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Journal Articles

A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-γ–induced CD38 expression

Mariam Murtadha, Miso Park, Yinghui Zhu, Enrico Caserta, Ottavio Napolitano, Theophilus Tandoh, Milad Moloudizargari, Alex Pozhitkov, Mahmoud Singer, Ada Alice Dona, Hawa Vahed, Asaul Gonzalez, Kevin Ly, Ching Ouyang, James F. Sanchez, Lokesh Nigam, Amanda Duplan, Arnab Chowdhury, Lucy Ghoda, Ling Li, Bin Zhang, Amrita Krishnan, Guido Marcucci, John C. Williams, Flavia Pichiorri
Journal: Blood
Blood (2024) 143 (16): 1599–1615.
https://doi.org/10.1182/blood.2023021570
Published: 2024
Includes: Supplemental data
Journal Articles

CD19/BCMA Dual-Targeting Fastcar-T GC012F for Patients with Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma: An Update

Xinfeng Chen, Yu Ping, Ling Li, Lei Zhang, Xudong Zhang, Jianmin Huang, Jia Liu, Gui Li, Huan Shi, Jiaping He, Yi Liang, Lihong Weng, Wenjie Yin, Lianjun Shen, Wei William Cao, Wenling Li, Mingzhi Zhang, Yi Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 6847.
https://doi.org/10.1182/blood-2023-185476
Published: 2023
Journal Articles

GB261, an Fc-Function Enabled and CD3 Affinity De-Tuned CD20/CD3 Bispecific Antibody, Demonstrated a Highly Advantageous Safety/Efficacy Balance in an Ongoing First-in-Human Dose-Escalation Study in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma

Yuqin Song, Zengjun Li, Ling Li, Zhengzi Qian, Keshu Zhou, Lei Fan, Peter Tan, Pratyush Giri, Zhiming Li, Melita Kenealy, Jie Jin, Wei Liu, Shafqat Inam, Yan Xie, Xia Guo, Wenduo He, Raymond Xu, Tong Li, Jun Zhu
Journal: Blood
Blood (2023) 142 (Supplement 1): 1719.
https://doi.org/10.1182/blood-2023-188444
Published: 2023
Journal Articles

CD38-Directed, Single-Chain T Cell-Engager Targets Leukemia Stem Cells through IFNγ-Induced CD38 Expression

Mariam Murtadha, Miso Park, Yinghui Zhu, Enrico Caserta, Ottavio Napolitano, Theophilus Tandoh, Milad Moloudizargari, Alexander Pozhitkov, Mahmoud Singer, Ada Alice Dona, Hawa Vahed, Asaul Gonzalez, Kevin Ly, Ching Ouyang, James Sanchez, Lokesh Nigam, Arnab Chowdhury, Lucy Y. Ghoda, Ling Li, Bin Zhang, Amrita Krishnan, Guido Marcucci, John C. Williams, Flavia Pichiorri
Journal: Blood
Blood (2023) 142 (Supplement 1): 2797.
https://doi.org/10.1182/blood-2023-189901
Published: 2023
Journal Articles

Venetoclax Combined with Daunorubicin and Cytarabine (2 + 6) in Acute Myeloid Leukemia: Updated Results of a Phase II Trial

Xiaohui Suo, Dongmei Wang, Fang Zheng, Suping Zhang, Congcong Zhang, Yinling Li, Rui Shi, Yan Wu, Sisi Yang, Liyun Zhao, Zongjiu Jiao, Jie Liu, Ling Zhang, Ling Li, Zhihua Zhang, Xinxiao Lu, Linyu Yuan, Sifeng Gao, Jilei Zhang, Xingli Zhao, Guanchen Bai, Yingchang Mi, Kaiqi Liu
Journal: Blood
Blood (2023) 142 (Supplement 1): 969.
https://doi.org/10.1182/blood-2023-179205
Published: 2023
Journal Articles

Efficacy and Safety of Chemotherapy (DDGP vs VIPD) Followed Radiotherapy Vs Radiotherapy Followed Chemotherapy (DDGP vs VIPD) Vs Radiotherapy Alone for Newly Diagnosed Early Stage Extranodal Natural Killer/T Cell Lymphoma: Final Results of a Prospective, Multicenter, Randomized, Controlled Clinical Trial

Mingzhi Zhang, Lei Zhang, Xin Li, Ling Li, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Yu Chang, Xudong Zhang, Hui Yu, Feifei Nan, Zhiyuan Zhou, Xiyang Liu, Xiaolong Wu, Liqun Zou, Hui Zhou, Hongwei Xue
Journal: Blood
Blood (2023) 142 (Supplement 1): 1690.
https://doi.org/10.1182/blood-2023-188245
Published: 2023
Journal Articles

Targeting ADSS2 Enhances BH3 Mimetics Treatment Induced Mitochondrial Apoptosis in AML Cells

Xin He, Lei Zhang, Yang Li, Haojie Dong, Lianjun Zhang, Daisuke Nakada, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 577.
https://doi.org/10.1182/blood-2023-186907
Published: 2023
Journal Articles

SAMHD1 Inhibitor Combined with Immune Checkpoint Inhibitor Elicits an Anti-AML Immunity

Lei Zhang, Haojie Dong, Xin He, Amandeep Salhotra, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 47.
https://doi.org/10.1182/blood-2023-182463
Published: 2023
Journal Articles

Baricitinib in Combination with High-Dose Dexamethasone As First-Line Treatment for Newly Diagnosed Immune Thrombocytopenia: A Prospective, Multicenter, Randomized Trial

