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Journal Articles

Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

Qiyang Chen, Rimi Hazra, Danielle Crosby, Diane Lenhart, Shane C. Lenhart, Paritosh Mondal, Yingze Zhang, Seyed M. Nouraie, Roderick J. Tan, Charles T. Esmon, L. Vijay Mohan Rao, Kang Kim, Samit Ghosh

Blood (2024) 144 (5): 552–564.

https://doi.org/10.1182/blood.2023023528

Published: 2024

Includes: Supplemental data

Journal Articles

20-HETE As an Emerging Target to Improve Renal Health in Sickle Cell Disease

Dario Vitturi, Danielle Crosby, Shane C Lenhart, Mara Carreno, Diane Lenhart, Samit Ghosh

Blood (2023) 142 (Supplement 1): 3857.

https://doi.org/10.1182/blood-2023-189344

Published: 2023

Journal Articles

White Matter Injury in Sickle Cell Mice Is Associated with Reduced Neurocognitive Function and Activation of Astrocytes

Rimi Hazra, Hongjan Pu, Lesley M. Foley, T. Kevin Hitchens, Lynda Little-Ihrig, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Xiaoming Hu, Enrico M. Novelli

Blood (2022) 140 (Supplement 1): 441–442.

https://doi.org/10.1182/blood-2022-169094

Published: 2022

Journal Articles

Heme Induced Progressive Loss of Endothelial Protein C Receptor Promotes Development of Chronic Kidney Disease in Sickle Cell Disorders

Rimi Hazra, Qiyang Chen, Danielle Crosby, Diane Lenhart, Roderick Tan, Kang Kim, L. Vijaya Mohan Rao, Solomon Fiifi Ofori-Acquah, Samit Ghosh

Blood (2021) 138 (Supplement 1): 188.

https://doi.org/10.1182/blood-2021-154027

Published: 2021

Journal Articles

The T117S Variant of Cytochrome b5 Reductase 3 Increases the Risk for Ischemic Stroke with Enhanced Anemia in Mice with Sickle Cell Disease

Katherine C Wood, PhD, Heidi M Schmidt, Scott Hahn, MS, Subramaniam Sanker, PhD, Samit Ghosh, PhD, Solomon Fiifi Ofori-Acquah, PhD, Seyed Mehdi Nouraie, MD PhD, Mark T Gladwin, MD, Adam C Straub, PhD

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-142076

Published: 2020

Journal Articles

Nonhematopoietic Nrf2 Deficiency Worsens Chronic Intravascular Hemolysis but Not Cardiomyopathy in Transgenic Sickle Cell Mice

Maureen Mburu, Samit Ghosh, PhD, Xucai Chen, PhD, Solomon Fiifi Ofori-Acquah, PhD, Flordeliza S Villanueva, MD

Blood (2020) 136 (Supplement 1): 18.

https://doi.org/10.1182/blood-2020-142783

Published: 2020

Journal Articles

Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Solomon F. Ofori-Acquah, Rimi Hazra, Oluwaseun O. Orikogbo, Danielle Crosby, Bethany Flage, Ezekiel B. Ackah, Diane Lenhart, Roderick J. Tan, Dario A. Vitturi, Vivian Paintsil, Ellis Owusu-Dabo, Samit Ghosh, in collaboration with the SickleGenAfrica Network

Blood (2020) 135 (13): 1044–1048.

https://doi.org/10.1182/blood.2019002653

Published: 2020

Includes: Supplemental data

Journal Articles

Hemopexin Replacement Therapy Protects Sickle Cell Disease Mice from Acute Kidney Injury

Samit Ghosh, Oluwaseun Orikogbo, Rimi Hazra, Bethany Flage, Danielle Crosby, Solomon Fiifi Ofori-Acquah

Blood (2019) 134 (Supplement_1): 78.

