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John Scholler
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Journal Articles

Disinhibition of T Cell Activation Via CD5 Knockout Is a Universal Strategy to Enhance Adoptive T Cell Immunotherapies

Ruchi P. Patel, Guido Ghilardi, Yunlin Zhang, Puneeth Guruprasad, Mathew G. Angelos, Raymone Pajarillo, Khatuna Gabunia, Chong Xu, Tatiana Blanchard, John Scholler, Patrizia Porazzi, Gerald Linette, Beatriz M. Carreno, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 102.
https://doi.org/10.1182/blood-2023-186611
Published: 2023
Journal Articles

Interleukin-18 Secreting Autologous Anti-CD19 CAR T-Cells (huCART19-IL18) in Patients with Non-Hodgkin Lymphomas Relapsed or Refractory to Prior CAR T-Cell Therapy

Jakub Svoboda, James N. Gerson, Daniel J. Landsburg, Elise A. Chong, Stefan K. Barta, Sunita Dwivedy Nasta, Marco Ruella, Elizabeth O. Hexner, Amy Marshall, Rachel Leskowitz, Megan Four, Joanne Shea, Tina Matlawski, Amanda Cervini, Megan M. Davis, Mercy Gohil, John Scholler, Donald Hasenmayer, Juliana Rojas Amortegui, Andrea Brennan, Gabriela Plesa, Wei-Ting Hwang, David L. Porter, Joseph Fraietta, Stephen J. Schuster, Carl H. June
Journal: Blood
Blood (2022) 140 (Supplement 1): 4612–4614.
https://doi.org/10.1182/blood-2022-162393
Published: 2022
Journal Articles

Gut Microbiota Tuning Promotes Tumor-Associated Antigen Cross Presentation and Enhances CAR T Antitumor Effects

Marco Ruella, Mireia Uribe-Herranz, Silvia Beghi, Kalpana Parvathaneni, Nektarios Kostopoulos, Guido Ghilardi, Kimberly Amelsberg, Yong Gu Gu Lee, Raymone Pajarillo, Noelle V Frey, Simon F Lacey, Khatuna Gabunia, John Scholler, Elise A Chong, Carl H June, David L. Porter, Stephen J. Schuster, Vijay Bhoj, Andrea Facciabene
Journal: Blood
Blood (2021) 138 (Supplement 1): 163.
https://doi.org/10.1182/blood-2021-151093
Published: 2021
Journal Articles

Durable Remissions with Humanized CD19-Targeted Chimeric Antigen Receptor (CAR)-Modified T Cells in CAR-Naive and CAR-Exposed Children and Young Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia

Shannon L Maude, MD PhD, George E Hucks, Colleen Callahan, Diane Baniewicz, Christina Fasano, Christine Barker, Susan R. Rheingold, MD, Richard Aplenc, MD, Amanda M. Dinofia, MD, Amanda Li, MD BSc, David T Teachey, MD, David M. Barrett, Jennifer Brogdon, PhD, Regina M Young, PhD, John Scholler, Katherine T Marcucci, PhD, Bruce L Levine, PhD, Noelle Frey, MD, David L Porter, MD, Simon F Lacey, PhD BS, J. Joseph Melenhorst, PhD, Carl H June, MD, Stephan A Grupp, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1319.
https://doi.org/10.1182/blood.V130.Suppl_1.1319.1319
Published: 2017
Journal Articles

Cars in Leukemia: Relapse with Antigen-Negative Leukemia Originating from a Single B Cell Expressing the Leukemia-Targeting CAR

Simon Francis Lacey, PhD BS, Jun Xu, PhD, Marco Ruella, MD, David M. Barrett, MD PhD, Irina Kulikovskaya, PhD, David E Ambrose, BS, Prachi R. Patel, BS, Tyler Reich, John Scholler, Farzana Nazimuddin, Joseph A. Fraietta, PhD, Shannon L Maude, MD PhD, Saar I. Gill, MD PhD, Bruce L Levine, PhD, Christopher L Nobles, PhD, Frederic D Bushman, PhD, Elena Orlando, PhD, Stephan A. Grupp, MD PhD, Carl H June, MD, Jan Joseph Melenhorst, PhD
Journal: Blood
Blood (2016) 128 (22): 281.
https://doi.org/10.1182/blood.V128.22.281.281
Published: 2016
Journal Articles

