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Shiva Keshava
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Journal Articles

A potential mechanism for the cytoprotective effects of activated protein C–released endothelial extracellular vesicles

Kaushik Das, Shiva Keshava, Tanmoy Mukherjee, L. Vijaya Mohan Rao
Journal: Blood
Blood (2024) 143 (16): 1670–1675.
https://doi.org/10.1182/blood.2023023518
Published: 2024
Journal Articles

The Gab2–MALT1 axis regulates thromboinflammation and deep vein thrombosis

Vijay Kondreddy, Shiva Keshava, Kaushik Das, Jhansi Magisetty, L. Vijaya Mohan Rao, Usha R. Pendurthi
Journal: Blood
Blood (2022) 140 (13): 1549–1564.
https://doi.org/10.1182/blood.2022016424
Published: 2022
Includes: Supplemental data
Journal Articles

Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice

Jhansi Magisetty, Vijay Kondreddy, Shiva Keshava, Kaushik Das, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao
Journal: Blood
Blood (2022) 139 (18): 2830–2841.
https://doi.org/10.1182/blood.2021013119
Published: 2022
Includes: Supplemental data
Journal Articles

Factor VIIa suppresses inflammation and barrier disruption through the release of EEVs and transfer of microRNA 10a

Kaushik Das, Shiva Keshava, Usha R. Pendurthi, L. Vijaya Mohan Rao
Journal: Blood
Blood (2022) 139 (1): 118–133.
https://doi.org/10.1182/blood.2021012358
Published: 2022
Includes: Supplemental data
Journal Articles

Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect

Kaushik Das, Shiva Keshava, Shabbir A. Ansari, Vijay Kondreddy, Charles T. Esmon, John H. Griffin, Usha R. Pendurthi, L. Vijaya Mohan Rao
Journal: Blood
Blood (2021) 137 (24): 3428–3442.
https://doi.org/10.1182/blood.2020008417
Published: 2021
Includes: Supplemental data
Journal Articles

Therapeutic Doses of Recombinant FVIIa in Hemophilia Generates Thrombin in Platelet-Dependent and -Independent Manner

Shiva Keshava Gaddam Bala Krishna, PhD, Usha Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1136.
https://doi.org/10.1182/blood-2019-128474
Published: 2019
Journal Articles

A Lipid Peroxidation Product, 4-Hydroxy-2-Nonenal, Triggers Intravascular Coagulation and Inflammation through Generation of Tissue Factor-Positive Microvesicles

Shabbir Ansari, PhD, Shiva Keshava Gaddam Bala Krishna, PhD, Usha R. Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2383.
https://doi.org/10.1182/blood-2019-124498
Published: 2019
Journal Articles

Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1

Vijay Kondreddy, Jue Wang, Shiva Keshava, Charles T. Esmon, L. Vijaya Mohan Rao, Usha R. Pendurthi
Journal: Blood
Blood (2018) 131 (21): 2379–2392.
https://doi.org/10.1182/blood-2017-10-813527
Published: 2018
Includes: Supplemental data
Journal Articles

Factor VIIa Interaction with Endothelial Cell Protein C Receptor: Its Role in Hemostatic Effect of rFVIIa in Treating Hemophilia

Shiva Keshava, PhD, Jagan Sundaram, PhD, Anuradha Rajulapati, M.S., Charles T. Esmon, PhD, Usha R. Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2016) 128 (22): 562.
https://doi.org/10.1182/blood.V128.22.562.562
Published: 2016
Journal Articles

Endothelial Cell Protein C Receptor Promotes Apoptosis in Malignant Pleural Mesothelioma Cells

Shiva Keshava, PhD, L. Vijaya Mohan Rao, PhD, Usha R. Pendurthi, PhD
Journal: Blood
Blood (2015) 126 (23): 2241.
https://doi.org/10.1182/blood.V126.23.2241.2241
Published: 2015
Journal Articles

Pharmacological Concentrations of Recombinant Factor VIIa Restores Hemostasis in Acquired Hemophilia Primarily Independent of Tissue Factor

Shiva Keshava, PhD, Jagan Sundaram, PhD, Anuradha Rajulapati, M.S., Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2015) 126 (23): 293.
https://doi.org/10.1182/blood.V126.23.293.293
Published: 2015
Journal Articles

Role of Tissue Factor in Mycobacterium Tuberculosis- induced Inflammation and Disease Pathogenesis

Kothari Hema, PhD, Shiva Keshava, Ph. D., Rit Vatsyayan, Ph. D., Nigel Mackman, PhD, Usha R Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2014) 124 (21): 1505.
https://doi.org/10.1182/blood.V124.21.1505.1505
Published: 2014
Journal Articles

Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection

Prosenjit Sen, Ramakrishnan Gopalakrishnan, Hema Kothari, Shiva Keshava, Curtis A. Clark, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao
Journal: Blood
Blood (2011) 117 (11): 3199–3208.
https://doi.org/10.1182/blood-2010-09-310706
Published: 2011
Journal Articles

Role of Rab Proteins In Endocytosis and Trafficking of Factor VIIa and Endothelial Cell Protein C Receptor In Endothelial Cells.

Ramesh C Nayak, Ph.D., Shiva Keshava, Ph.D., Usha Pendurthi, Ph.D., L. Vijaya Mohan Rao, Ph.D.
Journal: Blood
Blood (2010) 116 (21): 1145.
https://doi.org/10.1182/blood.V116.21.1145.1145
Published: 2010