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Journal Articles

Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia

Shanshan Suo, Dandan Zhao, Fenglin Li, Yi Zhang, Sonia Rodriguez-Rodriguez, Le Xuan Truong Nguyen, Lucy Ghoda, Nadia Carlesso, Guido Marcucci, Bin Zhang, Jie Jin

Blood (2024) 144 (12): 1343–1347.

https://doi.org/10.1182/blood.2023023400

Published: 2024

Includes: Supplemental data

Journal Articles

A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-γ–induced CD38 expression

Blood (2024) 143 (16): 1599–1615.

https://doi.org/10.1182/blood.2023021570

Published: 2024

Includes: Supplemental data

Journal Articles

STI-8591, a Novel Tyrosine Kinase Inhibitor, Shows Excellent Antileukemic Activity in FLT3 -Mutated (mut) Acute Myeloid Leukemia (AML)

Yi Zhang, Wenwen Wei, Bin Zhang, Jie Sun, Dandan Zhao, Fang Chen, Yongfang Xu, Yu Qian, Yanchun Zhao, Yutong Zhou, Wanhong Xu, Xiaoying Zhang, Long Mao, Guido Marcucci, Xiao Xu, Jie Jin

Blood (2023) 142 (Supplement 1): 5010.

https://doi.org/10.1182/blood-2023-174745

Published: 2023

Journal Articles

Preliminary Safety, Pharmacological and Efficacy Data from Patients with Relapsed or Refractory B-Cell Malignancies Treated with the ICP-248, a Next Generation BCL2 Inhibitor

Shuhua Yi, Jie Jin, Keshu Zhou, Huayuan Zhu, Kate Ma, Rili Jiang, Weige Wang, Bin Zhang, Lugui Qiu

Blood (2023) 142 (Supplement 1): 6149.

https://doi.org/10.1182/blood-2023-182558

Published: 2023

Journal Articles

Pediatric Patients with Acute Lymphoblastic Leukemia Treated with Blinatumomab in a Real-World Study

Bin Zhang, Liangchun Hao

Blood (2023) 142 (Supplement 1): 5817.

https://doi.org/10.1182/blood-2023-181645

Published: 2023

Journal Articles

ZGGS15, a Novel IgG4 Bispecific Monoclonal Antibody Targeting Both LAG-3 and Tigit, Demonstrates Outstanding Anti-Tumor Activity and Can be Used As Monotherapy or in Combination with Anti-PD-1 Antibodies for Cancer Immunotherapy

Jifeng Yu, Tongcheng Dai, Hao Sun, Bin Zhang, Tyler Liban, Jessica Ochoa, Jackie Sheng, Yongping Song, Zhongxing Jiang, Zelin Sheng, Binhua Lv

Blood (2023) 142 (Supplement 1): 5764.

https://doi.org/10.1182/blood-2023-184775

Published: 2023

Journal Articles

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

Lianjun Zhang, Dinh Hoa Hoang, Hyunjun Kang, Ying-Chieh Chen, Yu-Hsuan Fu, Khyatiben V. Pathak, Melissa Valerio, Fang Chen, Katrina Estrella, Ralf Buettner, Bin Zhang, Patrick Pirrotte, Guido Marcucci, Ya-Huei Kuo, Le Xuan Truong Nguyen

Blood (2023) 142 (Supplement 1): 2953.

https://doi.org/10.1182/blood-2023-186936

Published: 2023

Journal Articles

Venetoclax Combined with Homoharringtonine and Cytarabine ( HAV) As Induction Treatment in Elder or Intensive Chemotherapy (IC) Ineligible Patients with Newly Diagnosed Acute Myeloid Leukemia

Kaiqi Liu, Xiaohui Suo, Guanchen Bai, Zhangsong Yan, Yang Li, Bin Zhang, Jinsong He, Jiesi Li, Shuning Wei, Qiuling Li, Bo Hu, Yingchang Mi

Blood (2023) 142 (Supplement 1): 4272.

https://doi.org/10.1182/blood-2023-179009

Published: 2023

Journal Articles

CD38-Directed, Single-Chain T Cell-Engager Targets Leukemia Stem Cells through IFNγ-Induced CD38 Expression

Blood (2023) 142 (Supplement 1): 2797.

https://doi.org/10.1182/blood-2023-189901

Published: 2023

Journal Articles

In Vivo Antileukemic Activity of Ost-01 in Acute Myeloid Leukemia (AML): A Novel Natural Product (NP) from Baccharis Coridifolia