Oncolytic Adenovirus Expressing Cytokines Enhances Anti-Tumor Efficacy of Mesothelin-Redirected CAR-T Cells

Keisuke Watanabe, MD PhD, Sonia Guedan, PhD, John Scholler, Shannon McGettigan, Yangpin Luo, Siri Tähtinen, Suvi Parviainen, PhD, Riikka Havunen, Mikko Siurala, Akseli Hemminki, MD PhD, Carl H June, MD
Journal: Blood
Blood (2016) 128 (22): 3360.
https://doi.org/10.1182/blood.V128.22.3360.3360
Published: 2016
Journal Articles

Efficacy of Humanized CD19-Targeted Chimeric Antigen Receptor (CAR)-Modified T Cells in Children and Young Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia

Shannon L Maude, MD PhD, David M. Barrett, MD PhD, Susan R. Rheingold, MD, Richard Aplenc, MD PhD, David T Teachey, MD, Colleen Callahan, MSN, Diane Baniewicz, MSN, Claire White, BSN, Mala K. Talekar, MD, Pamela A Shaw, PhD, Jennifer L Brogdon, PhD, Regina M Young, PhD, John Scholler, Katherine T. Marcucci, PhD, Bruce L Levine, PhD, Noelle Frey, MD MS, David L Porter, MD, Simon F. Lacey, PhD, J. Joseph Melenhorst, PhD, Carl H June, MD, Stephan A. Grupp, MD PhD
Journal: Blood
Blood (2016) 128 (22): 217.
https://doi.org/10.1182/blood.V128.22.217.217
Published: 2016
Journal Articles

Minimally Ex Vivo Manipulated Gene-Modified T Cells Display Enhanced Tumor Control

Saba Ghassemi, PhD, Patel Prachi, John Scholler, Selene Nunez-Cruz, PhD, David M. Barrett, MD PhD, Felipe Bedoya, PhD, Joseph A. Fraietta, PhD, Simon Francis Lacey, PhD BS, Bruce L Levine, PhD, Stephen A. Grupp, MD PhD, Carl H June, MD, Michael C. Milone, MD PhD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2016) 128 (22): 4549.
https://doi.org/10.1182/blood.V128.22.4549.4549
Published: 2016
Journal Articles

Combination of Anti-CD123 and Anti-CD19 Chimeric Antigen Receptor T Cells for the Treatment and Prevention of Antigen-Loss Relapses Occurring after CD19-Targeted Immunotherapies

Marco Ruella, MD, David M. Barrett, MD PhD, Saad S Kenderian, MD, Olga Shestova, PhD, Ted J. Hofmann, PhD, John Scholler, Simon F. Lacey, PhD BSc, J. Joseph Melenhorst, PhD, Farzana Nazimuddin, Jessica Perazzelli, PhD, David A Christian, PhD, Christopher A Hunter, PhD, David L Porter, MD, Carl H. June, MD, Stephan A. Grupp, MD PhD, Saar I Gill, MBBS, PhD
Journal: Blood
Blood (2015) 126 (23): 2523.
https://doi.org/10.1182/blood.V126.23.2523.2523
Published: 2015
Journal Articles

Efficacy and Safety of Humanized Chimeric Antigen Receptor (CAR)-Modified T Cells Targeting CD19 in Children with Relapsed/Refractory ALL

Shannon L Maude, MD PhD, David M. Barrett, MD PhD, David E Ambrose, Susan R. Rheingold, MD, Richard Aplenc, MD PhD, David T Teachey, MD, Colleen Callahan, MSN, Christine S Barker, Maya Mudambi, Pamela A Shaw, PhD, Jennifer Brogdon, PhD, Regina M Young, PhD, John Scholler, Andreas Loew, PhD, Katherine T. Marcucci, PhD, Jeffrey Finklestein, Irina Kulikovskaya, PhD, Farzana Nazimuddin, Zhaohui Zheng, MS, Bruce L. Levine, PhD, David L Porter, MD, Simon F. Lacey, PhD BS, Jan J. Melenhorst, PhD, Carl H. June, MD, Stephan A. Grupp, MD PhD
Journal: Blood
Blood (2015) 126 (23): 683.
https://doi.org/10.1182/blood.V126.23.683.683
Published: 2015
Journal Articles

A Novel Small Animal Model to Test on-Target Off-Tumor Cytoxicity of Adoptive Immune Therapies

