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Journal Articles

An Antibody Targeting Human FV Promotes Thrombin Generation and Reduces Bleeding in a Hemophilic Mouse Model

Sean Quinn, Lacramioara Ivanciu, Robert J. Davidson, Francis Ayombil, Rodney M. Camire

Blood (2022) 140 (Supplement 1): 963–964.

https://doi.org/10.1182/blood-2022-157997

Published: 2022

Journal Articles

Inhibiting Activated Protein C Cleavage of Factor VIII for Hemophilia a Gene Therapy

Anna R. Sternberg, Cristina Martos-Rus, Robert J. Davidson, Noelle C. Novak, Amelia R. Wilhelm, Lindsey A. George

Blood (2022) 140 (Supplement 1): 965–966.

https://doi.org/10.1182/blood-2022-170646

Published: 2022

Journal Articles

Protection of Human Factor V from Activated Protein C Using a Monoclonal Antibody-Biochemical Characterization and Evaluation Using a Mouse Injury Model

Sean Quinn, Lacramioara Ivanciu, Robert J. Davidson, Francis Ayombil, Jeffrey Crosby, Alexey Revenko, Robert A. MacLeod, Brett P Monia, Rodney M. Camire

Blood (2021) 138 (Supplement 1): 2092.

https://doi.org/10.1182/blood-2021-153527

Published: 2021

Journal Articles

Activated protein C has a regulatory role in factor VIII function

Amelia R. Wilhelm, Nicole A. Parsons, Benjamin J. Samelson-Jones, Robert J. Davidson, Charles T. Esmon, Rodney M. Camire, Lindsey A. George

Blood (2021) 137 (18): 2532–2543.

https://doi.org/10.1182/blood.2020007562

Published: 2021

Includes: Supplemental data

Journal Articles

The Un-BLyS-Ful State: Blocking Factor VIII Inhibitor Development with BLyS Depletion

Bhavya S Doshi, MD, Robert J. Davidson, BS, Valder R Arruda, MD PhD

Blood (2018) 132 (Supplement 1): 138.

https://doi.org/10.1182/blood-2018-99-114795

Published: 2018

Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD

Blood (2017) 130 (Supplement 1): 364.

https://doi.org/10.1182/blood.V130.Suppl_1.364.364

Published: 2017

Journal Articles

Regulation of Factor VIII By Activated Protein C: Assessment In Vitro and In Vivo

Nicole A. Parsons, B.S., Michelle D. Ho, BS, Robert J. Davidson, BS, Nabil K. Thalji, PhDMD, Ben J. Samelson-Jones, MD PhD, Rodney M Camire, PhD, Lindsey A. George, MD

Blood (2017) 130 (Supplement 1): 3650.

https://doi.org/10.1182/blood.V130.Suppl_1.3650.3650

Published: 2017

Journal Articles

Novel Human Factor VIII Variant with Impaired Intracellular Processing Exhibits Enhanced In Vivo Efficacy

Giang N. Nguyen, B.S., Christian M. Wood, Tanner Dirstine, B.S., Robert J. Davidson, B.S., Denise E. Sabatino, PhD

Blood (2016) 128 (22): 256.

https://doi.org/10.1182/blood.V128.22.256.256

Published: 2016

Journal Articles

Adeno-Associated Viral Vector Delivery of Optimized Human Factor VIII Achieves Therapeutic Factor VIII Levels in Non-Human Primates

Xavier M. Anguela, PhD, Liron Elkouby, PhD, Raffaella Toso, PhD, Marti DiPietro, MS, Robert J. Davidson, Katherine A. High, MD, Denise E. Sabatino, PhD

Blood (2015) 126 (23): 199.

https://doi.org/10.1182/blood.V126.23.199.199

Published: 2015

Journal Articles

In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair

Xavier M. Anguela, PhD, Rajiv Sharma, PhD, Yannick Doyon, PhD, Thomas Wechsler, PhD, David Paschon, PhD, Robert J. Davidson, Shangzhen Zhou, MD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Katherine A. High, MD

Blood (2015) 126 (23): 4422.

https://doi.org/10.1182/blood.V126.23.4422.4422

Published: 2015

Journal Articles

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

Rajiv Sharma, Xavier M. Anguela, Yannick Doyon, Thomas Wechsler, Russell C. DeKelver, Scott Sproul, David E. Paschon, Jeffrey C. Miller, Robert J. Davidson, David Shivak, Shangzhen Zhou, Julianne Rieders, Philip D. Gregory, Michael C. Holmes, Edward J. Rebar, Katherine A. High

Blood (2015) 126 (15): 1777–1784.

https://doi.org/10.1182/blood-2014-12-615492

Published: 2015

Includes: Supplemental data

Journal Articles

Human Factor VIII Variants with Diminished PACE-Furin Cleavage Exhibit Increased Biological Activity and Therapeutic Efficacy

Giang N. Nguyen, Joshua I. Siner, Robert J. Davidson, Valder R. Arruda, MD PhD, Rodney M. Camire, PhD, Denise E. Sabatino, PhD

Blood (2014) 124 (21): 104.