Hyunjun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben V. Pathak, Lianjun Zhang, Ralf Buettner, Fang Chen, Katrina Estrella, William Graff, Ya-Huei Kuo, Bin Zhang, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci

Blood (2023) 142 (Supplement 1): 1565.

https://doi.org/10.1182/blood-2023-187736

Published: 2023

Journal Articles

Venetoclax Combining with Homoharringtonine，Daunorubicin and Cytarabine (HAD) As Induction Treatment in Newly Diagnosed Adult Acute Myeloid Leukemia Patients

Zhangsong Yan, Yang Li, Bin Zhang, Jinsong He, Jiesi Li, Shuning Wei, Qi Wang, Qiuling Li, Bo Hu, Kaiqi Liu, Yingchang Mi

Blood (2023) 142 (Supplement 1): 2895.

https://doi.org/10.1182/blood-2023-179087

Published: 2023

Journal Articles

IL1RAP-Specific T Cell Engager (TCE) Antibody Efficiently Depletes Acute Myeloid Leukemia (AML) Leukemic Stem Cells (LSCs)

Blood (2023) 142 (Supplement 1): 586.

https://doi.org/10.1182/blood-2023-185405

Published: 2023

Journal Articles

Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)

Blood (2023) 142 (Supplement 1): 3152.

https://doi.org/10.1182/blood-2023-182587

Published: 2023

Journal Articles

A Phase Ib Study to Evaluate the Safety and Efficacy of Nivolumab in Combination with R-CHOP in High-Risk DLBCL

Oluwatobi Odetola, Shuo Ma, Jane N. Winter, Barbara Pro, Ishan Roy, Ping Xie, Bin Zhang, George Koulogeorgas, Xinlei Mi, Robert Bayer, Robert Eisner, Valerie Nelson, Habib Shaikh, Dean Tsarwhas, Faisal Saghir, Parameswaran Venugopal, Leo I. Gordon, Reem Karmali

Blood (2023) 142 (Supplement 1): 4462.

https://doi.org/10.1182/blood-2023-185065

Published: 2023

Journal Articles

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Lianjun Zhang, Yu-Hsuan Fu, Wei-Kai Hua, Le Xuan Truong Nguyen, Yinghui Zhu, Ying-Chieh Chen, Xin He, Man Li, Haojie Dong, Bin Zhang, Ling Li, Jeremy Stark, Guido Marcucci, Ya-Huei Kuo

Blood (2023) 142 (Supplement 1): 5700.

https://doi.org/10.1182/blood-2023-182215

Published: 2023

Journal Articles

Synergistic Activity of Adefovir Dipivoxil and Venetoclax to Target the Bioenergetic Metabolism of Acute Myeloid Leukemia

Xubo Gong, Yi Zhang, Ying-Chieh Chen, Dandan Zhao, Yongfang Xu, Xin He, Fang Chen, Lei Zhang, Lianjun Zhang, Katrina Estrella, Melissa Valerio, Lucy Y. Ghoda, Le Xuan Truong Nguyen, Ya-Huei Kuo, Weiwei Liu, Zhihua Tao, Guido Marcucci, Bin Zhang

Blood (2023) 142 (Supplement 1): 4161.

https://doi.org/10.1182/blood-2023-187183

Published: 2023

Journal Articles

Uncovering the Transcriptional Landscape of CML Development and Therapeutic Interventions Via State-Transition Modeling

David Frankhouser, Dandan Zhao, Russell C. Rockne, Sergio Branciamore, Lisa Uechi, Denis O'Meally, Ya-Huei Kuo, Bin Zhang, Guido Marcucci

Blood (2023) 142 (Supplement 1): 3154.

https://doi.org/10.1182/blood-2023-188645

Published: 2023

Journal Articles

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study Evaluating the Efficacy and Safety of Orelabrutinib Plus R-CHOP Versus Placebo Plus R-CHOP in Treatment-Naïve Patients with Mcd Subtype Diffuse Large B-Cell Lymphoma

Pengpeng Xu, Ni Fan, Yamin Tian, Xinran Tang, Bin Zhang, Wei Zhou, Renbin Zhao, Weili Zhao

Blood (2022) 140 (Supplement 1): 12110.

