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Daniel B. Lipka
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Journal Articles

Multi-Omics Profiling of JMML HSPCs Reveals Onco-Fetal Reprogramming and Identifies Novel Prognostic Biomarkers and Therapeutic Targets in High-Risk JMML

Mark Hartmann, Ling Hai, Joschka Hey, Maximilian Schönung, Valentin Maurer, Jovana Rajak, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Kathrin M. Bernt, Roland Roelz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Oliver Stegle, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Stefan Fröhling, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho, Marc Jan Bonder, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka
Journal: Blood
Blood (2022) 140 (Supplement 1): 8729–8730.
https://doi.org/10.1182/blood-2022-162224
Published: 2022
Journal Articles

The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13

Costanza Zanetti, Rahul Kumar, Joscha Ender, Parimala S. Godavarthy, Mark Hartmann, Joschka Hey, Kersten Breuer, Eva S. Weissenberger, Valentina R. Minciacchi, Christina Karantanou, Zhaohui Gu, Kathryn G. Roberts, Markus Metzler, Wendy Stock, Charles G. Mullighan, Clara D. Bloomfield, Natalie Filmann, Katrin Bankov, Sylvia Hartmann, Robert P. Hasserjian, Antony F. Cousins, Christina Halsey, Christoph Plass, Daniel B. Lipka, Daniela S. Krause
Journal: Blood
Blood (2021) 138 (19): 1870–1884.
https://doi.org/10.1182/blood.2021011557
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Age-Related Changes in Human HSC Methylomes Affect Gene Regulatory Elements Critical to HSC Function and Reveal Novel HSC Aging Candidate Genes

Abdul-Habib Rahimi, Reka Toth, Dieter Weichenhan, Julia K. Herzig, Ekaterina Panina, Michael Heuser, Maximilian Schönung, Daniel B. Lipka, Pavlo Lutsik, Christoph Plass, Christian Buske
Journal: Blood
Blood (2021) 138 (Supplement 1): 2166.
https://doi.org/10.1182/blood-2021-148293
Published: 2021
Journal Articles

DNA Methylation As a Biomarker of Outcome in JMML: An International Effort Towards Clinical Implementation

Julia Meyer, PhD, Maximillian Schönung, Christian Flotho, MD PhD, Adam B. Olshen, PhD, Mark Hartmann, PhD, Christoph Plass, PhD, Yusuke Okuno, MD PhD, Yoshiyuki Takahashi, MD PhD, Norihiro Murakami, MD PhD, Manabu Wakamatsu, MD, Mignon L. Loh, MD, Charlotte M. Niemeyer, MD, Hideki Muramatsu, MD PhD, Daniel B. Lipka, MD, Elliot Stieglitz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1693.
https://doi.org/10.1182/blood-2019-131279
Published: 2019
Journal Articles

No Evidence for Hematopoietic Stem Cell Self-Renewal in-Vivo Following Inflammatory Challenge

Ruzhica Bogeska, PhD, Paul Kaschutnig, PhD, Stella V Paffenholz, MSc, Julia Knoch, Jan-Philipp Mallm, PhD, Malak Fawaz, MSc, Florian Buettner, PhD, Dagmar Walter, PhD, Felix Frauhammer, MSc, Tim Holland-Letz, PhD, Noboru Asada, MD PhD, Ana-Matea Mikecin Drazic, PhD, Marleen Buechler-Schaff, MSc, Martha Correno-Gonzalez, Melanie Ball, Sina Staeble, MSc, Julius Gräsel, PhD, Simon Haas, PhD, Daniel B. Lipka, MD, Karsten Rippe, PhD, Benedikt Brors, PhD, Paul S. Frenette, MD, Michael A. Rieger, Marieke A. G. Essers, PhD, Michael D. Milsom, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 456.
https://doi.org/10.1182/blood-2019-125744
Published: 2019
Journal Articles

Deconvolution of Hematopoietic Commitment Decisions By Genome-Wide Analysis of Progressive DNA Methylation Changes

Sina Staeble, MSc, Stephen Kraemer, MSc, Jens Langstein, MSc, Ruzhica Bogeska, PhD, Mark Hartmann, PhD, Maximilian Schoenung, MSc, Melinda Czeh, PhD, Julia Knoch, Natasha Anstee, PhD, Simon Haas, PhD, Abdelrahman Mahmoud, MSc, Julius Graesel, MSc, Daniel Huebschmann, MD PhD, Lars Feuerbach, PhD, Weichenhan Dieter, PhD, Benedikt Brors, PhD, Karsten Rippe, PhD, Jan-Philipp Mallm, PhD, Frank Rosenbauer, PhD, Christoph Plass, PhD, Matthias Schlesner, PhD, Michael D. Milsom, PhD, Daniel B. Lipka, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1179.
https://doi.org/10.1182/blood-2019-124429
Published: 2019
Journal Articles

The Influence of the Age of the Bone Marrow Microenvironment on Leukaemia Progression

