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Patrizia Porazzi
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Journal Articles

Inhibition of EZH2 Improves CART19 Immunotherapy By Reprogramming Lymphoma Tumor Cells and Enhancing T-Cell Functionality

Patrizia Porazzi, Yusuke Isshiki, Guido Ghilardi, Siena Nason, Ziqi Yang, Alberto Carturan, Linhui Chen, Yunlin Zhang, Ruchi P. Patel, Puneeth Guruprasad, Ositadimma Ugwuanyi, Ivan J Cohen, Stephen J Schuster, Ari M Melnick, Wendy Béguelin, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 1018.
https://doi.org/10.1182/blood-2023-182440
Published: 2023
Journal Articles

Modulation of the Btla-HVEM Axis to Enhance CAR T Cell Immunotherapy Against Cancer

Puneeth Guruprasad, Alberto Carturan, Yunlin Zhang, Kingsley Gideon Kumashie, Ivan J Cohen, Guido Ghilardi, Ki-Hyun Kim, Jong-Seo Lee, Yoon Lee, Jong-Hoon Kim, Junho Chung, Maksim Shestov, Raymone Pajarillo, Jaryse Harris, Yong Gu Lee, Michael Wang, Hatcher Ballard, Aasha Gupta, Ositadimma Ugwuanyi, Seok Jae Hong, Linhui Chen, Luca Paruzzo, Shane Kammerman, Ruchi P. Patel, Olga Shestova, Laura Vella, Stephen J. Schuster, Jakub Svoboda, Patrizia Porazzi, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 768.
https://doi.org/10.1182/blood-2023-189633
Published: 2023
Journal Articles

Precision Targeting of the Malignant Clone in Diffuse Large B Cell Lymphoma Using Chimeric Antigen Receptor T Cells Against the Clonotypic IGHV4-34 B Cell Receptor

Ivan J Cohen, Audrey C Bochi-Layec, Ki Hyun Kim, Scott Jenks, Ositadimma Ugwuanyi, Guido Ghilardi, Giulia Gabrielli, Jaryse Harris, Li-Ping Wang, Yunlin Zhang, Raymone Pajarillo, Elisavet Vlachonikola, Patrizia Porazzi, Ignacio Sanz, Paolo Ghia, Kostas Stamatopoulos, Stephen J Schuster, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 1020.
https://doi.org/10.1182/blood-2023-187618
Published: 2023
Journal Articles

EZH2 Inhibitors Enhance CART Cell Quality, Efficacy, In Vivo Homing, Tumor Cell Binding and Killing of Fully Syngeneic Primary B Cell Lymphomas, As Well As Reprogramming Lymphoma Cells to a Highly Immunogenic and T Cell Adherent Phenotype

Yusuke Isshiki, Patrizia Porazzi, Xi Chen, Matthew Teater, Ioannis Karagiannidis, Henna S. Nam, Ari M Melnick, Marco Ruella, Wendy Béguelin
Journal: Blood
Blood (2023) 142 (Supplement 1): 432.
https://doi.org/10.1182/blood-2023-190610
Published: 2023
Journal Articles

Bendamustine Is Less Toxic Than Fludarabine-Cyclophosphamide-Based Lymphodepletion before CD28-Costimulated CART19 through Reduced Inflammatory Cytokines

Guido Ghilardi, Luca Paruzzo, Jakub Svoboda, Elise A. Chong, Alexander Shestov, Linhui Chen, Ivan J Cohen, Giulia Gabrielli, Dwivedy S. Nasta, Patrizia Porazzi, Daniel J. Landsburg, James Gerson, Jordan Carter, Stefan K. Barta, Rebecca Yelton, Raymone Pajarillo, Griffin W White, Hatcher Ballard, Elizabeth Weber, Ellen B. Napier, Emeline R. Chong, Joseph A Fraietta, Alfred L. Garfall, David L. Porter, Michael C. Milone, Roderick O'Connor, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 4483.
https://doi.org/10.1182/blood-2023-182234
Published: 2023
Journal Articles

A First-in-Human Phase I Study of AT101, a Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19 in Adults with Relapsed or Refractory B Cell Non-Hodgkin Lymphoma

Yunlin Zhang, Ruchi P. Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Cho, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung-Hyun Kim, Ji Hyun Lee, Mathew G. Angelos, Puneeth Guruprasad, Ivan J Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Soohwan Kim, Sung Min Kim, Hyun Jong Lee, Ji Ho Park, Lei Guang Cui, Tae Bum Lee, Insik Hwang, Youngha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong Hoon Kim, Jong Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 2096.
https://doi.org/10.1182/blood-2023-189369
Published: 2023
Journal Articles

