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Journal Articles

Double Step-up Dosing (2SUD) Regimen Mitigates Severe Icans and CRS While Maintaining High Efficacy in Subjects with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (NHL) Treated with AZD0486, a Novel CD19xCD3 T-Cell Engager (TCE): Updated Safety and Efficacy Data from the Ongoing First-in-Human (FIH) Phase 1 Trial

Sameh Gaballa, Ranjit Nair, Ryan W Jacobs, Sumana Devata, Seok-Goo Cho, Don A. Stevens, Dok Hyun Yoon, Nirav N. Shah, Denise Brennan, Jason Law, Robert Chen, David Sermer, Robin Lesley, Ben Buelow, Alessandra Forcina, Jing-Zhou Hou
Journal: Blood
Blood (2023) 142 (Supplement 1): 1662.
https://doi.org/10.1182/blood-2023-174668
Published: 2023
Journal Articles

Pembrolizumab plus vorinostat induces responses in patients with Hodgkin lymphoma refractory to prior PD-1 blockade

Clinical Trials & Observations
Matthew Mei, Lu Chen, James Godfrey, Joo Song, Colt Egelston, Sandrine Puverel, L. Elizabeth Budde, Saro Armenian, Liana Nikolaenko, Mary Nwangwu, Weihua Guo, Lei Gao, Peter Lee, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Jasmine Zain, Steven Rosen, Stephen Forman, Leslie Popplewell, Larry Kwak, Alex F. Herrera
Journal: Blood
Blood (2023) 142 (16): 1359–1370.
https://doi.org/10.1182/blood.2023020485
Published: 2023
Includes: Supplemental data
Journal Articles

Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma

Clinical Trials & Observations
Claire Roddie, Lazaros J. Lekakis, Maria A. V. Marzolini, Aravind Ramakrishnan, Yiyun Zhang, Yanqing Hu, Vijay G. R. Peddareddigari, Nushmia Khokhar, Robert Chen, Silvia Basilico, Meera Raymond, Frederick Arce Vargas, Kevin Duffy, Wolfram Brugger, Maeve A. O’Reilly, Leigh Wood, David C. Linch, Karl S. Peggs, Carlos Bachier, Elizabeth Lihua Budde, Connie Lee Batlevi, Nancy Bartlett, David Irvine, Eleni Tholouli, Wendy Osborne, Kirit M. Ardeshna, Martin A. Pule
Journal: Blood
Blood (2023) 141 (20): 2470–2482.
https://doi.org/10.1182/blood.2022018598
Published: 2023
Includes: Supplemental data
Journal Articles

Phase I Trial of Brentuximab Vedotin Plus Cyclosporine in Relapsed/Refractory Hodgkin Lymphoma

Swetha Kambhampati, Matthew Mei, Lu Chen, Sandrine Puverel, Robert Chen, Leslie L. Popplewell, Liana Nikolaenko, Lacolle Peters, Saro H. Armenian, Larry W. Kwak, Steve T Rosen, Stephen J Forman, Alex F. Herrera
Journal: Blood
Blood (2022) 140 (Supplement 1): 9418–9419.
https://doi.org/10.1182/blood-2022-157623
Published: 2022
Journal Articles

Response-adapted anti-PD-1–based salvage therapy for Hodgkin lymphoma with nivolumab alone or in combination with ICE

Clinical Trials & Observations
Matthew G. Mei, Hun Ju Lee, Joycelynne M. Palmer, Robert Chen, Ni-Chun Tsai, Lu Chen, Kathryn McBride, D. Lynne Smith, Ivana Melgar, Joo Y. Song, Kimberley-Jane Bonjoc, Saro Armenian, Mary Nwangwu, Peter P. Lee, Jasmine Zain, Liana Nikolaenko, Leslie Popplewell, Auayporn Nademanee, Ammar Chaudhry, Steven Rosen, Larry Kwak, Stephen J. Forman, Alex F. Herrera
Journal: Blood
Blood (2022) 139 (25): 3605–3616.
https://doi.org/10.1182/blood.2022015423
Published: 2022
Includes: Supplemental data
Journal Articles

Pembrolizumab Plus Vorinostat Induces Responses in Patients with Hodgkin Lymphoma Who Are Refractory to Prior PD-1 Blockade

Alex F. Herrera, Lu Chen, L. Elizabeth Budde, Saro Armenian, Liana Nikolaenko, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Steven T. Rosen, Stephen J Forman, Leslie L. Popplewell, Larry W. Kwak, Matthew Mei
Journal: Blood
Blood (2021) 138 (Supplement 1): 234.
https://doi.org/10.1182/blood-2021-150031
Published: 2021
Journal Articles

Ontogeny of the Alloimmune Anti-Canine Factor VIII Inhibitor Response in Severe Hemophilia Α Dogs

