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Journal Articles

O-linked sialic acid residues on platelet membrane glycoprotein IIb mask the human HPA-9b alloepitope

Nanyan Zhang, Mia J. Sullivan, Brian R. Curtis, Peter J. Newman

Blood (2023) 142 (22): 1909–1917.

https://doi.org/10.1182/blood.2023021122

Published: 2023

Includes: Supplemental data

Journal Articles

Bioengineered Glycoprotein-Deficient iPSC-Derived Megakaryocytes for the Sensitive Detection and Characterization of Patient Antibodies in Autoimmune Thrombocytopenia

Nanyan Zhang, Brian R. Curtis, Peter J. Newman

Blood (2023) 142 (Supplement 1): 700.

https://doi.org/10.1182/blood-2023-178049

Published: 2023

Journal Articles

Genetic Removal of Terminal Sialic Acid Residues from the O-Linked Glycans Adjacent to the HPA-9b Polymorphism of Platelet Membrane Glycoprotein IIb Improves the Binding and Detection of HPA-9b Patient Alloantibodies

Nanyan Zhang, Brian R. Curtis, Peter J. Newman

Blood (2021) 138 (Supplement 1): 352.

https://doi.org/10.1182/blood-2021-144718

Published: 2021

Journal Articles

A prospective, blinded study of a PF4-dependent assay for HIT diagnosis

Bethany Samuelson Bannow, Deepti M. Warad, Curtis G. Jones, Shannon M. Pechauer, Brian R. Curtis, Daniel W. Bougie, Ruchika Sharma, Diane E. Grill, Mary W. Redman, Parisa R. Khalighi, Rachel R. Leger, Rajiv K. Pruthi, Dong Chen, Daniel E. Sabath, Richard H. Aster, David A. Garcia, Anand Padmanabhan

Blood (2021) 137 (8): 1082–1089.

https://doi.org/10.1182/blood.2020008195

Published: 2021

Includes: Supplemental data

Journal Articles

Bioengineered iPSC-derived megakaryocytes for the detection of platelet-specific patient alloantibodies

Nanyan Zhang, Sentot Santoso, Richard H. Aster, Brian R. Curtis, Peter J. Newman

Blood (2019) 134 (22): e1–e8.

https://doi.org/10.1182/blood.2019002225

Published: 2019

Includes: Supplemental data

Journal Articles

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Deepti M. Warad, MD, Bethany T Samuelson Bannow, MD, Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhD, Daniel W. Bougie, PhD, Parisa R Khalighi, BS, Diane E. Grill, MS, Rachel Leger, BAE, Ruchika Sharma, MD, Dong Chen, MD PhD, Richard H. Aster, MD, David A. Garcia, MD, Anand Padmanabhan, MD PhD

Blood (2018) 132 (Supplement 1): 416.

https://doi.org/10.1182/blood-2018-99-112475

Published: 2018

Journal Articles

Atomic-Level Dissection of the Polyclonal Immune Response to the Human Platelet Alloantigen, HPA-1a (Pl A1 )

Huiying Zhi, PhD, Maria Therese Ahlen, PhD, Aye Myat Myat Thinn, PhD, Hartmut Weiler, PhD, Brian R. Curtis, PhD, Bjorn Skogen, MD, Jieqing Zhu, PhD, Peter Newman, PhD

Blood (2018) 132 (Supplement 1): 1258.

https://doi.org/10.1182/blood-2018-99-111327

Published: 2018

Journal Articles

Patients treated with oxaliplatin are at risk for thrombocytopenia caused by multiple drug-dependent antibodies

Brian R. Curtis, Yen-Michael S. Hsu, Nikolai Podoltsev, Jill Lacy, Susanna Curtis, Michael S. Samuel, Kristin Zutavern, Robert A. DeSimone, Daniel W. Bougie, Richard H. Aster

Blood (2018) 131 (13): 1486–1489.