Senza5 TM CART5 : An Autologous CD5-Deleted Anti-CD5 CART Product with Enhanced Anti-T-Cell Lymphoma Activity

Adam E. Snook, Ruchi P. Patel, Guido Ghilardi, Aditya Nimmagadda, Steven Yang, Dean Qian, Patrizia Porazzi, Rosemary Mazanet, Stephen J Schuster, Stefan K. Barta, Trang Vu, Marco Ruella, Nicholas A. Siciliano
Journal: Blood
Blood (2023) 142 (Supplement 1): 3462.
https://doi.org/10.1182/blood-2023-190386
Published: 2023
Journal Articles

Disinhibition of T Cell Activation Via CD5 Knockout Is a Universal Strategy to Enhance Adoptive T Cell Immunotherapies

Ruchi P. Patel, Guido Ghilardi, Yunlin Zhang, Puneeth Guruprasad, Mathew G. Angelos, Raymone Pajarillo, Khatuna Gabunia, Chong Xu, Tatiana Blanchard, John Scholler, Patrizia Porazzi, Gerald Linette, Beatriz M. Carreno, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 102.
https://doi.org/10.1182/blood-2023-186611
Published: 2023
Journal Articles

Overcoming CD19-Negative Relapses in Patients with B-Cell Lymphomas Treated with Tisagenlecleucel

Guido Ghilardi, Yong Gu Lee, Patrizia Porazzi, Ivan Cohen, Luca Paruzzo, Ositadimma H Ugwuanyi, Raymone Pajarillo, Yunlin Zhang, Puneeth Guruprasad, Ruchi P. Patel, Elise A. Chong, Sunita Dwivedy Nasta, Stefan K. Barta, Alfred L. Garfall, Daniel J. Landsburg, Sam Sadigh, Mariusz Wasik, Jakub Svoboda, Siddharth Bhattacharyya, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2022) 140 (Supplement 1): 7371–7373.
https://doi.org/10.1182/blood-2022-167601
Published: 2022
Journal Articles

Clinical Development of Senza5 TM CART5: a Novel Dual Population CD5 CRISPR-Cas9 Knocked out Anti-CD5 Chimeric Antigen Receptor T Cell Product for Relapsed and Refractory CD5+ Nodal T-Cell Lymphomas

Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Steven Yang, Dean Qian, Raymone Pajarillo, Michael Wang, Yunlin Zhang, Stephen J. Schuster, Stefan K. Barta, Aditya Nimmagadda, Adam Snook, Nicholas A. Siciliano, Marco Ruella
Journal: Blood
Blood (2022) 140 (Supplement 1): 1604–1605.
https://doi.org/10.1182/blood-2022-166605
Published: 2022
Journal Articles

Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs

Marco De Dominici, Patrizia Porazzi, Youcai Xiao, Allen Chao, Hsin-Yao Tang, Gaurav Kumar, Paolo Fortina, Orietta Spinelli, Alessandro Rambaldi, Luke F. Peterson, Svetlana Petruk, Camilla Barletta, Alexander Mazo, Gino Cingolani, Joseph M. Salvino, Bruno Calabretta
Journal: Blood
Blood (2020) 135 (18): 1560–1573.
https://doi.org/10.1182/blood.2019003604
Published: 2020
Includes: Supplemental data
Journal Articles

Targeting CDK6 and BCL2 Exploits the “MYB Addiction” of Ph+ Acute Lymphoblastic Leukemia

Marco De Dominici, MS, Angela Rachele Soliera, PhD, Patrizia Porazzi, PhD, Samanta A. Mariani, PhD, Sankar Addya, PhD, Luke F. Peterson, PhD, Orietta Spinelli, PhD, Alessandro Rambaldi, MD Prof, Giovanni Martinelli, MD, Ilaria Iacobucci, PhD, Anna Ferrari, PhD, Bruno Calabretta, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2490.
https://doi.org/10.1182/blood.V130.Suppl_1.2490.2490
Published: 2017
Journal Articles

Zebrafish Ortholog of Human DOT1L Regulates Primitive and Transient Definitive Hematopoiesis and Controls hoxa9 and meis1 Expression

Giulia Morello, BSc, Patrizia Porazzi, PhD, Enrico Moro, PhD, Francesco Argenton, PhD, Giuseppe Basso, MD, Carolyn A. Felix, MD, Giuseppe Germano, PhD
Journal: Blood
Blood (2012) 120 (21): 849.
https://doi.org/10.1182/blood.V120.21.849.849
Published: 2012