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Journal Articles

CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric b ALL

Blood (2025) 146 (Supplement 1): 648.

https://doi.org/10.1182/blood-2025-648

Published: 2025

Journal Articles

Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia

Blood (2025) 146 (Supplement 1): 646.

https://doi.org/10.1182/blood-2025-646

Published: 2025

Journal Articles

Single-cell transcriptomics of pediatric B-ALL bone marrow to determine mechanisms of durable CD19 CAR T cell persistence

Jeremy Grenier, Katherine Mueller, Steven Pastor, Gabrielle Zuern, Susan McClory, Matthew Bode, Gbemi Olarewaju, Caroline Diorio, Prabhat Sharma, Regina Myers, Stephan Grupp, Evan Weber

Blood (2025) 146 (Supplement 1): 500.

https://doi.org/10.1182/blood-2025-500

Published: 2025

Journal Articles

Delayed neurotoxicity, enterocolitis, and BCMA-CART-associated immune-related adverse events (CirAE) are caused by CD4+ CAR T-cells

Blood (2025) 146 (Supplement 1): 804.

https://doi.org/10.1182/blood-2025-804

Published: 2025

Journal Articles

Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes

Anh Ngo, Weronika Ortmann, Abigail Skidmore, Hyunjun Kim, Jenna Oberg, Amrita Sarkar, Veronica Bochenek, Nate Levine, Lubica Rauova, Irina Chernysh, Zachary Martinez, Caroline Diorio, Mark Goulian, Victor Nizet, Mortimer Poncz, Kandace Gollomp

Blood (2025) 146 (Supplement 1): 1322.

https://doi.org/10.1182/blood-2025-1322

Published: 2025

Journal Articles

CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia

Blood (2025) 146 (Supplement 1): 1643.

https://doi.org/10.1182/blood-2025-1643

Published: 2025

Journal Articles

Modeling the HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death

Anastasia Frank-Kamenetskii, Hannah Klinghoffer, Jemy Varghese, Vinh Dang, Jeremy Morrissette, Joseph A. Fraietta, Caroline Diorio, Janis K. Burkhardt, Scott W. Canna

Blood (2025) 146 (5): 558–570.

https://doi.org/10.1182/blood.2024027179

Published: 2025

Includes: Multimedia, Supplemental data

Journal Articles

Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome

Blood (2025) 145 (23): 2685–2700.

https://doi.org/10.1182/blood.2024027270

Published: 2025

Includes: Supplemental data

Journal Articles

STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL

Blood (2025) 145 (23): 2793–2798.

https://doi.org/10.1182/blood.2025028566

Published: 2025

Includes: Supplemental data

Journal Articles

Interferon-Activated Gene Signatures Associate with Chemotherapy Resistance and Sensitivity to JAK-Inhibition in Refractory ETP-ALL

Blood (2024) 144 (Supplement 1): 1464.

https://doi.org/10.1182/blood-2024-211090

Published: 2024

Journal Articles

Serum-Based Proteomic Analysis of Cytokine Release Syndrome in Pediatric AML Patients Receiving CART123

Saamia Farooki, Han R Fisher, Anand S Bhagwat, Tina Glisovic-Aplenc, Lusha Cao, Regina M. Myers, Haley Newman, Caroline Diorio, Saar Gill, Richard Aplenc

Blood (2024) 144 (Supplement 1): 2946.

https://doi.org/10.1182/blood-2024-201034

Published: 2024

Journal Articles

In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing

Blood (2024) 144 (Supplement 1): 3473.

https://doi.org/10.1182/blood-2024-210324

Published: 2024

Journal Articles

BEAM-201 for the Treatment of Relapsed and/or Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL): Initial Data from the Phase (Ph) 1/2 Dose-Exploration, Dose-Expansion, Safety, and Efficacy Study of Multiplex Base-Edited Allogeneic Anti-CD7 CAR-T-Cells

Caroline Diorio, Paul Shaughnessy, Nosha Farhadfar, Anjali S. Advani, Wen-Kai Weng, Hagop Youssoufian, Guo Chen, Felicia Nguyen Brown, Bahru Habtermariam, Lalit Kumar, Jigar Patel, Shangbin (Gary) Liu, Sunita Goyal, Amy Simon, Alex C. Minella, David T. Teachey

Blood (2024) 144 (Supplement 1): 4838.

https://doi.org/10.1182/blood-2024-203546

Published: 2024

Journal Articles

Preinfusion Risk Factors for the Development of Severe Immune Effector Cell Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T-Cell Infusion in Pediatric Patients

