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Journal Articles

Antiphospholipid syndrome (APS) is the newest member of the PF4 immunothrombotic family: Mechanistic and therapeutic insights

Amrita Sarkar, Conroy Field, Khalil Bdeir, Santosh Yadav, Kandace Gollomp, Keith McCrae, Thomas Ortel, Jason Knight, Jérôme Rollin, Yves Gruel, Gow Arepally, Lubica Rauova, Mortimer Poncz

Blood (2025) 146 (Supplement 1): 194.

https://doi.org/10.1182/blood-2025-194

Published: 2025

Journal Articles

Both platelet factor 4 (PF4) and b2-glycoprotein I (b2GPI) bind to von Willebrand factor (VWF) and inhibit ADAMTS13 cleavage: Mechanistic and clinical implications in thrombotic thrombocytopenic purpura (TTP)

Amrita Sarkar, Khalil Bdeir, Chloe Ro, Jenna Oberg, X. Long Zheng, Gow Arepally, Douglas Cines, Lubica Rauova, Mortimer Poncz

Blood (2025) 146 (Supplement 1): 4876.

https://doi.org/10.1182/blood-2025-4876

Published: 2025

Journal Articles

Platelet-activating antibodies to the chemokine, platelet factor 4, in cerebral malaria differ from those in heparin-induced thrombocytopenia and vaccine-induced thrombotic thrombocytopenia.

Lubica Rauova, Iset Vera, Jenna Oberg, Ruth Namazzi, Marcus Shackleford, Karl Seydel, Douglas Cines, Chandy John, Kami Kim, Mortimer Poncz

Blood (2025) 146 (Supplement 1): 4870.

https://doi.org/10.1182/blood-2025-4870

Published: 2025

Journal Articles

Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes

Anh Ngo, Weronika Ortmann, Abigail Skidmore, Hyunjun Kim, Jenna Oberg, Amrita Sarkar, Veronica Bochenek, Nate Levine, Lubica Rauova, Irina Chernysh, Zachary Martinez, Caroline Diorio, Mark Goulian, Victor Nizet, Mortimer Poncz, Kandace Gollomp

Blood (2025) 146 (Supplement 1): 1322.

https://doi.org/10.1182/blood-2025-1322

Published: 2025

Journal Articles

Hepatic intravital imaging reveals the contribution of peptidylarginine deiminase 4 (PAD4) to the spatiotemporal dynamics of neutrophil recruitment and NET release during bacterial infection

Weronika Ortmann, Anna Prykhodko, Hyunjun Kim, Abigail Skidmore, Steven Jiang, Lubica Rauova, Mortimer Poncz, Kandace Gollomp

Blood (2025) 146 (Supplement 1): 1221.

https://doi.org/10.1182/blood-2025-1221

Published: 2025

Journal Articles

Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Lubica Rauova, Khalil Bdeir, Ann H. Rux, Manu Thomas Kalathottukaren, Jenna Oberg, Chanel C. La, David T. E. Lim, Vincent Hayes, Gavin T. Koma, Amrita Sarkar, Mortimer Poncz, Jayachandran N. Kizhakkedathu, Douglas B. Cines

Blood (2025) 145 (25): 3030–3040.

https://doi.org/10.1182/blood.2024025653

Published: 2025

Includes: Supplemental data

Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2611.

https://doi.org/10.1182/blood-2024-200849

Published: 2024

Journal Articles

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Amrita Sarkar, Conroy O Field, Keith R. McCrae, Thomas L. Ortel, Gow Arepally, Roxanne Cofiell, Sung-Kwon Kim, Lubica Rauova, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2606.

https://doi.org/10.1182/blood-2024-198182

Published: 2024

Journal Articles

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Sooho S Myoung, Samuel Francis, Jonah Chen, Grace M Lee, Lubica Rauova, Mortimer Poncz, Douglas B. Cines, Maragatha Kuchibhatla, Sanjay Khandelwal, Gow Arepally

Blood (2024) 144 (Supplement 1): 2605.

https://doi.org/10.1182/blood-2024-208062

Published: 2024

Journal Articles

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Anh T.P. Ngo, Veronica Bochenek, Hyunjun Kim, Nate Levine, Samir Maarouf, Jenna Oberg, Manuela Roggiani, Amrita Sarkar, Lubica Rauova, Caroline Diorio, Zachary Martinez, Mark Goulian, Mortimer Poncz, Victor Nizet, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 1231.

