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Melinda Pauly
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Journal Articles

Feasibility and utility of unmatched whole-genome sequencing (uWGS)  for pediatric acute leukemias: An analysis of leukemia precision-based therapy (LEAP) study samples

Free
Jesús Gutiérrez-Abril, Dylan Domenico, Gunes Gundem, Juan Arango Ossa, Anu Amallraja, Konstantinos Liosis, Sarah Tasian, Todd Cooper, Melinda Pauly, Kelly Maloney, Michael Burke, Stacy Cooper, Nathan Gossai, Jennifer McNeer, Justine Kahn, Nobuko Hijiya, Matthew Barth, Jeffrey Magee, Mignon Loh, Kimberly Stegmaier, Marian Harris, Emily Stockfisch, Francesco Maura, Andrew Kung, Elli Papaemmanuil, Maria Luisa Sulis, Yana Pikman, Neerav Shukla
Journal: Blood
Blood (2025) 146 (Supplement 1): 2561.
https://doi.org/10.1182/blood-2025-2561
Published: 2025
Journal Articles

Identifying barriers to clinical trial enrollment for children with relapsed or refractory hematologic malignancies

Free
Kristen Kurtz, Erica Ma, Yueh-Yun Chi, Jemily Malvar, Yi Tan, Eric Schafer, Melinda Pauly, Joel Kaplan, Lauren Pommert, Jenna Rossoff, Paul Gaynon, Nobuko Hijiya, Van Huynh, Susan Rheingold, Reuven Schore, Kelly Faulk, Kenneth Heym, Andrew Place, Sandeep Batra, Peter Shaw, Stacy Cooper, Seth Karol, Seong Lin Khaw, Keith August, Julio Barredo, Jennifer Agrusa, Nathan Gossai, Maria Luisa Sulis, Susan Colace, Bill Chang, Mari Dallas, Todd Cooper, Karen McCleary, Michelle Hermiston, Mallorie Heneghan, Tamra Slone, Luciano Dalla-Pozza, Zachary Graff, Erika Shin-Kashiyama, Alan Wayne, Deepa Bhojwani
Journal: Blood
Blood (2025) 146 (Supplement 1): 4404.
https://doi.org/10.1182/blood-2025-4404
Published: 2025
Journal Articles

Inotuzumab ozogamacin in refractory or 1st or greater relapse of pediatric B-ALL as bridge to cure: A single center experience

Free
Waitman Aumann, Katherine Lee, Anna Bennett, Stephanie Bernardo, Lois Chukoian, Kathleen Kaspar, Amy Lahey, Kelly MacDonald, Jacqueline Schlesinger, Daniel John Bergsagel, Diana Fridlyand, Frank Keller, Melinda Pauly, Lauren Raney, Himalee Sabnis, Ryan Summers, Sharon Castellino, Tamara Miller
Journal: Blood
Blood (2025) 146 (Supplement 1): 3351.
https://doi.org/10.1182/blood-2025-3351
Published: 2025
Journal Articles

Anti-Leukemic Activity of Luveltamab Tazevibulin (LT, STRO-002), a Novel Folate Receptor-α (FR-α)-Targeting Antibody Drug Conjugate (ADC) in Relapsed/Refractory CBF2AT3::GLIS2 AML

Free
Robin Williams, Lane Miller, Stephanie Massaro, Elizabeth Krieger, Melinda Pauly, Catherine Nelson, Rebecca Johnson, Jennifer J.G. Welch, Deepa Bhojwani, Babak Moghimi, Philip Neff, Terzah M. Horton, Hamayun Imran, Raul C. Ribeiro, Terri L. Guinipero, Matthew A. Kutny, Felipe Bautista, Amy Johnson, Karen Lewing, Alan S Gamis, Julienne Brackett, David McCall, Teena Bhatla, Maria Luisa Sulis, Amy Tellinghuisen, Jill C. Beck, Soheil Meshinchi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4295.
https://doi.org/10.1182/blood-2023-180141
Published: 2023
Journal Articles

Results from the Phase 1 Portion of a Trial of Oral Ixazomib Combined with Chemotherapy in Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoma in Children, Adolescents and Young Adults: A Report from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium

