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Journal Articles

Modulation of the Btla-HVEM Axis to Enhance CAR T Cell Immunotherapy Against Cancer

Puneeth Guruprasad, Alberto Carturan, Yunlin Zhang, Kingsley Gideon Kumashie, Ivan J Cohen, Guido Ghilardi, Ki-Hyun Kim, Jong-Seo Lee, Yoon Lee, Jong-Hoon Kim, Junho Chung, Maksim Shestov, Raymone Pajarillo, Jaryse Harris, Yong Gu Lee, Michael Wang, Hatcher Ballard, Aasha Gupta, Ositadimma Ugwuanyi, Seok Jae Hong, Linhui Chen, Luca Paruzzo, Shane Kammerman, Ruchi P. Patel, Olga Shestova, Laura Vella, Stephen J. Schuster, Jakub Svoboda, Patrizia Porazzi, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 768.
https://doi.org/10.1182/blood-2023-189633
Published: 2023
Journal Articles

Cytokine Release Syndrome Results in Reduced AML Killing By CD123 CAR T Cells

Anand S Bhagwat, Leonel Torres, Olga Shestova, Maksim Shestov, Noelle V. Frey, Elizabeth O Hexner, Selina M Luger, Alison W Loren, Mary Ellen Martin, Shannon R McCurdy, Alexander Perl, Edward A. Stadtmauer, James K. Mangan, Jennifer Brogdon, Joseph A Fraietta, Wei-Ting Hwang, Don L. Siegel, Saad S. Kenderian, David L. Porter, Carl June, Saar Gill
Journal: Blood
Blood (2023) 142 (Supplement 1): 217.
https://doi.org/10.1182/blood-2023-182104
Published: 2023
Journal Articles

Molecular Attributes of CAR T Cell Fitness in Patients with Chronic Lymphocytic Leukemia

Xiaoli Mi, Dennis Yuan, Rebecca Murray, Jani Huuhtanen, Beatrice Zhang, Jean Quentin, Olga Shestova, David L. Porter, Satu Mustjoki, Saar Gill, Dan A. Landau
Journal: Blood
Blood (2023) 142 (Supplement 1): 3452.
https://doi.org/10.1182/blood-2023-187956
Published: 2023
Journal Articles

G-CSF Mobilized Apheresis As an Alternative Source of CAR T-Cells

Katherine D Cummins, Arjun Gupta, Ofrat Beyar-Katz, Ye Li, Paramita Chatterjee, Linda Kippner, Olga Shestova, Monika A Eiva, January Salas-Mckee, Carolyn Yeago, Krishnendu Roy, Saar Gill
Journal: Blood
Blood (2022) 140 (Supplement 1): 7415–7416.
https://doi.org/10.1182/blood-2022-165916
Published: 2022
Journal Articles

Repurposing Bi-Specific Chimeric Antigen Receptor (CAR) Approach to Enhance CAR T Cell Activity Against Low Antigen Density Tumors

Sherly Mardiana, Olga Shestova, Stephan A. Grupp, Marco Ruella, David M. Barrett, Saar Gill
Journal: Blood
Blood (2021) 138 (Supplement 1): 1727.
https://doi.org/10.1182/blood-2021-146995
Published: 2021
Journal Articles

Anti-FLT3 CAR T Cells in Acute Myeloid Leukemia

Sara Sleiman, Olga Shestova, Francisco Santiago, Elina Shrestha, Raymond Liang, Ronen Ben Jehuda, Vladislav Sandler, Saar Gill
Journal: Blood
Blood (2021) 138 (Supplement 1): 1703.
https://doi.org/10.1182/blood-2021-151196
Published: 2021
Journal Articles

Repurposing Bi-Specific Chimeric Antigen Receptor (CAR) Approach to Enhance CAR T Cell Activity Against Low Antigen Density Tumors

Sherly Mardiana, PhD, Olga Shestova, PhD, Marco Ruella, MD, Saar Gill, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30.
https://doi.org/10.1182/blood-2020-140092
Published: 2020
Journal Articles

CRISPR-Cas9 Knock out of CD5 Enhances the Anti-Tumor Activity of Chimeric Antigen Receptor T Cells

