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Journal Articles

Prothrombotic Antibodies Targeting the Spike Protein's Receptor-Binding Domain in Severe COVID-19

Blood blood.2024025010.

https://doi.org/10.1182/blood.2024025010

Published: 2024

Includes: Supplemental data

Journal Articles

Monoclonal gammopathy of thrombotic/thrombocytopenic significance

Adam J. Kanack, Jordan K. Schaefer, Meera Sridharan, Noah P. Splinter, Mindy C. Kohlhagen, Bandana Singh, Silvana B. De Lorenzo, Emily E. Mauch, Maen A. Hussein, Marwan Shaikh, Shaji Kumar, Renren Wen, Demin Wang, David Murray, Anand Padmanabhan

Blood (2023) 141 (14): 1772–1776.

https://doi.org/10.1182/blood.2022018797

Published: 2023

Includes: Supplemental data

Journal Articles

Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis

Wen Zhu, Yongwei Zheng, Mei Yu, Yaling Wu, Jianhui Wei, Lu Zhou, Guoping Fu, Nicholas Schneider, Curtis Jones, Mehraboon Irani, Anand Padmanabhan, Richard Aster, Demin Wang, Renren Wen

Blood (2023) 141 (9): 1060–1069.

https://doi.org/10.1182/blood.2022017612

Published: 2023

Includes: Supplemental data

Journal Articles

Off-the-shelf cryopreserved platelets for the detection of HIT and VITT antibodies

Adam J. Kanack, Curtis G. Jones, Bandana Singh, Rachel R. Leger, Noah P. Splinter, Nahla M. Heikal, Rajiv K. Pruthi, Dong Chen, Gemlyn George, Mouhamed Y. Abou-Ismail, Geoffrey D. Wool, Krishna Gundabolu, Anand Padmanabhan

Blood (2022) 140 (25): 2722–2729.

https://doi.org/10.1182/blood.2022017283

Published: 2022

Includes: Supplemental data

Journal Articles

No Difference in Venous Thromboembolism Outcomes after COVID-19 and Influenza Vaccinations

Damon E. Houghton, David M Scott, Waldemar E. Wysokinski, Rajiv K. Pruthi, Meera Sridharan, Leslie Padrnos, Surbhi Shah, Aneel A. Ashrani, Anand Padmanabhan, Ewa Wysokinska, Robert D. McBane, Lisa Baumann Kreuziger

Blood (2022) 140 (Supplement 1): 8545–8547.

https://doi.org/10.1182/blood-2022-168142

Published: 2022

Journal Articles

"Autoimmune HIT", a Potential Diagnostic Artifact Due to Remnant Heparin in HIT Samples, Is Not Associated with More Severe Outcomes

Adam Kanack, Rachel Leger, Abdulrahman Saadalla, Nahla Heikal, Dong Chen, David Garcia, Rajiv K. Pruthi, Anand Padmanabhan

Blood (2022) 140 (Supplement 1): 1963–1964.

https://doi.org/10.1182/blood-2022-169711

Published: 2022

Journal Articles

Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

Adam J. Kanack, Antonios Bayas, Gemlyn George, Mouhamed Yazan Abou-Ismail, Bandana Singh, Mindy C. Kohlhagen, Noah P. Splinter, Monika Christ, Markus Naumann, Karen A. Moser, Kristi J. Smock, Alison Grazioli, Renren Wen, Demin Wang, David L. Murray, Anand Padmanabhan

Blood (2022) 140 (1): 73–77.

https://doi.org/10.1182/blood.2021014588

Published: 2022

Includes: Supplemental data

Journal Articles

A Thrombospondin-1 Release Assay (TRA) Coupled to PF4-Treated Cryopreserved Platelets for the Detection of Pathogenic HIT and VITT Antibodies

Adam Kanack, Curtis Jones, Bandana Singh, Gemlyn George, Mouhamed Yazan Abou-Ismail, David L. Green, Alison Grazioli, Rachel Leger, Nahla M. Heikal, Dong Chen, Rajiv K. Pruthi, Anand Padmanabhan

