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Journal Articles

Extrafollicular B cell expansion in COVID-19 patients with prothrombotic antibodies linked to inflammatory and Th1 signatures

Nathan Witman, Mei Yu, Yuqi Zhang, Kexin Gai, Yuhong Chen, Lu Zhou, Christine Nguyen, Wen Zhu, Yongwei Zheng, Shawn Jobe, Mary Beth Graham, Weiguo Cui, Demin Wang, Renren Wen

Blood (2025) 146 (Supplement 1): 1232.

https://doi.org/10.1182/blood-2025-1232

Published: 2025

Journal Articles

Sepsis induces platelet‑activating anti‑PF4 antibodies with potential protective role against secondary bacterial infection

Tao Liu, Daniel Villalobos, Shiqi Cai, Archana Mollangiri, Pawjai Khampang, Kenneth Brockman,, Demin Wang, Renren Wen

Blood (2025) 146 (Supplement 1): 4875.

https://doi.org/10.1182/blood-2025-4875

Published: 2025

Journal Articles

JMJD1C-mediated epigenetic control of HIT antibody production

Mei Yu, Yongguang Zhang, Yuhong Chen, Lu Zhou, Yongwei Zheng, David W Wang, Nan Zhu, Renren Wen, Demin Wang

Blood (2025) 146 (Supplement 1): 3110.

https://doi.org/10.1182/blood-2025-3110

Published: 2025

Journal Articles

HIT antibodies activate platelets by interacting with a negatively charged epitope on human PF4

Guoping Fu, Daniel Villalobos, Demin Wang, Renren Wen

Blood (2025) 146 (Supplement 1): 3100.

https://doi.org/10.1182/blood-2025-3100

Published: 2025

Journal Articles

Novel PF4/heparin complexes drive platelet activation in heparin-induced thrombocytopenia

Daniel Villalobos, Renren Wen, Demin Wang, Nathan Witman

Blood (2025) 146 (Supplement 1): 3097.

https://doi.org/10.1182/blood-2025-3097

Published: 2025

Journal Articles

Targeting pathogenic alloantibody generation using a chimeric HPA-1a-containing fc fusion protein: A novel treatment for fetal and neonatal alloimmune thrombocytopenia (FNAIT)

Huiying Zhi, Cathy Paddock, Guoping Fu, Jieqing Zhu, Renren Wen, Debra Newman, Peter Newman

Blood (2025) 146 (Supplement 1): 198.

https://doi.org/10.1182/blood-2025-198

Published: 2025

Journal Articles

Prothrombotic antibodies targeting the spike protein's receptor-binding domain in severe COVID-19

Blood (2025) 145 (6): 635–647.

https://doi.org/10.1182/blood.2024025010

Published: 2025

Includes: Supplemental data

Journal Articles

Identification of Platelet-Activating Antibodies That Do Not Bind to PF4/Heparin Complexes in Heparin-Induced Thrombocytopenia

Lu Zhou, Daniel Villalobos, Richard H. Aster, Anand Pabmanabhan, Demin Wang, Renren Wen

Blood (2024) 144 (Supplement 1): 5588.

https://doi.org/10.1182/blood-2024-210295

Published: 2024

Journal Articles

A Subset of Antibodies to the Spike Protein's Receptor-Binding Domain in Severe COVID-19 Activate Platelets

Wen Zhu, Yongwei Zheng, Mei Yu, Nathan Witman, Anand Pabmanabhan, Lisa Baumann Kreuziger, Gilbert C. White, Tongjun Gu, Alexander Fields, Lucy Kornblith, Richard H. Aster, Weiguo Cui, Shawn M. Jobe, Mary Beth Graham, Demin Wang, Renren Wen

Blood (2024) 144 (Supplement 1): 1229.

https://doi.org/10.1182/blood-2024-211524

Published: 2024

Journal Articles

Polycomb Group Protein Yin Yang 1 Controls DNA Methylation in Murine T Lymphocyte Development

Yinghua Wang, Xuan Pan, Mei Yu, Renren Wen

Blood (2023) 142 (Supplement 1): 3928.

https://doi.org/10.1182/blood-2023-190263

Published: 2023

Journal Articles

Epigenetic Control of B Cell Autoimmunity By Jmjd1c

Yongguang Zhang, Mei Yu, Yongwei Zheng, Yuhong Chen, Jesus Izaguirre-Carbonell, Nan Zhu, Renren Wen, Demin Wang

Blood (2023) 142 (Supplement 1): 155.

https://doi.org/10.1182/blood-2023-182034

Published: 2023

Journal Articles

Gab3 Plays an Essential Role in CD8 + T-Cell Expansion through Regulating IL-2-Mediated Activation of PI3K/AKT/mTOR and Erk/FoxO Pathways

Guoping Fu, Yongwei Zheng, Gang Xin, Zhengqi Wang, Kevin D. Bunting, Weiguo Cui, Arthur Salomon, Renren Wen

Blood (2023) 142 (Supplement 1): 3931.

https://doi.org/10.1182/blood-2023-185077

Published: 2023

Journal Articles

MiR-9-1 Controls Osteoblastic Regulation of Lymphopoiesis

Yongguang Zhang, Yongwei Zheng, Yuhong Chen, Mei Yu, Karen-Sue Carlson, Renren Wen, Demin Wang

Blood (2023) 142 (Supplement 1): 1333.

