blood (2011) 118 (21): 3399.

https://doi.org/10.1182/blood.V118.21.3399.3399

Published: 2011

Journal Articles

Cited2 Regulates Hematopoietic Stem Cell Quiescence Through HIF-1α Dependent and Independent Pathways

Jinwei Du, Yu Chen, Qiang Li, Zhengqi Wang, Sally Dunwoodie, Kevin D. Bunting, PhD, Yu-Chung Yang, PhD

Blood (2011) 118 (21): 912.

https://doi.org/10.1182/blood.V118.21.912.912

Published: 2011

Journal Articles

Multiple Apoptotic Defects In Hematopoietic Cellsfrom Mice Lacking Lipocalin 24p3.

L.R. Devireddy, DVM, PhD, Zhuoming Liu, Alieta Ciocea, Amy Yang, Zhengqi Wang, Kevin D. Bunting, PhD, Michael Green

Blood (2010) 116 (21): 1560.

https://doi.org/10.1182/blood.V116.21.1560.1560

Published: 2010

Journal Articles

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease

Geqiang Li, Kristy L. Miskimen, Zhengqi Wang, Xiu Yan Xie, Jennifer Brenzovich, John J. Ryan, William Tse, Richard Moriggl, Kevin D. Bunting

Blood (2010) 115 (7): 1416–1424.

https://doi.org/10.1182/blood-2009-07-234963

Published: 2010

Includes: Supplemental data

Journal Articles

Genetic and Pharmacologic Targeting of STAT5/Gab2/PI3K/mTOR Signaling in a Mouse Myeloproliferative Disease Model.

Geqiang Li, Ph.D., Zhengqi Wang, Ph.D., Kristy L. Miskimen, Ph.D., Xiu Yan Xie, M.D., William Tse, M.D., Fabrice Gouilleux, Ph.D., Richard Moriggl, Ph.D., Kevin D. Bunting, Ph.D.

Blood (2009) 114 (22): 3902.

https://doi.org/10.1182/blood.V114.22.3902.3902

Published: 2009

Journal Articles

Regulation of Hematopoietic Stem Cell Quiescence by Ku70.

Yulan Qing, PhD, Zhengqi Wang, Ph.D., Min Liu, Kevin D. Bunting, PhD, Stanton L. Gerson, MD

Blood (2009) 114 (22): 3613.

https://doi.org/10.1182/blood.V114.22.3613.3613

Published: 2009

Journal Articles

STAT5 Requires the N-Domain for Suppression of miR15/16, Induction of Bcl-2, and Survival Signaling in Myeloproliferative Disease.

Geqiang Li, Ph.D., Kristy L. Miskimen, Ph.D., Zhengqi Wang, Ph.D., Xiu Yan Xie, M.D., Jennifer Brenzovich, B.S., John J Ryan, Ph.D., William Tse, M.D., Richard Moriggl, Ph.D., Kevin D. Bunting, Ph.D.

Blood (2009) 114 (22): 211.

https://doi.org/10.1182/blood.V114.22.211.211

Published: 2009

Journal Articles

Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement

Zhengqi Wang, Geqiang Li, William Tse, Kevin D. Bunting

Blood (2009) 113 (20): 4856–4865.

https://doi.org/10.1182/blood-2008-09-181107

Published: 2009

Includes: Supplemental data

Journal Articles

STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34 pos cells into tumor-competent dendritic cells

Peter A. Cohen, Gary K. Koski, Brian J. Czerniecki, Kevin D. Bunting, Xin-Yuan Fu, Zhengqi Wang, Wen-Jun Zhang, Charles S. Carter, Mohamed Awad, Christopher A. Distel, Hassan Nagem, Christopher C. Paustian, Terrence D. Johnson, John F. Tisdale, Suyu Shu

Blood (2008) 112 (5): 1832–1843.

https://doi.org/10.1182/blood-2007-12-130138

Published: 2008

Includes: Supplemental data

Journal Articles

Conditional Deletion of STAT5 in Non-Myeloablated Recipient Mice Promotes Donor Hematopoietic Stem Cell Engraftment.

Zhengqi Wang, PhD, Geqiang Li, Ph.D., Eleonora Haviernikova, M.S., William Tse, M.D., Kevin D. Bunting, Ph.D.

Blood (2007) 110 (11): 178.

https://doi.org/10.1182/blood.V110.11.178.178

Published: 2007

Journal Articles

Physiologically Significant Genetic Interaction between STAT5 and Gab2 during Normal and Pathologic Hematopoiesis.

Geqiang Li, PhD, Zhengqi Wang, Ph.D., Yi Zhang, Ph.D., Eleonora Haviernikova, M.S., William Tse, M.D., Kevin D. Bunting, Ph.D.

Blood (2007) 110 (11): 87.

https://doi.org/10.1182/blood.V110.11.87.87

Published: 2007

NARROW

Gab3 Plays an Essential Role in CD8 + T-Cell Expansion through Regulating IL-2-Mediated Activation of PI3K/AKT/mTOR and Erk/FoxO Pathways

Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Multipotent Progenitor Niche Factors

Unique Roles for Grb2-Associated Binding (Gab) Adaptors in Hematopoietic Stem Cell Homeostasis and Repopulation

Dysregulated Macrophage Pro-Inflammatory Cytokine Production and Chronic Colitis in Mice Lacking Both Gab2 and Gab3

Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence

Rescue of the HSC Maintenance Defects in Ku70-Deficient Mice by Overexpression of Bcl2 Reveals a Novel Role of Bcl2 in HSC

STAT5 Promotes Hematopoietic Stem Cell Maintenance by Increasing Quiescence-Associated Gene Expression and Suppressing Lymphoid Commitment

HIF-1 α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma

Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a,

Cited2 Regulates Hematopoietic Stem Cell Quiescence Through HIF-1α Dependent and Independent Pathways

Multiple Apoptotic Defects In Hematopoietic Cellsfrom Mice Lacking Lipocalin 24p3.

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease

Genetic and Pharmacologic Targeting of STAT5/Gab2/PI3K/mTOR Signaling in a Mouse Myeloproliferative Disease Model.

Regulation of Hematopoietic Stem Cell Quiescence by Ku70.

STAT5 Requires the N-Domain for Suppression of miR15/16, Induction of Bcl-2, and Survival Signaling in Myeloproliferative Disease.

Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement

STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34 pos cells into tumor-competent dendritic cells

Conditional Deletion of STAT5 in Non-Myeloablated Recipient Mice Promotes Donor Hematopoietic Stem Cell Engraftment.

Physiologically Significant Genetic Interaction between STAT5 and Gab2 during Normal and Pathologic Hematopoiesis.

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American Society of Hematology

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American Society of Hematology

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