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Bruce S. Sachais
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Journal Articles

The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)

Free
Sanjay Khandelwal, Grace M. Lee, C. Garren Hester, Mortimer Poncz, Steven E. McKenzie, Bruce S. Sachais, Lubica Rauova, Garnett Kelsoe, Douglas B. Cines, Michael Frank, Gowthami M. Arepally
Journal: Blood
Blood (2016) 128 (14): 1789–1799.
https://doi.org/10.1182/blood-2016-04-709634
Published: 2016
Includes: Supplemental data
Journal Articles

Efficacy of transfusion with granulocytes from G-CSF/dexamethasone–treated donors in neutropenic patients with infection

Free
Clinical Trials & Observations
Thomas H. Price, Michael Boeckh, Ryan W. Harrison, Jeffrey McCullough, Paul M. Ness, Ronald G. Strauss, W. Garrett Nichols, Taye H. Hamza, Melissa M. Cushing, Karen E. King, Jo-Anne H. Young, Eliot Williams, Janice McFarland, Jennifer Holter Chakrabarty, Steven R. Sloan, David Friedman, Samir Parekh, Bruce S. Sachais, Joseph E. Kiss, Susan F. Assmann
Journal: Blood
Blood (2015) 126 (18): 2153–2161.
https://doi.org/10.1182/blood-2015-05-645986
Published: 2015
Includes: Supplemental data
Journal Articles

Novel diagnostic assays for heparin-induced thrombocytopenia

Free
Adam Cuker, Ann H. Rux, Jillian L. Hinds, May Dela Cruz, Serge V. Yarovoi, Isola A. M. Brown, Wei Yang, Barbara A. Konkle, Gowthami M. Arepally, Stephen P. Watson, Douglas B. Cines, Bruce S. Sachais
Journal: Blood
Blood (2013) 121 (18): 3727–3732.
https://doi.org/10.1182/blood-2013-01-479576
Published: 2013
Journal Articles

Novel Diagnostic Assays for Heparin-Induced Thrombocytopenia

Free
Adam Cuker, MD, MS, Ann H Rux, PhD, Jillian L Hinds, BS, May Dela Cruz, MD, Serge Yarovoi, PhD, Wei Yang, PhD, Barbara A. Konkle, MD, Gowthami M Arepally, MD, Steve P Watson, PhD, Douglas B. Cines, Bruce S Sachais, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 267.
https://doi.org/10.1182/blood.V120.21.267.267
Published: 2012
Journal Articles

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders

Free
Douglas B. Cines, Keith R. McCrae, X. Long Zheng, Bruce S. Sachais, Eline T. Luning Prak, Don L. Siegel
Journal: Blood
Blood (2012) 120 (20): 4134–4142.
https://doi.org/10.1182/blood-2012-06-389445
Published: 2012
Journal Articles

Dynamic antibody-binding properties in the pathogenesis of HIT

Free
Bruce S. Sachais, Rustem I. Litvinov, Serge V. Yarovoi, Lubica Rauova, Jillian L. Hinds, Ann H. Rux, Gowthami M. Arepally, Mortimer Poncz, Adam Cuker, John W. Weisel, Douglas B. Cines
Journal: Blood
Blood (2012) 120 (5): 1137–1142.
https://doi.org/10.1182/blood-2012-01-407262
Published: 2012
Includes: Supplemental data
Journal Articles

Rational design and characterization of platelet factor 4 antagonists for the study of heparin-induced thrombocytopenia

Free
Bruce S. Sachais, Ann H. Rux, Douglas B. Cines, Serge V. Yarovoi, Lee I. Garner, Stephen P. Watson, Jillian L. Hinds, John J. Rux
Journal: Blood
Blood (2012) 119 (25): 5955–5962.
https://doi.org/10.1182/blood-2012-01-406801
Published: 2012
Journal Articles

Rational Design and Characterization of Platelet Factor 4 Antagonists

Free
Bruce S Sachais, MD, PhD, Ann H Rux, PhD, Jillian L Hinds, BS, John J Rux, PhD
Journal: Blood
Blood (2010) 116 (21): 724.
https://doi.org/10.1182/blood.V116.21.724.724
Published: 2010
Journal Articles

Low Density Lipoprotein Apheresis Reduces PF4 on the Surface of Platelets: a Possible Protective Mechanism Against HIT

Free
Yvette C Tanhehco, MD, PhD, Ann H Rux, PhD, Bruce S Sachais, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2530.
https://doi.org/10.1182/blood.V116.21.2530.2530
Published: 2010
Journal Articles

Platelets may serve up biomarkers

Free
Bruce S. Sachais
Journal: Blood
Blood (2008) 111 (3): 974.
https://doi.org/10.1182/blood-2007-10-118059
Published: 2008
Journal Articles

The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow

Free
Ping Zhang, Weilan Pan, Ann H. Rux, Bruce S. Sachais, X. Long Zheng
Journal: Blood
Blood (2007) 110 (6): 1887–1894.
https://doi.org/10.1182/blood-2007-04-083329
Published: 2007
Journal Articles

The Middle and Distal Carboxyl Terminal Domains of ADAMTS13 Are Critical for Docking ADAMTS13 to von Willebrand Factor.

