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Kathrin M. Bernt
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Journal Articles

Menin dependence: UBTF- ITD AML joins the club

Kathrin M. Bernt
Journal: Blood
Blood (2024) 143 (7): 567–569.
https://doi.org/10.1182/blood.2023023041
Published: 2024
Journal Articles

Transcriptomic without Clinical Response to Menin Inhibition As a Mechanism of Upfront Resistance in Samples from Mutliply Relapsed Patients with KMT2A-Rearranged Leukemia

Leila Mahdavi, Haley Goodrow, Hongbo Xie, Alexandra Lenard, Fatemeh Alikarami, Simone Stefanie Riedel, Sarah K. Tasian, Gerald Wertheim, Sarah Skuli, Martin Carroll, Jerry McGeehan, Kathrin M. Bernt
Journal: Blood
Blood (2023) 142 (Supplement 1): 4166.
https://doi.org/10.1182/blood-2023-180967
Published: 2023
Journal Articles

The Role of GATA2 in Drug Resistance in AML

Fatemeh Alikarami, Simone S. Riedel, Qinglan Li, Changya Chen, Taylor Yamauchi, Etienne Danis, Kai Tan, Liling Wan, Tobias Neff, Kathrin M. Bernt
Journal: Blood
Blood (2022) 140 (Supplement 1): 97–98.
https://doi.org/10.1182/blood-2022-166666
Published: 2022
Journal Articles

Single-Cell Transcriptomics Reveals Similarity of Aggressive Infant Acute Lymphoblastic Leukemia Cells to Early Hematopoietic Progenitors

Irina Pushel, Midhat S. Farooqi, Byunggil Yoo, Kai Tan, Kathrin M. Bernt, Erin Guest
Journal: Blood
Blood (2022) 140 (Supplement 1): 6339–6340.
https://doi.org/10.1182/blood-2022-170028
Published: 2022
Journal Articles

Single-Cell Pan-Cancer Analysis Reveals Treatment Resistance Stem/Progenitor-like Subpopulation in the High-Risk Pediatric Leukemia

Changya Chen, Jason Xu, Tiffaney L. Vincent, Wenbao Yu, Yang Y Ding, Chia-hui Chen, Samuel Kim, Elizabeth Li, Shovik Bandyopadhyay, Petri Pölönen, Abdelrahman Elsayed, Haley Newman, Brent L. Wood, Jianzhong Hu, Rawan Shraim, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Stanley B. Pounds, Jun J. Yang, Charles G. Mullighan, David Frank, Kathrin M. Bernt, David T. Teachey, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1273–1274.
https://doi.org/10.1182/blood-2022-167057
Published: 2022
Journal Articles

Multi-Omics Profiling of JMML HSPCs Reveals Onco-Fetal Reprogramming and Identifies Novel Prognostic Biomarkers and Therapeutic Targets in High-Risk JMML

Mark Hartmann, Ling Hai, Joschka Hey, Maximilian Schönung, Valentin Maurer, Jovana Rajak, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Kathrin M. Bernt, Roland Roelz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Oliver Stegle, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Stefan Fröhling, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho, Marc Jan Bonder, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka
Journal: Blood
Blood (2022) 140 (Supplement 1): 8729–8730.
https://doi.org/10.1182/blood-2022-162224
Published: 2022
Journal Articles

Proteotranscriptomic Strategy to Discover Acute Myeloid Leukemia Immunotherapy Targets

Lusha Cao, Yang Xu, Tina Glisovic-Aplenc, Kevin Nestler, Saar Gill, Kathrin M. Bernt, Benjamin A Garcia, Hossein Fazelinia, Lingyu Guan, Yi Xing, Richard Aplenc
Journal: Blood
Blood (2022) 140 (Supplement 1): 3425–3426.
https://doi.org/10.1182/blood-2022-167378
Published: 2022
Journal Articles

Do you need the immune system to cure ALL?

