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Alan S. Gamis
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Journal Articles

Anti-Leukemic Activity of Luveltamab Tazevibulin (LT, STRO-002), a Novel Folate Receptor-α (FR-α)-Targeting Antibody Drug Conjugate (ADC) in Relapsed/Refractory CBF2AT3::GLIS2 AML

Robin Williams, Lane Miller, Stephanie Massaro, Elizabeth Krieger, Melinda Pauly, Catherine Nelson, Rebecca Johnson, Jennifer J.G. Welch, Deepa Bhojwani, Babak Moghimi, Philip Neff, Terzah M. Horton, Hamayun Imran, Raul C. Ribeiro, Terri L. Guinipero, Matthew A. Kutny, Felipe Bautista, Amy Johnson, Karen Lewing, Alan S Gamis, Julienne Brackett, David McCall, Teena Bhatla, Maria Luisa Sulis, Amy Tellinghuisen, Jill C. Beck, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4295.
https://doi.org/10.1182/blood-2023-180141
Published: 2023
Journal Articles

ACS10- Cytarabine Pharmacogenomics Score Impacts Survival in Pediatric AML Patients Treated on AAML1031 Trial and Associates with Outcome Differences in Black AML Patients

Richard J Marrero, Vivek M. Shastri, Richard Aplenc, Todd Cooper, Todd A. Alonzo, Alan S Gamis, Jim Wang, Soheil Meshinchi, E. Anders Kolb, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 4314.
https://doi.org/10.1182/blood-2023-187515
Published: 2023
Journal Articles

A DNA Methylation Signature Predicts Clinical Outcome in Pediatric AML Patients

Francisco Marchi, Marieke Landwehr, Fernando Sckaff, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 835.
https://doi.org/10.1182/blood-2023-186505
Published: 2023
Journal Articles

DNMT3A Mutants Are Enriched in NPMc+ AML and Associated with Adverse Outcome in Childhood AML

Rhonda E Ries, Xiaotu Ma, Claudia Tregnago, Todd A. Alonzo, Jim Wang, Tiffany Hylkema, Benjamin J Huang, Alireza Torabi, Jack H Peplinski, Logan K Wallace, Richard Aplenc, Alan S Gamis, Katherine Tarlock, Franco Locatelli, Martina Pigazzi, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4306.
https://doi.org/10.1182/blood-2023-181060
Published: 2023
Journal Articles

Leveraging Custom CRISPR/Cas9 Screens to Identify AraC-Daunorubicin-Etoposide (ADE), Gemtuzumab Ozogamicin (GO), and Bortezomib Response Modulators Association with Clinical Outcomes in Pediatric AML

Nam Nguyen, Phani Krishna Parcha, Abderrahmane Tagmount, Bailey Gregory, Jeffrey E. Rubnitz, Raul C. Ribeiro, Xueyuan Cao, Todd A. Alonzo, Richard Aplenc, Alan S Gamis, Todd Cooper, E. Anders Kolb, Soheil Meshinchi, Stanley Pounds, Christopher Vulpe, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 1558.
https://doi.org/10.1182/blood-2023-178832
Published: 2023
Journal Articles

The Methylome Atlas of Acute Leukemia Enables Novel Clinical Diagnostic Tool for AML

Francisco Marchi, Marieke Landwehr, Fernando Sckaff, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 121.
https://doi.org/10.1182/blood-2023-186894
Published: 2023
Journal Articles

Impact of Molecular Risk on Efficacy of Blood and Marrow Transplantation for Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Benjamin J Huang, Lauren K. Meyer, Adam Lamble, Jim Wang, Rhonda E Ries, Alan S Gamis, Richard Aplenc, Katherine Tarlock, Todd Cooper, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Joseph Chewning, William G. Woods, John T. Horan
Journal: Blood
Blood (2023) 142 (Supplement 1): 655.
https://doi.org/10.1182/blood-2023-186955
Published: 2023
Journal Articles

Relapse-Enriched Gene Expression Signature of Prognostic Relevance in Pediatric Acute Myeloid Leukemia

Satyavardhan Rao Nittu, Francisco Marchi, Nam Nguyen, Vivek M. Shastri, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Alan S Gamis, E. Anders Kolb, Richard Aplenc, Jeffery Klco, Stanley Pounds, Todd A. Alonzo, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 2926.
https://doi.org/10.1182/blood-2023-189029
Published: 2023
Journal Articles

Integrated Methylation and Transcriptional Landscape and Evolution of Pediatric AML

Benjamin J Huang, Hamid Bolouri, Colin Y. Smith, Jim Wang, Rhonda E Ries, Elizabeth Conran, Alan S Gamis, Richard Aplenc, Todd A. Alonzo, Xiaotu Ma, Timothy Junius Triche, Jason E Farrar, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2956.
https://doi.org/10.1182/blood-2023-187819
Published: 2023
Journal Articles

Single-Cell RNA Sequencing Facilitates Study of Cancer Mechanisms across Pediatric Leukemias