Free
Ping Zhang, MD, Pan Weilan, MD, Ann H. Rux, PhD, Bruce S. Sachais, MD, PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 332.
https://doi.org/10.1182/blood.V108.11.332.332
Published: 2006
Journal Articles

Elimination of Platelet Factor 4 (PF4) from Platelets Reduces Atherosclerosis and Increases HDL Cholesterol in C57Bl/6 and ApoE −/− Mice.

Free
Bruce S. Sachais, MD, PhD, Tiffany Turrentine, BS, Jeanine M. Dawicki-McKenna, BS, Daniel J. Rader, MD, M. Anna Kowalska, PhD
Journal: Blood
Blood (2006) 108 (11): 418.
https://doi.org/10.1182/blood.V108.11.418.418
Published: 2006
Journal Articles

Dietary Hypercholesterolemia Enhances Heparin-Induced Thrombocytopenia/Thrombosis: A Prothrombotic Risk Factor in a Transgenic Mouse Model.

Free
Michael P. Reilly, PhD, Scott K. Dessain, MD, PhD, Scott M. Taylor, MS, M. Anna Kowalska, PhD, Mortimer Poncz, MD, Bruce S. Sachais, MD, PhD, Douglas B. Cines, MD, Gowthami Arepally, MD, Kevin Jon Williams, MD, Steven E. McKenzie, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 56.
https://doi.org/10.1182/blood.V106.11.56.56
Published: 2005
Journal Articles

A Human Antibody, Cloned from a Patient with Heparin-Induced Thrombocytopenia, That Binds Heparin/Platelet Factor 4 Complexes.

Free
Scott K. Dessain, MD, PhD, Katherine E. Rybinski, Sharad P. Adekar, MD, Lubica Rauova, MD, PhD, Bruce S. Sachais, MD, PhD, Steven E. McKenzie, MD, PhD, Michael P. Reilly, PhD
Journal: Blood
Blood (2005) 106 (11): 58.
https://doi.org/10.1182/blood.V106.11.58.58
Published: 2005
Journal Articles

Two Specific Domains on the Upper Surface of the αIib β Propeller Determine the Sensitivity of αIibβ3 for RGD-Containing Peptides.

Free
Ramesh B. Basani, PhD, Michael A. Thornton, PhD, Bruce S. Sachais, MD, PhD, M. Anna Kowalska, PhD, William F. Degrado, PhD, Joel S. Bennett, MD, Mortimer Poncz, MD
Journal: Blood
Blood (2005) 106 (11): 2653.
https://doi.org/10.1182/blood.V106.11.2653.2653
Published: 2005
Journal Articles

PF4/heparin complexes are T cell–dependent antigens

Free
Brief Report
Shayela Suvarna, Lubica Rauova, Emily K. E. McCracken, Christina M. Goss, Bruce S. Sachais, Steven E. McKenzie, Michael P. Reilly, Michael Dee Gunn, Douglas B. Cines, Mortimer Poncz, Gowthami Arepally
Journal: Blood
Blood (2005) 106 (3): 929–931.
https://doi.org/10.1182/blood-2004-12-4955
Published: 2005
Journal Articles

Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-κB–dependent manner

Free
Guangyao Yu, Ann H. Rux, Peihong Ma, Khalil Bdeir, Bruce S. Sachais
Journal: Blood
Blood (2005) 105 (9): 3545–3551.
https://doi.org/10.1182/blood-2004-07-2617
Published: 2005
Journal Articles

Minibodies to maximize platelets?

Free
Bruce S. Sachais
Journal: Blood
Blood (2005) 105 (2): 434–435.
https://doi.org/10.1182/blood-2004-10-4015
Published: 2005
Journal Articles

Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia

Free
Lubica Rauova, Mortimer Poncz, Steven E. McKenzie, Michael P. Reilly, Gowthami Arepally, John W. Weisel, Chandrasekaran Nagaswami, Douglas B. Cines, Bruce S. Sachais
Journal: Blood
Blood (2005) 105 (1): 131–138.
https://doi.org/10.1182/blood-2004-04-1544
Published: 2005