Blood (2021) 138 (Supplement 1): 2130.

https://doi.org/10.1182/blood-2021-152953

Published: 2021

Journal Articles

Monoclonal and Oligoclonal Anti-PF4 Antibodies Mediate VITT

Bandana Singh, Adam Kanack, Antonios Bayas, Gemlyn George, Mouhamed Yazan Abou Abou-Ismail, Mindy Kohlhagen, Monika Christ, Markus Naumann, Karen A Moser, Kristi J Smock, Alison Grazioli, David L Murray, Anand Padmanabhan

Blood (2021) 138 (Supplement 1): 3220.

https://doi.org/10.1182/blood-2021-153307

Published: 2021

Journal Articles

Deep Vein Thrombosis after COVID-19 Vaccinations

Damon E. Houghton, Anand Padmanabhan, Aneel A. Ashrani, Ewa Wysokinska, Rahul Chaudhary, Leslie Padrnos, Rajiv K. Pruthi, Meera Sridharan, Surbhi Shah, Waldemar E. Wysokinski

Blood (2021) 138 (Supplement 1): 291.

https://doi.org/10.1182/blood-2021-151396

Published: 2021

Journal Articles

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Lubica Rauova, Andy Wang, Serge Yarovoi, Sanjay Khandelwal, Anand Padmanabhan, Olga Oleshko, Matthew J. Charman, Andreas Tiede, Charles S. Abrams, Matthew D. Weitzman, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz

Blood (2021) 138 (Supplement 1): 292.

https://doi.org/10.1182/blood-2021-151685

Published: 2021

Journal Articles

Diagnostic Utility of High Dose Heparin Confirmation Step in Heparin Induced Thrombocytopenia ELISA Assay

Abdulrahman Saadalla, Rachel Leger, Aneel A. Ashrani, Rajiv K. Pruthi, Dong Chen, Anand Padmanabhan, Nahla Heikal

Blood (2021) 138 (Supplement 1): 3228.

https://doi.org/10.1182/blood-2021-154504

Published: 2021

Journal Articles

No Diagnostic Utility of Zero Heparin Control Buffer in Serotonin Release Assay: Findings from a Validation Study

Abdulrahman Saadalla, Rachel Leger, Aneel A. Ashrani, Rajiv K. Pruthi, Dong Chen, Anand Padmanabhan, Nahla Heikal

Blood (2021) 138 (Supplement 1): 3227.

https://doi.org/10.1182/blood-2021-154209

Published: 2021

Journal Articles

A prospective, blinded study of a PF4-dependent assay for HIT diagnosis

Bethany Samuelson Bannow, Deepti M. Warad, Curtis G. Jones, Shannon M. Pechauer, Brian R. Curtis, Daniel W. Bougie, Ruchika Sharma, Diane E. Grill, Mary W. Redman, Parisa R. Khalighi, Rachel R. Leger, Rajiv K. Pruthi, Dong Chen, Daniel E. Sabath, Richard H. Aster, David A. Garcia, Anand Padmanabhan

Blood (2021) 137 (8): 1082–1089.

https://doi.org/10.1182/blood.2020008195

Published: 2021

Includes: Supplemental data

Journal Articles

Polyreactivity and Somatic Hypermutation Analysis Reveals the Innate B Cell Origin of Human PF4/Heparin Reactive Antibodies

Wen Zhu, MBBS,MS, Lu Zhou, Ting Zhao, Yongwei Zheng, PhD, Mei Yu, PhD, Jianhui Wei, Anand Padmanabhan, M.B.B.S., PhD, Richard H. Aster, MD, Demin Wang, PhD, Renren Wen, PhD

Blood (2020) 136 (Supplement 1): 34–35.

https://doi.org/10.1182/blood-2020-138781

Published: 2020

Journal Articles

Antibody Cloning Identifies Pathogenic and Non-Pathogenic Antibodies in Heparin-Induced Thrombocytopenia and Defines the Molecular Signatures That Differentiate the Two Types of Antibodies

