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Journal Articles

CCR5 blockade: A therapeutic approach to uncouple CART-BCMA expansion from CART-mediated immune toxicities.

Free
Luca Paruzzo, Matthew Ho, Julia Han Noll, Federico Stella, Ivan Cohen, Angel Ramirez-Fernandez, Adam Waxman, Shivani Kapur, Fang Chen, Andrew Huff, Danuta Jarocha, Owen Koucky, Caitlin Hopkins, Alex Dimitri, Maya Lavorando, Dan Vogl, John Scholler, Aoife Doto, John Everett, Frederic Bushman, Katherine Nathanson, Patrizia Porazzi, Edward Stadtmauer, Sandra Susanibar-Adaniya, Alfred Garfall, Adam Cohen, Joseph Fraietta, Marco Ruella
Journal: Blood
Blood (2025) 146 (Supplement 1): 5945.
https://doi.org/10.1182/blood-2025-5945
Published: 2025
Journal Articles

Delayed neurotoxicity, enterocolitis, and BCMA-CART-associated immune-related adverse events (CirAE)  are caused by CD4+ CAR T-cells

Free
Julia Han Noll, Matthew Ho, Luca Paruzzo, Federico Stella, Pooja Devi, Sonia Ndeupen, Gregory Chen, Ivan Cohen, Angel Ramirez-Fernandez, Adam Waxman, Shivani Kapur, Fang Chen, Rong Xu, Andrew Huff, Danuta Jarocha, Vrutti Patel, Audrey Bochi-Layec, Ranjani Ramasubramanian, Shan Liu, Riemke Bouvier, Vitor Souza, Heta Patel, Ziyu Li, Alberto Carturan, Peter Michener, Caitlin Hopkins, Owen Koucky, Janna Minehart, Alex Dimitri, Neel Nabar, Zainul Hasanali, Bryan Ciccarelli, Erik Williams, Robert Bartoszek, Maya Lavorando, Suyash Mohan, Vanessa Gonzalez, Patrizia Porazzi, Vijay Bhoj, Sokratis Apostolidis, Dan Vogl, David Porter, John Scholler, Caroline Diorio, Aoife Doto, John Everett, Frederic Bushman, Katherine Nathanson, Edward Stadtmauer, Sandra Susanibar-Adaniya, Alfred Garfall, Marco Ruella, Adam Cohen, Joseph Fraietta
Journal: Blood
Blood (2025) 146 (Supplement 1): 804.
https://doi.org/10.1182/blood-2025-804
Published: 2025
Journal Articles

Loss of endothelial mir-126 drives age-related reduction of hematopoietic activity

Free
Dandan Zhao, Le Xuan Truong Nguyen, Xubo Gong, Fang Chen, Min-Hsuan Chen, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2025) 146 (Supplement 1): 1392.
https://doi.org/10.1182/blood-2025-1392
Published: 2025
Journal Articles

Microrna-142 improves IL1RAP CAR-T cell activity in Acute Myeloid Leukemia

Free
Kaito Harada, Dandan Zhao, Miso Park, Fang Chen, Yongfang Xu, Yi Zhang, Yile Zhou, Bea Parcutela, Yead Jewel, Ashlie Munoz, Idoroenyi Amanam, Le Xuan Truong Nguyen, Jianjun Chen, Lucy Ghoda, Stephen Forman, John Williams, Bin Zhang, Guido Marcucci
Journal: Blood
Blood (2025) 146 (Supplement 1): 2340.
https://doi.org/10.1182/blood-2025-2340
Published: 2025
Journal Articles

Acquired microRNA (miR)-142 Deficit Drives Immune Escape in Acute Myeloid Leukemia (AML)

Free
Fang Chen, Dandan Zhao, Yongfang Xu, Huafeng Wang, Shawn Sharkas, Le Xuan Truong Nguyen, Lucy Y. Ghoda, Mark Boldin, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2024) 144 (Supplement 1): 2944.
https://doi.org/10.1182/blood-2024-210855
Published: 2024
Journal Articles

Deficit of microRNA (miR)-142 Promotes Transformation of Clonal Myeloid Disorder into Acute Myeloid Leukemia (AML)

Free
Yongfang Xu, Huafeng Wang, Fang Chen, Jihyun Irizarry, Shawn Sharkas, Dandan Zhao, Mark Boldin, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2024) 144 (Supplement 1): 348.
https://doi.org/10.1182/blood-2024-211467
Published: 2024
Journal Articles

