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Journal Articles

Platelet factor 4 regulates hematopoietic stem cell aging

Sen Zhang, Charles E. Ayemoba, Anna M. Di Staulo, Kenneth Joves, Chandani M. Patel, Eva Hin Wa Leung, Maura Lima Pereira Bueno, Xiaoping Du, Mortimer Poncz, Sang-Ging Ong, Claus Nerlov, Maria Maryanovich, Constantinos Chronis, Sandra Pinho

Blood (2025) 146 (23): 2765–2778.

https://doi.org/10.1182/blood.2024027432

Published: 2025

Includes: Supplemental data

Journal Articles

Hepatic intravital imaging reveals the contribution of peptidylarginine deiminase 4 (PAD4) to the spatiotemporal dynamics of neutrophil recruitment and NET release during bacterial infection

Weronika Ortmann, Anna Prykhodko, Hyunjun Kim, Abigail Skidmore, Steven Jiang, Lubica Rauova, Mortimer Poncz, Kandace Gollomp

Blood (2025) 146 (Supplement 1): 1221.

https://doi.org/10.1182/blood-2025-1221

Published: 2025

Journal Articles

Cell-free DNA is associated with central venous catheter-associated deep venous thrombosis in critically ill children

Hilary Whitworth, Hem Regmi, Anna Prykhodko, Leslie Raffini, Mortimer Poncz, E. Vincent Faustino, Kandace Gollomp

Blood (2025) 146 (Supplement 1): 317.

https://doi.org/10.1182/blood-2025-317

Published: 2025

Journal Articles

Both platelet factor 4 (PF4) and b2-glycoprotein I (b2GPI) bind to von Willebrand factor (VWF) and inhibit ADAMTS13 cleavage: Mechanistic and clinical implications in thrombotic thrombocytopenic purpura (TTP)

Amrita Sarkar, Khalil Bdeir, Chloe Ro, Jenna Oberg, X. Long Zheng, Gow Arepally, Douglas Cines, Lubica Rauova, Mortimer Poncz

Blood (2025) 146 (Supplement 1): 4876.

https://doi.org/10.1182/blood-2025-4876

Published: 2025

Journal Articles

Platelet-activating antibodies to the chemokine, platelet factor 4, in cerebral malaria differ from those in heparin-induced thrombocytopenia and vaccine-induced thrombotic thrombocytopenia.

Lubica Rauova, Iset Vera, Jenna Oberg, Ruth Namazzi, Marcus Shackleford, Karl Seydel, Douglas Cines, Chandy John, Kami Kim, Mortimer Poncz

Blood (2025) 146 (Supplement 1): 4870.

https://doi.org/10.1182/blood-2025-4870

Published: 2025

Journal Articles

Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes

Anh Ngo, Weronika Ortmann, Abigail Skidmore, Hyunjun Kim, Jenna Oberg, Amrita Sarkar, Veronica Bochenek, Nate Levine, Lubica Rauova, Irina Chernysh, Zachary Martinez, Caroline Diorio, Mark Goulian, Victor Nizet, Mortimer Poncz, Kandace Gollomp

Blood (2025) 146 (Supplement 1): 1322.

https://doi.org/10.1182/blood-2025-1322

Published: 2025

Journal Articles

Mechanistic insights into how g protein-coupled receptor kinases (GRKs) regulate thrombopoiesis

Xuefei Zhao, Hyun Ahn, Yanki Yarman, Hannah Thomson, Christopher Mansi, Matthew Cooper, Hyunjun Kim, Timothy Stalker, Elizabeth Gardiner, Mortimer Poncz, Peisong Ma

Blood (2025) 146 (Supplement 1): 195.

https://doi.org/10.1182/blood-2025-195

Published: 2025

Journal Articles

Antiphospholipid syndrome (APS) is the newest member of the PF4 immunothrombotic family: Mechanistic and therapeutic insights

Amrita Sarkar, Conroy Field, Khalil Bdeir, Santosh Yadav, Kandace Gollomp, Keith McCrae, Thomas Ortel, Jason Knight, Jérôme Rollin, Yves Gruel, Gow Arepally, Lubica Rauova, Mortimer Poncz

Blood (2025) 146 (Supplement 1): 194.

https://doi.org/10.1182/blood-2025-194

Published: 2025

Journal Articles

Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Lubica Rauova, Khalil Bdeir, Ann H. Rux, Manu Thomas Kalathottukaren, Jenna Oberg, Chanel C. La, David T. E. Lim, Vincent Hayes, Gavin T. Koma, Amrita Sarkar, Mortimer Poncz, Jayachandran N. Kizhakkedathu, Douglas B. Cines

Blood (2025) 145 (25): 3030–3040.

https://doi.org/10.1182/blood.2024025653

Published: 2025

Includes: Supplemental data

Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2611.

https://doi.org/10.1182/blood-2024-200849

Published: 2024

Journal Articles

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Veronica Bochenek, Abigail E Skidmore, Anh T.P. Ngo, Samir Maarouf, Weiming Hu, Santosh K Yadav, Ethan Mack, M. Anna Kowalska, Mortimer Poncz, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 2528.

