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Michael C. Milone
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Journal Articles

Bendamustine Is Less Toxic Than Fludarabine-Cyclophosphamide-Based Lymphodepletion before CD28-Costimulated CART19 through Reduced Inflammatory Cytokines

Guido Ghilardi, Luca Paruzzo, Jakub Svoboda, Elise A. Chong, Alexander Shestov, Linhui Chen, Ivan J Cohen, Giulia Gabrielli, Dwivedy S. Nasta, Patrizia Porazzi, Daniel J. Landsburg, James Gerson, Jordan Carter, Stefan K. Barta, Rebecca Yelton, Raymone Pajarillo, Griffin W White, Hatcher Ballard, Elizabeth Weber, Ellen B. Napier, Emeline R. Chong, Joseph A Fraietta, Alfred L. Garfall, David L. Porter, Michael C. Milone, Roderick O'Connor, Stephen J. Schuster, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 4483.
https://doi.org/10.1182/blood-2023-182234
Published: 2023
Journal Articles

Sequential T-Cell Engagement for Myeloma (“STEM”) Trial: A Phase 2 Study of Cevostamab Consolidation Following BCMA CAR T Cell Therapy

Adam D. Cohen, Wei-Ting Hwang, Sandra Susanibar-Adaniya, Dan T. Vogl, Alfred L. Garfall, Adam Waxman, Danielle Zubka, Chau Nguyen, Cynthia Diaczynsky, Marco Ruella, Michael C. Milone, Edward A. Stadtmauer
Journal: Blood
Blood (2023) 142 (Supplement 1): 3389.
https://doi.org/10.1182/blood-2023-187409
Published: 2023
Journal Articles

Ontogeny of the Alloimmune Anti-Canine Factor VIII Inhibitor Response in Severe Hemophilia Α Dogs

Robert Chen, Bhavya S Doshi, Timothy C. Nichols, Michael C. Milone, Ben J. Samelson-Jones, Valder R Arruda, Vijay Bhoj, Don L. Siegel
Journal: Blood
Blood (2021) 138 (Supplement 1): 3173.
https://doi.org/10.1182/blood-2021-149215
Published: 2021
Journal Articles

Perfecting CAR Engraftment to a Tee (Cell) through Characterization of Single Cell Transcriptome Product and Understanding Neurotoxicity

Wesley Wilson, Fei Miao, Alfred L Garfall, Dexiu Bu, Elena J Orlando, Jennifer L Brogdon, Iulian Pruteanu-Malinici, Adam D Cohen, Michael C. Milone
Journal: Blood
Blood (2021) 138 (Supplement 1): 1707.
https://doi.org/10.1182/blood-2021-151785
Published: 2021
Journal Articles

Human Orthogonal IL-2/IL-2Rβ As a Tunable Approach to Enhance CD19-Speific CAR-T Cell Antitumor Activity

Qian Zhang, MDPhD, Morgan Hresko, Michael Jacob Hollander, Lora Picton, Leon Su, Selene Nunez-Cruz, Jonathan T Sockolosky, K.Christopher Garcia, PhD, Michael C. Milone
Journal: Blood
Blood (2020) 136 (Supplement 1): 48.
https://doi.org/10.1182/blood-2020-140463
Published: 2020
Journal Articles

Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors

Meng Wang, BS, Iulian Pruteanu, PhD, Adam D. Cohen, MD, Alfred L Garfall, MD, Michael C. Milone, Lifeng Tian, PhD, Vanessa E. Gonzalez, Saar Gill, MD MRCP, FRCPath, Noelle V. Frey, MD, David M. Barrett, Marco Ruella, MD, Simon F Lacey, PhD, Jakub Svoboda, MD, Elise A. Chong, MD, Joseph A Fraietta, PhD, Megan Davis, PhD, Sunita D Nasta, MD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Shannon L. Maude, MD PhD, Stephen J. Schuster, MD, Edward A. Stadtmauer, MD FACP, Stephan Grupp, MD PhD, David L. Porter, MD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 622.
https://doi.org/10.1182/blood-2019-122513
Published: 2019
Journal Articles

Simple, 1-Day Manufacturing of Quiescent Chimeric Antigen Receptor T Cells for Adoptive Immunotherapy

Saba Ghassemi, PhD, Roddy S O'Connor, PhD, Selene Nunez-cruz, PhD, Jai Patel, John Leferovich, Michael C. Milone
Journal: Blood
Blood (2019) 134 (Supplement_1): 4436.
https://doi.org/10.1182/blood-2019-131147
Published: 2019
Journal Articles