https://doi.org/10.1182/blood-2024-211717

Published: 2024

Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 185.

https://doi.org/10.1182/blood-2024-201682

Published: 2024

Journal Articles

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Lubica Rauova, Jenna Oberg, Nate Levine, Khalil Bdeir, Douglas B. Cines, Sarah Gilbert, Mortimer Poncz, Gowthami Arepally

Blood (2023) 142 (Supplement 1): 2631.

https://doi.org/10.1182/blood-2023-186729

Published: 2023

Journal Articles

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Anh T.P. Ngo, Amrita Sarkar, Nathan Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M. Anna Kowalska, Kaitlyn Eckart, Nilam S. Mangalmurti, Ann Rux, Douglas B. Cines, Mortimer Poncz, Kandace Gollomp

Blood (2022) 140 (Supplement 1): 5529–5530.

https://doi.org/10.1182/blood-2022-169709

Published: 2022

Journal Articles

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Hailey Harris, Sanjay Khandelwal, Lubica Rauova, John Lambris, Brandon Garcia, Douglas B. Cines, Gowthami M. Arepally

Blood (2022) 140 (Supplement 1): 8372–8373.

https://doi.org/10.1182/blood-2022-165586

Published: 2022

Journal Articles

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Lubica Rauova, Khalil Bdeir, Zheng Cai, Serge Yarovoi, Gowthami M. Arepally, Sanjay Khandelwal, Mortimer Poncz, Mark Greene, Douglas B. Cines

Blood (2022) 140 (Supplement 1): 2643–2644.

https://doi.org/10.1182/blood-2022-163590

Published: 2022

Journal Articles

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

Kandace Gollomp, Irina Chernysh, Anh T.P. Ngo, Nathan Levine, Sergey Zaytsev, Veronica Bochenek, Lubica Rauova, Nicholas Parenti, Susan R Weiss, John W. Weisel, Douglas B. Cines, Mortimer Poncz

Blood (2022) 140 (Supplement 1): 1405–1406.

https://doi.org/10.1182/blood-2022-170781

Published: 2022

Journal Articles

Platelets get particular

Lubica Rauova, Douglas B. Cines

Blood (2022) 140 (5): 413–414.

https://doi.org/10.1182/blood.2022016773

Published: 2022

Journal Articles

A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice

Junsong Zhou, Yi Wu, Lubica Rauova, Gavin Koma, Lu Wang, Mortimer Poncz, Hong Li, Tong Liu, Karen P. Fong, Joel S. Bennett, Satya P. Kunapuli, David W. Essex

Blood (2022) 139 (13): 2050–2065.

https://doi.org/10.1182/blood.2021012055

Published: 2022

Includes: Supplemental data

Journal Articles

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Sanjay Khandelwal, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge V. Yarovoi, S. Sergei Zaitsev, John D. Lambris, Sooho S. Myoung, Alexandra Johnson, Grace M. Lee, Madelaine Duarte, Mortimer Poncz, Gowthami M. Arepally, Douglas B. Cines

Blood (2021) 138 (21): 2106–2116.

https://doi.org/10.1182/blood.2020009487

Published: 2021

Includes: Supplemental data

Journal Articles

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Amrita Sarkar, Sanjay Khandelwal, Serge Yarovoi, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, Lubica Rauova

Blood (2021) 138 (Supplement 1): 581.

https://doi.org/10.1182/blood-2021-146233

Published: 2021

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Antiphospholipid syndrome (APS) is the newest member of the PF4 immunothrombotic family: Mechanistic and therapeutic insights

Both platelet factor 4 (PF4) and b2-glycoprotein I (b2GPI) bind to von Willebrand factor (VWF) and inhibit ADAMTS13 cleavage: Mechanistic and clinical implications in thrombotic thrombocytopenic purpura (TTP)

Platelet-activating antibodies to the chemokine, platelet factor 4, in cerebral malaria differ from those in heparin-induced thrombocytopenia and vaccine-induced thrombotic thrombocytopenia.

Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes

Hepatic intravital imaging reveals the contribution of peptidylarginine deiminase 4 (PAD4) to the spatiotemporal dynamics of neutrophil recruitment and NET release during bacterial infection

Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

Platelets get particular

A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

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