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Sarah K. Tasian
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Journal Articles

ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies

Clinical Trials & Observations
Sarah Elitzur, Ruth Shiloh, Jan L. C. Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Thomas Lehrnbecher, Sarah K. Tasian, Oussama Abla, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Nicole Bodmer, Triantafyllia Brozou, Francesco Ceppi, Liliia Chugaeva, Luciano Dalla Pozza, Stephane Ducassou, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Stefanie Junk, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Nizar Mahlaoui, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Marion Strullu, Thai Hoa Tran, Marek Ussowicz, Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, A. Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Veronique Minard-Colin, Kjeld Schmiegelow, Ronit Nirel, Andishe Attarbaschi, Arndt Borkhardt
Journal: Blood
Blood (2024) 144 (11): 1193–1205.
https://doi.org/10.1182/blood.2024024283
Published: 2024
Includes: Supplemental data
Journal Articles

Tyrosine kinase inhibitor response of ABL-class acute lymphoblastic leukemia: the role of kinase type and SH3 domain

Inge van Outersterp, Sarah K. Tasian, Caitlin E. J. Reichert, Aurélie Boeree, Hester A. de Groot-Kruseman, Gabriele Escherich, Judith M. Boer, Monique L. den Boer
Journal: Blood
Blood (2024) 143 (21): 2178–2189.
https://doi.org/10.1182/blood.2023023120
Published: 2024
Includes: Supplemental data
Journal Articles

How I Treat Philadelphia Chromosome-like Acute Lymphoblastic Leukemia in Children, Adolescents, and Young Adults

Thai Hoa Tran, Sarah K Tasian
Journal: Blood
Blood blood.2023023153.
https://doi.org/10.1182/blood.2023023153
Published: 2024
Journal Articles

Alternative splicing of its 5′-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

Zhiwei Ang, Luca Paruzzo, Katharina E. Hayer, Carolin Schmidt, Manuel Torres Diz, Feng Xu, Urvi Zankharia, Yunlin Zhang, Samantha Soldan, Sisi Zheng, Catherine D. Falkenstein, Joseph P. Loftus, Scarlett Y. Yang, Mukta Asnani, Patricia King Sainos, Vinodh Pillai, Emeline Chong, Marilyn M. Li, Sarah K. Tasian, Yoseph Barash, Paul M. Lieberman, Marco Ruella, Stephen J. Schuster, Andrei Thomas-Tikhonenko
Journal: Blood
Blood (2023) 142 (20): 1724–1739.
https://doi.org/10.1182/blood.2023020400
Published: 2023
Includes: Supplemental data
Journal Articles

Europeanpediatric Acute Leukemia (EuPAL) Registry

Katarzyna Majstrowicz, Katharina Waack, Evangelia Antoniou, Naghmeh Niktoreh, Gwen Nichols, Laura Di Laurenzio, Michele S. Redell, Todd Cooper, E. Anders Kolb, Sarah K. Tasian, Franco Locatelli, C. Michel Zwaan, Dirk Reinhardt
Journal: Blood
Blood (2023) 142 (Supplement 1): 1496.
https://doi.org/10.1182/blood-2023-189684
Published: 2023
Journal Articles

CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial

Nirali N. Shah, Sarah K. Tasian, M. Eric Kohler, Emily M. Hsieh, Susanne H.C. Baumeister, Corinne Summers, Haneen Shalabi, Jessica A. Pollard, Bonnie Yates, Ruta Brazauskas, Eric Ndifon, Constance M. Yuan, Hao-Wei Wang, Hati K Kobusingye, Kayla Christianson, Allison A Weiss, Erin Leckrone, Bronwen E. Shaw, Jeffery J. Auletta, Hemalatha G. Rangarajan, John Roach, Julie Blake, Dennis Michiel, Brian Bowser, Sheryl Ruppel, George Mitra, Anthony Welch, Jason Yovandich, Rachelle Salomon, Leslie Kean, Katherine Tarlock, Michael A. Pulsipher, Michael R Verneris, Larisa Broglie, Terry J. Fry, Steven M. Devine, Richard Aplenc
Journal: Blood
Blood (2023) 142 (Supplement 1): 771.
https://doi.org/10.1182/blood-2023-179667
Published: 2023
Journal Articles

ATM Germline Pathogenic Variants Affect Treatment Outcomes in Children with Acute Lymphoblastic Leukemia/Lymphoma and Ataxia Telangiectasia

