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Journal Articles

Results from the Phase 1 Portion of a Trial of Oral Ixazomib Combined with Chemotherapy in Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoma in Children, Adolescents and Young Adults: A Report from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium

Eric S. Schafer, Yueh-Yun Chi, Jemily Malvar, Teresa Rushing, Andrew Doan, Holly L. Pacenta, Reuven J. Schore, Richard Sposto, Roy Leong, Paul S. Gaynon, Jeffrey E. Rubnitz, Julio C. Barredo, Tamra Slone, Melinda Pauly, Alan S. Wayne, Deepa Bhojwani, Terzah M. Horton

Blood (2023) 142 (Supplement 1): 2872.

https://doi.org/10.1182/blood-2023-180414

Published: 2023

Journal Articles

Stress-Induced AMPK Interactome Analysis Reveals Novel Protein-Protein Interactions Associated with Chromatin Remodeling and Transcription Machinery in Acute Lymphoblastic Leukemia

Ana Shvab, Guy J. Leclerc, Julio C. Barredo

Blood (2023) 142 (Supplement 1): 5732.

https://doi.org/10.1182/blood-2023-178095

Published: 2023

Journal Articles

AMPK Downregulates Histone Gene Expression Via Dissociation of a Chromatin-Associated Transcription Complex in Response to Metabolic Stress in Acute Lymphoblastic Leukemia

Guy Jacques LeClerc, Helena Gomes Dos Santos, Guangyan Sun, Ramin Shiekhattar, Julio C Barredo

Blood (2022) 140 (Supplement 1): 8770–8771.

https://doi.org/10.1182/blood-2022-167271

Published: 2022

Journal Articles

AMPK Reprograms Gene Expression and Promotes Adaptation/Survival in Response to Metabolic Stress through Binding to a Chromatin-Associated Transcription Complex in Acute Lymphoblastic Leukemia

Guangyan Sun, Guy Jacques Leclerc, Anna Shvab, Julio C Barredo

Blood (2021) 138 (Supplement 1): 3299.

https://doi.org/10.1182/blood-2021-151145

Published: 2021

Journal Articles

A Single Institution Experience of Bortezomib for Gvhd in a Pediatric HSCT Population

Devangi Shah, Jennifer Reichbach Douglas, DNP, APRN, CPHON, Jumana Ashy, Gregory Suhrheinrich, Edward Dela Ziga, MD, Asha B. Pillai, MD, Julio C Barredo, MD, Warren Alperstein, MD

Blood (2019) 134 (Supplement_1): 5680.

https://doi.org/10.1182/blood-2019-125884

Published: 2019

Journal Articles

Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress

Guangyan C Sun, PhD, Anna C Shvab, Bin C Li, PhD, Felipe C Beckedorff, Guy Jacques Leclerc, PhD, Ramin Shiekhattar, PhD, Julio C Barredo, MD

Blood (2018) 132 (Supplement 1): 1321.

https://doi.org/10.1182/blood-2018-99-112678

Published: 2018

Journal Articles

The NEDD8 Activating Enzyme Inhibitor Pevonedistat Induces ER Stress/UPR-Mediated Cell Death and Rebalances Homeostasis of Pro- and Anti-Apoptotic Proteins in Favor of Cell Death in Acute Lymphoblastic Leukemia Cells

Gilles M. Leclerc, PhD, Shuhua Zheng, BS, Guy J. Leclerc, PhD, Joanna DeSalvo, BSc, Ronan T. Swords, MDPhDFRCPI FRCPath, Julio C. Barredo, MD

Blood (2015) 126 (23): 1327.

https://doi.org/10.1182/blood.V126.23.1327.1327

Published: 2015

Journal Articles

BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression

Guy J. Leclerc, PhD, Joanna DeSalvo, B.Sc., Gilles M. Leclerc, PhD, Theodore J. Lampidis, PhD, Julio C. Barredo, MD

Blood (2014) 124 (21): 916.

https://doi.org/10.1182/blood.V124.21.916.916

Published: 2014

Journal Articles

A Phase I Dose Finding Study of Panobinostat in Children with Hematologic Malignancies: Initial Report of TACL Study T2009-012 in Children with Acute Leukemia

Blood (2014) 124 (21): 3705.

https://doi.org/10.1182/blood.V124.21.3705.3705

Published: 2014

Journal Articles

The NEDD8 Conjugation Pathway Inhibitor MLN4924 Activates AMPK and Induces The ER Stress/UPR-Mediated Cell Death Pathway In Acute Lymphoblastic Leukemia

Gilles M. Leclerc, Ph.D., Shuhua Zheng, B.Sc., Ronan T. Swords, MD, PhD, FRCPI, FRCPath, Guy J. Leclerc, Ph.D., Julio C. Barredo, M.D.

