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Richard Aplenc
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Journal Articles

DNMT3A Mutants Are Enriched in NPMc+ AML and Associated with Adverse Outcome in Childhood AML

Rhonda E Ries, Xiaotu Ma, Claudia Tregnago, Todd A. Alonzo, Jim Wang, Tiffany Hylkema, Benjamin J Huang, Alireza Torabi, Jack H Peplinski, Logan K Wallace, Richard Aplenc, Alan S Gamis, Katherine Tarlock, Franco Locatelli, Martina Pigazzi, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4306.
https://doi.org/10.1182/blood-2023-181060
Published: 2023
Journal Articles

Survival Disparities By Frontline Clinical Trial Enrollment Status for Treatment of Pediatric Acute Myeloid Leukemia

Daniel J. Zheng, Elsa van der Mei, Yimei Li, Yuan-Shung V. Huang, Catherine Aftandilian, Kira Bona, Emi Caywood, Anderson B. Collier, M. Monica Gramatges, Mallorie M. Heneghan, Meret Henry, Craig Lotterman, Kelly Maloney, Tamara P. Miller, Arunkumar Modi, Rajen Mody, Elaine Morgan, Naomi J. Winick, Jennifer J. Wilkes, Victor Wong, Haley Newman, Regina M. Myers, Caitlin W. Elgarten, Alix E. Seif, Brian T. Fisher, Richard Aplenc, Kelly D. Getz
Journal: Blood
Blood (2023) 142 (Supplement 1): 2430.
https://doi.org/10.1182/blood-2023-189240
Published: 2023
Journal Articles

ACS10- Cytarabine Pharmacogenomics Score Impacts Survival in Pediatric AML Patients Treated on AAML1031 Trial and Associates with Outcome Differences in Black AML Patients

Richard J Marrero, Vivek M. Shastri, Richard Aplenc, Todd Cooper, Todd A. Alonzo, Alan S Gamis, Jim Wang, Soheil Meshinchi, E. Anders Kolb, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 4314.
https://doi.org/10.1182/blood-2023-187515
Published: 2023
Journal Articles

Impact of Molecular Risk on Efficacy of Blood and Marrow Transplantation for Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Benjamin J Huang, Lauren K. Meyer, Adam Lamble, Jim Wang, Rhonda E Ries, Alan S Gamis, Richard Aplenc, Katherine Tarlock, Todd Cooper, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Joseph Chewning, William G. Woods, John T. Horan
Journal: Blood
Blood (2023) 142 (Supplement 1): 655.
https://doi.org/10.1182/blood-2023-186955
Published: 2023
Journal Articles

Comparative Effectiveness of Reinduction Approaches for Pediatric Relapsed Acute Myeloid Leukemia

Caitlin W. Elgarten, Regina M. Myers, Alix E. Seif, Yimei Li, Daniel J. Zheng, Naomi J Winick, Elaine Morgan, Rajen Mody, Arunkumar Modi, Tamara P. Miller, Kelly Maloney, Mallorie M. Heneghan, M. Monica Gramatges, Brian T. Fisher, Kelly D. Getz, Richard Aplenc
Journal: Blood
Blood (2023) 142 (Supplement 1): 551.
https://doi.org/10.1182/blood-2023-188044
Published: 2023
Journal Articles

Differences in Absolute Neutrophil Count Eligibility Criteria of Pediatric Phase I and Phase I/II Oncology Clinical Trials According to Sponsorship

Rebecca Kelly, Jenny Ruiz, Richard Aplenc, Theodore W. Laetsch, Alix E. Seif
Journal: Blood
Blood (2023) 142 (Supplement 1): 7327.
https://doi.org/10.1182/blood-2023-186392
Published: 2023
Journal Articles

Relapse-Enriched Gene Expression Signature of Prognostic Relevance in Pediatric Acute Myeloid Leukemia

Satyavardhan Rao Nittu, Francisco Marchi, Nam Nguyen, Vivek M. Shastri, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Jeffery Klco, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 2926.
https://doi.org/10.1182/blood-2023-189029
Published: 2023
Journal Articles

