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X. Long Zheng
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Journal Articles

Caplacizumab Frontline Added to Therapeutic Plasma Exchange and Immunosuppression Prevents Unfavorable Outcomes in Immune-Mediated TTP: An International Real-World Study of the TTP-IWG (The Capla 500 Project)

PAUL Coppo, Michaël Bubenheim, Ygal Benhamou, Linus A. Voelker, Paul T. Brinkkoetter, Lucas Kühne, Paul N. Knoebl, Maria Eva Mingot, Maria Cristina Pascual Izquierdo, Javier De La Rubia, Julio Del Rio Garma, Shruti Chaturvedi, Camila Masias, Marshall Mazepa, X. Long Zheng, Gyorgy Sinkovits, Marienn Reti, Christopher J. Patriquin, Katerina Pavenski, Tiago Boechat, Joao Farias, Eduardo Flavio Oliveira Ribeiro, Michaela Larissa Lobo de Andrade, Agnès Veyradier, Bérangère Joly, Sr., Raïda Bouzid, Kazuya Sakai, Masanori Matsumoto, Ilaria Mancini, Pasquale Agosti, Flora Peyvandi, Matthew James Stubbs, Amjad Hmaid, Sobia Sharif, Tina Dutt, Spero Cataland, Bernhard Lammle, Marie Scully
Journal: Blood
Blood (2023) 142 (Supplement 1): 2636.
https://doi.org/10.1182/blood-2023-179316
Published: 2023
Journal Articles

A Mutation in Complement Factor H (W1183R) Enhances VWF Proteolysis By ADAMTS13 Under Shear

Wenjing Cao, Yi Liu, X. Frank Zhang, X. Long Zheng
Journal: Blood
Blood (2023) 142 (Supplement 1): 24.
https://doi.org/10.1182/blood-2023-190083
Published: 2023
Journal Articles

Thermodynamic Effects of Antibodies on VWF73 Cleavage By ADAMTS13

Chan Meng, Konstantine Halkidis, Szumam Liu, X. Long Zheng
Journal: Blood
Blood (2023) 142 (Supplement 1): 4005.
https://doi.org/10.1182/blood-2023-190088
Published: 2023
Journal Articles

Sars-CoV2 ORF7a Protein Stimulates Synthesis and Secretion of Endothelial Von Willebrand Factor

Quan Zhang, Xiaohu Huang, Szumam Liu, Noritaka Yada, Zhe Han, X. Long Zheng
Journal: Blood
Blood (2023) 142 (Supplement 1): 2570.
https://doi.org/10.1182/blood-2023-185248
Published: 2023
Journal Articles

Mechanisms of inhibition of human monoclonal antibodies in immune thrombotic thrombocytopenic purpura

Konstantine Halkidis, Chan Meng, Szumam Liu, Leland Mayne, Don L. Siegel, X. Long Zheng
Journal: Blood
Blood (2023) 141 (24): 2993–3005.
https://doi.org/10.1182/blood.2022019252
Published: 2023
Includes: Supplemental data
Journal Articles

Arginine Methylation on ADAMTS13 By Protein Arginine Methyltransferase 1 (PRMT1) Affects ADAMTS13 Secretion and Proteolytic Activity

Szumam Liu, Xinyang Zhao, X. Long Zheng
Journal: Blood
Blood (2022) 140 (Supplement 1): 331–332.
https://doi.org/10.1182/blood-2022-162950
Published: 2022
Journal Articles

The Mechanism of Antibody-Mediated Inhibition of ADAMTS13 in Immune Thrombotic Thrombocytopenic Purpura

Chan Meng, Konstantine Halkidis, Szumam Liu, Don L. Siegel, X. Long Zheng
Journal: Blood
Blood (2022) 140 (Supplement 1): 5527–5528.
https://doi.org/10.1182/blood-2022-166911
Published: 2022
Journal Articles

Coagulation Factor VIII Enhances the Cleavage of Von Willebrand Factor By ADAMTS13 In Vivo

Wenjing Cao, Aria Bales, Antonia Bignotti, Noritaka Yada, Liang Zheng, Lindsey George, Denise E. Sabatino, Marie Scully, Rodney M. Camire, X. Long Zheng
Journal: Blood
Blood (2022) 140 (Supplement 1): 5572–5573.
https://doi.org/10.1182/blood-2022-167539
Published: 2022
Journal Articles

Netosis and the Formation of Neutrophil Extracellular Traps (NETs) in Patients with Severe and Critical COVID-19 May Contribute to Disease Progression and Thrombosis

Noritaka Yada, Quan Zhang, Antonia Bignotti, Liang Zheng, Zhan Ye, X. Long Zheng
Journal: Blood
Blood (2022) 140 (Supplement 1): 8491–8492.
https://doi.org/10.1182/blood-2022-163782
Published: 2022
Journal Articles

Elevated Plasma Levels of Von Willebrand Factor and Syndecan-1 Predict 60-Day Mortality in Patients with Severe and Critical COVID-19

Quan Zhang, Zhan Ye, Antonia Bignotti, X. Long Zheng
Journal: Blood
Blood (2022) 140 (Supplement 1): 5642–5643.
https://doi.org/10.1182/blood-2022-163715
Published: 2022
Journal Articles