Blood (2013) 122 (21): 1285.

https://doi.org/10.1182/blood.V122.21.1285.1285

Published: 2013

Journal Articles

The BCR-ABL Fusion Protein Sensitizes Acute Lymphoblastic Leukemia to Apoptotic Death Induced by the Dual Glycolytic and Glycosylation Inhibitor 2-Deoxy-D-Glucose.

Guy J Leclerc, Ph.D., Jianfeng Du, Ph.D., Joanna DeSalvo, B.Sc., Gilles M. Leclerc, Ph.D., Julio C. Barredo, M.D.

Blood (2012) 120 (21): 2439.

https://doi.org/10.1182/blood.V120.21.2439.2439

Published: 2012

Journal Articles

PIM2 Upregulation Leads to Physiological Buffering of Metformin-Induced Cell Death Mediated by ER Stress/UPR in Acute Lymphoblastic Leukemia,

Gilles M. Leclerc, Ph.D., Guy J. Leclerc, Ph.D., Jeffim N. Kuznetsov, B.Sc., Julio C. Barredo, M.D.

Blood (2011) 118 (21): 3496.

https://doi.org/10.1182/blood.V118.21.3496.3496

Published: 2011

Journal Articles

Inhibition of Akt Increases the Sensitivity of Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG)

Jianfeng Du, Ph.D., Joanna DeSalvo, B.Sc., Antti Muranen, B.Sc., Carlos T. Moraes, Ph.D., Julio C. Barredo, M.D.

Blood (2010) 116 (21): 3254.

https://doi.org/10.1182/blood.V116.21.3254.3254

Published: 2010

Journal Articles

Mechanisms of Sensitivity of B-Precursor, T-Lineage and BCR/ABL Positive Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG).

Jianfeng Du, Ph.D., Joanna DeSalvo, Julio C Barredo, M.D.

Blood (2009) 114 (22): 3081.

https://doi.org/10.1182/blood.V114.22.3081.3081

Published: 2009

Journal Articles

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury

Blood (2009) 114 (21): 4632–4638.

https://doi.org/10.1182/blood-2009-02-203323

Published: 2009

Journal Articles

Histone Deacetylase Inhibitors Induce FPGS mRNA Expression and Intracellular Accumulation of Long-Chain Methotrexate Polyglutamates in Childhood Acute Lymphoblastic Leukemia: Implications for Combination Therapy

Guy J Leclerc, Ph.D., Caihong Mou, M.D., Gilles M Leclerc, Ph.D., Abdul M Mian, Ph.D., Julio C Barredo, M.D.

Blood (2008) 112 (11): 2923.

https://doi.org/10.1182/blood.V112.11.2923.2923

Published: 2008

Journal Articles

Histone Deacetylase Inhibitor Induces FPGS mRNA Expression in Childhood B-Precursor and T Acute Lymphoblastic Leukemia: Implication of Combination Therapy with Methotrexate To Enhance Cytotoxicity.

Guy J. Leclerc, PhD, Julio C. Barredo, M.D.

Blood (2007) 110 (11): 864.

https://doi.org/10.1182/blood.V110.11.864.864

Published: 2007

Journal Articles

Outcomes after HLA-Matched Sibling Transplants or Chemotherapy in Children with Acute Lymphoblastic Leukemia in a Second Remission after an Isolated Central Nervous System Relapse.

Mary Eapen, MBBS, Mei-Jie Zhang, PhD, Elizabeth Raetz, MD, Meenakshi Devidas, PhD, William L. Carroll, MD, Arthur K. Ritchey, MD, Julio C. Barredo, MD, Kamar Godder, MD, Stephan A. Grupp, MD, Victor A. Lewis, MD, Stella Davies, MBBS, Bruce Camitta, MD

Blood (2006) 108 (11): 49.

https://doi.org/10.1182/blood.V108.11.49.49

Published: 2006

Journal Articles

Serum Ferritin in Children with Sickle Cell Disease on Chronic Transfusion: Measure of Iron Overload or End Organ Injury? STOP/STOP II Liver Iron Ancillary Study.

