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Journal Articles

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Peng Huang, Scott A. Peslak, Vanessa Shehu, Cheryl A. Keller, Belinda Giardine, Junwei Shi, Ross C. Hardison, Gerd A. Blobel, Eugene Khandros

Blood (2024) 143 (19): 1980–1991.

https://doi.org/10.1182/blood.2023023399

Published: 2024

Includes: Supplemental data

Journal Articles

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Scott A. Peslak, Talla Abbas, Eugene Khandros, Elizabeth A. Traxler, Osheiza Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2023) 142 (Supplement 1): 13.

https://doi.org/10.1182/blood-2023-181989

Published: 2023

Journal Articles

Genome-Scale CRISPR-Cas12a Screen Identifies Novel Fetal Hemoglobin Regulators

Elizabeth A. Traxler, Chad Komar, Megan Saari, A Josephine Thrasher, Kunhua Qin, Eugene Khandros, Quynn Hotan, Osheiza Abdulmalik, Claire Shao, Qingzhou Chen, Andy J. Minn, Cheryl A. Keller, Junwei Shi, Gerd A. Blobel

Blood (2023) 142 (Supplement 1): 1101.

https://doi.org/10.1182/blood-2023-189547

Published: 2023

Journal Articles

Selective Globin Gene Regulation By the Non-Canonical Baf Chromatin Remodeling Complex

Sindhu Billakanti, Vanessa Shehu, Kathryn M. Farrell, Osheiza Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, Eugene Khandros

Blood (2023) 142 (Supplement 1): 553.

https://doi.org/10.1182/blood-2023-179001

Published: 2023

Journal Articles

DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance

Nan Zhou, Jaewoo Choi, Grant Grothusen, Bang-Jin Kim, Diqiu Ren, Zhendong Cao, Yiman Liu, Qinglan Li, Arati Inamdar, Thomas Beer, Hsin-Yao Tang, Eric Perkey, Ivan Maillard, Roberto Bonasio, Junwei Shi, Marco Ruella, Liling Wan, Luca Busino

Blood (2023) 142 (11): 973–988.

https://doi.org/10.1182/blood.2022018752

Published: 2023

Includes: Supplemental data

Journal Articles

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S. Saari, Eugene Khandros, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2023) 141 (22): 2756–2770.

https://doi.org/10.1182/blood.2022019578

Published: 2023

Includes: Supplemental data

Journal Articles

Mechanisms of Polycomb Group Protein-Mediated Fetal Hemoglobin Silencing

Kunhua Qin, Peng Huang, Xianjiang Lan, Megan S. Saari, Eugene Khandros, Osheiza Y. Abdulmalik, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 5382–5383.

https://doi.org/10.1182/blood-2022-165560

Published: 2022

Journal Articles

Examining the Role of Individual Baf Chromatin Remodeling Complex Components in Globin Gene Regulation

Kathryn M. Farrell, Peng Huang, Osheiza Y. Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel, Eugene Khandros

Blood (2022) 140 (Supplement 1): 1943.

https://doi.org/10.1182/blood-2022-159347

Published: 2022

Journal Articles

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Scott A. Peslak, Eugene Khandros, Peng Huang, Aoi Wakabayashi, Talla Abbas, Osheiza Y. Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 2502–2503.

https://doi.org/10.1182/blood-2022-165286

Published: 2022

Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

V. S. S. Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll, Christian Hurtz

Blood (2022) 140 (Supplement 1): 3486–3488.

https://doi.org/10.1182/blood-2022-162782

Published: 2022

Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Christian Hurtz, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll

Blood (2021) 138 (Supplement 1): 506.

https://doi.org/10.1182/blood-2021-144476

Published: 2021

Journal Articles

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, Mathieu Quesnel-Vallieres, Osheiza Abdulmalik, Scott A. Peslak, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 3079.

https://doi.org/10.1182/blood-2021-151488

Published: 2021

Journal Articles

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Peng Huang, Scott A. Peslak, Eugene Khandros, Xianjiang Lan, Kunhua Qin, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 571.

https://doi.org/10.1182/blood-2021-146637

Published: 2021

Journal Articles

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

Scott A. Peslak, Eugene Khandros, Peng Huang, Maryanne Kihiu, Osheiza Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 2031.

https://doi.org/10.1182/blood-2021-147275

Published: 2021

Journal Articles

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

Kunhua Qin, Peng Huang, PhD, Anran Huang, BS, Ruopeng Feng, PhD, Thiyagaraj Mayuranathan, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Mitchell J. Weiss, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD

Blood (2020) 136 (Supplement 1): 54.

https://doi.org/10.1182/blood-2020-136167

Published: 2020

Journal Articles

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Blood (2020) 136 (Supplement 1): 54.

https://doi.org/10.1182/blood-2020-137564

Published: 2020

Journal Articles

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Martin P. Carroll, MD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, MDPhD, Sung June Lee, BA, Anil Kumar, PhD, Anne Lehman, Joseph Patrick Loftus, BS, Grace Jeschke, PhD, John D. Crispino, PhD, Thierry Besson, PhD, Junwei Shi, PhD, Srividya Swaminathan, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-141258

Published: 2020

Journal Articles

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2020) 135 (24): 2121–2132.

https://doi.org/10.1182/blood.2020005301

Published: 2020

Includes: Supplemental data

Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 3557.

https://doi.org/10.1182/blood-2019-125664

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 814.

https://doi.org/10.1182/blood-2019-123837

Published: 2019

NARROW

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Genome-Scale CRISPR-Cas12a Screen Identifies Novel Fetal Hemoglobin Regulators

Selective Globin Gene Regulation By the Non-Canonical Baf Chromatin Remodeling Complex

DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance

Molecular basis of polycomb group protein–mediated fetal hemoglobin repression

Mechanisms of Polycomb Group Protein-Mediated Fetal Hemoglobin Silencing

Examining the Role of Individual Baf Chromatin Remodeling Complex Components in Globin Gene Regulation

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

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American Society of Hematology

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ASH Publications

American Society of Hematology

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