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Amanda R. Leonti
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Journal Articles

Identifying a Relapse Signature in CBFB-MYH11 Acute Myeloid Leukemia

Jack H Peplinski, Logan K Wallace, Rhonda E Ries, Benjamin J Huang, Amanda R Leonti, Danielle C Kirkey, Xiaotu Ma, Scott N Furlan, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2955.
https://doi.org/10.1182/blood-2023-187637
Published: 2023
Journal Articles

A Robust Long Non-Coding RNA Expression Classifier for Risk Stratification in Pediatric AML

Jason E Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda E. Ries, Tiffany A. Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda R. Leonti, Timothy I. Shaw, Timothy Junius Triche, Jr., Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Xiaotu Ma, Derek Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9173–9174.
https://doi.org/10.1182/blood-2022-168296
Published: 2022
Journal Articles

Integrated Genomic Analysis Identifies UBTF Tandem Duplications As a Subtype-Defining Lesion in Pediatric Acute Myeloid Leukemia

Masayuki Umeda, Jing Ma, Benjamin J. Huang, Kohei Hagiwara, Tamara Westover, Sherif Abdelhamed, Juan Martin Barajas, Melvin Edward Thomas, III, Michael P Walsh, Guangchun Song, Liqing Tian, Yanling Liu, Xiaolong Chen, Pandurang Kolekar, Quang Tran, Scott Foy, Jamie L. Maciaszek, Andrew B Kleist, Amanda R. Leonti, Bensheng Ju, John Easton, Huiyun Wu, Virginia Valentine, Marc Valentine, Yen-Chun Liu, Rhonda E. Ries, Jenny L. Smith, Evan Parganas, Ilaria Iacobucci, Ryan Hiltenbrand, Jonathan Miller, Jason Myers, Evadnie Rampersaud, Delaram Rahbarinia, Michael Rusch, Gang Wu, Hiroto Inaba, Yi-Cheng Wang, Todd A. Alonzo, James R. Downing, Charles G. Mullighan, Stanley B Pounds, M. Madan Babu, Jinghui Zhang, Jeffrey E. Rubnitz, Soheil Meshinchi, Xiaotu Ma, Jeffery M. Klco
Journal: Blood
Blood (2021) 138 (Supplement 2): LBA-4.
https://doi.org/10.1182/blood-2021-155134
Published: 2021
Journal Articles

Integrated Transcriptomics and Proteomics Identifies Therapeutic Targets in Pediatric Acute Myeloid Leukemia

Benjamin J. Huang, Jenny L. Smith, Timothy I. Shaw, Scott N Furlan, Rhonda E. Ries, Amanda R. Leonti, Erin Lynn Crowgey, Lisa Wei, Jason E Farrar, Tim Triche, Xiaotu Ma, Quy Le, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 1296.
https://doi.org/10.1182/blood-2021-153970
Published: 2021
Journal Articles

Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor Natural Killer Cell Therapy in Acute Myeloid Leukemia

Thao T. Tang, Lindsey F Call, Sommer Castro, Cynthia Nourigat-Mckay, LaKeisha Perkins, Laura Pardo, Amanda R. Leonti, Soheil Meshinchi, Quy Le
Journal: Blood
Blood (2021) 138 (Supplement 1): 1712.
https://doi.org/10.1182/blood-2021-153156
Published: 2021
Journal Articles

Project Stella: Development and Preclinical Assessment of FOLR1-Directed Chimeric Antigen Receptor T Cells in CBF2AT3-GLIS2/RAM AML

Quy Le, Sommer Castro, Thao T. Tang, Cynthia Nourigat-Mckay, LaKeisha Perkins, Tiffany A. Hylkema, Laura Pardo, Jenny L. Smith, Amanda R. Leonti, Rhonda E. Ries, Lisa Eidenschink Brodersen, Michael R. Loken, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2788.
https://doi.org/10.1182/blood-2021-151836
Published: 2021
Journal Articles

Immunotherapeutic Targeting of TSLPR with Chimeric Antigen Receptor T Cells in AML

Lindsey F Call, Sommer Castro, Thao T. Tang, Cynthia Nourigat-Mckay, LaKeisha Perkins, Laura Pardo, Amanda R. Leonti, Soheil Meshinchi, Quy Le
Journal: Blood
Blood (2021) 138 (Supplement 1): 2789.
https://doi.org/10.1182/blood-2021-153815
Published: 2021
Journal Articles

Therapeutic Targeting of CD74 with STRO-001 Antibody-Drug Conjugate in AML and ALL

Quy Le, Amanda R. Leonti, Thao T. Tang, Sommer Castro, Cynthia Nourigat-Mckay, LaKeisha Perkins, Rhonda E. Ries, Jenny L. Smith, Tiffany A. Hylkema, Laura Pardo, Cristina Abrahams, Kristin Bedard, Arturo Molina, Lisa Eidenschink Brodersen, Michael R. Loken, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 509.
https://doi.org/10.1182/blood-2021-151160
Published: 2021
Journal Articles

Biology and Clinical Implications of Complex Landscape of Cooperating Events in FLT3 -ITD Acute Myeloid Leukemia

Katherine Tarlock, Leila Robinson, Todd A. Alonzo, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Amanda R. Leonti, Jenny L. Smith, Tiffany A. Hylkema, Quy Le, Xiaotu Ma, E. Anders Kolb, Richard Aplenc, Jessica A. Pollard, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3454.
https://doi.org/10.1182/blood-2021-153703
Published: 2021
Journal Articles

Functional Consequence and Therapeutic Targeting of Cryptic ALK Fusions (ALK fus ) in Monosomy7 AML