Combination Anti-Bcma and Anti-CD19 CAR T Cells As Consolidation of Response to Prior Therapy in Multiple Myeloma

Alfred L. Garfall, MD, Adam D. Cohen, MD, Simon F Lacey, PhD, Lifeng Tian, PhD, Wei-Ting Hwang, PhD, Dan T. Vogl, MD, Adam Waxman, MD, Eric Lancaster, MD, Anne Marie Nelson, Regina Ferthio, Andrew Fesnak, MD, Anne Lamontagne, Andrea Brennan, Jamie Guilliams, Whitney Lynn Gladney, PhD, J. Joseph Melenhorst, PhD, Regina M Young, PhD, Don L. Siegel, MD PhD, Bruce L Levine, PhD, Jennifer Brogdon, PhD, Randi E. Isaacs, MD, Carl H June, MD, Michael C. Milone, Edward A. Stadtmauer, MD FACP
Journal: Blood
Blood (2019) 134 (Supplement_1): 1863.
https://doi.org/10.1182/blood-2019-131515
Published: 2019
Journal Articles

Response to Anti-Bcma CAR T Cell Therapy Correlates with T Cell Exhaustion and Activation Status in T Cells at Baseline in Myeloma

Meng Wang, BS, Iulian Pruteanu, PhD, Adam D. Cohen, MD, Alfred L. Garfall, MD, Lifeng Tian, PhD, Simon F Lacey, PhD, Joseph A Fraietta, PhD, Jennifer Brogdon, PhD, Megan Davis, PhD, Vanessa E. Gonzalez, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Michael C. Milone, Edward A. Stadtmauer, MD FACP, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1909.
https://doi.org/10.1182/blood-2019-122396
Published: 2019
Journal Articles

Prophylactic Itacitinib (INCB039110) for the Prevention of Cytokine Release Syndrome Induced By Chimeric Antigen Receptor T-Cells (CAR-T-cells) Therapy

Eduardo Huarte, PhD, Roddy S O'Connor, PhD, Melissa Parker, Taisheng Huang, Michael C. Milone, Paul Smith
Journal: Blood
Blood (2019) 134 (Supplement_1): 1934.
https://doi.org/10.1182/blood-2019-128288
Published: 2019
Journal Articles

Clinical Predictors of T Cell Fitness for CAR T Cell Manufacturing and Efficacy in Multiple Myeloma

Ehren Dancy, MD, Alfred L. Garfall, MD, Adam D. Cohen, MD, Joseph A Fraietta, PhD, Megan Davis, PhD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Edward A. Stadtmauer, MD FACP, Dan T. Vogl, MD, Adam Waxman, MD, Aaron P. Rapoport, MD, Michael C. Milone, MD PhD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1886.
https://doi.org/10.1182/blood-2018-99-115319
Published: 2018
Journal Articles

4-1BB-Costimulated CAR-Mediated Non-Canonical NF-Kb Signaling Enhances CAR T Cell Survival and Suppresses Bim Expression

Michael C. Milone, MD PhD, Roddy OConnor, PhD, Michael May, PhD, Steven Albelda, MD, Benjamin Philipson, BA
Journal: Blood
Blood (2018) 132 (Supplement 1): 3713.
https://doi.org/10.1182/blood-2018-99-119522
Published: 2018
Journal Articles

Optimized FVIII-Domain-Based Chimeric Antigen Receptors to Specifically Target FVIII Inhibitor-Producing B Cells in Hemophilia a

Vijay Bhoj, MD PhD, Lucy Li, Benjamin J. Samelson-Jones, MD PhD, Bhavya S Doshi, MD, Christoph Ellebrecht, MD, Aimee Payne, MD PhD, Valder R Arruda, MD PhD, Michael C. Milone, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2196.
https://doi.org/10.1182/blood-2018-99-120031
Published: 2018
Journal Articles

PD-1 Inhibitor Combinations As Salvage Therapy for Relapsed/Refractory Multiple Myeloma (MM) Patients Progressing after Bcma-Directed CAR T Cells

Luca Bernabei, Alfred L. Garfall, MD, J. Joseph Melenhorst, PhD, Simon F Lacey, PhD BS, Edward A. Stadtmauer, MD FACP, Dan T. Vogl, MD, Vanessa Gonzalez, Gabriela Plesa, MD, Regina M Young, PhD, Adam Waxman, MD, Bruce L Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD, Adam D. Cohen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1973.
https://doi.org/10.1182/blood-2018-99-119514
Published: 2018
Journal Articles

