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Journal Articles

Protection of Human Factor V from Activated Protein C Using a Monoclonal Antibody-Biochemical Characterization and Evaluation Using a Mouse Injury Model

Sean Quinn, Lacramioara Ivanciu, Robert J. Davidson, Francis Ayombil, Jeffrey Crosby, Alexey Revenko, Robert A. MacLeod, Brett P Monia, Rodney M. Camire

Blood (2021) 138 (Supplement 1): 2092.

https://doi.org/10.1182/blood-2021-153527

Published: 2021

Journal Articles

Unveiling a Critical Role of Thrombin in Enhanced CD8+ T Cell Response to Cancer

Rachel Cantrell, BS, Leah A. Rosenfeldt, BS, Duaa Mureb, BS, Balkrishan Sharma, PhD, Alexey Revenko, PhD, Brett P Monia, PhD, Joseph S. Palumbo, MD

Blood (2019) 134 (Supplement_1): 4918.

https://doi.org/10.1182/blood-2019-128739

Published: 2019

Journal Articles

Rationale and Design of a Phase 3 Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Rodney H Falk, MD, Morie A Gertz, MD, Merrill D Benson, MD, Gustavo Buchele, MD PhD, Michela Brambatti, MD MS, Sotirios Tsimikas, MD, Nicholas J Viney, Bsc, Li-Jung Tai, MD PhD, Cecilia Monteiro, MD PhD, Qingqing Yang, MS, Louis St L O'Dea, MB B.Ch. BAO, FRCP, Ewa Karwatowska-Prokopczuk, MD PhD, Eugene Schneider, MD, Richard S Geary, PhD, Brett P Monia, PhD

Blood (2019) 134 (Supplement_1): 5764.

https://doi.org/10.1182/blood-2019-129269

Published: 2019

Journal Articles

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

Toshiaki Shirai, PhD, Alexey Revenko, PhD, Justin Tibbits, MS, Lisa M Coussens, PhD, Owen JT McCarty, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2018) 132 (Supplement 1): 989.

https://doi.org/10.1182/blood-2018-99-114157

Published: 2018

Journal Articles

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-L RX ) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Michael McCaleb, PhD, Jason Lickliter, MBBS, PhD, Andrew Dibble, PhD, Eugene Schneider, MD, Mariam Aghajan, Shuling Guo, Steve Hughes, MD MBA, Richard S Geary, PhD, Brett P. Monia, PhD

Blood (2018) 132 (Supplement 1): 3634.

https://doi.org/10.1182/blood-2018-99-115339

Published: 2018

Journal Articles

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Lacramioara Ivanciu, PhD, Jeffrey Crosby, PhD, Alexey Revenko, PhD, A. Robert MacLeod, PhD, Brett P. Monia, PhD, Robert J. Davidson, BS, Rodney M Camire, PhD

Blood (2017) 130 (Supplement 1): 364.

https://doi.org/10.1182/blood.V130.Suppl_1.364.364

Published: 2017

Journal Articles

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Mariam Aghajan, PhD, Carla Casu, PhD, Vania lo Presti, Sheri Booten, Brett P. Monia, PhD, Stefano Rivella, PhD, Shuling Guo, PhD

Blood (2016) 128 (22): 1013.

https://doi.org/10.1182/blood.V128.22.1013.1013

Published: 2016

Journal Articles

Thrombin and Factor XII Drive Prostate Tumor Growth In Vivo

Gregory Adams, PhD, Leah Rosenfeldt, BS, Malinda Frederick, BS, Keith Kombrinck, MS, Brett P. Monia, PhD, Alexey Revenko, PhD, Joseph S. Palumbo, MD

Blood (2015) 126 (23): 424.

https://doi.org/10.1182/blood.V126.23.424.424

Published: 2015

Journal Articles

Targeting TMPRSS6 Using Antisense Technology for the Treatment of Beta-Thalassemia

Shuling Guo, PhD, Mariam Aghajan, PhD, Carla Casu, PhD, Sara Gardenghi, PhD, Sheri Booten, Stefano Rivella, PhD, Brett P. Monia, PhD

Blood (2015) 126 (23): 753.

https://doi.org/10.1182/blood.V126.23.753.753

Published: 2015

Journal Articles

Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

Blood (2015) 126 (23): 2192.

https://doi.org/10.1182/blood.V126.23.2192.2192

Published: 2015

Journal Articles

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice

Paritha I. Arumugam, Eric S. Mullins, Shiva Kumar Shanmukhappa, Brett P. Monia, Anastacia Loberg, Maureen A. Shaw, Tilat Rizvi, Janaka Wansapura, Jay L. Degen, Punam Malik

Blood (2015) 126 (15): 1844–1855.

https://doi.org/10.1182/blood-2015-01-625707

Published: 2015

Includes: Supplemental data

Journal Articles

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein

Trang T. Vu, Ji Zhou, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Ran Ni, Shengjun Qiao, Nima Vaezzadeh, Willi Jahnen-Dechent, Brett P. Monia, Peter L. Gross, Jeffrey I. Weitz

Blood (2015) 125 (17): 2712–2719.

https://doi.org/10.1182/blood-2014-11-611319

Published: 2015

Includes: Supplemental data

Journal Articles

Thrombin Drives Colorectal Cancer Pathogenesis at the Level of Primary Tumor Growth, Tumor Invasion and Metastasis

Gregory N Adams, PhD, Dusty Waltz, Leah Rosenfeldt, Malinda Frederick, Whitney Miller, Alexey S Revenko, PhD, Brett P. Monia, PhD, Joseph S. Palumbo, MD