Wen Zhu, Yongwei Zheng, PhD, Mei Yu, PhD, Yaling Wu, Jianhui Wei, Nicholas Schneider, Anand Padmanabhan, MD PhD, Richard H. Aster, MD, Demin Wang, PhD, Renren Wen, PhD

Blood (2019) 134 (Supplement_1): 439.

https://doi.org/10.1182/blood-2019-126097

Published: 2019

Journal Articles

New Monoclonal Antibodies Reveal Distinct Specificities for Platelet Factor 4 Bound to Heparin Vs. Platelets: Implications for HIT Pathogenesis

Anand Padmanabhan, MD PhD, Shannon Pechauer, Curtis Jones, BS, Daniel Bougie, PhD, Richard H. Aster, MD

Blood (2019) 134 (Supplement_1): 1144.

https://doi.org/10.1182/blood-2019-127169

Published: 2019

Journal Articles

New IDEaS for HIT treatment, anyone?

Anand Padmanabhan

Blood (2019) 133 (22): 2355–2356.

https://doi.org/10.1182/blood.2019000695

Published: 2019

Journal Articles

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Deepti M. Warad, MD, Bethany T Samuelson Bannow, MD, Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhD, Daniel W. Bougie, PhD, Parisa R Khalighi, BS, Diane E. Grill, MS, Rachel Leger, BAE, Ruchika Sharma, MD, Dong Chen, MD PhD, Richard H. Aster, MD, David A. Garcia, MD, Anand Padmanabhan, MD PhD

Blood (2018) 132 (Supplement 1): 416.

https://doi.org/10.1182/blood-2018-99-112475

Published: 2018

Journal Articles

Use of Intravenous Immunoglobulin G in HIT: Impact on Thrombosis and Mortality in a Population-Based Study

Binod Dhakal, MBBS, Rein Lisa, Aniko Szabo, PhD, Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2018) 132 (Supplement 1): 2512.

https://doi.org/10.1182/blood-2018-99-117190

Published: 2018

NARROW

Prothrombotic Antibodies Targeting the Spike Protein's Receptor-Binding Domain in Severe COVID-19

Monoclonal gammopathy of thrombotic/thrombocytopenic significance

Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis

Off-the-shelf cryopreserved platelets for the detection of HIT and VITT antibodies

No Difference in Venous Thromboembolism Outcomes after COVID-19 and Influenza Vaccinations

"Autoimmune HIT", a Potential Diagnostic Artifact Due to Remnant Heparin in HIT Samples, Is Not Associated with More Severe Outcomes

Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

A Thrombospondin-1 Release Assay (TRA) Coupled to PF4-Treated Cryopreserved Platelets for the Detection of Pathogenic HIT and VITT Antibodies

Monoclonal and Oligoclonal Anti-PF4 Antibodies Mediate VITT

Deep Vein Thrombosis after COVID-19 Vaccinations

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Diagnostic Utility of High Dose Heparin Confirmation Step in Heparin Induced Thrombocytopenia ELISA Assay

No Diagnostic Utility of Zero Heparin Control Buffer in Serotonin Release Assay: Findings from a Validation Study

A prospective, blinded study of a PF4-dependent assay for HIT diagnosis

Polyreactivity and Somatic Hypermutation Analysis Reveals the Innate B Cell Origin of Human PF4/Heparin Reactive Antibodies

Antibody Cloning Identifies Pathogenic and Non-Pathogenic Antibodies in Heparin-Induced Thrombocytopenia and Defines the Molecular Signatures That Differentiate the Two Types of Antibodies

New Monoclonal Antibodies Reveal Distinct Specificities for Platelet Factor 4 Bound to Heparin Vs. Platelets: Implications for HIT Pathogenesis

New IDEaS for HIT treatment, anyone?

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Use of Intravenous Immunoglobulin G in HIT: Impact on Thrombosis and Mortality in a Population-Based Study

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American Society of Hematology

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ASH Publications

American Society of Hematology

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