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Journal Articles

Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia

Free
Lili Ren, Honghai Zhang, Olga Bobileva, Francesco Nai, Hongjie Bi, Genevieve Baker, Lei Dong, David Guarin, Anthony Chan, Weidong Hu, Wei Li, Irena Leite, Xueer Wang, Xiaoxu Zhang, Meilin Xue, Haixia Wang, Hanjun Qin, Xiwei Wu, Lucy Ghoda, Lin Xu, Bin Zhang, Ling Li, Mark Wunderlich, James Mulloy, Courtney Jones, Seán O'Leary, Steven Rosen, Chun-Wei Chen, Nora Heisterkamp, J. Jefferson Perry, Yunsun Nam, Jianjun Chen, Xiaobo Li, Amedeo Caflisch, Rui Su
Journal: Blood
Blood (2025) 146 (Supplement 1): 2539.
https://doi.org/10.1182/blood-2025-2539
Published: 2025
Journal Articles

Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells and averts lupus nephritis

Free
Kory Hamane, Zunsong Hu, Joao Rodrigues Lima-Junior, Adeleh Taghi Khani, Anil Kumar, Ashly Sanchez Ortiz, Da Hae Jung, Hanjun Qin, Shu Tao, Ignacio Sanz, Eric Meffre, Katherine Marzan, Jean Koff, Zhaohui Gu, Xiwei Wu, Ameae Walker, Srividya Swaminathan
Journal: Blood
Blood (2025) 146 (Supplement 1): 3003.
https://doi.org/10.1182/blood-2025-3003
Published: 2025
Journal Articles

Tumor-induced dendritic cell dysfunction impairs T-cell proliferation and confers poor prognosis in high-risk acute lymphoblastic leukemia

Free
Anil Kumar, Kory Hamane, Caroline Duault, Joao Rodrigues Lima-Junior, Da Hae Jung, Hanjun Qin, Sheyla Salcido, Min Huang, Xinying Guo, Adeleh Taghi Khani, Ashly Sanchez Ortiz, Lucy Ghoda, Guido Marcucci, Norman Lacayo, Kathleen Sakamoto, Christian Hurtz, Martin Carroll, Sarah Tasian, Huimin Geng, Lingyun Ji, Saro Armenian, Shai Izraeli, Holden Maecker, Xiwei Wu, Srividya Swaminathan
Journal: Blood
Blood (2025) 146 (Supplement 1): 5138.
https://doi.org/10.1182/blood-2025-5138
Published: 2025
Journal Articles

DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

Free
Xueer Wang, Hongjie Bi, Wei Li, Lili Ren, Honghai Zhang, Lei Dong, Anthony Chan, Lu Yang, Xiaoxu Zhang, Meilin Xue, Hanjun Qin, Xiwei Wu, Johanna ten, Bin Zhang, Ling Li, Mark Wunderlich, James Mulloy, Steven Rosen, Jianjun Chen, Xiaobo Li, Chun-Wei Chen, Rui Su
Journal: Blood
Blood (2025) 146 (Supplement 1): 212.
https://doi.org/10.1182/blood-2025-212
Published: 2025
Journal Articles

Clonal Expansion and Differentiation of Stem-like Memory T Cells to Tissue-Resident Memory T Cells Perpetuates Pathogenesis of Chronic Graft-Versus-Host Disease

Free
Xiaohui Kong, Bixin Wang, Xiwei Wu, Hyejin Cho, Moqian Zheng, Yuankun Zhang, Shanshan Tang, Qinjian Li, Ubaydah Nasri, Alyssa Wu, Hanjun Qin, Raju Pillai, Ryotaro Nakamura, Paul J. Martin, Yuanzhong Chen, Defu Zeng
Journal: Blood
Blood (2023) 142 (Supplement 1): 2044.
https://doi.org/10.1182/blood-2023-174768
Published: 2023
Journal Articles

Trafficking between clonally related peripheral T-helper cells and tissue-resident T-helper cells in chronic GVHD

Free
Xiaohui Kong, Xiwei Wu, Bixin Wang, Deye Zeng, Kaniel Cassady, Ubaydah Nasri, Moqian Zheng, Alyssa Wu, Hanjun Qin, Weimin Tsai, Amandeep Salhotra, Ryotaro Nakamura, Paul J. Martin, Defu Zeng
Journal: Blood
Blood (2022) 140 (25): 2740–2753.
https://doi.org/10.1182/blood.2022016581
Published: 2022
Includes: Supplemental data
Journal Articles

Phosphorylation Stabilized TET1 Acts As an Oncoprotein and Therapeutic Target in B-Cell Acute Lymphoblastic Leukemia

