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Robin Lesley
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Journal Articles

Three-year follow-up of the Phase 1 first-in-human study investigating surovatamig, a novel CD19xCD3 T-cell engager, in patients with Relapsed/Refractory (R/R) follicular lymphoma (FL)

Free
Jing-Zhou Hou, Tae Min Kim, Seok-Goo Cho, Sameh Gaballa, Ranjit Nair, Koji Izutsu, Sumana Devata, Dok Hyun Yoon, Won-Seog Kim, Yazeed Sawalha, Ryan Jacobs, Eliza Hawkes, Ming-Chung Wang, Constantine Tam, Don Stevens, Hisayuki Yokoyama, Jin Seok Kim, Matthew Matasar, Aravind Ramakrishnan, Denise Brennan, David Sermer, Robin Lesley, Mihail Obrocea, Dai Maruyama
Journal: Blood
Blood (2025) 146 (Supplement 1): 1005.
https://doi.org/10.1182/blood-2025-1005
Published: 2025
Journal Articles

Surovatamig (AZD0486), a CD19xCD3 T-cell engager (TCE), demonstrates high rate of minimal residual disease (MRD)–Negative complete responses in Relapsed/Refractory (R/R) diffuse large B-cell lymphoma (DLBCL), including in patients who previously progressed on CD20 TCE and CD19 CAR T-cell therapies

Free
Tae Min Kim, Jing-Zhou Hou, Sameh Gaballa, Ranjit Nair, Dai Maruyama, Koji Izutsu, Sumana Devata, Dok Hyun Yoon, Won-Seog Kim, Yazeed Sawalha, Ryan Jacobs, Eliza Hawkes, Ming-Chung Wang, Constantine Tam, Don Stevens, Hisayuki Yokoyama, Jin Seok Kim, Matthew Matasar, Aravind Ramakrishnan, Denise Brennan, David Sermer, Robin Lesley, Xu (Sue) Zhu, Mihail Obrocea, Seok-Goo Cho
Journal: Blood
Blood (2025) 146 (Supplement 1): 5514.
https://doi.org/10.1182/blood-2025-5514
Published: 2025
Journal Articles

SOUNDTRACK-B: A phase 2 single-arm study to evaluate the efficacy and safety of surovatamig (AZD0486) in relapsed or refractory B-cell non-Hodgkin lymphoma

Free
Chan Cheah, Monique Menzies Wojtowicz, Catherine Thieblemont, Martin Hutchings, Prof. Dr. Max S Topp, Won-Seog Kim, Dai Maruyama, Azadeh Shohoudi, Robin Lesley, Wendy Chang, Marlene Zuraek, Mihail Obrocea, Jing-Zhou Hou
Journal: Blood
Blood (2025) 146 (Supplement 1): 3747.
https://doi.org/10.1182/blood-2025-3747
Published: 2025
Journal Articles

Development of a High-Throughput Multiplex Immunofluorescence Pipeline in Classic Hodgkin Lymphoma Whole Slide Formalin-Fixed Paraffin-Embedded Tissue Samples

Free
Kenesha Riley-Burns, Michael Surace, Robin Lesley, Rachel Kositsky, Veerendra Munugalavadla, April Chiu, Daniel Auclair, Christine Palmer
Journal: Blood
Blood (2024) 144 (Supplement 1): 7517.
https://doi.org/10.1182/blood-2024-211077
Published: 2024
Journal Articles

High-Risk Subgroups and MRD: An Updated Analysis of the Phase 3 ECHO Trial of Acalabrutinib with Bendamustine/Rituximab in Previously Untreated Mantle Cell Lymphoma

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Martin Dreyling, Jiri Mayer, David Belada, Yuqin Song, Wojciech Jurczak, Jonas Paludo, Michael P. Chu, Iryna Kryachok, Laura Maria Fogliatto, Chan Y. Cheah, Marta Morawska, Juan-Manuel Sancho, Yufu Li, Caterina Patti, Cecily Forsyth, Jingyang Zhang, Robin Lesley, Safaa Ramadan, Simon Rule, Michael Wang
Journal: Blood
Blood (2024) 144 (Supplement 1): 1626.
https://doi.org/10.1182/blood-2024-200290
Published: 2024
Journal Articles

Exposure-Response Analysis and Quantitative Systems Pharmacology Modeling for Optimal RP2D Selection of AZD0486 in Follicular Lymphoma Patients

Free
Xu (Sue) Zhu, Damilola Olabode, Massimo Lai, Cesar Pichardo-Almarza, Kevin Smart, Denise Brennan, David Sermer, Robin Lesley
Journal: Blood
Blood (2024) 144 (Supplement 1): 2794.
https://doi.org/10.1182/blood-2024-197995
Published: 2024
Journal Articles

Evaluation of AZD0486, a Novel CD19xCD3 T-Cell Engager, in Relapsed/Refractory Diffuse Large B-Cell Lymphoma in an Ongoing First-in-Human Phase 1 Study: High Complete Responses Seen in CAR-T-Naive and CAR-T-Exposed Patients