IL1RAP-Specific T Cell Engager (TCE) Antibody Efficiently Depletes Acute Myeloid Leukemia (AML) Leukemic Stem Cells (LSCs)

Free
Yi Zhang, Miso Park, Bin Zhang, Lucy Y. Ghoda, Dandan Zhao, Melissa Valerio, Ebtesam Nafie, Xubo Gong, Fang Chen, Yongfang Xu, Katrina Estrella, Kaito Harada, Shawn Sharkas, Hyunjun Kang, Dinh Hoa Hoang, Le Xuan Truong Nguyen, Stephen J. Forman, Idoroenyi Amanam, Flavia Pichiorri, Jie Jin, John C. Williams, Guido Marcucci
Journal: Blood
Blood (2023) 142 (Supplement 1): 586.
https://doi.org/10.1182/blood-2023-185405
Published: 2023
Journal Articles

Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)

Free
Fang Chen, Dandan Zhao, Yi Zhang, Yongfang Xu, Min-Hsuan Chen, Khyatiben V. Pathak, Yong Liang, Wei-Le Wang, Katrina Estrella, Xiwei Wu, Lucy Y. Ghoda, Ya-Huei Kuo, Haris Ali, Jianhua Yu, Michael A Caligiuri, Mark Boldin, Piotr Swiderski, Marcin Kortylewski, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 3152.
https://doi.org/10.1182/blood-2023-182587
Published: 2023
Journal Articles

Synergistic Activity of Adefovir Dipivoxil and Venetoclax to Target the Bioenergetic Metabolism of Acute Myeloid Leukemia

Free
Xubo Gong, Yi Zhang, Ying-Chieh Chen, Dandan Zhao, Yongfang Xu, Xin He, Fang Chen, Lei Zhang, Lianjun Zhang, Katrina Estrella, Melissa Valerio, Lucy Y. Ghoda, Le Xuan Truong Nguyen, Ya-Huei Kuo, Weiwei Liu, Zhihua Tao, Guido Marcucci, Bin Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4161.
https://doi.org/10.1182/blood-2023-187183
Published: 2023
Journal Articles

In Vivo Antileukemic Activity of Ost-01 in Acute Myeloid Leukemia (AML): A Novel Natural Product (NP) from Baccharis Coridifolia

Free
Hyunjun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben V. Pathak, Lianjun Zhang, Ralf Buettner, Fang Chen, Katrina Estrella, William Graff, Ya-Huei Kuo, Bin Zhang, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci
Journal: Blood
Blood (2023) 142 (Supplement 1): 1565.
https://doi.org/10.1182/blood-2023-187736
Published: 2023
Journal Articles

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

Free
Lianjun Zhang, Dinh Hoa Hoang, Hyunjun Kang, Ying-Chieh Chen, Yu-Hsuan Fu, Khyatiben V. Pathak, Melissa Valerio, Fang Chen, Katrina Estrella, Ralf Buettner, Bin Zhang, Patrick Pirrotte, Guido Marcucci, Ya-Huei Kuo, Le Xuan Truong Nguyen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2953.
https://doi.org/10.1182/blood-2023-186936
Published: 2023
Journal Articles

STI-8591, a Novel Tyrosine Kinase Inhibitor, Shows Excellent Antileukemic Activity in FLT3 -Mutated (mut) Acute Myeloid Leukemia (AML)

Free
Yi Zhang, Wenwen Wei, Bin Zhang, Jie Sun, Dandan Zhao, Fang Chen, Yongfang Xu, Yu Qian, Yanchun Zhao, Yutong Zhou, Wanhong Xu, Xiaoying Zhang, Long Mao, Guido Marcucci, Xiao Xu, Jie Jin
Journal: Blood
Blood (2023) 142 (Supplement 1): 5010.
https://doi.org/10.1182/blood-2023-174745
Published: 2023
Journal Articles

Homoharringtonine Synergizes Strongly with Venetoclax Against the Early T-Cell Progenitor Acute Lymphoblastic Leukemia：from Bench to Bed

