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Journal Articles

Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development

Nadine Müller-Calleja, Kristin Grunz, T. Son Nguyen, Jens Posma, Denise Pedrosa, Myriam Meineck, Anne Hollerbach, Johannes Braun, Sabine Muth, Hansjörg Schild, Kathrin Saar, Norbert Hübner, Sriram Krishnaswamy, Jennifer Royce, Luc Teyton, Niels Lemmermann, Julia Weinmann-Menke, Karl J. Lackner, Wolfram Ruf

Blood (2024) 143 (12): 1167–1180.

https://doi.org/10.1182/blood.2023022276

Published: 2024

Includes: Supplemental data

Journal Articles

Design of a Superior Factor VIIIa Mimetic By Coupling a Membrane Binding Domain to a Factor IXa Binding Antibody Fragment

Shekhar Kumar, Sriram Krishnaswamy

Blood (2023) 142 (Supplement 1): 22.

https://doi.org/10.1182/blood-2023-187228

Published: 2023

Journal Articles

Aptamer-Small Molecule Conjugates As Potent and Reversible Surgical Anticoagulants Targeting Thrombin

Haixiang Yu, Juliana Layzer, Sriram Krishnaswamy, Bruce A. Sullenger

Blood (2022) 140 (Supplement 1): 4953–4954.

https://doi.org/10.1182/blood-2022-163703

Published: 2022

Journal Articles

X-Ray Structure of Thrombin Bound to a Heterobifunctional Aptamer-Drug Conjugate Reveals the Mechanistic Basis for a Novel Tethered Inhibition Strategy

Shekhar Kumar, Haixiang Yu, Bruce A. Sullenger, Sriram Krishnaswamy

Blood (2022) 140 (Supplement 1): 1668–1669.

https://doi.org/10.1182/blood-2022-163410

Published: 2022

Journal Articles

A Spacer Sequence Inserted between the A1 and A2 Domains of Factor VIII Overcomes the Requirement for Proteolytic Cleavage at Arg 372 in the Generation of Cofactor Activity

Manjunath Goolyam Basavaraj, PhD, Sriram Krishnaswamy, PhD

Blood (2020) 136 (Supplement 1): 21.

https://doi.org/10.1182/blood-2020-142522

Published: 2020

Journal Articles

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

Douglas B. Cines, Sergei Zaitsev, Lubica Rauova, Ann H. Rux, Victoria Stepanova, Sriram Krishnaswamy, Amrita Sarkar, M. Anna Kowalska, Guohua Zhao, Alan E. Mast, Laurence J. Blumberg, Keith R. McCrae, Mortimer Poncz, Jonathan J. Hubbard, Michal Pyzik, Richard S. Blumberg

Blood (2020) 135 (23): 2085–2093.

https://doi.org/10.1182/blood.2019001133

Published: 2020

Includes: Supplemental data

Journal Articles

JNJ-64179375 Inhibits Exosite I-Mediated Thrombin Activity While Preserving Exosite II and Active Site Function in Vitro

Matthew Bunce, PhD, Madhu Chintala, PhD, Sriram Krishnaswamy, PhD, Harlan N Bradford, BA

Blood (2018) 132 (Supplement 1): 24.

https://doi.org/10.1182/blood-2018-99-116291

Published: 2018

Journal Articles

A Novel Variant of Factor VIII Yields Cofactor Activity without Proteolysis between the A1 and A2 Domains

Manjunath Goolyam Basavaraj, PhD, Sriram Krishnaswamy, PhD

Blood (2018) 132 (Supplement 1): 3771.

https://doi.org/10.1182/blood-2018-99-116267

Published: 2018

Journal Articles

A Single Cleavage Reaction in the Proteolytic Activation of Factor V to the Cofactor Is Rate-Limiting in a Step That Is Selectively Dependent on Anion Binding Exosite 2 of Thrombin

Harlan N Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2017) 130 (Supplement 1): 3649.

https://doi.org/10.1182/blood.V130.Suppl_1.3649.3649

Published: 2017

Journal Articles

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Yuichi Kamikubo, G. Loredana Mendolicchio, Antonella Zampolli, Patrizia Marchese, Andrea S. Rothmeier, Jennifer Nagrampa Orje, Andrew J. Gale, Sriram Krishnaswamy, András Gruber, Henrik Østergaard, Lars C. Petersen, Wolfram Ruf, Zaverio M. Ruggeri

Blood (2017) 130 (14): 1661–1670.

https://doi.org/10.1182/blood-2017-02-767079

Published: 2017

Includes: Supplemental data

Journal Articles

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

Shekhar Kumar, PhD, Wei Deng, PhD, Steven Stayrook, PhD, Renhao Li, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2016) 128 (22): 253.

https://doi.org/10.1182/blood.V128.22.253.253

Published: 2016

Journal Articles

Long-Range Allosteric Linkage Between Exosites Reciprocally Regulates the Zymogenicity of Prothrombin Derivatives