Makia K. Manselle, Tiffany A. Hylkema, Amanda R. Leonti, Rhonda E. Ries, Quy Le, Scott N Furlan, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2357.
https://doi.org/10.1182/blood-2021-148179
Published: 2021
Journal Articles

ETS Family Transcription Factor Fusions in Childhood AML: Distinct Expression Networks and Clinical Implications

Jenny L. Smith, Rhonda E. Ries, Yi-Cheng Wang, Amanda R. Leonti, Todd A. Alonzo, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Benjamin J. Huang, Xiaotu Ma, Timothy I. Shaw, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2356.
https://doi.org/10.1182/blood-2021-148894
Published: 2021
Journal Articles

Targeting PRAME with TCR-Mimic CAR T Cells in AML

Anisha M Loeb, Sommer Castro, Cynthia Nourigat-Mckay, LaKeisha Perkins, Laura Pardo, Amanda R. Leonti, Thao T. Tang, Lindsey F Call, Tiffany A. Hylkema, David A. Scheinberg, Soheil Meshinchi, Quy Le
Journal: Blood
Blood (2021) 138 (Supplement 1): 733.
https://doi.org/10.1182/blood-2021-148677
Published: 2021
Journal Articles

Epigenetic Silencing of CD34 in AML and Association with Outcome in KMT2A Fusions

Rhonda E. Ries, Lisa Eidenschink Brodersen, Laura Pardo, Timothy Junius Triche, Jr., Amanda R. Leonti, Jenny L. Smith, Todd A. Alonzo, Jason E Farrar, Yi-Cheng Wang, Alice Dang, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Michael R. Loken, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 802.
https://doi.org/10.1182/blood-2021-149210
Published: 2021
Journal Articles

KMT2A Partial Tandem Duplications ( KMT2A -PTD) Is a Rare, but Recurrent Genomic Event in Childhood AML and Associated with High Rate of Co-Occurring FLT3 Mutations

Danielle C. Kirkey, Katherine Tarlock, Rhonda E. Ries, Yi-Cheng Wang, Amanda R. Leonti, Quy Le, Jenny L. Smith, Leila Robinson, Yanling Liu, Quang Tran, Richard Aplenc, Jessica A. Pollard, Anders E. Kolb, Todd A. Alonzo, Xiaotu Ma, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 609.
https://doi.org/10.1182/blood-2021-147565
Published: 2021
Journal Articles

EZH2-Mediated MHC Class II Silencing Drives Immune Evasion in AML with t(16;21) ( FUS-ERG)

Nate J Buteyn, Connor G Burke, Jenny L. Smith, Rhonda E. Ries, Amanda R. Leonti, Timothy I. Shaw, Benjamin J. Huang, Todd A. Alonzo, Scott N. Furlan, Jason E Farrar, Soheil Meshinchi, Timothy Junius Triche, Jr.
Journal: Blood
Blood (2021) 138 (Supplement 1): 374.
https://doi.org/10.1182/blood-2021-153256
Published: 2021
Journal Articles

Endothelial Cell Niche Promotes Leukemic Transformation of Human Cord Blood Stem/Progenitor Cells Expressing CBFA2T3-GLIS2 Oncogenic Fusion

Quy Le, Tiffany A. Hylkema, Sommer Castro, Jenny L. Smith, Amanda R. Leonti, Thao T. Tang, Cynthia Nourigat-Mckay, LaKeisha Perkins, Laura Pardo, Lisa Eidenschink Brodersen, Michael R. Loken, Rhonda E. Ries, Keith R. Loeb, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 360.
https://doi.org/10.1182/blood-2021-148916
Published: 2021
Journal Articles

Targeting FOLR1 in High-Risk CBF2AT3-GLIS2 AML with Stro-002 FOLR1-Directed Antibody-Drug Conjugate

Quy Le, Jenny L. Smith, Thao T. Tang, Sommer Castro, Cynthia Nourigat-Mckay, LaKeisha Perkins, Benjamin J. Huang, Rhonda E. Ries, Amanda R. Leonti, Tiffany A. Hylkema, Laura Pardo, Cristina Abrahams, Kristin Bedard, Arturo Molina, Lisa Eidenschink Brodersen, Michael R. Loken, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 209.
https://doi.org/10.1182/blood-2021-153076
Published: 2021
Journal Articles

Heat shock factor 1 (HSF1-pSer 326 ) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report

Clinical Trials & Observations
Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Peter P. Ruvolo, Robert B. Gerbing, Amanda R. Leonti, Gaye N. Jenkins, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S. J. M. de Bont, Sophia W. M. Bruggeman, Steven M. Kornblau, Terzah M. Horton
Journal: Blood
Blood (2021) 137 (8): 1050–1060.
https://doi.org/10.1182/blood.2020005208
Published: 2021
Includes: Supplemental data
Journal Articles

Therapeutic Targeting of Mesothelin in Acute Myeloid Leukemia with Chimeric Antigen Receptor T Cell Therapy

Quy Le, PhD, Sommer Castro, BS, Thao T. Tang, Anisha Loeb, BA, Amanda R. Leonti, MS, Laura Pardo, Michael R. Loken, PhD, Colin Correnti, PhD, Soheil Meshinchi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11.
https://doi.org/10.1182/blood-2020-143140
Published: 2020
Journal Articles

Target-Informed Repurposing of Immunotherapies in AML - a Transcriptome Based Approach for Identifying Immediately Available Therapeutics

Amanda R. Leonti, MS, Makia Manselle, Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Anders E. Kolb, MD, Soheil Meshinchi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-138566
Published: 2020