Establishing Real-World Data-Driven Response Criteria in Pediatric Acute Myeloid Leukemia

Richard Aplenc, Yimei Li, Julianne Ani, Caitlin W. Elgarten, Lisa D'Errico, Todd Cooper, E. Anders Kolb, Maria Monica Gramatges, Meret Henry, Tamara P. Miller, Rajen Mody, Elaine Morgan, Regina M. Myers, Jessica A. Pollard, Alix Seif, Brian T. Fisher, Kelly D. Getz
Journal: Blood
Blood (2023) 142 (Supplement 1): 726.
https://doi.org/10.1182/blood-2023-185647
Published: 2023
Journal Articles

Integrated Methylation and Transcriptional Landscape and Evolution of Pediatric AML

Benjamin J Huang, Hamid Bolouri, Colin Y. Smith, Jim Wang, Rhonda E Ries, Elizabeth Conran, Alan S Gamis, Richard Aplenc, Todd A. Alonzo, Xiaotu Ma, Timothy Junius Triche, Jason E Farrar, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2956.
https://doi.org/10.1182/blood-2023-187819
Published: 2023
Journal Articles

CD33 CAR T-Cells (CD33CART) for Children and Young Adults with Relapsed/Refractory AML: Dose-Escalation Results from a Phase I/II Multicenter Trial

Nirali N. Shah, Sarah K. Tasian, M. Eric Kohler, Emily M. Hsieh, Susanne H.C. Baumeister, Corinne Summers, Haneen Shalabi, Jessica A. Pollard, Bonnie Yates, Ruta Brazauskas, Eric Ndifon, Constance M. Yuan, Hao-Wei Wang, Hati K Kobusingye, Kayla Christianson, Allison A Weiss, Erin Leckrone, Bronwen E. Shaw, Jeffery J. Auletta, Hemalatha G. Rangarajan, John Roach, Julie Blake, Dennis Michiel, Brian Bowser, Sheryl Ruppel, George Mitra, Anthony Welch, Jason Yovandich, Rachelle Salomon, Leslie Kean, Katherine Tarlock, Michael A. Pulsipher, Michael R Verneris, Larisa Broglie, Terry J. Fry, Steven M. Devine, Richard Aplenc
Journal: Blood
Blood (2023) 142 (Supplement 1): 771.
https://doi.org/10.1182/blood-2023-179667
Published: 2023
Journal Articles

Leveraging Custom CRISPR/Cas9 Screens to Identify AraC-Daunorubicin-Etoposide (ADE), Gemtuzumab Ozogamicin (GO), and Bortezomib Response Modulators Association with Clinical Outcomes in Pediatric AML

Nam Nguyen, Phani Krishna Parcha, Abderrahmane Tagmount, Bailey Gregory, Jeffrey E. Rubnitz, Raul C. Ribeiro, Xueyuan Cao, Todd A. Alonzo, Richard Aplenc, Alan S Gamis, Todd Cooper, E. Anders Kolb, Soheil Meshinchi, Stanley Pounds, Christopher Vulpe, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 1558.
https://doi.org/10.1182/blood-2023-178832
Published: 2023
Journal Articles

Racial and Ethnic Differences in Acuity and Cumulative Frontline Organ Toxicity at the Time of Relapse in Pediatric Acute Myeloid Leukemia

Daniel J. Zheng, Yimei Li, Yuan-Shung V. Huang, Catherine Aftandilian, Kira Bona, Emi Caywood, Anderson B. Collier, M. Monica Gramatges, Mallorie M. Heneghan, Meret Henry, Craig Lotterman, Kelly Maloney, Tamara P. Miller, Arunkumar Modi, Rajen Mody, Elaine Morgan, Naomi J. Winick, Jennifer J. Wilkes, Victor Wong, Cody Gathers, Haley Newman, Reneé H. Moore, Regina M. Myers, Caitlin W. Elgarten, Alix E. Seif, Brian T. Fisher, Richard Aplenc, Kelly D. Getz
Journal: Blood
Blood (2023) 142 (Supplement 1): 387.
https://doi.org/10.1182/blood-2023-180713
Published: 2023
Journal Articles