Irina Pushel, Byunggil Yoo, Daniel Louiselle, Margaret Gibson, Alan S Gamis, Keith J. August, Terrie Flatt, Tomi Pastinen, Erin M. Guest, Midhat S Farooqi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1614.
https://doi.org/10.1182/blood-2023-187340
Published: 2023
Journal Articles

Pathogenic TP53 mutations Are Associated with a Poor Prognosis in De Novo AML

Adam J. Lamble, Rhonda E. Ries, Alice Dang, Todd A. Alonzo, Karen Chisholm, Pandurang Kolekar, Yanling Liu, Quang Tran, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Xiaotu Ma, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6297–6298.
https://doi.org/10.1182/blood-2022-162832
Published: 2022
Journal Articles

Distinct Latent Trajectory Phenotypes of Left Ventricular Function Associated with Differential Survival Among Children Treated for Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Kelly D. Getz, Robert B. Gerbing, Todd A. Alonzo, Yimei Li, Kasey J Leger, Jessica A. Pollard, Dava Szalda, Lillian Sung, Todd M. Cooper, Edward A. Kolb, Alan S. Gamis, Bonnie Ky, Richard Aplenc
Journal: Blood
Blood (2022) 140 (Supplement 1): 1014–1015.
https://doi.org/10.1182/blood-2022-170218
Published: 2022
Journal Articles

A Robust Long Non-Coding RNA Expression Classifier for Risk Stratification in Pediatric AML

Jason E Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda E. Ries, Tiffany A. Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda R. Leonti, Timothy I. Shaw, Timothy Junius Triche, Jr., Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Xiaotu Ma, Derek Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9173–9174.
https://doi.org/10.1182/blood-2022-168296
Published: 2022
Journal Articles

Desensitization to Pegaspargase in Children with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Is Safe and Does Not Require Intensive Care - a Single Center Experience

Keith J August, Tristan Flatt, Joy M. Fulbright, Alan S. Gamis, Julia A. Hays, Maxine J Hetherington, Karen Lewing, Amanda August, Erin Guest
Journal: Blood
Blood (2022) 140 (Supplement 1): 6037–6038.
https://doi.org/10.1182/blood-2022-167549
Published: 2022
Journal Articles

Clinical and Functional Implications of MYC Variants As a New Class of Pathogenic Variants in AML

Danielle C. Kirkey, Xiaoying Wu, Rhonda E. Ries, Tiffany A. Hylkema, Yanling Liu, Pandurang Kolekar, Quang Tran, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Todd A. Alonzo, Katherine Tarlock, Robert Eisenman, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3395–3396.
https://doi.org/10.1182/blood-2022-168469
Published: 2022
Journal Articles

Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia

Adam J. Lamble, Rhonda E. Ries, Todd A. Alonzo, Yi-Cheng Wang, Jason E Farrar, Benjamin J. Huang, Matthew A. Kutny, Jessica A. Pollard, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Todd M. Cooper, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3393–3394.
https://doi.org/10.1182/blood-2022-167680
Published: 2022
Journal Articles

Significant Improvements in Survival for Patients with t(6;9)(p23;q34)/ DEK-NUP214 in Contemporary Trials with Intensification of Therapy: A Report from the Children's Oncology Group

Katherine Tarlock, Todd A. Alonzo, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Betsy A Hirsch, Beverly Lange, William G. Woods, Todd M. Cooper, Alan S. Gamis, Jessica A. Pollard, Richard Aplenc, Anders E. Kolb, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 519.
https://doi.org/10.1182/blood-2021-147576
Published: 2021
Journal Articles

Valosin-Containing Protein (VCP/p97) Is Prognostically Unfavorable in Subtypes of Acute Leukemia, and Negatively Correlates with UPR-Proteins IRE1 and GRP78

Fieke W Hoff, Yihua Qiu, Brandon Brown, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Gaye Jenkins, Terzah M. Horton, Steven M. Kornblau
Journal: Blood
Blood (2021) 138 (Supplement 1): 3447.
https://doi.org/10.1182/blood-2021-147066
Published: 2021
Journal Articles

A Polygenic DNA Damage Repair Pharmacogenomics (DDR_PGx8) Score Predicts GO Response in AML

Vivek M. Shastri, Lata Chauhan, Todd A. Alonzo, Yi-Cheng Wang, Richard Aplenc, Betsy A Hirsch, Alan S. Gamis, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2021) 138 (Supplement 1): 3456.
https://doi.org/10.1182/blood-2021-153181
Published: 2021
Journal Articles

ETS Family Transcription Factor Fusions in Childhood AML: Distinct Expression Networks and Clinical Implications

Jenny L. Smith, Rhonda E. Ries, Yi-Cheng Wang, Amanda R. Leonti, Todd A. Alonzo, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Benjamin J. Huang, Xiaotu Ma, Timothy I. Shaw, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2356.
https://doi.org/10.1182/blood-2021-148894
Published: 2021