Inkook Chun, MS, Ki Hyun Kim, PhD, Yi-Hao Chiang, MD, Wei Xie, MD, Yong Gu Gu Lee, PhD, Raymone Pajarillo, MS, Antonia Rotolo, MD PhD, Olga Shestova, PhD, Seok Jae Hong, MS, Mohamed Abdel-Mohsen, PhD, Maria Wysocka, PhD, Hatcher J. Ballard, BS, David M. Barrett, Avery D. Posey, PhD, Daniel Powell, Jr., PhD, Saar I. Gill, MDPhD, Stephen J. Schuster, MD, Stefan K. Barta, MDMRCP,MS, Alain H Rook, MD, Carl H June, MD, Marco Ruella, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 51–52.
https://doi.org/10.1182/blood-2020-136860
Published: 2020
Journal Articles

A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor–positive cells

Brief Report
Marco Ruella, David M. Barrett, Olga Shestova, Jessica Perazzelli, Avery D. Posey, Jr, Seok Jae Hong, Miroslaw Kozlowski, Simon F. Lacey, J. Joseph Melenhorst, Carl H. June, Saar I. Gill
Journal: Blood
Blood (2020) 135 (7): 505–509.
https://doi.org/10.1182/blood.2019001859
Published: 2020
Includes: Supplemental data
Journal Articles

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Nathan Singh, MD, Noelle V. Frey, MD, Boris Engels, PhD, David M. Barrett, Olga Shestova, PhD, Pranali Ravikumar, MS, Amy Shyu, Steven Highfill, PhD, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xeuqing Maggie Lu, David A Christian, PhD, Jessica Perazzelli, Simon F Lacey, PhD, Nathan Roy, Janis K Burkhardt, PhD, Florent Colomb, Mohamed Abdel-Mohsen, Regina M Young, PhD, Jennifer Brogdon, PhD, Stephan Grupp, MD PhD, Carl H June, MD, Shannon L. Maude, MD PhD, Saar I. Gill, MD PhD, Marco Ruella, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 247.
https://doi.org/10.1182/blood-2019-131024
Published: 2019
Journal Articles

CAR T Cell Cytotoxicity Is Dependent on Death Receptor-Driven Apoptosis

Nathan Singh, MD, Olga Shestova, PhD, Katharina Hayer, Albert Hong, Pranali Ravikumar, MS, Atushi Hoshino, MD PhD, Ophir Shalem, PhD, Matthew D. Weitzman, PhD, Carl H June, MD, Saar I. Gill, MDPhD, Marco Ruella, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 698.
https://doi.org/10.1182/blood-2018-99-117328
Published: 2018
Journal Articles

A Cellular Antidote to Specifically Deplete Anti-CD19 Chimeric Antigen Receptor (CAR19) Positive Cells

Marco Ruella, MD, David M. Barrett, Olga Shestova, PhD, Jessica Perazzelli, PhD, Avery D. Posey, PhD, Miroslaw Kozlowski, PhD, Simon F Lacey, PhD BS, J. Joseph Melenhorst, PhD, Carl H June, MD, Saar I. Gill, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4463.
https://doi.org/10.1182/blood.V130.Suppl_1.4463.4463
Published: 2017
Journal Articles

Clinical Efficacy of Anti-CD22 Chimeric Antigen Receptor T Cells for B-Cell Acute Lymphoblastic Leukemia Is Correlated with the Length of the Scfv Linker and Can be Predicted Using Xenograft Models

Marco Ruella, MD, Shannon L Maude, MD PhD, Boris Engels, PhD, David M. Barrett, Noelle Frey, MD, Katherine T Marcucci, PhD, Olga Shestova, PhD, Nathan Singh, MD, Jessica Perazzelli, PhD, David A Christian, PhD, Dana Haagen, BS, Simon F Lacey, PhD BS, J. Joseph Melenhorst, PhD, Jennifer Brogdon, PhD, Regina M Young, PhD, David L Porter, MD, Carl H June, MD, Stephan A Grupp, MD PhD, Saar I. Gill, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 807.
https://doi.org/10.1182/blood.V130.Suppl_1.807.807
Published: 2017
Journal Articles

Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia

Sarah K. Tasian, Saad S. Kenderian, Feng Shen, Marco Ruella, Olga Shestova, Miroslaw Kozlowski, Yong Li, April Schrank-Hacker, Jennifer J. D. Morrissette, Martin Carroll, Carl H. June, Stephan A. Grupp, Saar Gill
Journal: Blood
Blood (2017) 129 (17): 2395–2407.
https://doi.org/10.1182/blood-2016-08-736041
Published: 2017
Includes: Supplemental data
Journal Articles

Engineering Resistance to Antigen-Specific Immunotherapy in Normal Hematopoietic Stem Cells By Gene Editing to Enable Targeting of Acute Myeloid Leukemia

Miriam Y Kim, MD, Saad S Kenderian, MD, Daniel Schreeder, MD PhD, Michael Klichinsky, PharmD, Miroslaw Kozlowski, PhD, Olga Shestova, PhD, Marco Ruella, MD, Saar I Gill, MBBS, PhD
Journal: Blood
Blood (2016) 128 (22): 1000.
https://doi.org/10.1182/blood.V128.22.1000.1000
Published: 2016
Journal Articles

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells

Marco Ruella, MD, Michael Klichinsky, PharmD, Saad S Kenderian, MD, Olga Shestova, PhD, Amy Ziober, Michael D Feldman, MD, Mariusz A Wasik, MD, Carl H June, MD, Saar I Gill, MBBS, PhD
Journal: Blood
Blood (2016) 128 (22): 43.
https://doi.org/10.1182/blood.V128.22.43.43
Published: 2016
Journal Articles

Kinase Inhibitor Ibrutinib Prevents Cytokine-Release Syndrome after Anti-CD19 Chimeric Antigen Receptor T Cells (CART) for B Cell Neoplasms

Marco Ruella, MD, Saad S Kenderian, MD, Olga Shestova, PhD, Michael Klichinsky, PharmD, J. Joseph Melenhorst, PhD, Mariusz A Wasik, MD, Simon F. Lacey, PhD, Carl H June, MD, Saar I Gill, MBBS, PhD
Journal: Blood
Blood (2016) 128 (22): 2159.
https://doi.org/10.1182/blood.V128.22.2159.2159
Published: 2016
Journal Articles

Leukemia Stem Cells Are Characterized By CLEC12A Expression and Chemotherapy Refractoriness That Can be Overcome By Targeting with Chimeric Antigen Receptor T Cells

Saad S Kenderian, MD, Marco Ruella, MD, Olga Shestova, PhD, Michael Klichinsky, PharmD, Miriam Y Kim, MD, Craig Soderquist, MD, Adam Bagg, MD, Reshma Singh, PhD, Celeste Richardson, PhD, Regina M Young, PhD, Carl H June, MD, Saar I. Gill, MD PhD
Journal: Blood
Blood (2016) 128 (22): 766.
https://doi.org/10.1182/blood.V128.22.766.766
Published: 2016
Journal Articles

Ruxolitinib Prevents Cytokine Release Syndrome after CART Cell Therapy without Impairing the Anti-Tumor Effect in a Xenograft Model

Saad S Kenderian, MD, Marco Ruella, MD, Olga Shestova, PhD, Miriam Y Kim, MD, Michael Klichinsky, PharmD, Fang Chen, PhD, Natalka Kengle, Simon Francis Lacey, PhD BS, J. Joseph Melenhorst, PhD, Carl H June, MD, Saar I. Gill, MD PhD
Journal: Blood
Blood (2016) 128 (22): 652.
https://doi.org/10.1182/blood.V128.22.652.652
Published: 2016
Journal Articles

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

Mark Y. Chiang, Qing Wang, Anna C. Gormley, Sarah J. Stein, Lanwei Xu, Olga Shestova, Jon C. Aster, Warren S. Pear
Journal: Blood
Blood (2016) 128 (18): 2229–2240.
https://doi.org/10.1182/blood-2016-01-692855
Published: 2016
Includes: Supplemental data