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Journal Articles

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Maureen A. Shaw, Keith W. Kombrinck, Kathryn E. McElhinney, David R. Sweet, Matthew J. Flick, Joseph S. Palumbo, Mei Cheng, Naomi L. Esmon, Charles T. Esmon, Alexander Brill, Denisa D. Wagner, Jay L. Degen, Eric S. Mullins

Blood (2016) 128 (5): 721–731.

https://doi.org/10.1182/blood-2015-11-680280

Published: 2016

Includes: Multimedia, Supplemental data

Journal Articles

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense

Joni M. Prasad, Oleg V. Gorkun, Harini Raghu, Sherry Thornton, Eric S. Mullins, Joseph S. Palumbo, Ya-Ping Ko, Magnus Höök, Tovo David, Shaun R. Coughlin, Jay L. Degen, Matthew J. Flick

Blood (2015) 126 (17): 2047–2058.

https://doi.org/10.1182/blood-2015-04-639849

Published: 2015

Includes: Supplemental data

Journal Articles

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice

Paritha I. Arumugam, Eric S. Mullins, Shiva Kumar Shanmukhappa, Brett P. Monia, Anastacia Loberg, Maureen A. Shaw, Tilat Rizvi, Janaka Wansapura, Jay L. Degen, Punam Malik

Blood (2015) 126 (15): 1844–1855.

https://doi.org/10.1182/blood-2015-01-625707

Published: 2015

Includes: Supplemental data

Journal Articles

Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion

Harini Raghu, Carolina Cruz, Cheryl L. Rewerts, Malinda D. Frederick, Sherry Thornton, Eric S. Mullins, Jonathan G. Schoenecker, Jay L. Degen, Matthew J. Flick

Blood (2015) 125 (3): 427–437.

https://doi.org/10.1182/blood-2014-08-594754

Published: 2015

Includes: Supplemental data

Journal Articles

Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis

Sherry Thornton, PhD, Harini Raghu, PhD, Alice Jone, BS, Carolina Cruz, BS, Cheryl L. Rewerts, MS, Malinda D. Frederick, Jay L. Degen, PhD, Matthew J. Flick, PhD

Blood (2014) 124 (21): 580.

https://doi.org/10.1182/blood.V124.21.580.580

Published: 2014

Journal Articles

Plasmin(ogen) Deficiency Is Protective Against The Development Of Neuroinflammatory Pathologies and Paralysis In a Murine Model Of Multiple Sclerosis

Eric S. Mullins, MD, Maureen A Shaw, MS, Kathryn E McElhinney, Keith W. Kombrinck, MS, Jay L. Degen, PhD

Blood (2013) 122 (21): 1090.

https://doi.org/10.1182/blood.V122.21.1090.1090

Published: 2013

Journal Articles

Diminished Multi-Organ Pathologies and Inflammation Associated With Sickle Cell Disease In Mice With Genetically Limited Prothrombin Levels

Paritha Arumugam, PhD, Eric S. Mullins, MD, Maureen A Shaw, MS, Kumar Shanmukhappa, BVSc., PhD, Anastacia Loberg, Tilat Rizvi, PhD, Janaka Wansapura, PhD, David Witte, MD, Punam Malik, MD, Jay L. Degen, PhD

Blood (2013) 122 (21): 729.

https://doi.org/10.1182/blood.V122.21.729.729

Published: 2013

Journal Articles

Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi,

Maria M. Aleman, BS, James R. Byrnes, BS, Jianguo Wang, PhD, Nigel Mackman, PhD, Jay L. Degen, PhD, Matthew J Flick, PhD, Alisa S. Wolberg, PhD

Blood (2013) 122 (21): 451.

https://doi.org/10.1182/blood.V122.21.451.451

Published: 2013

Journal Articles

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia

Matthew J. Flick, XinLi Du, Joni M. Prasad, Harini Raghu, Joseph S. Palumbo, Emanuel Smeds, Magnus Höök, Jay L. Degen

Blood (2013) 121 (10): 1783–1794.

https://doi.org/10.1182/blood-2012-09-453894

Published: 2013

Journal Articles

Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice

Henri M.H. Spronk, PhD, Julian I Borissoff, Oliver Soehnlein, Rory Koenen, Rene van Oerle, Sylvia Heeneman, Mat J.A.P. Daemen, Charles T Esmon, PhD, Jay L. Degen, PhD, Hartmut Weiler, PhD, Joanne van Ryn, MSc, PhD, Hugo Ten Cate, MD, PhD

Blood (2012) 120 (21): 103.

https://doi.org/10.1182/blood.V120.21.103.103

Published: 2012

Journal Articles

Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation

Eric S. Mullins, MD, Maureen A. Shaw, M.S, Kathryn E. McElhinney, Keith W. Kombrinck, M.S., Matthew J. Flick, PhD, Alexander Brill, MD, PhD, Denisa D. Wagner, PhD, Jay L. Degen, PhD

