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Joseph Patrick Loftus
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Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

V. S. S. Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll, Christian Hurtz
Journal: Blood
Blood (2022) 140 (Supplement 1): 3486–3488.
https://doi.org/10.1182/blood-2022-162782
Published: 2022
Journal Articles

Transcriptional Rewiring and Therapeutic Resistance in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Yang Y Ding, Joseph Patrick Loftus, Benjamin Mathier, Wenbao Yu, David Hottman Allen, Bing He, Catherine D Falkenstein, Sarah K Tasian, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 354–355.
https://doi.org/10.1182/blood-2022-169341
Published: 2022
Journal Articles

Precision Co-Targeting of the Thymic Stromal Lymphopoietin Receptor in Childhood CRLF2 -Rearranged Acute Lymphoblastic Leukemia

Asen Bagashev, Joseph Patrick Loftus, Savannah Ross, Lisa M Niswander, Haiying Qin, Terry J. Fry, Sarah K Tasian
Journal: Blood
Blood (2021) 138 (Supplement 1): 1705.
https://doi.org/10.1182/blood-2021-148602
Published: 2021
Journal Articles

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Christian Hurtz, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll
Journal: Blood
Blood (2021) 138 (Supplement 1): 506.
https://doi.org/10.1182/blood-2021-144476
Published: 2021
Journal Articles

Alisertib Synergistically Strengthens the Anti-Leukemia Activity of Venetoclax in TCF3-Hlf B-ALL

Asen Bagashev, Joseph Patrick Loftus, Colin Wakefield, Gerald Wertheim, Christian Hurtz, Martin P. Carroll, Kimberly Stegmaier, Yana Pikman, Sarah K Tasian
Journal: Blood
Blood (2021) 138 (Supplement 1): 705.
https://doi.org/10.1182/blood-2021-148671
Published: 2021
Journal Articles

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Martin P. Carroll, MD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, MDPhD, Sung June Lee, BA, Anil Kumar, PhD, Anne Lehman, Joseph Patrick Loftus, BS, Grace Jeschke, PhD, John D. Crispino, PhD, Thierry Besson, PhD, Junwei Shi, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-141258
Published: 2020
Journal Articles

Oncogene-Independent Adaptation of Pre-B Cell Receptor Signaling Confers Drug Resistance and Signaling Plasticity in Ph-like ALL

Christian Hurtz, PhD, Gerald Wertheim, MD, PhD, Joseph Patrick Loftus, BS, Daniel Blumenthal, PhD, Anne Lehman, Yong Li, Bryan Manning, Katherine D Cummins, BMBS, Janis K Burkhardt, PhD, Alexander E. Perl, MD, Martin Carroll, MD, Sarah K. Tasian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 747.
https://doi.org/10.1182/blood-2019-123514
Published: 2019
Journal Articles

Enhanced Efficacy of the SYK Inhibitor Entospletinib and Chemotherapy in Infant Acute Lymphoblastic Leukemia

Joseph Patrick Loftus, BS, Anella Yahiaoui, BS, Feng Shen, MDPhD, David Lopez, Igor Mikaelian, DVM, Patrick A Brown, MD, Stacey Tannheimer, PhD, Ann Forslund, PhD, Sarah K Tasian, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2611.
https://doi.org/10.1182/blood.V130.Suppl_1.2611.2611
Published: 2017