Joseph A. Micucci, PhD, Parvathi Kamath, PhD, Anuja Khan, PhD, Paul E. Bock, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 122.

https://doi.org/10.1182/blood.V126.23.122.122

Published: 2015

Journal Articles

The Affinity of Factor X for the Intrinsic Xase Is Determined By Exosite Interactions Between the Substrate and the Enzyme Complex

Manjunath Goolyam Basavaraj, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 1065.

https://doi.org/10.1182/blood.V126.23.1065.1065

Published: 2015

Journal Articles

The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox

Shekhar Kumar, PhD, Steven Stayrook, PhD, Rodney M. Camire, PhD, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 121.

https://doi.org/10.1182/blood.V126.23.121.121

Published: 2015

Journal Articles

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

Mikhail Galkin, PhD, Harlan Bradford, BA, Sriram Krishnaswamy, PhD

Blood (2015) 126 (23): 2267.

https://doi.org/10.1182/blood.V126.23.2267.2267

Published: 2015

Journal Articles

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

Lindsey A. Greene, MD, Nabil K. Thalji, BS, Harlan Bradford, BA, Sriram Krishnaswamy, PhD MD, Rodney M. Camire, PhD

Blood (2015) 126 (23): 124.

https://doi.org/10.1182/blood.V126.23.124.124

Published: 2015

Journal Articles

The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis

Kandace Gollomp, MD, Johnston Ian, Diarra Fatoumata, Guohua Zhao, Sriram Krishnaswamy, PhD MD, Mortimer Poncz, MD, M. Anna Kowalska, PhD

Blood (2015) 126 (23): 2197.

https://doi.org/10.1182/blood.V126.23.2197.2197

Published: 2015

Journal Articles

Platelet Pitp-Alpha Promotes Thrombin Generation and the Dissemination of Tumor Metastasis, but Has Minimal Effect on Vascular Plug Formation

Liang Zhao, PhD, Lurong Lian, Aae Suzuki, Timothy J. Stalker, PhD, Sang H Min, MD, Sriram Krishnaswamy, PhD MD, Amy Durham, VMD, Charles S. Abrams, MD

Blood (2015) 126 (23): 418.

https://doi.org/10.1182/blood.V126.23.418.418

Published: 2015

Journal Articles

FVIII-VWF dos-à-dos

Sriram Krishnaswamy

Blood (2015) 126 (8): 923–924.

https://doi.org/10.1182/blood-2015-06-652073

Published: 2015

Journal Articles

A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis

M. Anna Kowalska, PhD, Guohua Zhao, PhD, Ian Johnston, BS, Elsa Treffeisen, BA, Fatoumata Diarra, Sriram Krishnaswamy, PhD, Mortimer Poncz, MD

Blood (2014) 124 (21): 98.

https://doi.org/10.1182/blood.V124.21.98.98

Published: 2014

NARROW

Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development

Design of a Superior Factor VIIIa Mimetic By Coupling a Membrane Binding Domain to a Factor IXa Binding Antibody Fragment

Aptamer-Small Molecule Conjugates As Potent and Reversible Surgical Anticoagulants Targeting Thrombin

X-Ray Structure of Thrombin Bound to a Heterobifunctional Aptamer-Drug Conjugate Reveals the Mechanistic Basis for a Novel Tethered Inhibition Strategy

A Spacer Sequence Inserted between the A1 and A2 Domains of Factor VIII Overcomes the Requirement for Proteolytic Cleavage at Arg 372 in the Generation of Cofactor Activity

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

JNJ-64179375 Inhibits Exosite I-Mediated Thrombin Activity While Preserving Exosite II and Active Site Function in Vitro

A Novel Variant of Factor VIII Yields Cofactor Activity without Proteolysis between the A1 and A2 Domains

A Single Cleavage Reaction in the Proteolytic Activation of Factor V to the Cofactor Is Rate-Limiting in a Step That Is Selectively Dependent on Anion Binding Exosite 2 of Thrombin

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Structural Basis for the Procofactor to Cofactor Transition in Human Factor V

Long-Range Allosteric Linkage Between Exosites Reciprocally Regulates the Zymogenicity of Prothrombin Derivatives

The Affinity of Factor X for the Intrinsic Xase Is Determined By Exosite Interactions Between the Substrate and the Enzyme Complex

The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox

Assembly of Prothrombinase on Endothelial Cells: Receptor-Mediated or Phospholipid-Driven?

Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo

The NET Effect: Platelet Factor 4 and DNA-Histone Interactions in Sepsis

Platelet Pitp-Alpha Promotes Thrombin Generation and the Dissemination of Tumor Metastasis, but Has Minimal Effect on Vascular Plug Formation

FVIII-VWF dos-à-dos

A Proposed Role for Platelet Factor 4 in Histone Pathobiology in Sepsis

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American Society of Hematology

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American Society of Hematology

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