https://doi.org/10.1182/blood-2017-10-812461

Published: 2018

Includes: Supplemental data

Journal Articles

Normal plasma IgG inhibits HIT antibody–mediated platelet activation: implications for therapeutic plasma exchange

Curtis G. Jones, Shannon M. Pechauer, Brian R. Curtis, Daniel W. Bougie, Richard H. Aster, Anand Padmanabhan

Blood (2018) 131 (6): 703–706.

https://doi.org/10.1182/blood-2017-08-803031

Published: 2018

Includes: Supplemental data

Journal Articles

Structural and Functional Characterization of a Single Chain Î²3 Integrin in Solution and on the Cell Surface and the Implications on Integrin Activation and Pathogenesis of Anti-HPA-1a Alloantibodies

Aye Myat Myat Thinn, BS, Zhengli Wang, PhD, Dongwen Zhou, PhD, Yan Zhao, MD, Brian R. Curtis, PhDMT(ASCP), Jieqing Zhu, PhD

Blood (2017) 130 (Supplement 1): 2295.

https://doi.org/10.1182/blood.V130.Suppl_1.2295.2295

Published: 2017

Journal Articles

Drug-Induced Immune Thrombocytopenia (DITP) Caused By Multiple Drug-Dependent Platelet-Reactive Antibodies (DDAbs) in Patients Undergoing Oxaliplatin-Containing Combination Chemotherapy for Metastatic Colon Cancer

Brian R. Curtis, PhDMT(ASCP), Yen-Michael S. Hsu, MD PhD, Nikolai A. Podoltsev, MD PhD, Jill Lacy, MD, Susanna A Curtis, MD, Robert Andrew Desimone, MD, Michael Samuel, MD, Kristin Zutavern, BS, Daniel Bougie, PhD, Richard H. Aster, MD

Blood (2017) 130 (Supplement 1): 3625.

https://doi.org/10.1182/blood.V130.Suppl_1.3625.3625

Published: 2017

Journal Articles

A New Assay for Platelet-Activating HIT Antibodies, the PEA, Is Specific, Reproducible and Relatively Independent of the Choice of Platelet Donor

Shannon Pechauer, Curtis Jones, BS, Daniel W. Bougie, PhD, Brian R. Curtis, PhDMT(ASCP), Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2017) 130 (Supplement 1): 458.

https://doi.org/10.1182/blood.V130.Suppl_1.458.458

Published: 2017

Journal Articles

Immunoglobulin G in Normal Plasma Inhibits HIT Antibody-Mediated Platelet Activation: Implications for Therapeutic Plasma Exchange Treatment in HIT

Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhDMT(ASCP), Daniel W. Bougie, PhD, Richard H. Aster, MD, Anand Padmanabhan, MD PhD

Blood (2017) 130 (Supplement 1): 2402.

https://doi.org/10.1182/blood.V130.Suppl_1.2402.2402

Published: 2017

Journal Articles

A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Lisa M. Baumann Kreuziger, MD MS, Brenda M. Pierce, MD, Richard H. Aster, MD

Blood (2016) 128 (22): 2599.

https://doi.org/10.1182/blood.V128.22.2599.2599

Published: 2016

Journal Articles

Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Barbara J. Bryant, MD, Jack B. Alperin, MD, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Renren Wen, PhD, Demin Wang, PhD, Richard H. Aster, MD

Blood (2016) 128 (22): 2600.

https://doi.org/10.1182/blood.V128.22.2600.2600

Published: 2016

Journal Articles

CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes

Nanyan Zhang, Huiying Zhi, Brian R. Curtis, Sridhar Rao, Chintan Jobaliya, Mortimer Poncz, Deborah L. French, Peter J. Newman

Blood (2016) 127 (6): 675–680.

https://doi.org/10.1182/blood-2015-10-675751

Published: 2016

Includes: Supplemental data

Journal Articles

Involvement of the EGF Domain in the Formation of the Human Platelet Alloantigen, HPA-1a