The Potential Role of ANKRD36 in Immune Thrombotic Thrombocytopenic Purpura

Aria Bales, Liang Zheng, Antonia Bignotti, Mark Cunningham, X. Long Zheng
Journal: Blood
Blood (2022) 140 (Supplement 1): 2647–2648.
https://doi.org/10.1182/blood-2022-162931
Published: 2022
Journal Articles

Race, rituximab, and relapse in TTP

Clinical Trials & Observations
Shruti Chaturvedi, Ana G. Antun, Andrew M. Farland, Ryan Woods, Ara Metjian, Yara A. Park, Gustaaf de Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, J. Evan Sadler, Meera Sridharan, Ronald S. Go, Keith R. McCrae, Harsh Vardhan Upreti, Angela Liu, Ming Y. Lim, Radhika Gangaraju, X. Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Andrew Johnson, Elizabeth Davis, Michael D. Evans, Marshall A. Mazepa, for the United States Thrombotic Microangiopathies Consortium
Journal: Blood
Blood (2022) 140 (12): 1335–1344.
https://doi.org/10.1182/blood.2022016640
Published: 2022
Includes: Supplemental data
Journal Articles

Single B Cell Immunoglobulin Sequencing Identifies Distinct Features of Monoclonal Antibodies in Patients with Immmune Thrombotic Thrombocytoepenic Purpura

Szumam Liu, Mohammad Abdelgawwad, Shanrun Liu, X. Long Zheng
Journal: Blood
Blood (2021) 138 (Supplement 1): 2081.
https://doi.org/10.1182/blood-2021-149233
Published: 2021
Journal Articles

Neutrophil Extracellular Traps (NETs) Contribute to the Formation of Microvascular Thrombosis in Immune Thrombotic Thrombocytopenic Purpura

Noritaka Yada, Jingrui Sui, Liang Zheng, X. Long Zheng
Journal: Blood
Blood (2021) 138 (Supplement 1): 1020.
https://doi.org/10.1182/blood-2021-153272
Published: 2021
Journal Articles

Binding of Gpibα to VWF A2 Domain Alters Mechanical Unraveling of the A2 Domain

Yi Liu, MS, Wenpeng Cao, PhD, Wenjing Cao, MDPhD, X. Long Zheng, MDPhD, Xiaohui Zhang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24–25.
https://doi.org/10.1182/blood-2020-143275
Published: 2020
Journal Articles

Exome Sequencing Identifies Glycosylation Defects As a Probable Cause of Immune Thrombotic Thrombocytopenic Purpura

Felipe Massicano, PhD, Elizabeth M. Staley, MD, PhD, Konstantine Halkidis, MD PhD, Nicole K. Kocher, Lance A. Williams, III, MD, Marisa B. Marques, MD, Bryan K. Guillory, MD, Wenjing Cao, MD,PhD, Malay K. Basu, PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 217.
https://doi.org/10.1182/blood-2019-131511
Published: 2019
Journal Articles

Plasma Levels of Histone-DNA Complex and Cell-Free DNA Predict Mortality in Patients with Immune Thrombotic Thrombocytopenic Purpura

Jingrui (Jean) Sui, MD, Konstantine Halkidis, MD PhD, Nicole K. Kocher, Lance A. Williams, III, MD, Radhika Gangaraju, MD, Bryan K. Guillory, MD, Marisa B. Marques, MD, Wenjing Cao, MD,PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1070.
https://doi.org/10.1182/blood-2019-131585
Published: 2019
Journal Articles

Differential Effect of Rituximab on Relapse-Free Survival in De Novo and Relapsed Immune Thrombotic Thrombocytopenic Purpura in African-American and Caucasian Populations

Mazepa A. Marshall, MD, Michael Evans, MS, Elizabeth Davis, MD, Andrew Johnson, MD, Ana G. Antun, MD, Andrew M. Farland, MD, Ryan R Woods, MD, Ara Metjian, MD, Kristin Bagby, Yara Park, MD, Jay S Raval, MD, Gustaaf de Ridder, MD, Briana Gibson, MD, Raj S. Kasthuri, MD, Darla K Liles, MD, Susan Eubanks, Frank Akwaa, MD, Lisa Baumann Kreuziger, MD MS, J. Evan Sadler, MD PhD, Meera Sridharan, MD, Ronald S. Go, MD, Keith R McCrae, MD, Shruti Chaturvedi, MBBS, MS, Harsh Vardhan Upreti, Rahil Kohli, MD, Ming Y. Lim, MBBChir,MA, X. Long Zheng, MD, PhD, Nicole K. Kocher, Radhika Gangaraju, MD, Spero Cataland, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 90.
https://doi.org/10.1182/blood-2019-129383
Published: 2019
Journal Articles

Disruption of ADAMTS13-Autoantibody Complexes with an ADAMTS13 Spacer Domain As a Potential Therapeutic Strategy for Immune Thrombotic Thrombocytopenic Purpura

Konstantine Halkidis, MD PhD, X. Long Zheng, MD, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 88.
https://doi.org/10.1182/blood-2019-125965
Published: 2019
Journal Articles

Binding of Factor VIII to D'D3 and A2 Domains of Von Willebrand Factor Facilitates Mechanical Unraveling of the A2 Domain

Wenjing Cao, MD,PhD, Wenpeng Cao, Wei Zhang, X. Long Zheng, MD, PhD, Xiaohui (Frank) Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 95.
https://doi.org/10.1182/blood-2019-125115
Published: 2019