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Khurrum Shahzad
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Journal Articles

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad
Journal: Blood
Blood (2017) 130 (24): 2664–2677.
https://doi.org/10.1182/blood-2017-05-782102
Published: 2017
Includes: Supplemental data
Journal Articles

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Thati Madhusudhan, Hongjie Wang, Sanchita Ghosh, Wei Dong, Varun Kumar, Moh'd Mohanad Al-Dabet, Jayakumar Manoharan, Sumra Nazir, Ahmed Elwakiel, Fabian Bock, Shrey Kohli, Andi Marquardt, Ibrahim Sögüt, Khurrum Shahzad, Andreas J. Müller, Charles T. Esmon, Peter P. Nawroth, Jochen Reiser, Triantafyllos Chavakis, Wolfram Ruf, Berend Isermann
Journal: Blood
Blood (2017) 130 (12): 1445–1455.
https://doi.org/10.1182/blood-2017-02-767921
Published: 2017
Includes: Supplemental data
Journal Articles

Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

Shrey Kohli, Satish Ranjan, Juliane Hoffmann, Muhammed Kashif, Evelyn A. Daniel, Moh'd Mohanad Al-Dabet, Fabian Bock, Sumra Nazir, Hanna Huebner, Peter R. Mertens, Klaus-Dieter Fischer, Ana C. Zenclussen, Stefan Offermanns, Anat Aharon, Benjamin Brenner, Khurrum Shahzad, Matthias Ruebner, Berend Isermann
Journal: Blood
Blood (2016) 128 (17): 2153–2164.
https://doi.org/10.1182/blood-2016-03-705434
Published: 2016
Includes: Supplemental data
Journal Articles

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

Thati Madhusudhan, Hongjie Wang, Beate K. Straub, Elisabeth Gröne, Qianxing Zhou, Khurrum Shahzad, Sandra Müller-Krebs, Vedat Schwenger, Bruce Gerlitz, Brian W. Grinnell, John H. Griffin, Jochen Reiser, Hermann-Josef Gröne, Charles T. Esmon, Peter P. Nawroth, Berend Isermann
Journal: Blood
Blood (2012) 119 (3): 874–883.
https://doi.org/10.1182/blood-2011-07-365973
Published: 2012
Includes: Supplemental data
Journal Articles

Activated Protein C Controls p66shc: A Novel Defense Mechanism in Diabetic Nephropathy

Fabian M Bock, Khurrum Shahzad, Ph.D., Thati Madhusudhan, Ph.D., Hongjie Wang, Peter P Nawroth, MD, Berend H. Isermann, MD
Journal: Blood
Blood (2011) 118 (21): 2204.
https://doi.org/10.1182/blood.V118.21.2204.2204
Published: 2011
Journal Articles

Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy

Hongjie Wang, Thati Madhusudhan, Tao He, Björn Hummel, Simone Schmidt, Ilya A. Vinnikov, Khurrum Shahzad, Muhammed Kashif, Sandra Muller-Krebs, Vedat Schwenger, Angelika Bierhaus, Gottfried Rudofsky, Peter P. Nawroth, Berend Isermann
Journal: Blood
Blood (2011) 117 (19): 5231–5242.
https://doi.org/10.1182/blood-2010-10-314773
Published: 2011
Includes: Supplemental data
Journal Articles

The Lectin-Like Domain of Thrombomodulin Protects Against Diabetic Nephropathy by Inhibiting Complement Activation

Hongjie Wang, Ilya Vinnikov, Qianxing Zhou, Thati Madhusudhan, Khurrum Shahzad, Muhammed Kashif, Juliane Wolter, Angelika Bierhaus, Peter Nawroth, Edward M. Conway, MD, PhD, FRCPC, MBA, Berend Isermann
Journal: Blood
Blood (2010) 116 (21): 654.
https://doi.org/10.1182/blood.V116.21.654.654
Published: 2010