The Methylome Atlas of Acute Leukemia Enables Novel Clinical Diagnostic Tool for AML

Francisco Marchi, Marieke Landwehr, Fernando Sckaff, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 121.
https://doi.org/10.1182/blood-2023-186894
Published: 2023
Journal Articles

A DNA Methylation Signature Predicts Clinical Outcome in Pediatric AML Patients

Francisco Marchi, Marieke Landwehr, Fernando Sckaff, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 835.
https://doi.org/10.1182/blood-2023-186505
Published: 2023
Journal Articles

Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy

Clinical Trials & Observations
Haley Newman, Yimei Li, Hongyan Liu, Regina M. Myers, Vicky Tam, Amanda DiNofia, Lisa Wray, Susan R. Rheingold, Colleen Callahan, Claire White, Diane Baniewicz, Lena E. Winestone, Stephan Kadauke, Caroline Diorio, Carl H. June, Kelly D. Getz, Richard Aplenc, David T. Teachey, Shannon L. Maude, Stephan A. Grupp, Kira Bona, Allison Barz Leahy
Journal: Blood
Blood (2023) 141 (6): 609–619.
https://doi.org/10.1182/blood.2022017866
Published: 2023
Includes: Supplemental data
Journal Articles

A Robust Long Non-Coding RNA Expression Classifier for Risk Stratification in Pediatric AML

Jason E Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda E. Ries, Tiffany A. Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda R. Leonti, Timothy I. Shaw, Timothy Junius Triche, Jr., Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Xiaotu Ma, Derek Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9173–9174.
https://doi.org/10.1182/blood-2022-168296
Published: 2022
Journal Articles

The Influence of Genetic Ancestry on Disease Biology in Pediatric T-Cell Acute Lymphoblastic Leukemia

Haley Newman, Shawn Lee, Petri Pölönen, Rawan Shraim, Yimei Li, Hongyan Liu, Tiffaney L. Vincent, Richard Aplenc, Changya Chen, Zhiguo Chen, Caroline Diorio, Kimberly P. Dunsmore, Sumit Gupta, Gang Wu, Kai Tan, Meenakshi Devidas, Stuart S. Winter, Brent L. Wood, Lena E. Winestone, Jason Xu, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Stanley B. Pounds, Kira O Bona, Charles G. Mullighan, Jun J. Yang, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 3458–3460.
https://doi.org/10.1182/blood-2022-159159
Published: 2022
Journal Articles

Targeting CD38 in T-ALL Upregulates the Targetable Polyamine Metabolism Pathway

Caroline Diorio, Tiffaney L. Vincent, Tori Fuller, Rawan Shraim, Tina Glisovic-Aplenc, Theresa Ryan, Kimberly Veliz, Haley Newman, Gerald Wertheim, Hamid Bassiri, Annette Vu, Michael Hogarty, Carl H June, Stephan A. Grupp, Sarah K Tasian, Richard Aplenc, Saar Gill, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 10285–10286.
https://doi.org/10.1182/blood-2022-167893
Published: 2022
Journal Articles

Proteotranscriptomic Strategy to Discover Acute Myeloid Leukemia Immunotherapy Targets

Lusha Cao, Yang Xu, Tina Glisovic-Aplenc, Kevin Nestler, Saar Gill, Kathrin M. Bernt, Benjamin A Garcia, Hossein Fazelinia, Lingyu Guan, Yi Xing, Richard Aplenc
Journal: Blood
Blood (2022) 140 (Supplement 1): 3425–3426.
https://doi.org/10.1182/blood-2022-167378
Published: 2022
Journal Articles

Clinical and Functional Implications of MYC Variants As a New Class of Pathogenic Variants in AML

Danielle C. Kirkey, Xiaoying Wu, Rhonda E. Ries, Tiffany A. Hylkema, Yanling Liu, Pandurang Kolekar, Quang Tran, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Todd A. Alonzo, Katherine Tarlock, Robert Eisenman, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3395–3396.
https://doi.org/10.1182/blood-2022-168469
Published: 2022