Free
Zhenhua Chen, Keren Zhou, Jianhuang Xue, Andrew Small, Gang Xiao, Le Xuan Truong Nguyen, Zheng Zhang, Emily Prince, Hengyou Weng, Huilin Huang, Zhicong Zhao, Ying Qing, Chao Shen, Li Han, Brandon Tan, Wei Li, Rui Su, Hanjun Qin, Yangchan Li, Dong Wu, Zhaohui Gu, Vu N Ngo, Xin He, Jianfei Chao, Keith Leung, Kitty Wang, Lei Dong, Xi Qin, Zhenming Cai, Yue Sheng, Yu Chen, Xiwei Wu, Bin Zhang, Yanhong Shi, Guido Marcucci, Zhijian Qian, Mingjiang Xu, Markus Müschen, Xiaolan Deng, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 998–1000.
https://doi.org/10.1182/blood-2022-165469
Published: 2022
Journal Articles

Targeting Intestinal Epithelial Ceacam1 Expands Peripheral Tregs and Prevents Steroid-Refractory Acute Gut Graft-Versus-Host Disease

Free
Qingxiao Song, Moqian Zheng, Qinjian Li, Xiwei Wu, Hanjun Qin, Tae Hyuk Kang, Yaqun Hong, Bixin Wang, Maciej Kujawski, Jack Shively, Ryotaro Nakamura, Paul J Martin, Defu Zeng
Journal: Blood
Blood (2022) 140 (Supplement 1): 10225–10226.
https://doi.org/10.1182/blood-2022-163572
Published: 2022
Journal Articles

Blockade of the Immune Checkpoint CD47 By TTI-621 Potentiates the Response to Anti-PD-L1 in Cutaneous T Cell Lymphoma

Free
Zhen Han, Xiwei Wu, Yate-Ching Yuan, Hanjun Qin, Chingyu Su, Jasmine Zain, Oleg E Akilov, Steve T Rosen, Mingye Feng, Christiane Querfeld
Journal: Blood
Blood (2022) 140 (Supplement 1): 6376–6377.
https://doi.org/10.1182/blood-2022-167670
Published: 2022
Journal Articles

Genomic Analysis of Cutaneous CD30-Positive Lymphoproliferative Disorders

Free
Farah R Abdulla, Weiwei Zhang, Xiwei Wu, Kord Honda, Hanjun Qin, Hyejin Cho, Christiane Querfeld, Jasmine Zain, Steven T. Rosen, Wing C. Chan, Vishwas Parekh, Joo Y. Song
Journal: Blood
Blood (2021) 138 (Supplement 1): 4487.
https://doi.org/10.1182/blood-2021-152051
Published: 2021
Journal Articles

Tolerogenic anti–IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity

Free
Qingxiao Song, Xiaoning Wang, Xiwei Wu, Hanjun Qin, Yingfei Li, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Journal: Blood
Blood (2021) 137 (16): 2243–2255.
https://doi.org/10.1182/blood.2020006345
Published: 2021
Includes: Supplemental data
Journal Articles

Tnfα Promotes an Immunosuppressive Microenvironment in Cutaneous T Cell Lymphoma and Regulates PD-L1 Expression

Free
Emine Gulsen Gunes, PhD, Sung Hee Kil, PhD, Xiwei Wu, PhD, Chingyu Su, Zhen Han, Hanjun Qin, PhD, Ting-Fang He, PhD, Jing Chen, Yukiko Yamaguchi, PhD, Jasmine M. Zain, MD, Farah Abdulla, MD, Saul Priceman, PhD, Mingye Feng, PhD, Peter P. Lee, MD, Steven T. Rosen, MD, Christiane Querfeld, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-141070
Published: 2020
Journal Articles

Paired Single Cell RNA and TCR Sequencing Analysis Following PD-L1 Blockade in Cutaneous T-Cell Lymphoma

Free
Christiane Querfeld, MDPhD, Xiwei Wu, PhD, Hanjun Qin, PhD, Chingyu Su, Zhen Han, Steven T. Rosen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-139992
Published: 2020
Journal Articles

Tissue-Resident PSGL1 lo CD4 + T Cells Interact with B Cells Via PD-1 and PD-L2 in Gvhd Target Tissues to Augment Autoimmune-like Chronic Gvhd

Free
Xiaohui Kong, PhD, Deye Zeng, MD, Xiwei Wu, PhD, Shijie Yang, PhD, Bixin Wang, Qingxiao Song, MD PhD, Yongping Zhu, Martha Salas, Hanjun Qin, Ubaydah Nasri, Ryotaro Nakamura, MD, Paul J Martin, MD, Aimin Huang, Defu Zeng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5607.
https://doi.org/10.1182/blood-2019-126315
Published: 2019
Journal Articles

Stat3 -/- Alloreactive Donor T Cells Reduce FAO but Increase Leakage of ROS in Response to PD-1 Signaling Triggered By Host-Tissue PD-L1, Leading to Prevention of Gvhd While Preserving GVL Effect

Free
Xiaoqi Wang, MD, Shijie Yang, PhD, Yating Wang, PhD, Xiwei Wu, PhD, Martha Salas, Qingxiao Song, MD PhD, Hanjun Qin, Ubaydah Nasri, Arthur D. Riggs, PhD, Paul J Martin, MD, Xi Zhang, Defu Zeng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 198.
https://doi.org/10.1182/blood-2019-127228
Published: 2019
Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Free
Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019