https://doi.org/10.1182/blood-2019-127161

Published: 2019

Journal Articles

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Rimi Hazra, Samit Ghosh, Bethany Flage, Matthew Crouthamel, Clark Pan, Xiuxia Sun, Bohong Zhang, Joseph Sypek, Solomon Fiifi Ofori-Acquah

Blood (2019) 134 (Supplement_1): 74.

https://doi.org/10.1182/blood-2019-127198

Published: 2019

Journal Articles

Macrophage Hypercellularity Accompanies Erythroid Hyperplasia in Sickle Cell Mice and during Recovery from Blood Loss in Wild Type Mice

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Samit Ghosh, Frances Weidert, MS, Grant C. Bullock, MD PhD, Solomon Fiifi Ofori-Acquah, Gregory J Kato, MD

Blood (2019) 134 (Supplement_1): 3528.

https://doi.org/10.1182/blood-2019-127224

Published: 2019

Journal Articles

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Katherine Wood, PhD BA, Brittany Durgin, PhD, Heidi M Schmidt, BSE, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, PhD, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, MD, Mark T Gladwin, MD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3619.

https://doi.org/10.1182/blood-2019-124159

Published: 2019

Journal Articles

Nrf2 Null Mice Are Deficient in CD169 + Macrophages, Associated with Impaired Erythroid Response and Delayed Recovery from Acute Blood Loss

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Mark A Ross, Samit Ghosh, Frances Weidert, MS, Grant C. Bullock, MD PhD, Solomon Fiifi Ofori-Acquah, Gregory J Kato, MD, Simon Watkins

Blood (2019) 134 (Supplement_1): 1038.

https://doi.org/10.1182/blood-2019-127295

Published: 2019

Journal Articles

Heterogeneity in Multi-Organ Expression of HO-1 and PlGF in Sickle Mice Mimic Exposure of Non-Sickle Mice to Extracellular Heme Via Nrf2-Dependent Pathways

Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Samit Ghosh, PhD, Yu Lin, Frances Weidert, MSc, Solomon Fiifi Ofori-Acquah, PhD, Gregory J. Kato, MD

Blood (2018) 132 (Supplement 1): 2392.

https://doi.org/10.1182/blood-2018-99-113451

Published: 2018

Journal Articles

Cardiomyopathy Associated with Worsening Intravascular Hemolysis in Transgenic Knock-in Mouse Model of Sickle Cell Disease

Maureen Mburu, MD, Rafey Feroze, BS, Daniel Whitehurst, BS, Xucai Chen, PhD, Samit Ghosh, PhD, Solomon Fiifi Ofori-Acquah, PhD, Flordeliza S Villanueva, MD

Blood (2017) 130 (Supplement 1): 3512.

https://doi.org/10.1182/blood.V130.Suppl_1.3512.3512

Published: 2017

Journal Articles

Enhanced Renal Clearance of Heme Triggers Acute Kidney Injury in Sickle Cell Disease

Samit Ghosh, PhD, Vivian Paintsil, MD, Rimi Hazra, PhD, Oluowaseun O. Orikogbo, Bethany Flage, Ezekiel Bonwin Ackah, Ellis Owusu-Dabo, PhD, Solomon Fiifi Ofori-Acquah, PhD

Blood (2017) 130 (Supplement 1): 441.

https://doi.org/10.1182/blood.V130.Suppl_1.441.441

Published: 2017

Journal Articles

A Novel Role for P-Selectin in the Pathogenesis of Acute Chest Syndrome

Samit Ghosh, PhD, Frances Weidert, MS, Bethany Flage, BS, Prithu Sundd, PhD, Solomon F Ofori-Acquah, PhD

Blood (2016) 128 (22): 157.

https://doi.org/10.1182/blood.V128.22.157.157

Published: 2016

Journal Articles

Nrf2 Activation Attenuates Hemolysis but Promotes Pulmonary Vascular Dysfunction in Sickle Mice