Free
Eric S. Schafer, Yueh-Yun Chi, Jemily Malvar, Teresa Rushing, Andrew Doan, Holly L. Pacenta, Reuven J. Schore, Richard Sposto, Roy Leong, Paul S. Gaynon, Jeffrey E. Rubnitz, Julio C. Barredo, Tamra Slone, Melinda Pauly, Alan S. Wayne, Deepa Bhojwani, Terzah M. Horton
Journal: Blood
Blood (2023) 142 (Supplement 1): 2872.
https://doi.org/10.1182/blood-2023-180414
Published: 2023
Journal Articles

Anti-Leukemic Activity of STRO-002 a Novel Folate Receptor-α (FR-α)-Targeting ADC in Relapsed/Refractory CBF2AT3-GLIS2 AML

Free
Soheil Meshinchi, Lane Miller, Stephanie Massaro, Robin Williams, Elizabeth Krieger, Melinda Pauly, Catherine Nelson, Deepa Bhojwani, Rebecca Johnson, Terzah M. Horton, Hamayun Imran, Wen-I Chang, Philip Neff, Matthew Kutny, Raul C. Ribeiro, Felipe Bautista, Terri Guinipero, Kate Murray, Alex Butte, Arturo Molina
Journal: Blood
Blood (2022) 140 (Supplement 1): 159–161.
https://doi.org/10.1182/blood-2022-162842
Published: 2022
Journal Articles

A Pilot Study of Azacitidine As Epigenetic Priming for Chemotherapy in Infants Less Than 1 Year of Age with KMT2A -Rearranged Acute Lymphoblastic Leukemia (ALL); Results from the Children's Oncology Group (COG) Trial AALL15P1

Free
Erin Guest, John Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly Kubaney, Amanda August, Melinda Pauly, Daniel Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown
Journal: Blood
Blood (2022) 140 (Supplement 1): 3256–3257.
https://doi.org/10.1182/blood-2022-167765
Published: 2022
Journal Articles

Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Free
Michael J. Burke, David S. Ziegler, Francisco Bautista, Andishe Attarbaschi, Lia Gore, Franco Locatelli, Maureen M. O'Brien, Melinda Pauly, Mihaela Obreja, Christopher L. Morris, Andre Baruchel
Journal: Blood
Blood (2021) 138 (Supplement 1): 1235.
https://doi.org/10.1182/blood-2021-147588
Published: 2021
Journal Articles

Single Cell Transcriptomics Revealed AML and Non-AML Cell Clusters Relevant to Relapse and Remission in Pediatric AML

Free
Beena E Thomas, Pruthvi Perumalla, MS, Swati S Bhasin, PhD, Debasree Sarkar, PhD, Bhakti Dwivedi, PhD, Sunita I Park, MD, Deborah DeRyckere, BS,PhD, Curtis J. Henry, PhD, Sunil S. Raikar, MD, Christopher C. Porter, MD, Melinda Pauly, MD, Ryan J Summers, MD, Sharon M. Castellino, MD MSc, Daniel S. Wechsler, MD PhD, Douglas K Graham, MD PhD, Manoj Bhasin, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24–25.
https://doi.org/10.1182/blood-2020-142513
Published: 2020
Journal Articles

Phase 1b Study of Carfilzomib in Combination with Induction Chemotherapy in Children with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Free
Michael J. Burke, MD, David S. Ziegler, MBBS, FRACP, MD, Francisco José Bautista Sirvent, MD PhD, Andishe Attarbaschi, MD, Lia Gore, MD, Franco Locatelli, MD PhD, Maureen M O'Brien, MD, Melinda Pauly, MD, Mihaela Obreja, PhD, Christopher L. Morris, PhDMD, Andre Baruchel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3873.
https://doi.org/10.1182/blood-2019-127350
Published: 2019
Journal Articles

Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-Risk Leukemias: A Report from the LEAP Consortium