Blood (2014) 124 (21): 2812.

https://doi.org/10.1182/blood.V124.21.2812.2812

Published: 2014

Journal Articles

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Harry Roger Buller, MD PhD, Claudette Bethune, PhD, Sanjay Bhanot, MDPhD, David Gailani, MD, Brett P. Monia, PhD, Gary E. Raskob, PhD, Annelise Segers, Peter Verhamme, MD PhD, Jeffrey I. Weitz, MDFRCPC

Blood (2014) 124 (21): LBA-1.

https://doi.org/10.1182/blood.V124.21.LBA-1.LBA-1

Published: 2014

Journal Articles

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Michael Wallisch, PhD, Greisel Jennifer, BS, Erik I Tucker, PhD, Owen J.T. McCarty, PhD, Monica T Hinds, PhD, Sue Murray, Jeff Crosby, PhD, Brett P. Monia, PhD, Andras Gruber, MD

Blood (2014) 124 (21): 1485.

https://doi.org/10.1182/blood.V124.21.1485.1485

Published: 2014

Journal Articles

Combination of Tmprss6 -ASO and the Iron Chelator Deferiprone Improves Erythropoiesis and Reduces Iron Overload in a Mouse Model of Beta-Thalassemia

Carla Casu, PhD, Mariam Aghajan, PhD, Rea Oikonomidau, MD, Shuling Guo, PhD, Brett P. Monia, PhD, Stefano Rivella, PhD

Blood (2014) 124 (21): 4024.

https://doi.org/10.1182/blood.V124.21.4024.4024

Published: 2014

Journal Articles

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits

Jonathan W. Yau, Peng Liao, James C. Fredenburgh, Alan R. Stafford, Alexey S. Revenko, Brett P. Monia, Jeffrey I. Weitz

Blood (2014) 123 (13): 2102–2107.

https://doi.org/10.1182/blood-2013-12-540872

Published: 2014

Includes: Supplemental data

Journal Articles

Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway

Shiri Gur Cohen, MSc, Tomer Itkin, PhD, Orit Kollet, PhD, Sagarika Chakrabarty, PhD, Aya Ludin, DMD, PhD, Karin Golan, MSc, Alexander Kalinkovich, MD, PhD, Xin-Jiang Lu, PhD, Jeff R. Crosby, PhD, Brett P. Monia, PhD, Charles T Esmon, PhD, Wolfram Ruf, MD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 456.

https://doi.org/10.1182/blood.V122.21.456.456

Published: 2013

Journal Articles

Target TMPRSS6 Using Antisense Technology for the Treatment of Hereditary Hemochromatosis and β-Thalassemia

Shuling Guo, PhD, Carla Casu, Sara Gardenghi, PhD, Sheri Booten, Andy Watt, Susan Freier, Ph.D, Stefano Rivella, PhD, Brett P. Monia, PhD

Blood (2012) 120 (21): 481.

https://doi.org/10.1182/blood.V120.21.481.481

Published: 2012

Journal Articles

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

Jeff R. Crosby, PhD, Ulla M Marzec, MS, Chenguang Zhao, Dacao Gao, Alexey S Revenko, PhD, Anton Matafonov, MD, David Gailani, MD, Robert MacLeod, Ph.D., Andras Gruber, MD, Stephen Hanson, PhD, Brett P. Monia, PhD

Blood (2011) 118 (21): 2250.

https://doi.org/10.1182/blood.V118.21.2250.2250

Published: 2011

NARROW

Protection of Human Factor V from Activated Protein C Using a Monoclonal Antibody-Biochemical Characterization and Evaluation Using a Mouse Injury Model

Unveiling a Critical Role of Thrombin in Enhanced CD8+ T Cell Response to Cancer

Rationale and Design of a Phase 3 Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Antisense Oligonucleotide Targeting of Thrombopoietin Synthesis Reduces Platelet Count within the Hemostatic Range and Slows Progression of De Novo Mammary Carcinogenesis in the Mmtv-Pymt Mouse

Transmembrane Protease, Serine 6 (TMPRSS6) Antisense Oligonucleotide (IONIS-TMPRSS6-L RX ) Reduces Plasma Iron Levels of Healthy Volunteers in a Phase 1 Clinical Study

Differential Role of Plasma and Platelet-Derived Factor V In Vivo

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Thrombin and Factor XII Drive Prostate Tumor Growth In Vivo

Targeting TMPRSS6 Using Antisense Technology for the Treatment of Beta-Thalassemia

Platelet-Localized FXI Promotes a Glycoprotein Ib Alpha Dependent Feedback Loop in Arterial Hypertension and Vascular Inflammation

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein

Thrombin Drives Colorectal Cancer Pathogenesis at the Level of Primary Tumor Growth, Tumor Invasion and Metastasis

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

Lack of Substantial Antithrombotic Effect of Low Circulating Coagulation Factor VII Levels in a Baboon Model of Acute Vascular Graft Thrombosis

Combination of Tmprss6 -ASO and the Iron Chelator Deferiprone Improves Erythropoiesis and Reduces Iron Overload in a Mouse Model of Beta-Thalassemia

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits

Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway

Target TMPRSS6 Using Antisense Technology for the Treatment of Hereditary Hemochromatosis and β-Thalassemia

Antisense Oligonucleotide Mediated Depletion of Factor XI Prevents Vascular Occlusion in An Experimental Thrombosis Model in Primates

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American Society of Hematology

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American Society of Hematology

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