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Journal Articles

Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Qiyang Chen, Rimi Hazra, Danielle Crosby, Diane Lenhart, Shane C. Lenhart, Paritosh Mondal, Yingze Zhang, Seyed M. Nouraie, Roderick J. Tan, Charles T. Esmon, L. Vijay Mohan Rao, Kang Kim, Samit Ghosh

Blood (2024) 144 (5): 552–564.

https://doi.org/10.1182/blood.2023023528

Published: 2024

Includes: Supplemental data

Journal Articles

Safety and efficacy of an anti–human APC antibody for prophylaxis of congenital factor deficiencies in preclinical models

Blood (2023) 142 (12): 1071–1081.

https://doi.org/10.1182/blood.2023020005

Published: 2023

Includes: Supplemental data

Journal Articles

Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice

Jhansi Magisetty, Vijay Kondreddy, Shiva Keshava, Kaushik Das, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2022) 139 (18): 2830–2841.

https://doi.org/10.1182/blood.2021013119

Published: 2022

Includes: Supplemental data

Journal Articles

Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis

Tanya T. Marar, Chelsea N. Matzko, Jie Wu, Charles T. Esmon, Talid Sinno, Lawrence F. Brass, Timothy J. Stalker, Maurizio Tomaiuolo

Blood (2022) 139 (12): 1892–1902.

https://doi.org/10.1182/blood.2021014338

Published: 2022

Includes: Multimedia, Supplemental data

Journal Articles

Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect

Kaushik Das, Shiva Keshava, Shabbir A. Ansari, Vijay Kondreddy, Charles T. Esmon, John H. Griffin, Usha R. Pendurthi, L. Vijaya Mohan Rao

Blood (2021) 137 (24): 3428–3442.

https://doi.org/10.1182/blood.2020008417

Published: 2021

Includes: Supplemental data

Journal Articles

Activated protein C has a regulatory role in factor VIII function

Amelia R. Wilhelm, Nicole A. Parsons, Benjamin J. Samelson-Jones, Robert J. Davidson, Charles T. Esmon, Rodney M. Camire, Lindsey A. George

Blood (2021) 137 (18): 2532–2543.

https://doi.org/10.1182/blood.2020007562

Published: 2021

Includes: Supplemental data

Journal Articles

EPCR deficiency or function-blocking antibody protects against joint bleeding–induced pathology in hemophilia mice

Jhansi Magisetty, Usha R. Pendurthi, Charles T. Esmon, L. Vijaya Mohan Rao

Blood (2020) 135 (25): 2211–2223.

https://doi.org/10.1182/blood.2019003824

Published: 2020

Includes: Supplemental data

Journal Articles

EPCR Deficiency Prevents Development of Hemophilic Arthropathy

Jhansi Magisetty, PhD MSc, Usha Pendurthi, PhD, Charles T. Esmon, PhD, L. Vijaya Mohan Rao, PhD

Blood (2019) 134 (Supplement_1): 159.

https://doi.org/10.1182/blood-2019-124972

Published: 2019

Journal Articles

In Vivo hemostatic Significance of Activated Protein C in Factor VIIIa Regulation

Amelia R. Wilhelm, B.S., Nicole A. Parsons, B.S., Charles T. Esmon, PhD, Rodney M. Camire, PhD, Lindsey A. George, MD

Blood (2019) 134 (Supplement_1): 93.

https://doi.org/10.1182/blood-2019-124493

Published: 2019

Journal Articles

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

Miguel Alejandro Lopez-Ramirez, Angela Pham, Romuald Girard, Tine Wyseure, Preston Hale, Atsuki Yamashita, Janne Koskimäki, Sean Polster, Laleh Saadat, Ignacio A. Romero, Charles T. Esmon, Frederic Lagarrigue, Issam A. Awad, Laurent O. Mosnier, Mark H. Ginsberg

Blood (2019) 133 (3): 193–204.

https://doi.org/10.1182/blood-2018-06-856062

Published: 2019

Includes: Supplemental data

Journal Articles

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

Vijay Kondreddy, Jue Wang, Shiva Keshava, Charles T. Esmon, L. Vijaya Mohan Rao, Usha R. Pendurthi

Blood (2018) 131 (21): 2379–2392.

https://doi.org/10.1182/blood-2017-10-813527

Published: 2018

Includes: Supplemental data

Journal Articles

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad

Blood (2017) 130 (24): 2664–2677.