Free
Yana Pikman, MD, Sarah K. Tasian, MD, Maria Luisa Sulis, MD, Todd M Cooper, DO, Melinda Pauly, MD, Kelly W. Maloney, MD, Michael J. Burke, MD, Patrick Brown, MD, Nathan Gossai, MD, Peter Cole, MD, Jennifer McNeer, MD MS, Neerav Shukla, MD, Beth Apsel Winger, MD PhD, Asmani A Adhav, Traci M. Blonquist, MS, Amy Conway, Andrew E. Place, MD PhD, Lia Gore, MD, Stephen P. Hunger, MD, Katherine Janeway, MD MMSc, Lewis B. Silverman, MD, Jeffrey W. Tyner, PhD, Marian H. Harris, MD PhD, Mignon L. Loh, MD, Kimberly Stegmaier, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 261.
https://doi.org/10.1182/blood-2018-99-116948
Published: 2018
Journal Articles

Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Free
Andrew E. Place, MD PhD, Traci M. Blonquist, MS, Elliot Stieglitz, MD, Todd M Cooper, DO, Lia Gore, MD, Richard Aplenc, MD PhD, Mignon L. Loh, MD, Melinda Pauly, MD, Rachel E. Rau, MD, Michael J. Burke, MD, Julia Etchin, PhD, A. Thomas Look, MD, Maria Luisa Sulis, MD, Lewis B. Silverman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1405.
https://doi.org/10.1182/blood-2018-99-116689
Published: 2018
Journal Articles

Absence of Silent Inactivation Using Intravenous Pegaspargase in Pediatric Acute Lymphoblastic Leukemia

Free
Sarayu Kumar, BA, BSPH, Curtis D Travers, MPH, John Bergsagel, MD, Frank G Keller, MD, Melinda Pauly, MD, Himalee Sabnis, MDMS, Sharon M. Castellino, MD MSc, Glen Lew, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 100.
https://doi.org/10.1182/blood.V130.Suppl_1.100.100
Published: 2017
Journal Articles

A Phase 1 Study of Denintuzumab Mafodotin (SGN-CD19A) in Adults with Relapsed or Refractory B-Lineage Acute Leukemia (B-ALL) and Highly Aggressive Lymphoma

Free
Amir T Fathi, MD, Uma Borate, MD, Daniel J. DeAngelo, MD PhD, Maureen M. O'Brien, MD, Tanya Trippett, MD, Bijal D Shah, Gregory A. Hale, MD, James M. Foran, MD, Lewis B. Silverman, MD, Raoul Tibes, MD PhD, Stuart Cramer, D.O., Melinda Pauly, MD, Stella Kim, Ana Kostic, MD, Xiaohui Huang, Yang Pan, PhD, Robert Chen
Journal: Blood
Blood (2015) 126 (23): 1328.
https://doi.org/10.1182/blood.V126.23.1328.1328
Published: 2015
Journal Articles

Preliminary Report of the Phase 1 Study of the DOT1L Inhibitor, Pinometostat, EPZ-5676, in Children with Relapsed or Refractory MLL-r Acute Leukemia: Safety, Exposure and Target Inhibition

Free
Neerav Shukla, MD, Maureen M. O'Brien, MD, Lewis B. Silverman, MD, Melinda Pauly, MD, Cynthia Wetmore, MD PhD, Mignon L. Loh, MD, James A. Whitlock, MD, Patrick Brown, MD, Blythe Thomson, MD, Stephen J. Blakemore, PhD, Scott Daigle, Patricia Pimentel, Nigel J. Waters, PhD, Andrei V Krivstov, PhD, Richard Koche, PhD, Scott A. Armstrong, MD PhD, Peter T Ho, PhD MD, Lia Gore, MD
Journal: Blood
Blood (2015) 126 (23): 3792.
https://doi.org/10.1182/blood.V126.23.3792.3792
Published: 2015
Journal Articles

Phase Ib Trial of the mTOR Inhibitor Everolimus Given in Combination with Multiagent Chemotherapy in Relapsed Acute Lymphoblastic Leukemia

Free
Andrew E. Place, MDPhD, Yana Pikman, MD, Kristen Stevenson, MS, Marian H. Harris, MD PhD, Todd M. Cooper, DO, Lia Gore, MD, Nobuko Hijiya, MD, Mignon L. Loh, MD, Melinda Pauly, MD, Maria Luisa Sulis, MD, Donna S Neuberg, ScD, Kimberly Stegmaier, MD, Stephen E. Sallan, MD, Lewis B. Silverman, MD
Journal: Blood
Blood (2015) 126 (23): 3765.
https://doi.org/10.1182/blood.V126.23.3765.3765
Published: 2015