Costanza Zanetti, MSc, Joscha Ender, Mark Hartmann, Joschka Hey, MSc, BSc, Parimala Sonika Godavarthy, MSc, Eva Weissenberger, Rahul Kumar, PhD, Markus Metzler, MD PhD, Zhaohui Gu, PhD, Kathryn G. Roberts, PhD, Natalie Filmann, Clara D. Bloomfield, MD, Wendy Stock, MD, Charles G. Mullighan, MBBS, MD, Daniel B. Lipka, Daniela S. Krause, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2748.
https://doi.org/10.1182/blood-2019-122797
Published: 2019
Journal Articles

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

Swati Garg, Armando Reyes-Palomares, Lixiazi He, Anne Bergeron, Vincent-Philippe Lavallée, Sébastien Lemieux, Patrick Gendron, Christian Rohde, Jianglong Xia, Prarabdha Jagdhane, Carsten Müller-Tidow, Daniel B. Lipka, Suzan Imren, R. Keith Humphries, Claudia Waskow, Binje Vick, Irmela Jeremias, Guillaume Richard-Carpentier, Josée Hébert, Guy Sauvageau, Judith B. Zaugg, Frédéric Barabé, Caroline Pabst
Journal: Blood
Blood (2019) 134 (3): 263–276.
https://doi.org/10.1182/blood.2018862383
Published: 2019
Includes: Supplemental data
Journal Articles

DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia: An International Collaborative Analysis and Development of a Common Diagnostic Platform

Maximilian Schoenung, Elliot Stieglitz, Hideki Muramatsu, MD PhD, Norihiro Murakami, MD, Mark Hartmann, Manuel Wiesenfarth, Yusuke Okuno, MD PhD, Adam B. Olshen, PhD, Christoph Plass, Mignon L. Loh, MD, Charlotte Niemeyer, MD, Christian Flotho, Daniel B. Lipka
Journal: Blood
Blood (2018) 132 (Supplement 1): 3093.
https://doi.org/10.1182/blood-2018-99-114918
Published: 2018
Journal Articles

Modeling of the Epigenome of the Cell-of-Origin Identifies Cancer-Specific DNA Methylation Patterns in CLL

Justyna Anna Wierzbinska, Reka Toth, Naveed Ishaque, Jan-Phillip Mallm, Karsten Rippe, Daniel Mertens, Thomas Hielscher, Thorsten Zenz, MD, Marc Seifert, Ralf Küppers, Yassen Assenov, Stephan Stilgenbauer, John C. Byrd, MD, Christopher C. Oakes, Daniel B. Lipka, Christoph Plass
Journal: Blood
Blood (2018) 132 (Supplement 1): 3885.
https://doi.org/10.1182/blood-2018-99-115941
Published: 2018
Journal Articles

5-Azacytidine Is Effective for Targeting Leukemia-Initiating Cells in Juvenile Myelomonocytic Leukemia

Christopher Felix Krombholz, PhD, Lorena Gallego Villar, PhD, Pritam Kumar Panda, MSc, MS, BSc, Sushree Sangita Sahoo, MSc, Marcin W. Wlodarski, MD PhD, Daniel B. Lipka, Christoph Plass, Charlotte Niemeyer, MD, Miriam Erlacher, MD PhD, Christian Flotho
Journal: Blood
Blood (2018) 132 (Supplement 1): 4342.
https://doi.org/10.1182/blood-2018-99-116594
Published: 2018
Journal Articles

Cooperative Effects of a Dnmt Inhibitor and All- Trans Retinoic Acid in an AML Cell Line Model Lacking PML-Rara

Ruth Meier, Gabriele Greve, Christoph Niemöller, Heiko Becker, Tobias Ma, Ralitsa Langova, Björn Grüning, Lars Feuerbach, Daniel B. Lipka, Justus Duyster, Prof., Benedikt Brors, Christoph Plass, Michael Lübbert
Journal: Blood
Blood (2018) 132 (Supplement 1): 1359.
https://doi.org/10.1182/blood-2018-99-113450
Published: 2018
Journal Articles

Hematopoietic Stem Cells Fail to Regenerate In Vivo Following Inflammatory Stress

Ruzhica Bogeska, PhD, Paul Kaschutnig, Stella Paffenholz, Julia Maassen, Jan-Philipp Mallm, Felix Wertek, Dagmar Walter, PhD, Blaszkiewicz Sandra, Tim Holland-Letz, Noboru Asada, MD PhD, Julius Gräsel, Sina Stäble, Milena Block, Özge Gizlenci, Áine M. Prendergast, PhD, Simon Haas, Daniel B Lipka, Karsten Rippe, Benedikt Brors, Paul S. Frenette, MD, Marieke A. G. Essers, Michael D. Milsom, PhD
Journal: Blood
Blood (2016) 128 (22): 1472.
https://doi.org/10.1182/blood.V128.22.1472.1472
Published: 2016
Journal Articles

