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Journal Articles

Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis

Pengfei Liang, Yang Zhang, Yui Chun S. Wan, Shang Ma, Ping Dong, Augustus J. Lowry, Samuel J. Francis, Sanjay Khandelwal, Martha Delahunty, Marilyn J. Telen, John J. Strouse, Gowthami M. Arepally, Huanghe Yang

Blood (2024) 143 (4): 357–369.

https://doi.org/10.1182/blood.2023021465

Published: 2024

Includes: Multimedia, Supplemental data

Journal Articles

PIEZO1-TMEM16F Interplay in Hereditary Xerocytosis

Pengfei Liang, Yang Zhang, Yui Chun Serena Wan, Shang Ma, Ping Dong, Augustus Lowry, Samuel Francis, Sanjay Khandelwal, Martha Delahunty, Marilyn J. Telen, John J Strouse, Gowthami Arepally, Huanghe Yang

Blood (2023) 142 (Supplement 1): 3818.

https://doi.org/10.1182/blood-2023-178911

Published: 2023

Journal Articles

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Lubica Rauova, Khalil Bdeir, Zheng Cai, Serge Yarovoi, Gowthami M. Arepally, Sanjay Khandelwal, Mortimer Poncz, Mark Greene, Douglas B. Cines

Blood (2022) 140 (Supplement 1): 2643–2644.

https://doi.org/10.1182/blood-2022-163590

Published: 2022

Journal Articles

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Hailey Harris, Sanjay Khandelwal, Lubica Rauova, John Lambris, Brandon Garcia, Douglas B. Cines, Gowthami M. Arepally

Blood (2022) 140 (Supplement 1): 8372–8373.

https://doi.org/10.1182/blood-2022-165586

Published: 2022

Journal Articles

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Sanjay Khandelwal, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge V. Yarovoi, S. Sergei Zaitsev, John D. Lambris, Sooho S. Myoung, Alexandra Johnson, Grace M. Lee, Madelaine Duarte, Mortimer Poncz, Gowthami M. Arepally, Douglas B. Cines

Blood (2021) 138 (21): 2106–2116.

https://doi.org/10.1182/blood.2020009487

Published: 2021

Includes: Supplemental data

Journal Articles

Minimal Role for the Alternative Pathway in Complement Activation By HIT Immune Complexes

Ayiesha Barnes, Sanjay Khandelwal, Simone Sartoretto, Grace M Lee, Sooho Myoung, Samuel Francis, Lubica Rauova, Douglas B. Cines, Brandon Garcia, Jon Skare, Charles Booth, Gowthami M. Arepally

Blood (2021) 138 (Supplement 1): 2076.

https://doi.org/10.1182/blood-2021-150946

Published: 2021

Journal Articles

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Lubica Rauova, Andy Wang, Serge Yarovoi, Sanjay Khandelwal, Anand Padmanabhan, Olga Oleshko, Matthew J. Charman, Andreas Tiede, Charles S. Abrams, Matthew D. Weitzman, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz

Blood (2021) 138 (Supplement 1): 292.

https://doi.org/10.1182/blood-2021-151685

Published: 2021

Journal Articles

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Amrita Sarkar, Sanjay Khandelwal, Serge Yarovoi, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, Lubica Rauova

Blood (2021) 138 (Supplement 1): 581.

https://doi.org/10.1182/blood-2021-146233

Published: 2021

Journal Articles

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Ayiesha Barnes, MS, Ann Rux, Serge Yarovoi, Sooho S Myoung, Alexandra Johnson, Grace M Lee, MD, Madelaine Duarte, BA, Mortimer Poncz, MD, Gowthami M. Arepally, MD, Douglas B. Cines, MD

Blood (2020) 136 (Supplement 1): 11–12.

https://doi.org/10.1182/blood-2020-138631

Published: 2020

Journal Articles

Variation in Neutrophil Function Among Healthy Subjects Influences Response to Bacteria

Madelaine Duarte, BA, Stacey A Maskarinec, MD PhD, Sanjay Khandelwal, PhD, Gowthami M. Arepally, MD, Grace M Lee, MD