Sarah Elitzur, Ruth Shiloh, Jan Loeffen, Agata Pastorczak, Masatoshi Takagi, Simon Bomken, Andre Baruchel, Stephane Ducassou, Nizar Mahlaoui, Marion Strullu, Thomas Lehrnbecher, Kjeld Schmiegelow, Oussama Abla, Liliia Anderzhanova, Nira Arad-Cohen, Itziar Astigarraga, Miriam Ben-Harosh, Francesco Ceppi, Nicole Bodmer, Triantafyllia Brozou, Luciano Dalla-Pozza, Gabriele Escherich, Roula Farah, Amber Gibson, Henrik Hasle, Julieta Hoveyan, Elad Jacoby, Janez Jazbec, Alexandra Kolenova, Jelena Lazic, Luca Lo Nigro, Lane Miller, Vassilios Papadakis, Lucie Pecheux, Marta Pillon, Ifat Sarouk, Jan Stary, Eftichia Stiakaki, Sarah K. Tasian, Thai Hoa Tran, Marek Ussowicz, Jose Jaime Verdu-Amoros, Anna Wakulinska, Joanna Zawitkowska, Dominique Stoppa-Lyonnet, Malcolm Taylor, Yosef Shiloh, Shai Izraeli, Ronit Nirel, Veronique Minard-Colin, Andishe Attarbaschi, Arndt Borkhardt
Journal: Blood
Blood (2023) 142 (Supplement 1): 520.
https://doi.org/10.1182/blood-2023-179333
Published: 2023
Journal Articles

Risk Stratified Treatment for Patients with Newly Diagnosed Juvenile Myelomonocytic Leukemia: A Phase 1/2 Non-Randomized Study of Trametinib and Azacitidine with or without Chemotherapy

Elliot Stieglitz, Yueh-Yun Chi, Bill H. Chang, Sarah K. Tasian, Marielle Yohe, Christopher C Dvorak, Erica Southworth, Janel R. Long-Boyle, Jessica Van Ziffle, Zied Abdullaev, Roy Leong, Alan S. Wayne, Deepa Bhojwani, Mignon L. Loh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3210.
https://doi.org/10.1182/blood-2023-177838
Published: 2023
Journal Articles

APAL2020SC Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias

Michele S. Redell, Todd A. Alonzo, Robert Gerbing, Jim Wang, Maureen M. O'Brien, Gwen Nichols, Laura Di Laurenzio, Sarah K. Tasian, C. Michel Zwaan, Dirk Reinhardt, E. Anders Kolb, Todd Cooper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1492.
https://doi.org/10.1182/blood-2023-190947
Published: 2023
Journal Articles

Transcriptomic without Clinical Response to Menin Inhibition As a Mechanism of Upfront Resistance in Samples from Mutliply Relapsed Patients with KMT2A-Rearranged Leukemia

Leila Mahdavi, Haley Goodrow, Hongbo Xie, Alexandra Lenard, Fatemeh Alikarami, Simone Stefanie Riedel, Sarah K. Tasian, Gerald Wertheim, Sarah Skuli, Martin Carroll, Jerry McGeehan, Kathrin M. Bernt
Journal: Blood
Blood (2023) 142 (Supplement 1): 4166.
https://doi.org/10.1182/blood-2023-180967
Published: 2023
Journal Articles

Preliminary Safety and Efficacy of Venetoclax and Selinexor in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia: Selclax

Sara Zarnegar-Lumley, Seth E. Karol, Stanley Pounds, Jeffery M. Klco, Maria Luisa Sulis, Dennis John Kuo, Kenneth Matthew Heym, Kathleen Ludwig, Alexandra McLean Stevens, Thomas B. Alexander, Kelly Elizabeth Faulk, Himalee S. Sabnis, Sarah K. Tasian, Jeffrey Taub, Andrew E. Place, Jeffrey E. Rubnitz
Journal: Blood
Blood (2023) 142 (Supplement 1): 56.
https://doi.org/10.1182/blood-2023-174342
Published: 2023
Journal Articles

Transcriptional Rewiring and Therapeutic Resistance in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Yang Y Ding, Joseph Patrick Loftus, Benjamin Mathier, Wenbao Yu, David Hottman Allen, Bing He, Catherine D Falkenstein, Sarah K Tasian, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 354–355.
https://doi.org/10.1182/blood-2022-169341
Published: 2022
Journal Articles