Epigenetic Drug Treatment Globally Induces Cryptic Transcription Start Sites Encoded in Long Terminal Repeats

Michael Daskalakis, David Brocks, Christopher Schmidt, Daofeng Li, Jing Li, Hyo S. Jang, Bo Zhang, Daniel B Lipka, Johanna Schott, Holger Bierhoff, Yassen Assenov, Monika Helf, Alzbeta Ressnerova, Anders Lindroth, Simon Haas, Marieke A. G. Essers, Charles D. Imbusch, Benedikt Brors, Ina Oehme, Olaf Witt, Michael Lübbert, MD, Georg Stoecklin, Clarissa Gerhäuser, Christopher C Oakes, PhD, Ting Wang, Christoph Plass
Journal: Blood
Blood (2016) 128 (22): 3931.
https://doi.org/10.1182/blood.V128.22.3931.3931
Published: 2016
Journal Articles

Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

Christopher C. Oakes, PhD, Marc Seifert, Yassen Assenov, Lei Gu, Martina Przekopowitz, Amy S. Ruppert, MAS, Qi Wang, Charles Imbusch, Andrius Serva, Sandra Koser, David Brocks, Daniel B Lipka, Olga Bogatyrova, Benedikt Brors, Dieter Weichenhan, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Daniel Mertens, PhD, Marc Zapatka, Peter Lichter, Hartmut Döhner, MD, Ralf Kueppers, Thorsten Zenz, Stephan Stilgenbauer, MD, John C Byrd, MD, Christoph Plass, PhD
Journal: Blood
Blood (2015) 126 (23): 2436.
https://doi.org/10.1182/blood.V126.23.2436.2436
Published: 2015
Journal Articles

5-Azacytidine Reduces Leukemic Burden in a Xenograft Model of Juvenile Myelomonocytic Leukemia

Christopher Felix Krombholz, Angelina Meier, Konrad Aumann, Silvia Fluhr, Matthias Kollek, Daniel B Lipka, Christoph Plass, Tania Witte, Charlotte Niemeyer, Miriam Erlacher, Christian Flotho
Journal: Blood
Blood (2015) 126 (23): 1655.
https://doi.org/10.1182/blood.V126.23.1655.1655
Published: 2015
Journal Articles

Efficacy, Safety, and Confirmation of the Recommended Phase 2 Starting Dose of the Combination of Ruxolitinib (RUX) and Panobinostat (PAN) in Patients (Pts) with Myelofibrosis (MF)

Claire N. Harrison, Jean-Jacques Kiladjian, MD PhD, Florian H. Heidel, MD, Alessandro M. Vannucchi, MD, Francesco Passamonti, Amjad Hayat, MBBS, MRCP, FRCPath, PhD, Eibhlin Conneally, MB, MRCP, MRCPath, PhD, Bruno Martino, MD, Thomas Kindler, MD, Daniel B. Lipka, MD, Suddhasatta Acharyya, PhD, Prashanth Gopalakrishna, MBBS, MRCS, Susan Ide, PhD, Tracy Liu, Song Mu, PhD, Vincent Ribrag, MD
Journal: Blood
Blood (2015) 126 (23): 4060.
https://doi.org/10.1182/blood.V126.23.4060.4060
Published: 2015
Journal Articles

Efficacy, Safety, and Confirmation of the Recommended Phase 2 Dose of Ruxolitinib Plus Panobinostat in Patients with Intermediate or High-Risk Myelofibrosis

Jean-Jacques Kiladjian, MD PhD, Florian H Heidel, MD, Alessandro M. Vannucchi, MD, Vincent Ribrag, MD, Francesco Passamonti, MD, Amjad Hayat, MBBS, PhD, Eibhlin Conneally, MB, MRCP, MRCPath, PhD, Bruno Martino, MD, Thomas Kindler, Daniel B. Lipka, MD, Suddhasatta Acharyya, Prashanth Gopalakrishna, MBBS, MRCS, Susan E Ide, PhD, Sabine Loechner, Song Mu, Claire N Harrison, DM, FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 711.
https://doi.org/10.1182/blood.V124.21.711.711
Published: 2014
Journal Articles

Epo-Induced Erythroid Maturation Is Dependent On Plcγ1 Signalling

Tina M Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, Inga Griehl, cand. med., Lars Bullinger, MD, PhD, Konstanze Doehner, MD, Christoph Plass, PhD, Daniel B Lipka, MD, Florian H Heidel, MD, Thomas Fischer, M.D. Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1182.
https://doi.org/10.1182/blood.V122.21.1182.1182
Published: 2013
Journal Articles

Identification of Phospholipase C Gamma 1 As a Key Regulator of Erythropoiesis

Tina M Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, Inga Griehl, cand. med., Daniel B Lipka, MD, Florian H Heidel, MD, Thomas Fischer, MD
Journal: Blood
Blood (2012) 120 (21): 4744.
https://doi.org/10.1182/blood.V120.21.4744.4744
Published: 2012