Robert Chen, Bhavya S Doshi, Timothy C. Nichols, Michael C. Milone, Ben J. Samelson-Jones, Valder R Arruda, Vijay Bhoj, Don L. Siegel
Journal: Blood
Blood (2021) 138 (Supplement 1): 3173.
https://doi.org/10.1182/blood-2021-149215
Published: 2021
Journal Articles

A phase 1b study of AFM13 in combination with pembrolizumab in patients with relapsed or refractory Hodgkin lymphoma

Clinical Trials & Observations
Nancy L. Bartlett, Alex F. Herrera, Eva Domingo-Domenech, Amitkumar Mehta, Andres Forero-Torres, Ramon Garcia-Sanz, Philippe Armand, Sumana Devata, Antonia Rodriguez Izquierdo, Izidore S. Lossos, Craig Reeder, Taimur Sher, Robert Chen, Sylvia E. Schwarz, Leila Alland, Andras Strassz, Kim Prier, Cassandra Choe-Juliak, Stephen M. Ansell
Journal: Blood
Blood (2020) 136 (21): 2401–2409.
https://doi.org/10.1182/blood.2019004701
Published: 2020
Includes: Supplemental data
Journal Articles

Ibrutinib Plus Venetoclax in Patients With Relapsed/Refractory Mantle Cell Lymphoma: Results From the Safety Run-In Period of the Phase 3 Sympatico Study

Constantine S. Tam, MD, Radhakrishnan Ramchandren, MD, Robert Chen, MD, Lionel Karlin, MD, Geoffrey Chong, MD, Wojciech Jurczak, MD PhD, Ka Lung Wu, MD PhD, Mark Bishton, MBChB, MRCP, FRCPath, PhD, Graham P. Collins, MD DPhil, Paul Eliadis, MBBS, FRACP, FRCPA, Frédéric Peyrade, MD, Edith Szafer-Glusman, PhD, Yihua Lee, PhD, Karl Eckert, BA, Jutta K. Neuenburg, MD PhD, Michael Wang, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–41.
https://doi.org/10.1182/blood-2020-134392
Published: 2020
Journal Articles

Consolidation with Nivolumab and Brentuximab Vedotin after Autologous Hematopoietic Cell Transplantation in Patients with High-Risk Hodgkin Lymphoma

Alex F. Herrera, MD, Lu Chen, PhD, Yago Nieto, MD, Leona Holmberg, MD PhD, Patrick B. Johnston, Matthew Mei, MD, Leslie Popplewell, MD, Saro H. Armenian, DO, MPH, Thai Cao, MD, Len Farol, MD, Firoozeh Sahebi, MD, Ricardo Spielberger, MD, Robert Chen, MD, Auayporn P. Nademanee, MDBS, Lacolle Peters, Neena Kennedy, Steven T. Rosen, MD, Larry W Kwak, MD PhD, Stephen J. Forman, MD, Tatyana A. Feldman, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 19–20.
https://doi.org/10.1182/blood-2020-136384
Published: 2020
Journal Articles

Real-World IgG Testing Frequency and Characteristics Associated with Hypogammaglobulinemia after Anti-CD20 Exposure in Patients with Chronic Lymphocytic Leukemia (CLL)

Ian J. Hooley, Kathleen Maignan, NP, Alexandra Jacob, Angelica Medina, MSRA, Lauren Benderoff, Robert Chen, PhD, Scott F. Huntington, MD MPH
Journal: Blood
Blood (2020) 136 (Supplement 1): 43–44.
https://doi.org/10.1182/blood-2020-137094
Published: 2020
Journal Articles

Phase 1/2 Study of AUTO3 the First Bicistronic Chimeric Antigen Receptor (CAR) Targeting CD19 and CD22 Followed By an Anti-PD1 in Patients with Relapsed/Refractory (r/r) Diffuse Large B Cell Lymphoma (DLBCL): Results of Cohort 1 and 2 of the Alexander Study

Kirit M. Ardeshna, MBBChir, Maria A V Marzolini, Jane Norman, MD, Muhammad Al-Hajj, Simon Thomas, PhD, Jim Faulkner, Ekaterini Kotsopoulou, Martin Pule, MD, Vijay G R Peddareddigari, Nushmia Z Khokhar, Maud Jonnaert, PhD, Robert Chen, MD, Wendy Osborne, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 246.
https://doi.org/10.1182/blood-2019-122724
Published: 2019
Journal Articles

Machine Learning Based Predictive Model of 5-Year Survival in Multiple Myeloma Autologous Transplant Patients

Robert Chen, PhD, Sankeerth Garapati, David Wu, Sean Ko, Sam Falk, Djamilia Dierov, Adam Stasiw, Adomah S. Opong, ANP, Kenneth R. Carson, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2156.
https://doi.org/10.1182/blood-2019-129432
Published: 2019
Journal Articles