Free
Sameh Gaballa, Jing-Zhou Hou, Sumana Devata, Seok-Goo Cho, Ranjit Nair, Dok Hyun Yoon, Ryan Jacobs, Koji Izutsu, Don A. Stevens, Dai Maruyama, Constantine S. Tam, Yazeed Sawalha, Aravind Ramakrishnan, Matthew Matasar, Denise Brennan, Sue Zhu, Robin Lesley, Yasuhiro Oki, David Sermer, Tae Min Kim
Journal: Blood
Blood (2024) 144 (Supplement 1): 868.
https://doi.org/10.1182/blood-2024-193681
Published: 2024
Journal Articles

Escalating Doses of AZD0486, a Novel CD19xCD3 T-Cell Engager, Result in High Complete Remissions with Rapid Clearance of Minimal Residual Disease in Patients with Relapsed/Refractory Follicular Lymphoma

Free
Jing-Zhou Hou, Ranjit Nair, Ryan Jacobs, Tae Min Kim, Seok-Goo Cho, Dai Maruyama, Sumana Devata, Yazeed Sawalha, Dok Hyun Yoon, Constantine S. Tam, Koji Izutsu, Matthew Matasar, Don A. Stevens, Aravind Ramakrishnan, Denise Brennan, Xu Zhu, Robin Lesley, Yasuhiro Oki, David Sermer, Sameh Gaballa
Journal: Blood
Blood (2024) 144 (Supplement 1): 341.
https://doi.org/10.1182/blood-2024-193589
Published: 2024
Journal Articles

Safety and Preliminary Efficacy of Sabestomig (AZD7789), an Anti-PD-1 and Anti-TIM-3 Bispecific Antibody, in Patients with Relapsed or Refractory Classical Hodgkin Lymphoma Previously Treated with Anti-PD-(L)1 Therapy

Free
Matthew G. Mei, Gaetano Corazzelli, Frank Morschhauser, Elizabeth Phillips, Graham P. Collins, Hun Ju Lee, Steve M Ansell, Craig H. Moskowitz, Nathalie A. Johnson, John Kuruvilla, Martin Hutchings, María José Terol Castera, George Hawkins, Anna Vossenkaemper, Teresa Collins, Robin Lesley, Emma Dean, Ting Yu, Connor Hall, Virginie Cerec, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 4433.
https://doi.org/10.1182/blood-2023-180926
Published: 2023
Journal Articles

Double Step-up Dosing (2SUD) Regimen Mitigates Severe Icans and CRS While Maintaining High Efficacy in Subjects with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (NHL) Treated with AZD0486, a Novel CD19xCD3 T-Cell Engager (TCE): Updated Safety and Efficacy Data from the Ongoing First-in-Human (FIH) Phase 1 Trial

Free
Sameh Gaballa, Ranjit Nair, Ryan W Jacobs, Sumana Devata, Seok-Goo Cho, Don A. Stevens, Dok Hyun Yoon, Nirav N. Shah, Denise Brennan, Jason Law, Robert Chen, David Sermer, Robin Lesley, Ben Buelow, Alessandra Forcina, Jing-Zhou Hou
Journal: Blood
Blood (2023) 142 (Supplement 1): 1662.
https://doi.org/10.1182/blood-2023-174668
Published: 2023
Journal Articles

A Phase 1 First in Human (FIH) Study of AMG 701, an Anti-B-Cell Maturation Antigen (BCMA) Half-Life Extended (HLE) BiTE ® (bispecific T-cell engager) Molecule, in Relapsed/Refractory (RR) Multiple Myeloma (MM)

Free
Simon J Harrison, MBBS MRCP (UK) PhDFRCPath (UK) FRACP, Monique C. Minnema, MD PhD, Hans C. Lee, MD, Andrew Spencer, MBBS, FRACP, FRCPA, DM, Prashant Kapoor, MD, Deepu Madduri, MD, Jeremy Larsen, Sikander Ailawadhi, Jonathan L. Kaufman, MD, Marc S. Raab, MD, Parameswaran Hari, MD MRCP, Shinsuke Iida, MD PhD, Ravi Vij, MBBS, Faith E. Davies, Robin Lesley, PhD, Vijay V. Upreti, PhD, Zhao Yang, PhD, Anjali Sharma, MD, Alex Minella, MD, Suzanne Lentzsch, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-134063
Published: 2020
Journal Articles

Peripheral Blood As a Substitute for Bone Marrow for Assessing the Immune Profile in AML

Free
Robin Lesley, PhD, Karl Beutner, Abraham A Anderson, Dan Fitzpatrick, Robert Loberg, Bhakti Mehta, Cedric E. Dos Santos
Journal: Blood
Blood (2017) 130 (Supplement 1): 3924.
https://doi.org/10.1182/blood.V130.Suppl_1.3924.3924
Published: 2017