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Todd A. Alonzo
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Journal Articles

DNMT3A Mutants Are Enriched in NPMc+ AML and Associated with Adverse Outcome in Childhood AML

Rhonda E Ries, Xiaotu Ma, Claudia Tregnago, Todd A. Alonzo, Jim Wang, Tiffany Hylkema, Benjamin J Huang, Alireza Torabi, Jack H Peplinski, Logan K Wallace, Richard Aplenc, Alan S Gamis, Katherine Tarlock, Franco Locatelli, Martina Pigazzi, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4306.
https://doi.org/10.1182/blood-2023-181060
Published: 2023
Journal Articles

Nucleophosmin (NPM1) Type D Genotype Is Associated with Distinct Outcome in Acute Myeloid Leukemia - an AIEOP-BFM and COG-SWOG Intergroup Collaboration

Martina Pigazzi, Claudia Tregnago, Rhonda E Ries, Maddalena Benetton, Todd A. Alonzo, Nicolas Duployez, Edwin Sonneveld, Jonas Abrahamsson, Linda Fogelstrand, Nils Von Neuhoff, Henrik Hasle, Dirk Reinhardt, Franco Locatelli, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 840.
https://doi.org/10.1182/blood-2023-181872
Published: 2023
Journal Articles

ACS10- Cytarabine Pharmacogenomics Score Impacts Survival in Pediatric AML Patients Treated on AAML1031 Trial and Associates with Outcome Differences in Black AML Patients

Richard J Marrero, Vivek M. Shastri, Richard Aplenc, Todd Cooper, Todd A. Alonzo, Alan S Gamis, Jim Wang, Soheil Meshinchi, E. Anders Kolb, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 4314.
https://doi.org/10.1182/blood-2023-187515
Published: 2023
Journal Articles

Combining Menin and MEK Inhibition to Target Poor Prognostic KMT2A -Rearranged RAS Pathway-Mutant Acute Leukemia

Nastassja Scheidegger, Gabriela Alexe, Delan Khalid, Rhonda E Ries, Jim Wang, Todd A. Alonzo, Jennifer Perry, Scott A Armstrong, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 166.
https://doi.org/10.1182/blood-2023-185561
Published: 2023
Journal Articles

Impact of Molecular Risk on Efficacy of Blood and Marrow Transplantation for Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Benjamin J Huang, Lauren K. Meyer, Adam Lamble, Jim Wang, Rhonda E Ries, Alan S Gamis, Richard Aplenc, Katherine Tarlock, Todd Cooper, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Joseph Chewning, William G. Woods, John T. Horan
Journal: Blood
Blood (2023) 142 (Supplement 1): 655.
https://doi.org/10.1182/blood-2023-186955
Published: 2023
Journal Articles

Relapse-Enriched Gene Expression Signature of Prognostic Relevance in Pediatric Acute Myeloid Leukemia

Satyavardhan Rao Nittu, Francisco Marchi, Nam Nguyen, Vivek M. Shastri, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Jeffery Klco, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 2926.
https://doi.org/10.1182/blood-2023-189029
Published: 2023
Journal Articles

Integrated Methylation and Transcriptional Landscape and Evolution of Pediatric AML

Benjamin J Huang, Hamid Bolouri, Colin Y. Smith, Jim Wang, Rhonda E Ries, Elizabeth Conran, Alan S Gamis, Richard Aplenc, Todd A. Alonzo, Xiaotu Ma, Timothy Junius Triche, Jason E Farrar, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2956.
https://doi.org/10.1182/blood-2023-187819
Published: 2023
Journal Articles

Reclassification of ETS Family Transcription Factor Fusions in Pediatric AML Based on Molecular Drivers

Nathaniel J Buteyn, Connor Burke, Eve Gardner, Vincent J Sartori, Rhonda E Ries, Todd A. Alonzo, Soheil Meshinchi, Timothy Triche, Jr.
Journal: Blood
Blood (2023) 142 (Supplement 1): 4298.
https://doi.org/10.1182/blood-2023-189474
Published: 2023
Journal Articles

Leveraging Custom CRISPR/Cas9 Screens to Identify AraC-Daunorubicin-Etoposide (ADE), Gemtuzumab Ozogamicin (GO), and Bortezomib Response Modulators Association with Clinical Outcomes in Pediatric AML

Nam Nguyen, Phani Krishna Parcha, Abderrahmane Tagmount, Bailey Gregory, Jeffrey E. Rubnitz, Raul C. Ribeiro, Xueyuan Cao, Todd A. Alonzo, Richard Aplenc, Alan S Gamis, Todd Cooper, E. Anders Kolb, Soheil Meshinchi, Stanley Pounds, Christopher Vulpe, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 1558.
https://doi.org/10.1182/blood-2023-178832
Published: 2023
Journal Articles

The Methylome Atlas of Acute Leukemia Enables Novel Clinical Diagnostic Tool for AML

Francisco Marchi, Marieke Landwehr, Fernando Sckaff, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 121.
https://doi.org/10.1182/blood-2023-186894
Published: 2023
Journal Articles