https://doi.org/10.1182/blood-2017-05-782102

Published: 2017

Includes: Supplemental data

Journal Articles

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Blood (2017) 130 (12): 1445–1455.

https://doi.org/10.1182/blood-2017-02-767921

Published: 2017

Includes: Supplemental data

Journal Articles

Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

Braedon McDonald, Rachelle P. Davis, Seok-Joo Kim, Mandy Tse, Charles T. Esmon, Elzbieta Kolaczkowska, Craig N. Jenne

Blood (2017) 129 (10): 1357–1367.

https://doi.org/10.1182/blood-2016-09-741298

Published: 2017

Includes: Multimedia, Supplemental data

Journal Articles

Factor VIIa Interaction with Endothelial Cell Protein C Receptor: Its Role in Hemostatic Effect of rFVIIa in Treating Hemophilia

Shiva Keshava, PhD, Jagan Sundaram, PhD, Anuradha Rajulapati, M.S., Charles T. Esmon, PhD, Usha R. Pendurthi, PhD, L. Vijaya Mohan Rao, PhD

Blood (2016) 128 (22): 562.

https://doi.org/10.1182/blood.V128.22.562.562

Published: 2016

Journal Articles

EPCR Guides Hematopoietic Stem Cells Homing to the Bone Marrow Independently of Niche Clearance

Blood (2016) 128 (22): 4538.

https://doi.org/10.1182/blood.V128.22.4538.4538

Published: 2016

Journal Articles

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Maureen A. Shaw, Keith W. Kombrinck, Kathryn E. McElhinney, David R. Sweet, Matthew J. Flick, Joseph S. Palumbo, Mei Cheng, Naomi L. Esmon, Charles T. Esmon, Alexander Brill, Denisa D. Wagner, Jay L. Degen, Eric S. Mullins

Blood (2016) 128 (5): 721–731.

https://doi.org/10.1182/blood-2015-11-680280

Published: 2016

Includes: Multimedia, Supplemental data

Journal Articles

EPCR/PAR1 Signaling Navigates Long-Term Repopulating Hematopoietic Stem Cell Bone Marrow Homing to Thrombomodulin-Enriched Blood Vessels

Shiri Gur Cohen, PhD, Tomer Itkin, PhD, Sagarika Chakrabarty, PhD, Claudine Graf, MD, Orit Kollet, PhD, Karin Golan, PhD, Alexander Kalinkovich, MDPhD, Charles T. Esmon, PhD, Wolfram Ruf, MD, Irit Sagi, PhD, Ayelet Erez, PhD, Tsvee Lapidot, PhD

Blood (2015) 126 (23): 33.

https://doi.org/10.1182/blood.V126.23.33.33

Published: 2015

Journal Articles

Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment

Jagan Sundaram, Usha R. Pendurthi, Charles T. Esmon, L. Vijaya Mohan Rao

Blood (2014) 124 (19): 3031–3033.

https://doi.org/10.1182/blood-2014-09-600254

Published: 2014

Journal Articles

Endothelial cell protein C receptor: a multiliganded and multifunctional receptor

L. Vijaya Mohan Rao, Charles T. Esmon, Usha R. Pendurthi

Blood (2014) 124 (10): 1553–1562.

https://doi.org/10.1182/blood-2014-05-578328

Published: 2014

NARROW

Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Safety and efficacy of an anti–human APC antibody for prophylaxis of congenital factor deficiencies in preclinical models

Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice

Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis

Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect

Activated protein C has a regulatory role in factor VIII function

EPCR deficiency or function-blocking antibody protects against joint bleeding–induced pathology in hemophilia mice

EPCR Deficiency Prevents Development of Hemophilic Arthropathy

In Vivo hemostatic Significance of Activated Protein C in Factor VIIIa Regulation

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

Factor VIIa Interaction with Endothelial Cell Protein C Receptor: Its Role in Hemostatic Effect of rFVIIa in Treating Hemophilia

EPCR Guides Hematopoietic Stem Cells Homing to the Bone Marrow Independently of Niche Clearance

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

EPCR/PAR1 Signaling Navigates Long-Term Repopulating Hematopoietic Stem Cell Bone Marrow Homing to Thrombomodulin-Enriched Blood Vessels

Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment

Endothelial cell protein C receptor: a multiliganded and multifunctional receptor

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American Society of Hematology

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ASH Publications

American Society of Hematology

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