https://doi.org/10.1182/blood-2024-203321

Published: 2024

Journal Articles

Platelet Factor 4 (PF4) Binding to Neutrophil Extracellular Traps (NETs) and Von Willebrand Factor (vWF) Improves Bacterial Capture and Killing in an Electrostatic Charge-Dependent Manner

Santosh K Yadav, Abigail E Skidmore, Anh T.P. Ngo, Veronica Bochenek, Manuela Roggiani, Mark Goulian, Mortimer Poncz, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 3986.

https://doi.org/10.1182/blood-2024-206506

Published: 2024

Journal Articles

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Amrita Sarkar, Conroy O Field, Keith R. McCrae, Thomas L. Ortel, Gow Arepally, Roxanne Cofiell, Sung-Kwon Kim, Lubica Rauova, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2606.

https://doi.org/10.1182/blood-2024-198182

Published: 2024

Journal Articles

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Sooho S Myoung, Samuel Francis, Jonah Chen, Grace M Lee, Lubica Rauova, Mortimer Poncz, Douglas B. Cines, Maragatha Kuchibhatla, Sanjay Khandelwal, Gow Arepally

Blood (2024) 144 (Supplement 1): 2605.

https://doi.org/10.1182/blood-2024-208062

Published: 2024

Journal Articles

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Anh T.P. Ngo, Veronica Bochenek, Hyunjun Kim, Nate Levine, Samir Maarouf, Jenna Oberg, Manuela Roggiani, Amrita Sarkar, Lubica Rauova, Caroline Diorio, Zachary Martinez, Mark Goulian, Mortimer Poncz, Victor Nizet, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 1231.

https://doi.org/10.1182/blood-2024-211717

Published: 2024

Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 185.

https://doi.org/10.1182/blood-2024-201682

Published: 2024

Journal Articles

Mechanistic Insights and Clinical Implications of the Thrombotic Risks of a Highly Prevalent GRK5 Variant Affecting Platelets

Yanki Yarman, Xuefei Zhao, Hyun Sook Ahn, Hannah Thomson, Meghan Roberts, Deborah L. French, Jeffrey Benovic, Timothy J. Stalker, Mortimer Poncz, Peisong Ma

Blood (2024) 144 (Supplement 1): 424.

https://doi.org/10.1182/blood-2024-205760

Published: 2024

Journal Articles

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Veronica Bochenek, Nate Levine, Anh T.P. Ngo, Samir Maarouf, Abigail E Skidmore, M. Anna Kowalska, Caroline Diorio, Zachary Martinez, Mortimer Poncz, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 1169.

https://doi.org/10.1182/blood-2023-189931

Published: 2023

Journal Articles

Murine Infusion Studies of Infused Human Megakaryocytes Support a “Catch-and-Release” Model of Thrombopoiesis

Hyunjun Kim, Kiwon Lee, Gavin Merschel, Mortimer Poncz

Blood (2023) 142 (Supplement 1): 2561.

https://doi.org/10.1182/blood-2023-181421

Published: 2023

Journal Articles

RUNX1 Haplodeficiency Reduces Platelet Endocytosis of Albumin and Fibrinogen and Impairs Megakaryocyte Intracellular Trafficking

Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Liying Guan, Afaque Mohammad Alam, Kiwon Lee, Mortimer Poncz, Angara Koneti Rao

Blood (2023) 142 (Supplement 1): 1218.

https://doi.org/10.1182/blood-2023-186668

Published: 2023

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Platelet factor 4 regulates hematopoietic stem cell aging

Hepatic intravital imaging reveals the contribution of peptidylarginine deiminase 4 (PAD4) to the spatiotemporal dynamics of neutrophil recruitment and NET release during bacterial infection

Cell-free DNA is associated with central venous catheter-associated deep venous thrombosis in critically ill children

Both platelet factor 4 (PF4) and b2-glycoprotein I (b2GPI) bind to von Willebrand factor (VWF) and inhibit ADAMTS13 cleavage: Mechanistic and clinical implications in thrombotic thrombocytopenic purpura (TTP)

Platelet-activating antibodies to the chemokine, platelet factor 4, in cerebral malaria differ from those in heparin-induced thrombocytopenia and vaccine-induced thrombotic thrombocytopenia.

Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes

Mechanistic insights into how g protein-coupled receptor kinases (GRKs) regulate thrombopoiesis

Antiphospholipid syndrome (APS) is the newest member of the PF4 immunothrombotic family: Mechanistic and therapeutic insights

Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Platelet Factor 4 (PF4) Binding to Neutrophil Extracellular Traps (NETs) and Von Willebrand Factor (vWF) Improves Bacterial Capture and Killing in an Electrostatic Charge-Dependent Manner

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Mechanistic Insights and Clinical Implications of the Thrombotic Risks of a Highly Prevalent GRK5 Variant Affecting Platelets

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Murine Infusion Studies of Infused Human Megakaryocytes Support a “Catch-and-Release” Model of Thrombopoiesis

RUNX1 Haplodeficiency Reduces Platelet Endocytosis of Albumin and Fibrinogen and Impairs Megakaryocyte Intracellular Trafficking

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American Society of Hematology

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