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Journal Articles

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Veronica Bochenek, Nate Levine, Anh T.P. Ngo, Samir Maarouf, Abigail E Skidmore, M. Anna Kowalska, Caroline Diorio, Zachary Martinez, Mortimer Poncz, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 1169.

https://doi.org/10.1182/blood-2023-189931

Published: 2023

Journal Articles

Fusion of uPA to Anti-aII b b3 Scfv Facilitates Its Uptake By in Vitro-Generated CD34+ Megakaryocytes (MKs) to Promote Targeted Fibrinolysis

Sergey Zaytsev, Hyunsook Ahn, M. Anna Kowalska, Rodney Camire, Douglas B. Cines, Mortimer Poncz, Victoria Stepanova

Blood (2022) 140 (Supplement 1): 1969–1970.

https://doi.org/10.1182/blood-2022-168072

Published: 2022

Journal Articles

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Anh T.P. Ngo, Amrita Sarkar, Nathan Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M. Anna Kowalska, Kaitlyn Eckart, Nilam S. Mangalmurti, Ann Rux, Douglas B. Cines, Mortimer Poncz, Kandace Gollomp

Blood (2022) 140 (Supplement 1): 5529–5530.

https://doi.org/10.1182/blood-2022-169709

Published: 2022

Journal Articles

Insights into Endogenous Vs Exogenous Cargo-Containing Platelet Alpha-Granules

Sergey Zaytsev, Hyunsook Ahn, Victoria Stepanova, M. Anna Kowalska, Khalil Bdeir, Deborah L French, Rodney M. Camire, Douglas B. Cines, Mortimer Poncz

Blood (2021) 138 (Supplement 1): 1028.

https://doi.org/10.1182/blood-2021-153348

Published: 2021

Journal Articles

Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy

Anh T.P. Ngo, Irene Yarovoi, Guohua Zhao, Amrita Sarkar, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz, Kandace Gollomp

Blood (2021) 138 (Supplement 1): 2096.

https://doi.org/10.1182/blood-2021-153352

Published: 2021

Journal Articles

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

Douglas B. Cines, Sergei Zaitsev, Lubica Rauova, Ann H. Rux, Victoria Stepanova, Sriram Krishnaswamy, Amrita Sarkar, M. Anna Kowalska, Guohua Zhao, Alan E. Mast, Laurence J. Blumberg, Keith R. McCrae, Mortimer Poncz, Jonathan J. Hubbard, Michal Pyzik, Richard S. Blumberg

Blood (2020) 135 (23): 2085–2093.

https://doi.org/10.1182/blood.2019001133

Published: 2020

Includes: Supplemental data

Journal Articles

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis

Kandace Gollomp, Amrita Sarkar, Sanjiv Harikumar, Steven H. Seeholzer, Gowthami M. Arepally, Kristin Hudock, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz

Blood (2020) 135 (10): 743–754.

https://doi.org/10.1182/blood.2019002329

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Kandace Gollomp, MD, Amrita Sarkar, PhD, Gowthami Arepally, MD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD

Blood (2019) 134 (Supplement_1): 10.

https://doi.org/10.1182/blood-2019-123132

Published: 2019

Journal Articles

Analysis of the Frequency of Spontaneous, Functionally-Significant Mutations in Genes Associated with Platelet Disorders in >120,000 Healthy Individuals

Joseph H Oved, MD BA, MA, Michele P. Lambert, MD, M. Anna Kowalska, PhD, Mortimer Poncz, MD, Konrad Karczewski, PhD

Blood (2018) 132 (Supplement 1): 2438.

https://doi.org/10.1182/blood-2018-99-115567

Published: 2018

Journal Articles

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Amrita Sarkar, PhD, Gowthami Arepally, MD, M. Anna Kowalska, PhD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Kandace Gollomp, MD

Blood (2018) 132 (Supplement 1): 271.

https://doi.org/10.1182/blood-2018-99-111381

Published: 2018

Journal Articles

Platelet Factor 4 (PF4)-Mediated Neutrophil Extracellular Trap Compaction Limits Endothelial Injury and Promotes Survival Following Lipopolysaccharide Challenge

Kandace Gollomp, MD, Ian Johnston, BS, Minna Kim, Li Zhai, Guohua Zhao, M. Anna Kowalska, PhD, Mortimer Poncz, MD

Blood (2017) 130 (Supplement 1): 997.

https://doi.org/10.1182/blood.V130.Suppl_1.997.997

Published: 2017

Journal Articles

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

Kandace Gollomp, MD, Ian Johnston, BS, Lubica Rauova, MD PhD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Mortimer Poncz, MD

Blood (2016) 128 (22): 1023.

https://doi.org/10.1182/blood.V128.22.1023.1023

Published: 2016

Journal Articles

The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis

Kandace Gollomp, MD, Johnston Ian, Diarra Fatoumata, Guohua Zhao, Sriram Krishnaswamy, PhD MD, Mortimer Poncz, MD, M. Anna Kowalska, PhD