Mauro Castellarin, PhD, Joseph A. Fraietta, PhD, Jihyun Lee, PhD, John Scholler, Yangbing Zhao, PhD MD, Carl H. June, MD
Journal: Blood
Blood (2015) 126 (23): 5432.
https://doi.org/10.1182/blood.V126.23.5432.5432
Published: 2015
Journal Articles

Signaling Domain of Chimeric Antigen Receptors Can Reprogram T Cells

Omkar Uday Kawalekar, MS, BS, Roddy O'Connor, PhD, Sonia Guedan, PhD, Joseph Fraietta, PhD, Avery D. Posey, PhD, John Scholler, Michael C Milone, MD PhD, Carl H. June, MD
Journal: Blood
Blood (2014) 124 (21): 551.
https://doi.org/10.1182/blood.V124.21.551.551
Published: 2014
Journal Articles

Novel Chimeric Antigen Receptor T Cells for the Treatment of CD19-Negative Relapses Occurring after CD19-Targeted Immunotherapies

Marco Ruella, MD, David Barrett, MD PhD, Saad S. Kenderian, MD, Olga Shestova, PhD, Ted J. Hofmann, PhD, John Scholler, Simon F. Lacey, PhD BSc, Jan J Melenhorst, PhD, Farzana Nazimuddin, MS, Michael Kalos, PhD, David L. Porter, MD, Carl H. June, MD, Stephan A. Grupp, MD PhD, Saar I. Gill, MD PhD
Journal: Blood
Blood (2014) 124 (21): 966.
https://doi.org/10.1182/blood.V124.21.966.966
Published: 2014
Journal Articles

Novel Chimeric Antigen Receptor T Cells for the Treatment of Hodgkin Lymphoma

Marco Ruella, MD, Saad S Kenderian, MD, Olga Shestova, PhD, Taylor Chen, John Scholler, Mariusz A. Wasik, MD, Carl H. June, MD, Saar I. Gill, MD PhD
Journal: Blood
Blood (2014) 124 (21): 806.
https://doi.org/10.1182/blood.V124.21.806.806
Published: 2014
Journal Articles

ICOS-based chimeric antigen receptors program bipolar T H 17/T H 1 cells

Sonia Guedan, Xi Chen, Aviv Madar, Carmine Carpenito, Shannon E. McGettigan, Matthew J. Frigault, Jihyun Lee, Avery D. Posey, Jr, John Scholler, Nathalie Scholler, Richard Bonneau, Carl H. June
Journal: Blood
Blood (2014) 124 (7): 1070–1080.
https://doi.org/10.1182/blood-2013-10-535245
Published: 2014
Includes: Supplemental data
Journal Articles

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor–modified T cells

Clinical Trials & Observations
Saar Gill, Sarah K. Tasian, Marco Ruella, Olga Shestova, Yong Li, David L. Porter, Martin Carroll, Gwenn Danet-Desnoyers, John Scholler, Stephan A. Grupp, Carl H. June, Michael Kalos
Journal: Blood
Blood (2014) 123 (15): 2343–2354.
https://doi.org/10.1182/blood-2013-09-529537
Published: 2014
Includes: Supplemental data
Journal Articles

Distinct Signaling By Chimeric Antigen Receptors (CARs) Containing CD28 Signaling Domain Versus 4-1BB In Primary Human T Cells

Omkar Uday Kawalekar, MS, BS, Avery D. Posey, Jr., Joseph Fraietta, Jihyun Lee, John Scholler, Yangbing Zhao, Carl H. June, MD
Journal: Blood
Blood (2013) 122 (21): 2902.
https://doi.org/10.1182/blood.V122.21.2902.2902
Published: 2013
Journal Articles

Anti-CD123 Chimeric Antigen Receptor T Cells (CART-123) Provide A Novel Myeloablative Conditioning Regimen That Eradicates Human Acute Myeloid Leukemia In Preclinical Models

Saar Gill, MD, PhD, Sarah K Tasian, MD, Marco Ruella, MD, Olga Shestova, PhD, Yong Li, MD, MS, David L. Porter, MD, Martin Carroll, MD, Gwenn Danet-Desnoyers, PhD, John Scholler, Stephan A Grupp, MD, PhD, Carl H. June, MD, Michael Kalos, PhD
Journal: Blood
Blood (2013) 122 (21): 143.
https://doi.org/10.1182/blood.V122.21.143.143
Published: 2013