Predictors of T Cell Expansion and Clinical Responses Following B-Cell Maturation Antigen-Specific Chimeric Antigen Receptor T Cell Therapy (CART-BCMA) for Relapsed/Refractory Multiple Myeloma (MM)

Adam D. Cohen, MD, J. Joseph Melenhorst, PhD, Alfred L. Garfall, MD, Simon F Lacey, PhD BS, Megan Davis, PhD, Dan T. Vogl, MD, Lifeng Tian, PhD, Vanessa Gonzalez, Iulian Pruteanu, PhD, Anne Marie Nelson, Gabriela Plesa, MD, Adam Waxman, MD, Regina M Young, PhD, Bruce L Levine, PhD, Carl H June, MD, Edward A. Stadtmauer, MD FACP, Michael C. Milone, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1974.
https://doi.org/10.1182/blood-2018-99-119665
Published: 2018
Journal Articles

False-positive results with select HIV-1 NAT methods following lentivirus-based tisagenlecleucel therapy

Clinical Trials & Observations
Theodore W. Laetsch, Shannon L. Maude, Michael C. Milone, Kara L. Davis, Joerg Krueger, Ana Maria Cardenas, Lamis K. Eldjerou, Christopher H. Keir, Patricia A. Wood, Stephan A. Grupp
Journal: Blood
Blood (2018) 131 (23): 2596–2598.
https://doi.org/10.1182/blood-2017-12-822940
Published: 2018
Journal Articles

Safety and Efficacy of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) with Cyclophosphamide Conditioning for Refractory Multiple Myeloma (MM)

Adam D. Cohen, MD, Alfred L. Garfall, MD, Edward A. Stadtmauer, MD FACP, Simon F Lacey, PhD BS, Eric Lancaster, Dan T. Vogl, MD, Brendan M Weiss, MD, David E Ambrose, BS, Anne Marie Nelson, Fang Chen, PhD, Gabriela Plesa, MD, Irina Kulikovskaya, Vanessa Gonzalez, Minnal Gupta, Regina M Young, PhD, Karen Dengel, BSN, RN, Laura O'keefe, Samantha Le, Celeste Richardson, PhD, Randi E. Isaacs, MD, J. Joseph Melenhorst, PhD, Bruce L Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 505.
https://doi.org/10.1182/blood.V130.Suppl_1.505.505
Published: 2017
Journal Articles

B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) for Multiple Myeloma (MM): Initial Safety and Efficacy from a Phase I Study

Adam D. Cohen, MD, Alfred L. Garfall, MD, Edward A Stadtmauer, MD, Simon Francis Lacey, PhD BS, Eric Lancaster, MD PhD, Dan T. Vogl, MD, Karen Dengel, BSN, RN, David E Ambrose, BS, Fang Chen, PhD, Gabriela Plesa, PhD, Irina Kulikovskaya, PhD, Vanessa E Gonzalez, M.B.A, Minnal Gupta, MSc, Regina M Young, PhD, Tenesia Carey, Regina Ferthio, Brendan M. Weiss, MD, Celeste Richardson, PhD, Randi E. Isaacs, MD, J. Joseph Melenhorst, PhD, Bruce L. Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1147.
https://doi.org/10.1182/blood.V128.22.1147.1147
Published: 2016
Journal Articles

Minimally Ex Vivo Manipulated Gene-Modified T Cells Display Enhanced Tumor Control

Saba Ghassemi, PhD, Patel Prachi, John Scholler, Selene Nunez-Cruz, PhD, David M. Barrett, MD PhD, Felipe Bedoya, PhD, Joseph A. Fraietta, PhD, Simon Francis Lacey, PhD BS, Bruce L Levine, PhD, Stephen A. Grupp, MD PhD, Carl H June, MD, Michael C. Milone, MD PhD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2016) 128 (22): 4549.
https://doi.org/10.1182/blood.V128.22.4549.4549
Published: 2016
Journal Articles

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

Clinical Trials & Observations
Vijay G. Bhoj, Dimitrios Arhontoulis, Gerald Wertheim, James Capobianchi, Colleen A. Callahan, Christoph T. Ellebrecht, Amrom E. Obstfeld, Simon F. Lacey, Jan J. Melenhorst, Farzana Nazimuddin, Wei-Ting Hwang, Shannon L. Maude, Mariusz A. Wasik, Adam Bagg, Stephen Schuster, Michael D. Feldman, David L. Porter, Stephen A. Grupp, Carl H. June, Michael C. Milone
Journal: Blood
Blood (2016) 128 (3): 360–370.
https://doi.org/10.1182/blood-2016-01-694356
Published: 2016
Includes: Supplemental data