Pembrolizumab in relapsed or refractory Hodgkin lymphoma: 2-year follow-up of KEYNOTE-087

Clinical Trials & Observations
Robert Chen, Pier Luigi Zinzani, Hun Ju Lee, Philippe Armand, Nathalie A. Johnson, Pauline Brice, John Radford, Vincent Ribrag, Daniel Molin, Theodoros P. Vassilakopoulos, Akihiro Tomita, Bastian von Tresckow, Margaret A. Shipp, Jianxin Lin, Eunhee Kim, Akash Nahar, Arun Balakumaran, Craig H. Moskowitz
Journal: Blood
Blood (2019) 134 (14): 1144–1153.
https://doi.org/10.1182/blood.2019000324
Published: 2019
Includes: Supplemental data
Journal Articles

Hepatitis B Testing Rates in Patients with Chronic Lymphocytic Leukemia before and during Administration of Anti-CD20 Therapy

Ian J Hooley, BS, Robert Chen, PhD, Kathleen Maignan, NP, Kenneth R. Carson, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2249.
https://doi.org/10.1182/blood-2018-99-113636
Published: 2018
Journal Articles

Frontline brentuximab vedotin in combination with dacarbazine or bendamustine in patients aged ≥60 years with HL

Clinical Trials & Observations
Jonathan W. Friedberg, Andres Forero-Torres, Rodolfo E. Bordoni, Vivian J. M. Cline, Dipti Patel Donnelly, Patrick J. Flynn, Gregg Olsen, Robert Chen, Abraham Fong, Yinghui Wang, Christopher A. Yasenchak
Journal: Blood
Blood (2017) 130 (26): 2829–2837.
https://doi.org/10.1182/blood-2017-06-787200
Published: 2017
Includes: Supplemental data
Journal Articles

Ibrutinib Therapy in Patients with Relapsed/Refractory Marginal Zone Lymphoma: Analysis By Prior Rituximab Treatment and Baseline Mutations

Robert Chen, MD, Sven de Vos, MD PhD, Catherine Thieblemont, MD PhD, Peter Martin, FRCPC, MD MS, Christopher Flowers, MD, Franck Morschhauser, MD PhD, Graham Collins, MD PhD, Shuo Ma, MD, Morton Coleman, MD, Shachar Peles, MD, Stephen D. Smith, MD, Jacqueline C. Barrientos, MD, Alina Smith, Brian Munneke, PhD, Shiquan Wu, PhD, Leo Cheung, PhD, Kevin Kwei, PhD, Selda Samakoglu, MD PhD, Israel Arango-Hisijara, MD, Isaiah Dimery, MD, Ariela Noy, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3026.
https://doi.org/10.1182/blood.V130.Suppl_1.3026.3026
Published: 2017
Journal Articles

Targeting Bruton tyrosine kinase with ibrutinib in relapsed/refractory marginal zone lymphoma

Clinical Trials & Observations
Ariela Noy, Sven de Vos, Catherine Thieblemont, Peter Martin, Christopher R. Flowers, Franck Morschhauser, Graham P. Collins, Shuo Ma, Morton Coleman, Shachar Peles, Stephen Smith, Jacqueline C. Barrientos, Alina Smith, Brian Munneke, Isaiah Dimery, Darrin M. Beaupre, Robert Chen
Journal: Blood
Blood (2017) 129 (16): 2224–2232.
https://doi.org/10.1182/blood-2016-10-747345
Published: 2017
Includes: Supplemental data
Journal Articles

Five-year survival and durability results of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma

Clinical Trials & Observations Brief Report
Robert Chen, Ajay K. Gopal, Scott E. Smith, Stephen M. Ansell, Joseph D. Rosenblatt, Kerry J. Savage, Joseph M. Connors, Andreas Engert, Emily K. Larsen, Dirk Huebner, Abraham Fong, Anas Younes
Journal: Blood
Blood (2016) 128 (12): 1562–1566.
https://doi.org/10.1182/blood-2016-02-699850
Published: 2016
Includes: Supplemental data
Journal Articles

Phase 2 study of frontline brentuximab vedotin monotherapy in Hodgkin lymphoma patients aged 60 years and older

Clinical Trials & Observations
Andres Forero-Torres, Beata Holkova, Jerome Goldschmidt, Robert Chen, Gregg Olsen, Ralph V. Boccia, Rodolfo E. Bordoni, Jonathan W. Friedberg, Jeff P. Sharman, Maria Corinna Palanca-Wessels, Yinghui Wang, Christopher A. Yasenchak
Journal: Blood
Blood (2015) 126 (26): 2798–2804.
https://doi.org/10.1182/blood-2015-06-644336
Published: 2015
Includes: Supplemental data