Huiying Zhi, MD PhD, Panida Lertkiatmongkol, Brian R Curtis, PhD D(ABMLI), Peter J. Newman, PhD

Blood (2015) 126 (23): 2340.

https://doi.org/10.1182/blood.V126.23.2340.2340

Published: 2015

Journal Articles

Crispr/Cas9-Mediated Generation of Mouse Platelets Expressing the Human Platelet Alloantigen, HPA-1a

Huiying Zhi, MD PhD, Nanyan Zhang, MD PhD, Jamie Foeckler, Shawn Kalloway, PhD, Sridhar Rao, MD PhD, Brian R Curtis, PhD D(ABMLI), Hartmut Weiler, PhD, Peter J. Newman, PhD

Blood (2015) 126 (23): 2341.

https://doi.org/10.1182/blood.V126.23.2341.2341

Published: 2015

Journal Articles

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT)

Anand Padmanabhan, MBBS, MA, PhD, Curtis Jones, Brian R Curtis, MS, MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia Sullivan, Namrata Peswani, MD MBBS, Janice McFarland, MD, Daniel Eastwood, Demin Wang, PhD, Richard H. Aster, MD

Blood (2015) 126 (23): 764.

https://doi.org/10.1182/blood.V126.23.764.764

Published: 2015

Journal Articles

Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis

Anand Padmanabhan, Curtis G. Jones, Daniel W. Bougie, Brian R. Curtis, Janice G. McFarland, Demin Wang, Richard H. Aster

Blood (2015) 125 (1): 155–161.

https://doi.org/10.1182/blood-2014-06-580894

Published: 2015

Includes: Supplemental data

NARROW

O-linked sialic acid residues on platelet membrane glycoprotein IIb mask the human HPA-9b alloepitope

Bioengineered Glycoprotein-Deficient iPSC-Derived Megakaryocytes for the Sensitive Detection and Characterization of Patient Antibodies in Autoimmune Thrombocytopenia

Genetic Removal of Terminal Sialic Acid Residues from the O-Linked Glycans Adjacent to the HPA-9b Polymorphism of Platelet Membrane Glycoprotein IIb Improves the Binding and Detection of HPA-9b Patient Alloantibodies

A prospective, blinded study of a PF4-dependent assay for HIT diagnosis

Bioengineered iPSC-derived megakaryocytes for the detection of platelet-specific patient alloantibodies

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Atomic-Level Dissection of the Polyclonal Immune Response to the Human Platelet Alloantigen, HPA-1a (Pl A1 )

Patients treated with oxaliplatin are at risk for thrombocytopenia caused by multiple drug-dependent antibodies

Normal plasma IgG inhibits HIT antibody–mediated platelet activation: implications for therapeutic plasma exchange

Structural and Functional Characterization of a Single Chain Î²3 Integrin in Solution and on the Cell Surface and the Implications on Integrin Activation and Pathogenesis of Anti-HPA-1a Alloantibodies

Drug-Induced Immune Thrombocytopenia (DITP) Caused By Multiple Drug-Dependent Platelet-Reactive Antibodies (DDAbs) in Patients Undergoing Oxaliplatin-Containing Combination Chemotherapy for Metastatic Colon Cancer

A New Assay for Platelet-Activating HIT Antibodies, the PEA, Is Specific, Reproducible and Relatively Independent of the Choice of Platelet Donor

Immunoglobulin G in Normal Plasma Inhibits HIT Antibody-Mediated Platelet Activation: Implications for Therapeutic Plasma Exchange Treatment in HIT

A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes

Involvement of the EGF Domain in the Formation of the Human Platelet Alloantigen, HPA-1a

Crispr/Cas9-Mediated Generation of Mouse Platelets Expressing the Human Platelet Alloantigen, HPA-1a

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT)

Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis

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American Society of Hematology

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ASH Publications

American Society of Hematology

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