Peng Zhao, Zhuoyu An, Haixia Fu, Daihong Liu, Liping Dou, Yi Liu, Hui Liu, Zhao Wang, Yujun Dong, Hongmei Jing, Hebing Zhou, Zhen-Ling Li, Lihong Li, Qiu-Sha Huang, Jin Wu, Yejun Wu, Chen-Cong Wang, Xiaolu Zhu, Qi Chen, Yun He, Kaiyan Liu, Xiaohui Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1207.
https://doi.org/10.1182/blood-2023-181622
Published: 2023
Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5700.
https://doi.org/10.1182/blood-2023-182215
Published: 2023
Journal Articles

Targeting PRMT9 Elicits Cgas-Mediated Anti-Leukemia Immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yichun Lin, Songbai Liu, Huafeng Wang, Wenfeng Huang, Sierra Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 4931–4933.
https://doi.org/10.1182/blood-2022-167366
Published: 2022
Journal Articles

Targeting SAMHD1 Promotes Anti-Tumor Immunity in Acute Myeloid Leukemia

Lei Zhang, Haojie Dong, Xin He, Yichun Lin, Weidong Hu, Amandeep Salhotra, Saro H. Armenian, Guido Marcucci, Yun Luo, Ling Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 679–680.
https://doi.org/10.1182/blood-2022-167653
Published: 2022
Journal Articles

Multicenter Pilot Clinical Trial of Enasidenib As Maintenance Therapy after Allogeneic Hematopoietic Cell Transplantation in Patients with Acute Myeloid Leukemia (AML) Carrying IDH2 Mutations

Amandeep Salhotra, Nelli Bejanyan, Dongyun Yang, Sally Mokhtari, Monzr M. Al Malki, Karamjeet S. Sandhu, Rawan Faramand, Ibrahim Aldoss, Andrew S. Artz, Ahmed Aribi, Hany Elmariah, Firoozeh Sahebi, Joshua Mansour, Brian J Ball, Vaibhav Agrawal, Ling Li, Vinod A. Pullarkat, Stephen J Forman, Guido Marcucci, Ryotaro Nakamura, Anthony S. Stein
Journal: Blood
Blood (2022) 140 (Supplement 1): 1890–1892.
https://doi.org/10.1182/blood-2022-169964
Published: 2022
Journal Articles

Homoharringtonine Exhibits Anti-Tumor Effect in T-Cell Acute Lymphoblastic Leukemia By Targeting Notch1/Myc Pathway

Shanshan Suo, Dandan Zhao, Fenglin Li, Sonia Rodriguez, Junjing Qiao, Chen Liang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Nadia Carlesso, Bin Zhang, Guido Marcucci, Jie Jin
Journal: Blood
Blood (2022) 140 (Supplement 1): 362–363.
https://doi.org/10.1182/blood-2022-169679
Published: 2022
Journal Articles

A Phase I/II Study of Orelabrutinib Combined with Anti-Programmed Cell Death Protein-1 Antibody and Fotemustine for Patients with Newly Diagnosed Primary Central Nervous System Lymphoma (PCNSL)

Xudong Zhang, Wenhua Wang, Shanshan Ma, Mengke Fan, Linan Zhu, Lei Zhang, Xin Li, Ling Li, Zhenchang Sun, Xinhua Wang, Xiaorui Fu, Zhaoming Li, Jiaqin Yan, Mingzhi Zhang
Journal: Blood
Blood (2022) 140 (Supplement 1): 12075–12076.
https://doi.org/10.1182/blood-2022-159383
Published: 2022
Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Yangchan Li, Xiaolan Deng, Lei Dong, Li Han, Le Xuan Truong Nguyen, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Meilin Xue, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C Mulloy, Bin Zhang, David A Horne, Steve T Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Rui Su, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 2975–2977.
https://doi.org/10.1182/blood-2022-162619
Published: 2022
Journal Articles

Homoharringtonine Synergizes Strongly with Venetoclax Against the Early T-Cell Progenitor Acute Lymphoblastic Leukemia：from Bench to Bed

Shanshan Suo, Shu SUN, Jiejing Qian, Dandan Zhao, Wenjuan Yu, Yinjun Lou, Honghu Zhu, Hongyan Tong, Min Yang, Xin Huang, Shuqi Zhao, Junjing Qiao, Chen Liang, Fenglin Li, Huafeng Wang, Yi Zhang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Jie Sun, Ivan Rodriguez, Lucy Ghoda, Ling Li, Bin Zhang, Guido Marcucci, Jie Jin
Journal: Blood
Blood (2022) 140 (Supplement 1): 2263–2264.
https://doi.org/10.1182/blood-2022-170604
Published: 2022
Journal Articles

HDAC8 Disrupts DNA Damage Response By Deacetylation of U2AF1 in Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, Le Xuan Truong Nguyen, Wei-Kai Hua, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Yu-Hsuan Fu, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 8692–8693.
https://doi.org/10.1182/blood-2022-160280
Published: 2022
Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V. Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J. Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B. Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Journal: Blood
Blood (2022) 139 (26): 3752–3770.
https://doi.org/10.1182/blood.2021015108
Published: 2022
Includes: Supplemental data
Journal Articles

Acute Myeloid Leukemia Cell-Intrinsic PD-1 Functions Promoting Leukemia Development By Recruiting SHP2

Shanshan Suo, Le Xuan Truong Nguyen, Fenglin Li, Dandan Zhao, Junjing Qiao, Chen Liang, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Bin Amber Zhang, Jie Jin, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 1173.
https://doi.org/10.1182/blood-2021-154467
Published: 2021