Tom Adamkiewicz, MD, Miguel R. Abboud, MD, Julio C. Barredo, MD, Melanie Kirby-Allen, MD, Ofelia A. Alvarez, MD, James F. Casella, MD, Rathi V. Iyer, MD, Virgil McKie, MD, Gerald Milton Woods, MD, Abdullah Kutlar, MD, Carole Paley, MD, Jessica Peterson, Elizabeth Rackoff, Manuela Merelles-Pulcini, Elizabeth Dackiw, Kristin Stegenga, Nadine Odo, Mimi Lou, Robert J. Adams, MD

Blood (2006) 108 (11): 791.

https://doi.org/10.1182/blood.V108.11.791.791

Published: 2006

Journal Articles

Pharmacokinetics of Hydroxyurea in Young Children with Sickle Cell Anemia: A Report from the BABY HUG Trial.

Zora R. Rogers, MD, Bruce Thompson, PhD, Russell E. Ware, MD, PhD, Winfred C. Wang, MD, Rathi V. Iyer, MD, Scott T. Miller, MD, Caterina Minniti, MD, Sohail Rana, MD, Julio C. Barredo, MD, Stuart Toledano, MD, Sherri A. Zimmerman, MD, James F. Casella, MD, Beatrice A. Files, MD, Myron A. Waclawiw, PhD, A. Russell Gerber, MD, Duane R. Bonds, MD

Blood (2005) 106 (11): 3184.

https://doi.org/10.1182/blood.V106.11.3184.3184

Published: 2005

NARROW

Results from the Phase 1 Portion of a Trial of Oral Ixazomib Combined with Chemotherapy in Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoma in Children, Adolescents and Young Adults: A Report from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium

Stress-Induced AMPK Interactome Analysis Reveals Novel Protein-Protein Interactions Associated with Chromatin Remodeling and Transcription Machinery in Acute Lymphoblastic Leukemia

AMPK Downregulates Histone Gene Expression Via Dissociation of a Chromatin-Associated Transcription Complex in Response to Metabolic Stress in Acute Lymphoblastic Leukemia

AMPK Reprograms Gene Expression and Promotes Adaptation/Survival in Response to Metabolic Stress through Binding to a Chromatin-Associated Transcription Complex in Acute Lymphoblastic Leukemia

A Single Institution Experience of Bortezomib for Gvhd in a Pediatric HSCT Population

Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress

The NEDD8 Activating Enzyme Inhibitor Pevonedistat Induces ER Stress/UPR-Mediated Cell Death and Rebalances Homeostasis of Pro- and Anti-Apoptotic Proteins in Favor of Cell Death in Acute Lymphoblastic Leukemia Cells

BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression

A Phase I Dose Finding Study of Panobinostat in Children with Hematologic Malignancies: Initial Report of TACL Study T2009-012 in Children with Acute Leukemia

The NEDD8 Conjugation Pathway Inhibitor MLN4924 Activates AMPK and Induces The ER Stress/UPR-Mediated Cell Death Pathway In Acute Lymphoblastic Leukemia

The BCR-ABL Fusion Protein Sensitizes Acute Lymphoblastic Leukemia to Apoptotic Death Induced by the Dual Glycolytic and Glycosylation Inhibitor 2-Deoxy-D-Glucose.

PIM2 Upregulation Leads to Physiological Buffering of Metformin-Induced Cell Death Mediated by ER Stress/UPR in Acute Lymphoblastic Leukemia,

Inhibition of Akt Increases the Sensitivity of Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG)

Mechanisms of Sensitivity of B-Precursor, T-Lineage and BCR/ABL Positive Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG).

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury

Histone Deacetylase Inhibitors Induce FPGS mRNA Expression and Intracellular Accumulation of Long-Chain Methotrexate Polyglutamates in Childhood Acute Lymphoblastic Leukemia: Implications for Combination Therapy

Histone Deacetylase Inhibitor Induces FPGS mRNA Expression in Childhood B-Precursor and T Acute Lymphoblastic Leukemia: Implication of Combination Therapy with Methotrexate To Enhance Cytotoxicity.

Outcomes after HLA-Matched Sibling Transplants or Chemotherapy in Children with Acute Lymphoblastic Leukemia in a Second Remission after an Isolated Central Nervous System Relapse.

Serum Ferritin in Children with Sickle Cell Disease on Chronic Transfusion: Measure of Iron Overload or End Organ Injury? STOP/STOP II Liver Iron Ancillary Study.

Pharmacokinetics of Hydroxyurea in Young Children with Sickle Cell Anemia: A Report from the BABY HUG Trial.

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American Society of Hematology

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American Society of Hematology

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