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Don Siegel
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Journal Articles

IL18-armored CAR T cells in patients with CLL/SLL and Richter's transformation after prior BTK inhibitor and venetoclax failure

Free
Jakub Svoboda, Stephen Schuster, David Porter, Michael Cook, Sunita Dwivedy Nasta, Daniel Landsburg, Stefan Barta, Marco Ruella, Elise Chong, Jordan Carter, Colin Thomas, Emily Tomasulo, Noelle Frey, Matthew Connor, Joanne Shea, Amanda Cervini, Jean McConville, Charles Tongue, Megan Four, Amy Marshall, Wei-Ting Hwang, Rachel Leskowitz, Vanessa Gonzalez, Shannon Christensen, Gabriela Plesa, Don Siegel, Julie Jadlowsky, Joseph Fraietta, Bruce Levine, Elizabeth Hexner, Carl June
Journal: Blood
Blood (2025) 146 (Supplement 1): 2394.
https://doi.org/10.1182/blood-2025-2394
Published: 2025
Journal Articles

Precision targeting of autoantibody-producing IGHV1-69+ B cells in immune-mediated thrombotic thrombocytopenic purpura (iTTP) using chimeric antigen receptor T cells

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Ivan Cohen, Roman Khadka, Jean Lemoine, Audrey Bochi-Layec, Seul Jung, Ki Hyun Kim, Huiwu Zhao, Morgan Hresko, Don Siegel, Paolo Ghia, Kostas Stamatopoulos, Stephen Schuster, Vijay Bhoj, Marco Ruella
Journal: Blood
Blood (2025) 146 (Supplement 1): 426.
https://doi.org/10.1182/blood-2025-426
Published: 2025
Journal Articles

Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia

Free
Lucy Cain, Yimei Li, Hongyan Liu, Shannon Christensen, Regina Myers, Allison Barz Leahy, Caroline Diorio, Nancy Shapiro, Elizabeth McBride, Colleen Callahan, Diane Baniewicz, Amanda DiNofia, Susan Rheingold, Lisa Wray, Stephen Hunger, Richard Aplenc, Susan McClory, Mackenzie Stewart, Gerald Wertheim, Andrew Fesnak, Gabriela Plesa, Don Siegel, Joseph Fraietta, Vanessa Gonzalez, Caitlin Hopkins, Amy Marshall, Amanda Kotch, Bruce Levine, Anne Chew, Elizabeth Hexner, Carl June, Stephan Grupp, Shannon Maude
Journal: Blood
Blood (2025) 146 (Supplement 1): 646.
https://doi.org/10.1182/blood-2025-646
Published: 2025
Journal Articles

Precision targeting of immune-mediated thrombotic thrombocytopenic purpura (iTTP) with chimeric auto-antigen receptor (CAAR) T cells

Free
Roman Khadka, Ivan Cohen, Kalpana Parvathaneni, Jean Lemoine, Seul Jung, Audrey Bochi-Layec, Huiwu Zhao, Morgan Hresko, Don Siegel, Marco Ruella, Vijay Bhoj
Journal: Blood
Blood (2025) 146 (Supplement 1): 2341.
https://doi.org/10.1182/blood-2025-2341
Published: 2025
Journal Articles

IL18-armored CAR T cells in relapsed/refractory B cell acute lymphoblastic leukemia

Free
Matthew Connor, Wei-Ting Hwang, Saar Gill, Alexander Perl, Ximena Jordan Bruno, Nasheed Hossain, Catherine Lai, Alison Loren, Selina Luger, Andrew Matthews, Shannon McCurdy, Pashna Munshi, Keith Pratz, Amanda Cervini, Jean McConville, Joanne Shea, Charles Tongue, Heather Difilippo, Jacob Kesselman, Amy Marshall, Megan Four, Shannon Christensen, Vanessa Gonzalez, Julie Jadlowsky, Gabriela Plesa, Don Siegel, Rachel Leskowitz, Joseph Fraietta, Bruce Levine, David Porter, Elizabeth Hexner, Carl June, Jakub Svoboda, Noelle Frey
Journal: Blood
Blood (2025) 146 (Supplement 1): 812.
https://doi.org/10.1182/blood-2025-812
Published: 2025
Journal Articles

Synkir-310 split-signaling based KIR-CAR T cell therapy achieves faster and deeper anti-B cell tumor efficacy with reduced cytokine levels

Free
Megan Blair, Jun Xu, Nora Yucel, Tony Truong, William Stanley, Michael Milone, Don Siegel, Laura Johnson
Journal: Blood
Blood (2025) 146 (Supplement 1): 4103.
https://doi.org/10.1182/blood-2025-4103
Published: 2025
Journal Articles

Inhibitory ADAMTS13 Monoclonal Autoantibodies Cloned from TTP Patients Show Restricted Gene Usage, Inhibit Murine ADAMTS13, and Are Blocked by Rabbit Anti-Idiotypic Antibodies.

Free
Don Siegel, MD, PhD, Eric Ostertag, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 92.
https://doi.org/10.1182/blood.V108.11.92.92
Published: 2006