Kathrin M. Bernt
Journal: Blood
Blood (2022) 140 (13): 1457–1458.
https://doi.org/10.1182/blood.2022017282
Published: 2022
Journal Articles

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A -rearranged leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W. Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P. Hunger, Carolyn A. Felix, Hao Wu, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2022) 139 (14): 2198–2211.
https://doi.org/10.1182/blood.2021013442
Published: 2022
Includes: Supplemental data
Journal Articles

Single-Cell Multiomics Reveals Increased Plasticity, Resistant Populations and Stem-Cell-like Blasts in KMT2A-Rearranged Leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P Hunger, Hao Wu, Patrick A. Brown, Erin Guest, David M Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2203.
https://doi.org/10.1182/blood-2021-146102
Published: 2021
Journal Articles

FLT3 Inhibition Downregulates EZH2 in AML and Promotes Myeloid Differentiation

Pamela J. Sung, Simone Sidoli, Simone S. Riedel, Katarzyna Kulej, Hongbo Xie, Bryan Manning, Daniel Tsai, Gerald Wertheim, Benjamin A. Garcia, Sara E. Meyer, Kathrin M. Bernt, Martin P. Carroll
Journal: Blood
Blood (2021) 138 (Supplement 1): 785.
https://doi.org/10.1182/blood-2021-147313
Published: 2021
Journal Articles

SWI/SNF Dysregulation through a Prion-like Domain Causes AML

Simone S Riedel, PhD, Alexandra Lenard, BS, Kevin Nestler, BS, Congcong Lu, PhD, Hongbo Xie, PhD, Benjamin A Garcia, PhD, Kathrin M. Bernt, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2512.
https://doi.org/10.1182/blood-2019-129280
Published: 2019
Journal Articles

Menin Is a Therapeutic Target in MN1 High Leukemia

Clara Libbrecht, MD, Simone Stefanie Riedel, PhD, Jessica Haladyna, BA,MS, Kathrin M. Bernt, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 758.
https://doi.org/10.1182/blood-2018-99-115551
Published: 2018
Journal Articles

Tight Regulation of H3K79 Methylation Levels in KMT2A -Rearranged AML

Molly C. Kingsley, BS, Simone Stefanie Riedel, PhD, Hongbo Michael Xie, PhD, Sally P. Stabler, MD, Taylor Pastuer, BA, Kathrin M. Bernt, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3884.
https://doi.org/10.1182/blood-2018-99-114784
Published: 2018
Journal Articles

The Role of Gata2 in Murine Models of Acute Myeloid Leukemia

Taylor Yamauchi, B.A., Etienne Danis, PhD, Xi Zhang, B.A., Simone Riedel, PhD, Hua Huang, MD, PhD, Kathrin M Bernt, MD, Tobias Neff, MD
Journal: Blood
Blood (2016) 128 (22): 1516.
https://doi.org/10.1182/blood.V128.22.1516.1516
Published: 2016
Journal Articles

Meningeoma-1 Cooperates with MLL and DOT1L to Induce Leukemia

Simone Riedel, PhD, Jessica Haladyna, BA, Brett Stevens, Craig T Jordan, PhD, Daniel Pollyea, MD MS, Scott A. Armstrong, MD PhD, Qi Wei, PhD, Patricia Ernst, PhD, Tobias Neff, MD, Kathrin M Bernt, MD
Journal: Blood
Blood (2015) 126 (23): 2428.
https://doi.org/10.1182/blood.V126.23.2428.2428
Published: 2015
Journal Articles

Epigenetics Directing Therapy in Acute Lymphocytic Leukemia: Emerging Roles and New Therapies

Kathrin M Bernt, MD
Journal: Blood
Blood (2015) 126 (23): SCI-36.
https://doi.org/10.1182/blood.V126.23.SCI-36.SCI-36
Published: 2015
Journal Articles

Histone Profiling in Leukemia Using LC-MS/MS

Gina South, MD, Jessica Haladyna, BA, Kirk Hansen, PhD, Kathrin M Bernt, MD
Journal: Blood
Blood (2014) 124 (21): 2202.
https://doi.org/10.1182/blood.V124.21.2202.2202
Published: 2014
Journal Articles

MDR1 Mediated Drug Resistance to a Histone Methyltansferase Inhibitor (KMT)

Jessica Haladyna, BA, Taylor Yamauchi, BA, Tobias Neff, MD, Kathrin M Bernt, MD
Journal: Blood
Blood (2014) 124 (21): 3622.
https://doi.org/10.1182/blood.V124.21.3622.3622
Published: 2014
Journal Articles

Targeting Meningeoma-1 Driven AML through Epigenetic Modulation of the Cell of Origin

Simone Riedel, PhD, Kathrin M Bernt, MD, Jessica Haladyna, BA, Matthew Bezzant, Brett Stevens, PhD, Daniel A. Pollyea, MD MS, Amit U. Sinha, PhD, Scott A. Armstrong, MD PhD, Qi Wei, PhD, Craig T. Jordan, PhD, Tobias Neff, MD
Journal: Blood
Blood (2014) 124 (21): 838.
https://doi.org/10.1182/blood.V124.21.838.838
Published: 2014