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Keith J. August
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Journal Articles

Trajectory Inference Highlights Dynamic Expression of T-Cell Development Genes in Pediatric T-Cell Acute Lymphoblastic Leukemia

Irina Pushel, Byunggil Yoo, Daniel Louiselle, Margaret Gibson, Erin M. Guest, Midhat S Farooqi, Keith J. August
Journal: Blood
Blood (2023) 142 (Supplement 1): 2983.
https://doi.org/10.1182/blood-2023-187434
Published: 2023
Journal Articles

Single-Cell RNA Sequencing Facilitates Study of Cancer Mechanisms across Pediatric Leukemias

Irina Pushel, Byunggil Yoo, Daniel Louiselle, Margaret Gibson, Alan S Gamis, Keith J. August, Terrie Flatt, Tomi Pastinen, Erin M. Guest, Midhat S Farooqi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1614.
https://doi.org/10.1182/blood-2023-187340
Published: 2023
Journal Articles

Pharmacogenomics to Predict Asparaginase Premedication-Related Hypersensitivity in Pediatric and Adolescent Young Adults (AYAs) with Acute Lymphoblastic Leukemia or Lymphoma

Vivek M. Shastri, Jennifer Ahmed, Eva Spin, Yeniffer Nunez, Sonia Morales, Anurag Agrawal, Christine L Phillips, Keith J. August, Erin M. Guest, Beth Apsel Winger, Catherine Aftandilian, Van Thu Huynh, Jatinder K. Lamba
Journal: Blood
Blood (2023) 142 (Supplement 1): 6067.
https://doi.org/10.1182/blood-2023-187111
Published: 2023
Journal Articles

Frailty in Children and Adolescents with Lymphoblastic Leukemia or Lymphoma Receiving Maintenance Chemotherapy - a Pilot Study

Thomas Cochran, Joy M. Fulbright, Samantha Butrous, Brian Lee, Keith J. August, David White
Journal: Blood
Blood (2023) 142 (Supplement 1): 5815.
https://doi.org/10.1182/blood-2023-177699
Published: 2023
Journal Articles

Asparaginase-Associated Toxicities and Hypersensitivity Reactions in Pediatric and Adolescent Down Syndrome Patients with Acute Lymphoblastic Leukemia or Lymphoma

Van Thu Huynh, Carol Hwang Lin, Sonia Morales, Anurag K. Agrawal, Christine L Phillips, Keith J. August, Erin M. Guest, Beth Apsel Winger, Catherine Aftandilian, Janel R. Long-Boyle, Kirsten Kasper, Keri Zabokrtsky
Journal: Blood
Blood (2023) 142 (Supplement 1): 5809.
https://doi.org/10.1182/blood-2023-190734
Published: 2023
Journal Articles

Correlation of Minimal Residual Disease (MRD) at the End of Induction (EOI) and Event Free Survival (EFS) in T-Cell Lymphoblastic Lymphoma (T-LL), a Report from the Children's Oncology Group (COG) Trial AALL1231

Robert J. Hayashi, Michelle L. Hermiston, David T. Teachey, Meenakshi Devidas, Brent L. Wood, Zhiguo Chen, Robert D Annett, Barbara L Asselin, Keith J August, Steve Y Cho, Kimberly P. Dunsmore, Jason L. Freedman, Paul J. Galardy, Paul Harker-Murray, Terzah M. Horton, Alok I Jaju, Allison Lam, Yoav H. Messinger, Rodney R. Miles, Maki Okada, Samir I Patel, Eric S Schafer, Tal Schechter-Finkelstein, Kristin A. Shimano, Neelam Singh, Amii C. Steele, Maria Luisa Sulis, Sarah L Vargas, Stuart S. Winter, Charlotte Wood, Patrick A Zweidler-McKay, Mignon L. Loh, Stephen P. Hunger, Elizabeth A. Raetz, Catherine M Bollard, Carl Allen
Journal: Blood
Blood (2022) 140 (Supplement 1): 6387–6389.
https://doi.org/10.1182/blood-2022-159694
Published: 2022
Journal Articles

Desensitization to Pegaspargase in Children with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Is Safe and Does Not Require Intensive Care - a Single Center Experience

Keith J August, Tristan Flatt, Joy M. Fulbright, Alan S. Gamis, Julia A. Hays, Maxine J Hetherington, Karen Lewing, Amanda August, Erin Guest
Journal: Blood
Blood (2022) 140 (Supplement 1): 6037–6038.
https://doi.org/10.1182/blood-2022-167549
Published: 2022
Journal Articles