https://doi.org/10.1182/blood-2022-158865

Published: 2022

Journal Articles

Homoharringtonine Exhibits Anti-Tumor Effect in T-Cell Acute Lymphoblastic Leukemia By Targeting Notch1/Myc Pathway

Shanshan Suo, Dandan Zhao, Fenglin Li, Sonia Rodriguez, Junjing Qiao, Chen Liang, Le Xuan Truong Nguyen, Dinh Hoa Hoang, Fang Chen, Ivan Rodriguez, Lucy Ghoda, Tinisha McDonald, Ling Li, Nadia Carlesso, Bin Zhang, Guido Marcucci, Jie Jin

Blood (2022) 140 (Supplement 1): 362–363.

https://doi.org/10.1182/blood-2022-169679

Published: 2022

Journal Articles

Targeting Leukemic Stem Cells in Acute Myeloid Leukemia Using a CpG-Linked Anti-Mir-126 Oligonucleotide

Lucy Y Ghoda, Ebtesam Nafie, Elizabeth Bloom-Saldana, Patrick T. Fueger, Timothy Synold, James Simpson, Piotr Swiderski, Kokilah Muthaiyah, Bin Zhang, Marcin Kortylewski, Steven Vonderfecht, Le Xuan Truong Nguyen, Jianying Zhang, Joycelynne Palmer, Guido Marcucci

Blood (2022) 140 (Supplement 1): 10673–10674.

https://doi.org/10.1182/blood-2022-171147

Published: 2022

NARROW

Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia

A CD38-directed, single-chain T-cell engager targets leukemia stem cells through IFN-γ–induced CD38 expression

STI-8591, a Novel Tyrosine Kinase Inhibitor, Shows Excellent Antileukemic Activity in FLT3 -Mutated (mut) Acute Myeloid Leukemia (AML)

Preliminary Safety, Pharmacological and Efficacy Data from Patients with Relapsed or Refractory B-Cell Malignancies Treated with the ICP-248, a Next Generation BCL2 Inhibitor

Pediatric Patients with Acute Lymphoblastic Leukemia Treated with Blinatumomab in a Real-World Study

ZGGS15, a Novel IgG4 Bispecific Monoclonal Antibody Targeting Both LAG-3 and Tigit, Demonstrates Outstanding Anti-Tumor Activity and Can be Used As Monotherapy or in Combination with Anti-PD-1 Antibodies for Cancer Immunotherapy

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

Venetoclax Combined with Homoharringtonine and Cytarabine ( HAV) As Induction Treatment in Elder or Intensive Chemotherapy (IC) Ineligible Patients with Newly Diagnosed Acute Myeloid Leukemia

CD38-Directed, Single-Chain T Cell-Engager Targets Leukemia Stem Cells through IFNγ-Induced CD38 Expression

In Vivo Antileukemic Activity of Ost-01 in Acute Myeloid Leukemia (AML): A Novel Natural Product (NP) from Baccharis Coridifolia

Venetoclax Combining with Homoharringtonine，Daunorubicin and Cytarabine (HAD) As Induction Treatment in Newly Diagnosed Adult Acute Myeloid Leukemia Patients

IL1RAP-Specific T Cell Engager (TCE) Antibody Efficiently Depletes Acute Myeloid Leukemia (AML) Leukemic Stem Cells (LSCs)

Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)

A Phase Ib Study to Evaluate the Safety and Efficacy of Nivolumab in Combination with R-CHOP in High-Risk DLBCL

Dysregulated Alternative Splicing in Inv(16) Acute Myeloid Leukemia Via U2AF1 Deacetylation during DNA Damage Response

Synergistic Activity of Adefovir Dipivoxil and Venetoclax to Target the Bioenergetic Metabolism of Acute Myeloid Leukemia

Uncovering the Transcriptional Landscape of CML Development and Therapeutic Interventions Via State-Transition Modeling

A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study Evaluating the Efficacy and Safety of Orelabrutinib Plus R-CHOP Versus Placebo Plus R-CHOP in Treatment-Naïve Patients with Mcd Subtype Diffuse Large B-Cell Lymphoma

Homoharringtonine Exhibits Anti-Tumor Effect in T-Cell Acute Lymphoblastic Leukemia By Targeting Notch1/Myc Pathway

Targeting Leukemic Stem Cells in Acute Myeloid Leukemia Using a CpG-Linked Anti-Mir-126 Oligonucleotide

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American Society of Hematology

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ASH Publications

American Society of Hematology

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