Chibueze A. Ihunnah, PhD, Samit Ghosh, PhD, Scott A. Hahn, MS, Adam C Straub, PhD, Solomon F Ofori-Acquah, PhD

Blood (2016) 128 (22): 1296.

https://doi.org/10.1182/blood.V128.22.1296.1296

Published: 2016

Journal Articles

Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice

Samit Ghosh, PhD, Chibueze A. Ihunnah, PhD, Rimi Hazra, PhD, Amma T. Owusu-Ansah, MD, Jason M Hansen, PhD, David R. Archer, PhD, Solomon Fiifi Ofori-Acquah, PhD

Blood (2015) 126 (23): 3394.

https://doi.org/10.1182/blood.V126.23.3394.3394

Published: 2015

Journal Articles

Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice

Samit Ghosh, PhD, Jason Hansen, PhD, Rimi Hazra, PhD, David R. Archer, PhD, Solomon F. Ofori-Acquah, PhD

Blood (2014) 124 (21): 456.

https://doi.org/10.1182/blood.V124.21.456.456

Published: 2014

Journal Articles

Determinants Of Heme-Oxygenase-1 Upregulation In Patients With Sickle Cell Disease

Olufolake Adisa, MD, Benjamin Yaw Owusu, B.S., Yijuan Hu, PhD, Samit Ghosh, PhD, Fang Tan, PhD, Frederika Sey, MD, Ivy Ekem, MD, Isaac Quaye, PhD, Solomon F Ofori-Acquah, PhD

Blood (2013) 122 (21): 2235.

https://doi.org/10.1182/blood.V122.21.2235.2235

Published: 2013

NARROW

Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice

20-HETE As an Emerging Target to Improve Renal Health in Sickle Cell Disease

White Matter Injury in Sickle Cell Mice Is Associated with Reduced Neurocognitive Function and Activation of Astrocytes

Heme Induced Progressive Loss of Endothelial Protein C Receptor Promotes Development of Chronic Kidney Disease in Sickle Cell Disorders

The T117S Variant of Cytochrome b5 Reductase 3 Increases the Risk for Ischemic Stroke with Enhanced Anemia in Mice with Sickle Cell Disease

Nonhematopoietic Nrf2 Deficiency Worsens Chronic Intravascular Hemolysis but Not Cardiomyopathy in Transgenic Sickle Cell Mice

Hemopexin deficiency promotes acute kidney injury in sickle cell disease

Hemopexin Replacement Therapy Protects Sickle Cell Disease Mice from Acute Kidney Injury

Targeted Therapy of Acute Chest Syndrome with Recombinant Heme Oxygenase-1 Revealed By the Resistance of Young Transgenic Sickle Cell Mice to Heme-Induced Acute Lung Injury

Macrophage Hypercellularity Accompanies Erythroid Hyperplasia in Sickle Cell Mice and during Recovery from Blood Loss in Wild Type Mice

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Nrf2 Null Mice Are Deficient in CD169 + Macrophages, Associated with Impaired Erythroid Response and Delayed Recovery from Acute Blood Loss

Heterogeneity in Multi-Organ Expression of HO-1 and PlGF in Sickle Mice Mimic Exposure of Non-Sickle Mice to Extracellular Heme Via Nrf2-Dependent Pathways

Cardiomyopathy Associated with Worsening Intravascular Hemolysis in Transgenic Knock-in Mouse Model of Sickle Cell Disease

Enhanced Renal Clearance of Heme Triggers Acute Kidney Injury in Sickle Cell Disease

A Novel Role for P-Selectin in the Pathogenesis of Acute Chest Syndrome

Nrf2 Activation Attenuates Hemolysis but Promotes Pulmonary Vascular Dysfunction in Sickle Mice

Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice

Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice

Determinants Of Heme-Oxygenase-1 Upregulation In Patients With Sickle Cell Disease

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American Society of Hematology

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ASH Publications

American Society of Hematology

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