Premedication and Therapeutic Drug Monitoring (TDM) for Pegaspargase: A Prospective Multicenter Multi-Ethnic Study of Pediatric and Adolescent Patients

Van T Huynh, Sonia Morales, Anurag K. Agrawal, Christine L. Phillips, Keith J August, Erin Guest, Beth Apsel Winger, Catherine Aftandilian, Janel R. Long-Boyle, Kirsten Kasper, Keri Zabokrtsky, Carol Hwang Lin
Journal: Blood
Blood (2022) 140 (Supplement 1): 8893–8895.
https://doi.org/10.1182/blood-2022-159255
Published: 2022
Journal Articles

Intensification of Chemotherapy Using a Modified BFM Backbone for Children, Adolescents and Young Adults with T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Identifies Highly Chemorefractory Patients Who Benefit from Allogeneic Hematopoietic Stem Cell Transplantation

Paul Harker-Murray, Brent L. Wood, Meenakshi Devidas, Zhiguo Chen, Tal Schechter-Finkelstein, Robert J. Hayashi, Keith J August, Kimberly P. Dunsmore, Michelle L. Hermiston, Terzah M. Horton, Yoav H. Messinger, Sarah L Vargas, Eric S Schafer, Maria Luisa Sulis, Stuart S. Winter, Charlotte Wood, Catherine M Bollard, Mignon L. Loh, Stephen P Hunger, Elizabeth A. Raetz, David T. Teachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 3487.
https://doi.org/10.1182/blood-2021-151837
Published: 2021
Journal Articles

Cranial Radiation Can be Eliminated in Most Children with T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Bortezomib Potentially Improves Survival in Children with T-Cell Lymphoblastic Lymphoma (T-LL): Results of Children's Oncology Group (COG) Trial AALL1231

David T. Teachey, MD, Meenakshi Devidas, PhD, Brent L Wood, MD PhD, Zhiguo Chen, MS, Robert James Hayashi, MD, Robert D Annett, PhD, Barbara L Asselin, MD, Keith J August, MDMS, Steve Y Cho, MD, Kimberly P. Dunsmore, MD, Brian T. Fisher, DO, MSCE, Jason L. Freedman, MD, Paul J. Galardy, MD, Paul Harker-Murray, MD PhD, Michelle L. Hermiston, MD PhD, Terzah M Horton, MD PhD, Alok I Jaju, MD, Allison Lam, BCPS, Yoav H. Messinger, MD, Rodney R. Miles, MD PhD, Maki Okada, RN, Samir I Patel, MD, Eric S. Schafer, MD MHS, Tal Schechter-Finkelstein, MD, Kristin A. Shimano, MD, Neelam Singh, PhD, Amii C. Steele, PhD, Maria L. Sulis, MD, Sarah L Vargas, PhD, Stuart S. Winter, MD, Charlotte Wood, CCRP, Patrick Zweider McKay, MDPhD, Catherine M. Bollard, MD MBChB, Mignon L. Loh, MD, Stephen P. Hunger, MD, Elizabeth A. Raetz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-134730
Published: 2020
Journal Articles

Successful Treatment of Refractory Acute Lymphoblastic Leukemia with Tisagenlecleucel in the Setting of Life-Threatening Infection

Keith J August, MDMS, Terrie Flatt, DO,MA, Erin Marie Hall, MD, Doug Myers, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5125.
https://doi.org/10.1182/blood-2019-130880
Published: 2019
Journal Articles

Cuplike nuclear morphology is highly associated with IKZF1 deletion in pediatric precursor B-cell ALL

Weijie Li, Linda D. Cooley, Keith J. August, Aida I. Richardson, Lei Shao, Atif A. Ahmed, Midhat S. Farooqi, David L. Zwick
Journal: Blood
Blood (2019) 134 (3): 324–329.
https://doi.org/10.1182/blood.2019000604
Published: 2019
Journal Articles

Bortezomib Combined with Mitoxantrone, Vincristine, Peg-Asparaginase and Dexamethasone for Children with Relapsed Acute Lymphoblastic Leukemia

Keith J August, MD MS, Alan S Gamis, MD MPH, Julia A. Hays, MD, Karen Lewing, MD, Erin Guest, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5039.
https://doi.org/10.1182/blood.V130.Suppl_1.5039.5039
Published: 2017
Journal Articles