APAL2020SC Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias

Michele S. Redell, Todd A. Alonzo, Robert Gerbing, Jim Wang, Maureen M. O'Brien, Gwen Nichols, Laura Di Laurenzio, Sarah K. Tasian, C. Michel Zwaan, Dirk Reinhardt, E. Anders Kolb, Todd Cooper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1492.
https://doi.org/10.1182/blood-2023-190947
Published: 2023
Journal Articles

A DNA Methylation Signature Predicts Clinical Outcome in Pediatric AML Patients

Francisco Marchi, Marieke Landwehr, Fernando Sckaff, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 835.
https://doi.org/10.1182/blood-2023-186505
Published: 2023
Journal Articles

CREBBP alterations are associated with a poor prognosis in de novo AML

Adam J. Lamble, Kohei Hagiwara, Robert B. Gerbing, Jenny L. Smith, Pandurang Kolekar, Rhonda E. Ries, Edward A. Kolb, Todd A. Alonzo, Xiaotu Ma, Soheil Meshinchi
Journal: Blood
Blood (2023) 141 (17): 2156–2159.
https://doi.org/10.1182/blood.2022017545
Published: 2023
Includes: Supplemental data
Journal Articles

Characteristics and Prognostic Effects of DNMT3A Co-Mutations

Alireza Torabi, Todd A. Alonzo, Megan Othus, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Jerald P. Radich, Frederick R. Appelbaum, Kristin O'Dwyer, Harry P. Erba, Martin S. Tallman, Mark R. Litzow, Ehab L. Atallah, Selina M. Luger, Anders E. Kolb, Omar Abdel-Wahab, Derek Stirewalt, Ross L. Levine, Elisabeth Paietta, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 745–747.
https://doi.org/10.1182/blood-2022-162526
Published: 2022
Journal Articles

A Robust Long Non-Coding RNA Expression Classifier for Risk Stratification in Pediatric AML

Jason E Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda E. Ries, Tiffany A. Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda R. Leonti, Timothy I. Shaw, Timothy Junius Triche, Jr., Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Xiaotu Ma, Derek Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9173–9174.
https://doi.org/10.1182/blood-2022-168296
Published: 2022
Journal Articles

Clinical and Functional Implications of MYC Variants As a New Class of Pathogenic Variants in AML

Danielle C. Kirkey, Xiaoying Wu, Rhonda E. Ries, Tiffany A. Hylkema, Yanling Liu, Pandurang Kolekar, Quang Tran, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Todd A. Alonzo, Katherine Tarlock, Robert Eisenman, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3395–3396.
https://doi.org/10.1182/blood-2022-168469
Published: 2022
Journal Articles

Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia

Adam J. Lamble, Rhonda E. Ries, Todd A. Alonzo, Yi-Cheng Wang, Jason E Farrar, Benjamin J. Huang, Matthew A. Kutny, Jessica A. Pollard, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Todd M. Cooper, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3393–3394.
https://doi.org/10.1182/blood-2022-167680
Published: 2022
Journal Articles

CXCR4 (CD184) Expression in Pediatric AML Is Associated with Bone Marrow Retention, Specific Disease Characteristics, and Worse Outcomes: A Report of 1004 Patients from the Children's Oncology Group AAML1031 Protocol

Andrew J. Menssen, Chad A. Hudson, Todd A. Alonzo, Robert B. Gerbing, Laura Pardo, Fan-Chi Hsu, Loren L. Lott, Fangyan Dai, Keely Ghiradelli, Yi-Cheng Wang, E. Anders Kolb, Todd M. Cooper, Jessica A. Pollard, Michael R. Loken, Richard Aplenc, Lisa Eidenschink Brodersen, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3452–3453.
https://doi.org/10.1182/blood-2022-163682
Published: 2022
Journal Articles

Septic Shock and Septic Shock Mortality in Relation to Social Disorganization Index Among Children Being Treated for De Novo Acute Myeloid Leukemia on COG Clinical Trials

Jenny Ruiz, Yimei Li, Yuan-Shung V. Huang, Lusha Cao, Vicky Tam, Heather M. Griffis, Lena E. Winestone, Brian T. Fisher, Todd A. Alonzo, Anders E. Kolb, Karen Glanz, Kelly D. Getz, Richard Aplenc, Alix E. Seif
Journal: Blood
Blood (2022) 140 (Supplement 1): 11029–11031.
https://doi.org/10.1182/blood-2022-163573
Published: 2022
Journal Articles

RPPA-Profiling in Pediatric and Adult T-Cell Acute Lymphoblastic Leukemia Identifies Protein Patterns Associated with Outcome

Fieke W Hoff, Lourdes Sriraja, Yihua Qiu, Gaye Jenkins, Andrew Ligeralde, David T. Teachey, Brent L. Wood, Meenakshi Devidas, Mignon L. Loh, Todd A. Alonzo, Amina A Qutub, Evangelia Petsalaki, Steven M. Kornblau, Terzah M. Horton
Journal: Blood
Blood (2022) 140 (Supplement 1): 6352–6353.
https://doi.org/10.1182/blood-2022-163881
Published: 2022