Blood (2015) 126 (23): 2197.

https://doi.org/10.1182/blood.V126.23.2197.2197

Published: 2015

Journal Articles

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

Ronghua Meng, Jie Wu, Dawn C. Harper, Yuhuan Wang, M. Anna Kowalska, Charles S. Abrams, Lawrence F. Brass, Mortimer Poncz, Timothy J. Stalker, Michael S. Marks

Blood (2015) 125 (10): 1623–1632.

https://doi.org/10.1182/blood-2014-07-586727

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis

M. Anna Kowalska, PhD, Guohua Zhao, PhD, Ian Johnston, BS, Elsa Treffeisen, BA, Fatoumata Diarra, Sriram Krishnaswamy, PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 98.

https://doi.org/10.1182/blood.V124.21.98.98

Published: 2014

Journal Articles

Miniaturized T2MR Magnetic Resonance System for Analysis of Hemostasis and Detection of Impaired and Prothrombotic Blood Disorders

Douglas B. Cines, MD, Tatiana Lebedeva, M.D. Ph.D., M. Anna Kowalska, PhD, Mortimer Poncz, MD, Lubica Rauova, MD, PhD, Adam Cuker, MD, MS, John W. Weisel, Ph.D., Walter Massefski, Ph.D., Vyacheslav Papkov, M.S., Edward C. Thayer, Ph.D., Thomas J. Lowery, Ph.D.

Blood (2012) 120 (21): 1118.

https://doi.org/10.1182/blood.V120.21.1118.1118

Published: 2012

Journal Articles

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Rudy Fuentes, PhD, Hyun Sook Ahn, Vincent M. Hayes, Valerie Tutwiler, Yuhuan Wang, PhD, Daniel W. Bougie, PhD, M. Anna Kowalska, PhD, Lubica Rauova, M.D., Ph.D., Richard H. Aster, MD, Douglas B. Cines, MD, Vladimir R Muzykantov, MD PhD, Mortimer Poncz, MD, Sergei Zaitsev, PhD

Blood (2012) 120 (21): 1171.

https://doi.org/10.1182/blood.V120.21.1171.1171

Published: 2012

Journal Articles

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

Sergei Zaitsev, M. Anna Kowalska, Michael Neyman, Ronald Carnemolla, Samira Tliba, Bi-Sen Ding, Aaron Stonestrom, Dirk Spitzer, John P. Atkinson, Mortimer Poncz, Douglas B. Cines, Charles T. Esmon, Vladimir R. Muzykantov

Blood (2012) 119 (20): 4779–4785.

https://doi.org/10.1182/blood-2011-12-398149

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Histones, Like Platelet Factor 4 (PF4), Affect Generation of Activated Protein C: Implications for the Pathogenesis of Severe Sepsis

M. Anna Kowalska, PhD, Guohua Zhao, PhD, George David, III, Mortimer Poncz, MD

Blood (2011) 118 (21): 530.

https://doi.org/10.1182/blood.V118.21.530.530

Published: 2011

Journal Articles

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT

M. Anna Kowalska, Sriram Krishnaswamy, Lubica Rauova, Li Zhai, Vincent Hayes, Karine Amirikian, Jeffrey D. Esko, Daniel W. Bougie, Richard H. Aster, Douglas B. Cines, Mortimer Poncz

Blood (2011) 118 (10): 2882–2888.

https://doi.org/10.1182/blood-2011-02-335208

Published: 2011

Includes: Supplemental data

NARROW

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Fusion of uPA to Anti-aII b b3 Scfv Facilitates Its Uptake By in Vitro-Generated CD34+ Megakaryocytes (MKs) to Promote Targeted Fibrinolysis

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Insights into Endogenous Vs Exogenous Cargo-Containing Platelet Alpha-Granules

Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Analysis of the Frequency of Spontaneous, Functionally-Significant Mutations in Genes Associated with Platelet Disorders in >120,000 Healthy Individuals

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Platelet Factor 4 (PF4)-Mediated Neutrophil Extracellular Trap Compaction Limits Endothelial Injury and Promotes Survival Following Lipopolysaccharide Challenge

A Special Role for Neutrophil Extracellular Traps (NETs) and Neutrophils in the Prothombotic Nature of Heparin-Induced Thrombocytopenia

The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis

Miniaturized T2MR Magnetic Resonance System for Analysis of Hemostasis and Detection of Impaired and Prothrombotic Blood Disorders

Platelet-Targeted, Thrombin-Activatable Fibrinolytic Pro-Drugs As Novel Therapies: Application to the Prothrombotic Disorder of Heparin-Induced Thrombocytopenia (HIT)

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

Histones, Like Platelet Factor 4 (PF4), Affect Generation of Activated Protein C: Implications for the Pathogenesis of Severe Sepsis

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT

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American Society of Hematology

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ASH Publications

American Society of Hematology

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