https://doi.org/10.1182/blood-2023-181128

Published: 2023

Journal Articles

Monoclonal gammopathy of thrombotic/thrombocytopenic significance

Adam J. Kanack, Jordan K. Schaefer, Meera Sridharan, Noah P. Splinter, Mindy C. Kohlhagen, Bandana Singh, Silvana B. De Lorenzo, Emily E. Mauch, Maen A. Hussein, Marwan Shaikh, Shaji Kumar, Renren Wen, Demin Wang, David Murray, Anand Padmanabhan

Blood (2023) 141 (14): 1772–1776.

https://doi.org/10.1182/blood.2022018797

Published: 2023

Includes: Supplemental data

Journal Articles

Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis

Wen Zhu, Yongwei Zheng, Mei Yu, Yaling Wu, Jianhui Wei, Lu Zhou, Guoping Fu, Nicholas Schneider, Curtis Jones, Mehraboon Irani, Anand Padmanabhan, Richard Aster, Demin Wang, Renren Wen

Blood (2023) 141 (9): 1060–1069.

https://doi.org/10.1182/blood.2022017612

Published: 2023

Includes: Supplemental data

Journal Articles

CD4+ T Cells Are Required for Production of Disease-Causing Antibodies in an Alloantigen-Specific Murine Model of Fetal/Neonatal Alloimmune Thrombocytopenia

Huiying Zhi, Guoping Fu, Renren Wen, Demin Wang, Peter J. Newman, Debra K. Newman

Blood (2022) 140 (Supplement 1): 2828.

https://doi.org/10.1182/blood-2022-169883

Published: 2022

Journal Articles

MCD-DLBCL arises from germinal center B cells

Renren Wen, Demin Wang

Blood (2022) 140 (10): 1058–1059.

https://doi.org/10.1182/blood.2022017534

Published: 2022

Journal Articles

Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

Adam J. Kanack, Antonios Bayas, Gemlyn George, Mouhamed Yazan Abou-Ismail, Bandana Singh, Mindy C. Kohlhagen, Noah P. Splinter, Monika Christ, Markus Naumann, Karen A. Moser, Kristi J. Smock, Alison Grazioli, Renren Wen, Demin Wang, David L. Murray, Anand Padmanabhan

Blood (2022) 140 (1): 73–77.

https://doi.org/10.1182/blood.2021014588

Published: 2022

Includes: Supplemental data

Journal Articles

Abundance of B Cell Receptors Harboring Elongated Polytyrosine and Polyserine Rich Motifs within Their Heavy Chain CDR3 Distinguishes Catastrophic and Antiphospholipid Syndrome

Shadi Swaidani, Shruti Chaturvedi, Xiang-Zuo Pan, Robert Brodsky, Renren Wen, Alok A Khorana, Keith R. McCrae

Blood (2021) 138 (Supplement 1): 2117.

https://doi.org/10.1182/blood-2021-148158

Published: 2021

Journal Articles

High Plasma Apolipoprotein(a) Concentration and Low Plasmin Tpa Enzymatic Activity in Hospitalized Patients with COVID-19

Ziyu Zhang, Wen Dai, Wen Zhu, Maya Rodriguez, Mary Rau, Hayley Lund, Lisa Baumann Kreuziger, Renren Wen, Roy L. Silverstein, Ze Zheng

Blood (2021) 138 (Supplement 1): 2095.

https://doi.org/10.1182/blood-2021-151641

Published: 2021

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Extrafollicular B cell expansion in COVID-19 patients with prothrombotic antibodies linked to inflammatory and Th1 signatures

Sepsis induces platelet‑activating anti‑PF4 antibodies with potential protective role against secondary bacterial infection

JMJD1C-mediated epigenetic control of HIT antibody production

HIT antibodies activate platelets by interacting with a negatively charged epitope on human PF4

Novel PF4/heparin complexes drive platelet activation in heparin-induced thrombocytopenia

Targeting pathogenic alloantibody generation using a chimeric HPA-1a-containing fc fusion protein: A novel treatment for fetal and neonatal alloimmune thrombocytopenia (FNAIT)

Prothrombotic antibodies targeting the spike protein's receptor-binding domain in severe COVID-19

Identification of Platelet-Activating Antibodies That Do Not Bind to PF4/Heparin Complexes in Heparin-Induced Thrombocytopenia

A Subset of Antibodies to the Spike Protein's Receptor-Binding Domain in Severe COVID-19 Activate Platelets

Polycomb Group Protein Yin Yang 1 Controls DNA Methylation in Murine T Lymphocyte Development

Epigenetic Control of B Cell Autoimmunity By Jmjd1c

Gab3 Plays an Essential Role in CD8 + T-Cell Expansion through Regulating IL-2-Mediated Activation of PI3K/AKT/mTOR and Erk/FoxO Pathways

MiR-9-1 Controls Osteoblastic Regulation of Lymphopoiesis

Monoclonal gammopathy of thrombotic/thrombocytopenic significance

Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis

CD4+ T Cells Are Required for Production of Disease-Causing Antibodies in an Alloantigen-Specific Murine Model of Fetal/Neonatal Alloimmune Thrombocytopenia

MCD-DLBCL arises from germinal center B cells

Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

Abundance of B Cell Receptors Harboring Elongated Polytyrosine and Polyserine Rich Motifs within Their Heavy Chain CDR3 Distinguishes Catastrophic and Antiphospholipid Syndrome

High Plasma Apolipoprotein(a) Concentration and Low Plasmin Tpa Enzymatic Activity in Hospitalized Patients with COVID-19

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American Society of Hematology

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