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-141674

Published: 2020

Journal Articles

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

Sanjay Khandelwal, Joann Ravi, Lubica Rauova, Alexandra Johnson, Grace M. Lee, Jennifer B. Gilner, Sreenivasulu Gunti, Abner L. Notkins, Maragatha Kuchibhatla, Michael Frank, Mortimer Poncz, Douglas B. Cines, Gowthami M. Arepally

Blood (2018) 132 (23): 2431–2440.

https://doi.org/10.1182/blood-2018-03-834598

Published: 2018

Includes: Supplemental data

Journal Articles

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Sanjay Khandelwal, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Michael Frank, MD, Douglas B. Cines, MD, Gowthami Arepally, MD

Blood (2017) 130 (Supplement 1): 3617.

https://doi.org/10.1182/blood.V130.Suppl_1.3617.3617

Published: 2017

Journal Articles

Mechanism of Complement Activation By PF4/ Heparin Complexes

Sanjay Khandelwal, PhD, Johnson M Alexandra, BS, C. Garren Hester, Michael M Frank, MD, Gowthami M Arepally, MD

Blood (2016) 128 (22): 137.

https://doi.org/10.1182/blood.V128.22.137.137

Published: 2016

Journal Articles

Novel ELISA-Based Assay for Detection of Complement Activation By PF4/Heparin Complexes

Sanjay Khandelwal, PhD, Johnson M Alexandra, BS, Grace M. Lee, MD, Gowthami M Arepally, MD

Blood (2016) 128 (22): 3734.

https://doi.org/10.1182/blood.V128.22.3734.3734

Published: 2016

Journal Articles

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)

Sanjay Khandelwal, Grace M. Lee, C. Garren Hester, Mortimer Poncz, Steven E. McKenzie, Bruce S. Sachais, Lubica Rauova, Garnett Kelsoe, Douglas B. Cines, Michael Frank, Gowthami M. Arepally

Blood (2016) 128 (14): 1789–1799.

https://doi.org/10.1182/blood-2016-04-709634

Published: 2016

Includes: Supplemental data

Journal Articles

Characterization of Human and Murine Anti-Protamine/Heparin Antibodies

Grace M. Lee, MD, Manali Joglekar, MS, Sanjay Khandelwal, Rui Qi, BS, Lubica Rauova, MD PhD, Gowthami M Arepally, MD

Blood (2015) 126 (23): 3461.

https://doi.org/10.1182/blood.V126.23.3461.3461

Published: 2015

Journal Articles

Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells

Manali V. Joglekar, Sanjay Khandelwal, Mortimer Poncz, MD, Lubica Rauova, MD PhD, Gowthami M Arepally, MD

Blood (2014) 124 (21): 4197.

https://doi.org/10.1182/blood.V124.21.4197.4197

Published: 2014

NARROW

Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis

PIEZO1-TMEM16F Interplay in Hereditary Xerocytosis

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Complement Shields Fc Regions on HIT Immune Complexes and Prevents Recognition By Cellular Fcγ Receptors

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Minimal Role for the Alternative Pathway in Complement Activation By HIT Immune Complexes

Vaccine-Induced Thrombocytopenia and Thrombosis (VITT) Antibodies Recognize Neutrophil-Activating Peptide 2 (NAP2) As Well As Platelet Factor 4 (PF4): Mechanistic and Clinical Implications

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Complement Regulates the Procoagulant Effects of HIT Immune Complexes

Variation in Neutrophil Function Among Healthy Subjects Influences Response to Bacteria

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway

In Vitro Complement Activation By PF4/Heparin Complexes Is Mediated By Plasma IgM

Mechanism of Complement Activation By PF4/ Heparin Complexes

Novel ELISA-Based Assay for Detection of Complement Activation By PF4/Heparin Complexes

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)

Characterization of Human and Murine Anti-Protamine/Heparin Antibodies

Understanding the Underlying Immune Response in HIT: Uptake of PF4/Heparin Complexes By Monocytes & Dendritic Cells

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American Society of Hematology

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American Society of Hematology

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