Free
Shanshan Suo, Shu SUN, Jiejing Qian, Dandan Zhao, Wenjuan Yu, Yinjun Lou, Honghu Zhu, Hongyan Tong, Min Yang, Xin Huang, Shuqi Zhao, Junjing Qiao, Chen Liang, Fenglin Li, Huafeng Wang, Yi Zhang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Jie Sun, Ivan Rodriguez, Lucy Ghoda, Ling Li, Bin Zhang, Guido Marcucci, Jie Jin
Journal: Blood
Blood (2022) 140 (Supplement 1): 2263–2264.
https://doi.org/10.1182/blood-2022-170604
Published: 2022
Journal Articles

Homoharringtonine Exhibits Anti-Tumor Effect in T-Cell Acute Lymphoblastic Leukemia By Targeting Notch1/Myc Pathway

Free
Shanshan Suo, Dandan Zhao, Fenglin Li, Sonia Rodriguez, Junjing Qiao, Chen Liang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Nadia Carlesso, Bin Zhang, Guido Marcucci, Jie Jin
Journal: Blood
Blood (2022) 140 (Supplement 1): 362–363.
https://doi.org/10.1182/blood-2022-169679
Published: 2022
Journal Articles

Comprehensive Secretome Profiling Elucidates Novel Disease Biology and Identifies Pre-Infusion Candidate Biomarkers to Predict the Development of Severe Cytokine Release Syndrome in Pediatric Patients Receiving CART19

Free
Caroline Diorio, Rawan Shraim, Regina M. Myers, Chakkapong Burudpakdee, Allison Barz Leahy, Richard Aplenc, Michele P. Lambert, Hamid Bassiri, Edward M Behrens, Vanessa E. Gonzalez, Fang Chen, Bruce L Levine, Shannon L. Maude, Amanda M. DiNofia, Alix E. Seif, J. Joseph Melenhorst, Simon F Lacey, Carl H June, David Barrett, Stephan A. Grupp, David T. Teachey
Journal: Blood
Blood (2021) 138 (Supplement 1): 167.
https://doi.org/10.1182/blood-2021-149477
Published: 2021
Journal Articles

Acute Myeloid Leukemia Cell-Intrinsic PD-1 Functions Promoting Leukemia Development By Recruiting SHP2

Free
Shanshan Suo, Le Xuan Truong Nguyen, Fenglin Li, Dandan Zhao, Junjing Qiao, Chen Liang, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Bin Amber Zhang, Jie Jin, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 1173.
https://doi.org/10.1182/blood-2021-154467
Published: 2021
Journal Articles

Bleeding in Mild Hemophilia A Due to a Splice-Site F8 Mutation May be Fully Abrogated By Prothrombotic Gene Variants

Free
Peter H. Cygan, MD, Sarah E. Arnold-Croop, MS, Elizabeth A. Weidman, BS, Fang Chen, PhD, Dajiang J. Liu, PhD, M. Elaine Eyster, MD, Laura Carrel, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1125.
https://doi.org/10.1182/blood-2019-126026
Published: 2019
Journal Articles

On-Line Patient Portal Use By Caregivers in Pediatric Oncology: Are We Widening Sociodemographic Disparities?

Free
Corinna L Schultz, MD, Suzanne M McCahan, PhD, H. Timothy Bunnell, PhD, Fang Fang Chen, PhD, Melissa A Alderfer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2131.
https://doi.org/10.1182/blood-2019-131543
Published: 2019
Journal Articles

SRC-3 is involved in maintaining hematopoietic stem cell quiescence by regulation of mitochondrial metabolism in mice

Free
Mengjia Hu, Hao Zeng, Shilei Chen, Yang Xu, Song Wang, Yong Tang, Xinmiao Wang, Changhong Du, Mingqiang Shen, Fang Chen, Mo Chen, Cheng Wang, Jining Gao, Fengchao Wang, Yongping Su, Junping Wang
Journal: Blood
Blood (2018) 132 (9): 911–923.
https://doi.org/10.1182/blood-2018-02-831669
Published: 2018
Includes: Supplemental data
Journal Articles

IGF-1 facilitates thrombopoiesis primarily through Akt activation

Free
Shilei Chen, Mengjia Hu, Mingqiang Shen, Song Wang, Cheng Wang, Fang Chen, Yong Tang, Xinmiao Wang, Hao Zeng, Mo Chen, Jining Gao, Fengchao Wang, Yongping Su, Yang Xu, Junping Wang
Journal: Blood
Blood (2018) 132 (2): 210–222.
https://doi.org/10.1182/blood-2018-01-825927
Published: 2018
Includes: Supplemental data