CTL019 Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor (CAR) T Cells to Characterize the Impact of Tocilizumab on Expansion and to Identify Correlates of Cytokine Release Syndrome Severity

Andrew M Stein, Stephan A Grupp, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Bruce L Levine, PhD, Carl H June, MD, Lori Tomassian, MS, Sweta Shah, PharmD, Mimi Leung, MPH, Pai-Hsi Huang, Sebastien Jolivet, Rakesh Awasthi, PhD, Karen Thudium Mueller, PharmD,MSc, Patricia A Wood, MD PhD, Shannon L Maude, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2561.
https://doi.org/10.1182/blood.V130.Suppl_1.2561.2561
Published: 2017
Journal Articles

Impact of Humoral Immunogenicity (Anti-mCAR19 Antibodies) on CTL019 Cellular Kinetics, Efficacy, and Safety

Karen Thudium Mueller, PharmD,MSc, Edward Waldron, PhD, Denise Sickert, PhD, Stephan A Grupp, MD PhD, Shannon L Maude, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Rakesh Awasthi, PhD, Bruce L Levine, PhD, Carl H June, MD, Tetiana Taran, MD, Patricia A Wood, MD PhD, Gary Douglas Myers, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1281.
https://doi.org/10.1182/blood.V130.Suppl_1.1281.1281
Published: 2017
Journal Articles

Circulating CD2 Negative T Cells in Pediatric Acute Leukemia

Weijie Li, MD, Lei Shao, MD, Atif Ahmed, MD, Doug Myers, MD, Keith J August, MD MS
Journal: Blood
Blood (2016) 128 (22): 5151.
https://doi.org/10.1182/blood.V128.22.5151.5151
Published: 2016
Journal Articles

Efficacy and Safety of CTL019 in the First US Phase II Multicenter Trial in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of an Interim Analysis

Shannon L Maude, MD PhD, Michael A Pulsipher, MD, Michael W Boyer, MD, Stephan A Grupp, MD PhD, Stella M Davies, MBBS, PhD, Christine L Phillips, MD, Michael R Verneris, MD, Keith J August, MD MS, Krysta Schlis, MD, Timothy A Driscoll, MD, Rajen Mody, MD MS, Christian M Capitini, MD, Carl H June, MD, Bruce L Levine, PhD, Patricia A Wood, MD PhD, Lan Yi, PhD, John E Levine, MD MS
Journal: Blood
Blood (2016) 128 (22): 2801.
https://doi.org/10.1182/blood.V128.22.2801.2801
Published: 2016
Journal Articles

Effect of Intrathecal Methotrexate on CSF and RBC Folate Levels in Children Receiving Treatment for Acute Lymphoblastic Leukemia

Keith J. August, MD MS, Leon van Haandel, PhD, J. Steven Leeder, PharmD, PhD
Journal: Blood
Blood (2015) 126 (23): 2486.
https://doi.org/10.1182/blood.V126.23.2486.2486
Published: 2015
Journal Articles

Relative Oral Bioequivalence of Two 6-Mercaptopurine (6-MP) Liquid Formulations in Children with Acute Lymphoblastic Leukemia (ALL)

Jaszianne A. Tolbert, MD, Keith J. August, MD MS, Susan M Abdel-Rahman, PharmD, Scott J Weir, PharmD, PhD, J Steven Leeder, PharmD, PhD, Kathleen A Neville, MD MS
Journal: Blood
Blood (2014) 124 (21): 2242.
https://doi.org/10.1182/blood.V124.21.2242.2242
Published: 2014
Journal Articles

Adolescents and Young Adults (AYA) with Acute Myeloid Leukemia (AML) Have Increased Treatment-Related Mortality with Similar Outcomes -- a Report from the Children's Oncology Group Trials AAML03P1 and AAML0531

Keith J. August, MD MS, Richard Aplenc, MD PhD, Lillian Sung, MD PhD, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, John T. Horan, MD MPH, Todd A. Alonzo, PhD, Robert B. Gerbing, MA, Yi-Cheng Jim Wang, MS, Samir Kahwash, MD, Amy Heerema-McKenney, MD, Soheil Meshinchi, MD PhD, Alan S. Gamis, MD MPH
Journal: Blood
Blood (2014) 124 (21): 3672.
https://doi.org/10.1182/blood.V124.21.3672.3672
Published: 2014