Blood (2012) 120 (21): 496.

https://doi.org/10.1182/blood.V120.21.496.496

Published: 2012

Journal Articles

Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

Alexander Meyer, Wei Wang, Jiaxiang Qu, Lori Croft, Jay L. Degen, Barry S. Coller, Jasimuddin Ahamed

Blood (2012) 119 (4): 1064–1074.

https://doi.org/10.1182/blood-2011-09-377648

Published: 2012

Includes: Supplemental data

Journal Articles

Thrombin Control Mechanisms and Thrombin Targets in Cancer Biology

Jay L. Degen, PhD, Joseph S. Palumbo, MD

Blood (2011) 118 (21): SCI-17.

https://doi.org/10.1182/blood.V118.21.SCI-17.SCI-17

Published: 2011

Journal Articles

Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone

Nicholas Mignemi, Heather Cole, Masato Yausa, M.D., David Gailani, MD, Jay L. Degen, PhD, Jonathan G Schoenecker, MD PhD

Blood (2011) 118 (21): 857.

https://doi.org/10.1182/blood.V118.21.857.857

Published: 2011

Journal Articles

Factor XIII Deficiency Improves Motor Function in Mice Challenged with Experimental Autoimmune Encephalomyelitis, An Established Model of Multiple Sclerosis

Eric S. Mullins, MD, Kathryn E. Talmage, Keith W. Kombrinck, Whitney M Miller, Joseph S. Palumbo, MD, Jay L. Degen, PhD

Blood (2011) 118 (21): 858.

https://doi.org/10.1182/blood.V118.21.858.858

Published: 2011

Journal Articles

Mice with Megakaryocyte-Specific Deletion of TGF-β1 Are Partially Protected From Developing Cardiac Fibrosis and Systolic Dysfunction in a Pressure Overload Model

Alexander Meyer, Wei Wang, MD, Jay L. Degen, PhD, Barry S. Coller, MD, Jasimuddin Ahamed, PhD

Blood (2011) 118 (21): 362.

https://doi.org/10.1182/blood.V118.21.362.362

Published: 2011

Journal Articles

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Brian K. Turpin, DO, Whitney M Miller, Eric S. Mullins, MD, Jay L. Degen, PhD, Matthew J. Flick, PhD, Brett P. Monia, PhD, Robert MacLeod, Ph.D., Alexey S Revenko, PhD, Joseph S. Palumbo, MD

Blood (2011) 118 (21): 2237.

https://doi.org/10.1182/blood.V118.21.2237.2237

Published: 2011

Journal Articles

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain

Netanel A. Horowitz, Elizabeth A. Blevins, Whitney M. Miller, Ashley R. Perry, Kathryn E. Talmage, Eric S. Mullins, Matthew J. Flick, Karla C. S. Queiroz, Kun Shi, C. Arnold Spek, Edward M. Conway, Brett P. Monia, Hartmut Weiler, Jay L. Degen, Joseph S. Palumbo

Blood (2011) 118 (10): 2889–2895.

https://doi.org/10.1182/blood-2011-03-341222

Published: 2011

Includes: Supplemental data

Journal Articles

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A

Matthew J. Flick, Anil K. Chauhan, Malinda Frederick, Kathryn E. Talmage, Keith W. Kombrinck, Whitney Miller, Eric S. Mullins, Joseph S. Palumbo, Xunzhen Zheng, Naomi L. Esmon, Charles T. Esmon, Sherry Thornton, Ann Becker, Leslie A. Pelc, Enrico Di Cera, Denisa D. Wagner, Jay L. Degen

Blood (2011) 117 (23): 6326–6337.

https://doi.org/10.1182/blood-2010-08-304915

Published: 2011

Journal Articles

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

Michael W. Munks, Amy S. McKee, Megan K. MacLeod, Roger L. Powell, Jay L. Degen, Nichole A. Reisdorph, John W. Kappler, Philippa Marrack

Blood (2010) 116 (24): 5191–5199.

https://doi.org/10.1182/blood-2010-03-275529

Published: 2010

Includes: Supplemental data

NARROW

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice

Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion

Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis

Plasmin(ogen) Deficiency Is Protective Against The Development Of Neuroinflammatory Pathologies and Paralysis In a Murine Model Of Multiple Sclerosis

Diminished Multi-Organ Pathologies and Inflammation Associated With Sickle Cell Disease In Mice With Genetically Limited Prothrombin Levels

Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi,

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia

Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice

Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation

Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

Thrombin Control Mechanisms and Thrombin Targets in Cancer Biology

Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone

Factor XIII Deficiency Improves Motor Function in Mice Challenged with Experimental Autoimmune Encephalomyelitis, An Established Model of Multiple Sclerosis

Mice with Megakaryocyte-Specific Deletion of TGF-β1 Are Partially Protected From Developing Cardiac Fibrosis and Systolic Dysfunction in a Pressure Overload Model

Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

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