https://doi.org/10.1182/blood.V124.21.104.104

Published: 2014

Journal Articles

Improved Factor VIII Expression with the Introduction of a PACE-Furin Variant into Codon-Optimized Human Factor VIII

Liron Elkouby, PhD, Robert J. Davidson, Paris Margaritis, DPhil, Katherine A. High, MD, Denise E. Sabatino, PhD

Blood (2014) 124 (21): 3498.

https://doi.org/10.1182/blood.V124.21.3498.3498

Published: 2014

Journal Articles

ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A

Xavier M Anguela, PhD, Rajiv Sharma, Yannick Doyon, PhD, Thomas Wechsler, PhD, David E Paschon, PhD, Robert J Davidson, Shangzhen Zhou, MD, Philip D Gregory, PhD, Michael C. Holmes, PhD, Edward J Rebar, PhD, Katherine A. High, MD

Blood (2013) 122 (21): 720.

https://doi.org/10.1182/blood.V122.21.720.720

Published: 2013

Journal Articles

Robust ZFN-mediated genome editing in adult hemophilic mice

Xavier M. Anguela, Rajiv Sharma, Yannick Doyon, Jeffrey C. Miller, Hojun Li, Virginia Haurigot, Michelle E. Rohde, Sunnie Y. Wong, Robert J. Davidson, Shangzhen Zhou, Philip D. Gregory, Michael C. Holmes, Katherine A. High

Blood (2013) 122 (19): 3283–3287.

https://doi.org/10.1182/blood-2013-04-497354

Published: 2013

Includes: Supplemental data

Journal Articles

A Novel Strategy to Circumvent Pre-Existing Humoral Immunity to AAV

Federico Mingozzi, PhD, Xavier M Anguela, PhD, Giulia Pavani, MS, Yifeng Chen, MD, Robert J Davidson, Daniel J. Hui, Ph.D., Christian J Hinderer, MS, Armida Faella, Crolann Howard, BS, Alex Tai, MS, Gregory M Podsakoff, Margaret V. Ragni, MD, MPH, Shangzhen Zhou, MD, Etiena Basner-Tschakarjan, J. Fraser Wright, PhD, Katherine A. High, MD

Blood (2012) 120 (21): 2050.

https://doi.org/10.1182/blood.V120.21.2050.2050

Published: 2012

Journal Articles

In Vivo Genome Editing of Liver Albumin for Therapeutic Gene Expression: Rescue of Hemophilic Mice Via Integration of Factor 9

Xavier M Anguela, PhD, Rajiv Sharma, Yannick Doyon, PhD, Sunnie Y Wong, David E Paschon, Hojun Li, MD PhD, Virginia Haurigot, PhD, Robert J Davidson, Shangzhen Zhou, MD, Philip D. Gregory, PhD, Michael C. Holmes, PhD, Edward Rebar, PhD, Katherine A. High, MD

Blood (2012) 120 (21): 751.

https://doi.org/10.1182/blood.V120.21.751.751

Published: 2012

Journal Articles

Robust Factor IX Expression Following ZFN-Mediated Genome Editing in An Adult Mouse Model of Hemophilia B

Xavier M Anguela, Rajiv Sharma, Hojun Li, Virginia Haurigot, Anand Bhagwat, Robert J Davidson, Shangzhen Zhou, Yannick Doyon, Philip D. Gregory, PhD, Michael C. Holmes, PhD, Katherine A. High, MD

Blood (2011) 118 (21): 668.

https://doi.org/10.1182/blood.V118.21.668.668

Published: 2011

NARROW

An Antibody Targeting Human FV Promotes Thrombin Generation and Reduces Bleeding in a Hemophilic Mouse Model

Inhibiting Activated Protein C Cleavage of Factor VIII for Hemophilia a Gene Therapy

Protection of Human Factor V from Activated Protein C Using a Monoclonal Antibody-Biochemical Characterization and Evaluation Using a Mouse Injury Model

Activated protein C has a regulatory role in factor VIII function

The Un-BLyS-Ful State: Blocking Factor VIII Inhibitor Development with BLyS Depletion

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Regulation of Factor VIII By Activated Protein C: Assessment In Vitro and In Vivo

Novel Human Factor VIII Variant with Impaired Intracellular Processing Exhibits Enhanced In Vivo Efficacy

Adeno-Associated Viral Vector Delivery of Optimized Human Factor VIII Achieves Therapeutic Factor VIII Levels in Non-Human Primates

In Vivo Genome Editing in Neonatal Mouse Liver Preferentially Utilizes Homology Directed Repair

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

Human Factor VIII Variants with Diminished PACE-Furin Cleavage Exhibit Increased Biological Activity and Therapeutic Efficacy

Improved Factor VIII Expression with the Introduction of a PACE-Furin Variant into Codon-Optimized Human Factor VIII

ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A

Robust ZFN-mediated genome editing in adult hemophilic mice

A Novel Strategy to Circumvent Pre-Existing Humoral Immunity to AAV

In Vivo Genome Editing of Liver Albumin for Therapeutic Gene Expression: Rescue of Hemophilic Mice Via Integration of Factor 9

Robust Factor IX Expression Following ZFN-Mediated Genome Editing in An Adult Mouse Model of Hemophilia B

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American Society of Hematology

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American Society of Hematology

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