Caroline Diorio, Regina M. Myers, Yimei Li, Amanda M. Dinofia, Hongyan Liu, Allison Barz Leahy, Haley Newman, Jillian Dolan, Zachary Martinez, Amira Elhachimi, Cassidy Mullen, Alexander Lai Li, John Kim, David T. Teachey, Shannon L. Maude, Jennifer McGuire, Stephan A. Grupp

Blood (2024) 144 (Supplement 1): 3454.

https://doi.org/10.1182/blood-2024-204993

Published: 2024

Journal Articles

Genomic Biomarkers of Poor Outcome in Patients with T-Cell Lymphoblastic Lymphoma

Blood (2024) 144 (Supplement 1): 313.

https://doi.org/10.1182/blood-2024-203827

Published: 2024

Journal Articles

TCL1A Is Associated with Blinatumomab Response and Immune Activation in Pediatric B-ALL

Blood (2024) 144 (Supplement 1): 634.

https://doi.org/10.1182/blood-2024-203756

Published: 2024

Journal Articles

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Anh T.P. Ngo, Veronica Bochenek, Hyunjun Kim, Nate Levine, Samir Maarouf, Jenna Oberg, Manuela Roggiani, Amrita Sarkar, Lubica Rauova, Caroline Diorio, Zachary Martinez, Mark Goulian, Mortimer Poncz, Victor Nizet, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 1231.

https://doi.org/10.1182/blood-2024-211717

Published: 2024

Journal Articles

Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents

Caroline Diorio, Laura Hernandez-Miyares, Diego A. Espinoza, Brenda L. Banwell, Amit Bar-Or, Amanda M. DiNofia, Allison Barz Leahy, Zachary Martinez, Regina M. Myers, Sarah E. Hopkins, Susan R. Rheingold, David T. Teachey, Angela N. Viaene, Lisa M. Wray, Shannon L. Maude, Stephan A. Grupp, Jennifer L. McGuire

Blood (2024) 144 (13): 1387–1398.

https://doi.org/10.1182/blood.2024023933

Published: 2024

Includes: Supplemental data

Journal Articles

IL-10 Levels Differentially Regulate IFNg Signaling of CART19 and CART22

Caroline Diorio, Regina M. Myers, Anastasia Frank-Kamenetski, Rawan Shraim, Amanda M. Dinofia, Zachary Martinez, Ohaila Mustafa, Joseph A Fraietta, Vanessa Gonzalez, Vivian Yi, Lahari Uppuluri, Haley Newman, Edward Behrens, Carl June, Scott Canna, Stephan Grupp, David T. Teachey

Blood (2023) 142 (Supplement 1): 3431.

https://doi.org/10.1182/blood-2023-182377

Published: 2023

Journal Articles

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Veronica Bochenek, Nate Levine, Anh T.P. Ngo, Samir Maarouf, Abigail E Skidmore, M. Anna Kowalska, Caroline Diorio, Zachary Martinez, Mortimer Poncz, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 1169.

https://doi.org/10.1182/blood-2023-189931

Published: 2023

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CD19 CAR T cell therapy is an effective strategy for first CNS relapse in pediatric b ALL

Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia

Single-cell transcriptomics of pediatric B-ALL bone marrow to determine mechanisms of durable CD19 CAR T cell persistence

Delayed neurotoxicity, enterocolitis, and BCMA-CART-associated immune-related adverse events (CirAE) are caused by CD4+ CAR T-cells

Platelet factor 4 (PF4) modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes

CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia

Modeling the HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death

Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome

STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL

Interferon-Activated Gene Signatures Associate with Chemotherapy Resistance and Sensitivity to JAK-Inhibition in Refractory ETP-ALL

Serum-Based Proteomic Analysis of Cytokine Release Syndrome in Pediatric AML Patients Receiving CART123

In Vivo Persistence and Function of CAR19 T-Cell Products for Pediatric B-Cell Acute Lymphoblastic Leukemia Are Impacted By Media, Cytokine Supplementation and Metabolite Bioavailability during Ex Vivo Manufacturing

Preinfusion Risk Factors for the Development of Severe Immune Effector Cell Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T-Cell Infusion in Pediatric Patients

Genomic Biomarkers of Poor Outcome in Patients with T-Cell Lymphoblastic Lymphoma

TCL1A Is Associated with Blinatumomab Response and Immune Activation in Pediatric B-ALL

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents

IL-10 Levels Differentially Regulate IFNg Signaling of CART19 and CART22

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

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