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Journal Articles

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Peng Huang, Scott A. Peslak, Vanessa Shehu, Cheryl A. Keller, Belinda Giardine, Junwei Shi, Ross C. Hardison, Gerd A. Blobel, Eugene Khandros

Blood (2024) 143 (19): 1980–1991.

https://doi.org/10.1182/blood.2023023399

Published: 2024

Includes: Supplemental data

Journal Articles

Patients with Non-Transfusion-Dependent Thalassemia May Evolve to Transfusion-Dependent Thalassemia in Adulthood

Aaron Cheng, Elizabeth A. Traxler, Scott A. Peslak, Jennifer Cohen, J. Eric Russell, Farzana A Sayani

Blood (2023) 142 (Supplement 1): 2362.

https://doi.org/10.1182/blood-2023-191215

Published: 2023

Journal Articles

Adults with Transfusion-Dependent Thalassemia Have Variable Clinical Profiles Depending on Where They Receive Care: Thalassemia Treatment Center Vs Community

Farzana A Sayani, Michel Liu, Yvette Frimpong, Scott A. Peslak, Elizabeth A. Traxler, Jennifer Cohen, J. Eric Russell, Janet L. Kwiatkowski

Blood (2023) 142 (Supplement 1): 2382.

https://doi.org/10.1182/blood-2023-191295

Published: 2023

Journal Articles

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Scott A. Peslak, Talla Abbas, Eugene Khandros, Elizabeth A. Traxler, Osheiza Abdulmalik, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2023) 142 (Supplement 1): 13.

https://doi.org/10.1182/blood-2023-181989

Published: 2023

Journal Articles

Let-7 Inhibits HIC2 to Control BCL11A Transcription and Hemoglobin Switching

Peng Huang, Eugene Khandros, Scott A. Peslak, Cheryl A. Keller, Belinda M. Giardine, Ross C. Hardison, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 1937–1938.

https://doi.org/10.1182/blood-2022-157978

Published: 2022

Journal Articles

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Scott A. Peslak, Eugene Khandros, Peng Huang, Aoi Wakabayashi, Talla Abbas, Osheiza Y. Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2022) 140 (Supplement 1): 2502–2503.

https://doi.org/10.1182/blood-2022-165286

Published: 2022

Journal Articles

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

Scott A. Peslak, Eugene Khandros, Peng Huang, Maryanne Kihiu, Osheiza Abdulmalik, Cheryl A. Keller, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 2031.

https://doi.org/10.1182/blood-2021-147275

Published: 2021

Journal Articles

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, Mathieu Quesnel-Vallieres, Osheiza Abdulmalik, Scott A. Peslak, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 3079.

https://doi.org/10.1182/blood-2021-151488

Published: 2021

Journal Articles

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Peng Huang, Scott A. Peslak, Eugene Khandros, Xianjiang Lan, Kunhua Qin, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Osheiza Abdulmalik, Stella T. Chou, Junwei Shi, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 571.

https://doi.org/10.1182/blood-2021-146637

Published: 2021

Journal Articles

Isolated Changes in Chromatin Accessibility and Enhancer-Promoter Contacts at the β-Globin Locus Distinguish Fetal Hemoglobin Producing F-Cells from a-Cells

Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel

Blood (2021) 138 (Supplement 1): 855.

https://doi.org/10.1182/blood-2021-149877

Published: 2021

Journal Articles

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Malini Sharma, BS, Osheiza Abdulmalik, DVM, Belinda Giardine, Zhe Zhang, PhD, Cheryl A. Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MDPhD

Blood (2020) 136 (Supplement 1): 16–17.

https://doi.org/10.1182/blood-2020-137646

Published: 2020

Journal Articles

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison, Junwei Shi, Gerd A. Blobel

Blood (2020) 135 (24): 2121–2132.

https://doi.org/10.1182/blood.2020005301

Published: 2020

Includes: Supplemental data

Journal Articles

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda M. Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel

Blood (2020) 135 (22): 1957–1968.

https://doi.org/10.1182/blood.2020005058

Published: 2020

Includes: Supplemental data

Journal Articles

Implementation of an Evidence-Based Care Pathway for Emergency Department Management of Sickle Cell Vaso-Occlusive Crisis Leads to Improved Clinical Outcomes