Targeting CD38 in T-ALL Upregulates the Targetable Polyamine Metabolism Pathway

Caroline Diorio, Tiffaney L. Vincent, Tori Fuller, Rawan Shraim, Tina Glisovic-Aplenc, Theresa Ryan, Kimberly Veliz, Haley Newman, Gerald Wertheim, Hamid Bassiri, Annette Vu, Michael Hogarty, Carl H June, Stephan A. Grupp, Sarah K Tasian, Richard Aplenc, Saar Gill, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 10285–10286.
https://doi.org/10.1182/blood-2022-167893
Published: 2022
Journal Articles

Clinical Experience with Azacitidine and Venetoclax +/- Gemtuzumab in Pediatric Patients with Relapsed or Refractory Acute Leukemias: A Report from the Children's Hospital of Philadelphia

Lisa M Niswander, Perry Chung, Caroline Diorio, Sarah K Tasian
Journal: Blood
Blood (2022) 140 (Supplement 1): 6173–6174.
https://doi.org/10.1182/blood-2022-166232
Published: 2022
Journal Articles

Preclinical In Vivo Activity of the Menin Inhibitor Ziftomenib (KO-539) in Pediatric KMT2A -Rearranged Acute Lymphoblastic Leukemia

Catherine D Falkenstein, Lisa M Niswander, Linda Kessler, Blake Tomkinson, Francis Burrows, Sarah K Tasian
Journal: Blood
Blood (2022) 140 (Supplement 1): 3491–3492.
https://doi.org/10.1182/blood-2022-157225
Published: 2022
Journal Articles

Safety and Activity of Flotetuzumab in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia: Results from the COG PEPN1812 Phase 1 Trial

Adam J. Lamble, Xiaowei Liu, Charles Minard, Olga Militano, Melanie Brooke Bernhardt, Todd M. Cooper, Edward A. Kolb, Erin H. Breese, Elizabeth Fox, Sarah K Tasian, Brenda J. Weigel
Journal: Blood
Blood (2022) 140 (Supplement 1): 6209–6210.
https://doi.org/10.1182/blood-2022-158029
Published: 2022
Journal Articles

A Phase 2 Study of Ruxolitinib with Chemotherapy in Children with Philadelphia Chromosome-like Acute Lymphoblastic Leukemia (AALL1521/INCB18424-269): Biologic Characteristics and Minimal Residual Disease Response of Patients with Non- CRLF2 -Rearranged JAK Pathway Alterations

Sarah K Tasian, Deborah S Hunter, I-Ming L Chen, Richard C Harvey, Andrew J. Carroll, Elizabeth Wagner, Shalini C Reshmi, Michael J Borowitz, Brent L. Wood, Jeannie Daniel, Meenakshi Devidas, Elizabeth A. Raetz, Stephen P. Hunger, Albert Assad, Mignon L. Loh
Journal: Blood
Blood (2022) 140 (Supplement 1): 6117–6118.
https://doi.org/10.1182/blood-2022-164699
Published: 2022
Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

V. S. S. Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll, Christian Hurtz
Journal: Blood
Blood (2022) 140 (Supplement 1): 3486–3488.
https://doi.org/10.1182/blood-2022-162782
Published: 2022
Journal Articles

Non-Canonical Exon Usage in Pediatric Leukemia: Implications for Chemoresistance

Manuel Torres-Diz, Andrei Thomas-Tikhonenko, Clara Reglero, Adolfo Ferrando, Catherine D Falkenstein, Sarah K Tasian, Priyanka Sehgal, Zhiwei Ang, Yoseph Barash, Caleb Radens
Journal: Blood
Blood (2022) 140 (Supplement 1): 3264–3265.
https://doi.org/10.1182/blood-2022-167006
Published: 2022
Journal Articles

Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALL

Caroline Diorio, Ryan Murray, Mark Naniong, Luis Barrera, Adam Camblin, John Chukinas, Lindsey Coholan, Aaron Edwards, Tori Fuller, Claudia Gonzales, Stephan A. Grupp, Alden Ladd, Melissa Le, Angelica Messana, Faith Musenge, Haley Newman, Yeh-Chuin Poh, Henry Poulin, Theresa Ryan, Rawan Shraim, Sarah K. Tasian, Tiffaney Vincent, Lauren Young, Yingying Zhang, Giuseppe Ciaramella, Jason Gehrke, David T. Teachey
Journal: Blood
Blood (2022) 140 (6): 619–629.
https://doi.org/10.1182/blood.2022015825
Published: 2022
Includes: Supplemental data