Jennifer Yui, MD, Scott A. Peslak, MD PhD, David Lambert, MD, Eric Russell, MD, Farzana Sayani, MD

Blood (2019) 134 (Supplement_1): 4678.

https://doi.org/10.1182/blood-2019-123868

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Peng Huang, PhD, Jennifer A. Yano, BA, Jeremy D. Grevet, PhD, Osheiza Abdulmalik, DVM, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 3557.

https://doi.org/10.1182/blood-2019-125664

Published: 2019

Journal Articles

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Peng Huang, PhD, Scott A. Peslak, MD PhD, Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Malini Sharma, BS, Kunhua Qin, PhD, Cheryl A Keller, PhD, Belinda Giardine, Junwei Shi, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 814.

https://doi.org/10.1182/blood-2019-123837

Published: 2019

Journal Articles

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Eugene Khandros, MD PhD, Peng Huang, PhD, Scott A. Peslak, MD PhD, Belinda Giardine, Zhe Zhang, PhD, Cheryl A Keller, PhD, Ross C. Hardison, PhD, Gerd A. Blobel, MD PhD

Blood (2019) 134 (Supplement_1): 981.

https://doi.org/10.1182/blood-2019-124099

Published: 2019

Journal Articles

Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin

Xianjiang Lan, PhD, Eugene Khandros, MD PhD, Jeremy D. Grevet, BA, Scott A. Peslak, MD, Saurabh Bhardwaj, PhD, Cheryl A. Keller, PhD, Belinda Giardine, Ben A. Garcia, PhD, Ross C. Hardison, PhD, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2018) 132 (Supplement 1): 414.

https://doi.org/10.1182/blood-2018-99-119518

Published: 2018

Journal Articles

Heme-Regulated Inhibitor (HRI) Loss and Pharmacologic Treatments Cooperate to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Scott A. Peslak, MD, Jeremy D. Grevet, BA, Xianjiang Lan, PhD, Osheiza Abdulmalik, DVM, Junwei Shi, PhD, Gerd A. Blobel, MD PhD

Blood (2018) 132 (Supplement 1): 721.

https://doi.org/10.1182/blood-2018-99-117436

Published: 2018

Journal Articles

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress

Scott A. Peslak, Jesse Wenger, Jeffrey C. Bemis, Paul D. Kingsley, Anne D. Koniski, Kathleen E. McGrath, James Palis

Blood (2012) 120 (12): 2501–2511.

https://doi.org/10.1182/blood-2011-11-394304

Published: 2012

Includes: Supplemental data

NARROW

let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching

Patients with Non-Transfusion-Dependent Thalassemia May Evolve to Transfusion-Dependent Thalassemia in Adulthood

Adults with Transfusion-Dependent Thalassemia Have Variable Clinical Profiles Depending on Where They Receive Care: Thalassemia Treatment Center Vs Community

Protein Phosphatase 6 Complex: Novel Regulator of Fetal Hemoglobin and Potential Therapeutic Target in Sickle Cell Disease

Let-7 Inhibits HIC2 to Control BCL11A Transcription and Hemoglobin Switching

Regulation of Fetal Hemoglobin Production in Adult Erythroid Cells By Protein Phosphatase 6C (PPP6C)

Protein Phosphatase 6C (PPP6C) Loss Significantly Raises Fetal Hemoglobin Levels and Reduces Cell Sickling

Interrogating Post-Transcriptional Mechanisms of Fetal Hemoglobin Regulation

HIC2 Controls Developmental Hemoglobin Switching By Repressing BCL11A Transcription

Isolated Changes in Chromatin Accessibility and Enhancer-Promoter Contacts at the β-Globin Locus Distinguish Fetal Hemoglobin Producing F-Cells from a-Cells

A β-Globin Locus-Intrinsic Epigenetic Mechanism Underlies Fetal Globin Production in F-Cells

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

Implementation of an Evidence-Based Care Pathway for Emergency Department Management of Sickle Cell Vaso-Occlusive Crisis Leads to Improved Clinical Outcomes

Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing

Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells

Domain-Focused CRISPR-Cas9 Screen Identifies the E3 Ubiquitin Ligase Substrate Adaptor Protein SPOP as a Novel Repressor of Fetal Hemoglobin

Heme-Regulated Inhibitor (HRI) Loss and Pharmacologic Treatments Cooperate to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress

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American Society of Hematology

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American Society of Hematology

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